Mineral density volume gradients in normal and diseased human tissues
Abstract
Clinical computed tomography provides a single mineral density (MD) value for heterogeneous calcified tissues containing early and late stage pathologic formations. The novel aspect of this study is that, it extends current quantitative methods of mapping mineral density gradients to three dimensions, discretizes early and late mineralized stages, identifies elemental distribution in discretized volumes, and correlates measured MD with respective calcium (Ca) to phosphorus (P) and Ca to zinc (Zn) elemental ratios. To accomplish this, MD variations identified using polychromatic radiation from a high resolution micro-computed tomography (micro-CT) benchtop unit were correlated with elemental mapping obtained from a microprobe X-ray fluorescence (XRF) using synchrotron monochromatic radiation. Digital segmentation of tomograms from normal and diseased tissues (N=5 per group; 40-60 year old males) contained significant mineral density variations (enamel: 2820-3095mg/cc, bone: 570-1415mg/cc, cementum: 1240-1340mg/cc, dentin: 1480-1590mg/cc, cementum affected by periodontitis: 1100-1220mg/cc, hypomineralized carious dentin: 345-1450mg/cc, hypermineralized carious dentin: 1815-2740mg/cc, and dental calculus: 1290-1770mg/cc). A plausible linear correlation between segmented MD volumes and elemental ratios within these volumes was established, and Ca/P ratios for dentin (1.49), hypomineralized dentin (0.32-0.46), cementum (1.51), and bone (1.68) were observed. Furthermore, varying Ca/Zn ratios were distinguished in adapted compared to normal tissues, such as in bonemore »
- Authors:
-
- University of San Francisco, San Francisco, CA (United States)
- XradiaInc., Pleasanton, CA (United States)
- SLAC National Accelerator Lab., Menlo Park, CA (United States)
- Harvard Medical School, Cambridge, MA (United States)
- Publication Date:
- Research Org.:
- SLAC National Accelerator Laboratory (SLAC), Menlo Park, CA (United States)
- Sponsoring Org.:
- USDOE Office of Science (SC)
- OSTI Identifier:
- 1201659
- Grant/Contract Number:
- AC02-76SF00515
- Resource Type:
- Accepted Manuscript
- Journal Name:
- PLoS ONE
- Additional Journal Information:
- Journal Volume: 10; Journal Issue: 4; Conference: Naples (Italy), 3-5 Jun 2014; Journal ID: ISSN 1932-6203
- Publisher:
- Public Library of Science
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES
Citation Formats
Djomehri, Sabra I., Candell, Susan, Case, Thomas, Browning, Alyssa, Marshall, Grayson W., Yun, Wenbing, Lau, S. H., Webb, Samuel, Ho, Sunita P., and Aikawa, Elena. Mineral density volume gradients in normal and diseased human tissues. United States: N. p., 2015.
Web. doi:10.1371/journal.pone.0121611.
Djomehri, Sabra I., Candell, Susan, Case, Thomas, Browning, Alyssa, Marshall, Grayson W., Yun, Wenbing, Lau, S. H., Webb, Samuel, Ho, Sunita P., & Aikawa, Elena. Mineral density volume gradients in normal and diseased human tissues. United States. https://doi.org/10.1371/journal.pone.0121611
Djomehri, Sabra I., Candell, Susan, Case, Thomas, Browning, Alyssa, Marshall, Grayson W., Yun, Wenbing, Lau, S. H., Webb, Samuel, Ho, Sunita P., and Aikawa, Elena. Thu .
"Mineral density volume gradients in normal and diseased human tissues". United States. https://doi.org/10.1371/journal.pone.0121611. https://www.osti.gov/servlets/purl/1201659.
@article{osti_1201659,
title = {Mineral density volume gradients in normal and diseased human tissues},
author = {Djomehri, Sabra I. and Candell, Susan and Case, Thomas and Browning, Alyssa and Marshall, Grayson W. and Yun, Wenbing and Lau, S. H. and Webb, Samuel and Ho, Sunita P. and Aikawa, Elena},
abstractNote = {Clinical computed tomography provides a single mineral density (MD) value for heterogeneous calcified tissues containing early and late stage pathologic formations. The novel aspect of this study is that, it extends current quantitative methods of mapping mineral density gradients to three dimensions, discretizes early and late mineralized stages, identifies elemental distribution in discretized volumes, and correlates measured MD with respective calcium (Ca) to phosphorus (P) and Ca to zinc (Zn) elemental ratios. To accomplish this, MD variations identified using polychromatic radiation from a high resolution micro-computed tomography (micro-CT) benchtop unit were correlated with elemental mapping obtained from a microprobe X-ray fluorescence (XRF) using synchrotron monochromatic radiation. Digital segmentation of tomograms from normal and diseased tissues (N=5 per group; 40-60 year old males) contained significant mineral density variations (enamel: 2820-3095mg/cc, bone: 570-1415mg/cc, cementum: 1240-1340mg/cc, dentin: 1480-1590mg/cc, cementum affected by periodontitis: 1100-1220mg/cc, hypomineralized carious dentin: 345-1450mg/cc, hypermineralized carious dentin: 1815-2740mg/cc, and dental calculus: 1290-1770mg/cc). A plausible linear correlation between segmented MD volumes and elemental ratios within these volumes was established, and Ca/P ratios for dentin (1.49), hypomineralized dentin (0.32-0.46), cementum (1.51), and bone (1.68) were observed. Furthermore, varying Ca/Zn ratios were distinguished in adapted compared to normal tissues, such as in bone (855-2765) and in cementum (595-990), highlighting Zn as an influential element in prompting observed adaptive properties. Hence, results provide insights on mineral density gradients with elemental concentrations and elemental footprints that in turn could aid in elucidating mechanistic processes for pathologic formations.},
doi = {10.1371/journal.pone.0121611},
journal = {PLoS ONE},
number = 4,
volume = 10,
place = {United States},
year = {Thu Apr 09 00:00:00 EDT 2015},
month = {Thu Apr 09 00:00:00 EDT 2015}
}
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