Construction of Reconfigurable and Polymorphic DNA Origami Assemblies with Coiled‐Coil Patches and Patterns

Teng, Teng; Bernal‐Chanchavac, Julio; Stephanopoulos, Nicholas; Castro, Carlos E.

doi:10.1002/advs.202307257

Title: Construction of Reconfigurable and Polymorphic DNA Origami Assemblies with Coiled‐Coil Patches and Patterns

Abstract

Abstract DNA origami nanodevices achieve programmable structure and tunable mechanical and dynamic properties by leveraging the sequence‐specific interactions of nucleic acids. Previous advances have also established DNA origami as a useful building block to make well‐defined micron‐scale structures through hierarchical self‐assembly, but these efforts have largely leveraged the structural features of DNA origami. The tunable dynamic and mechanical properties also provide an opportunity to make assemblies with adaptive structures and properties. Here the integration of DNA origami hinge nanodevices and coiled‐coil peptides are reported into hybrid reconfigurable assemblies. With the same dynamic device and peptide interaction, it is made multiple higher‐order assemblies (i.e., polymorphic assembly) by organizing clusters of peptides into patches or arranging single peptides into patterns on the surfaces of DNA origami to control the relative orientation of devices. The coiled‐coil interactions are used to construct circular and linear assemblies whose structure and mechanical properties can be modulated with DNA‐based reconfiguration. Reconfiguration of linear assemblies leads to micron scale motions and ≈2.5‐10‐fold increase in bending stiffness. The results provide a foundation for stimulus‐responsive hybrid assemblies that can adapt their structure and properties in response to nucleic acid, peptide, protein, or other triggers.

Authors:

Teng, Teng ^[1]; Bernal‐Chanchavac, Julio ^[2];

^[2];

^[1]

Department of Mechanical and Aerospace Engineering The Ohio State University Columbus OH 43210 USA
School of Molecular Sciences Arizona State University Tempe AZ 85287 USA, Center for Molecular Design and Biomimetics The Biodesign Institute, Arizona State University Tempe AZ 85287 USA

Publication Date:: Fri Mar 08 00:00:00 EST 2024

Sponsoring Org.:: USDOE

OSTI Identifier:: 2322449

Alternate Identifier(s):: OSTI ID: 2322450

Resource Type:: Published Article

Journal Name:: Advanced Science

Additional Journal Information:: Journal Name: Advanced Science; Journal ID: ISSN 2198-3844

Publisher:: Wiley Blackwell (John Wiley & Sons)

Country of Publication:: Germany

Language:: English

Citation Formats


                    Teng, Teng, Bernal‐Chanchavac, Julio, Stephanopoulos, Nicholas, and Castro, Carlos E. Construction of Reconfigurable and Polymorphic DNA Origami Assemblies with Coiled‐Coil Patches and Patterns.  Germany: N. p., 2024. 
Web.  doi:10.1002/advs.202307257.

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                    Teng, Teng, Bernal‐Chanchavac, Julio, Stephanopoulos, Nicholas, & Castro, Carlos E. Construction of Reconfigurable and Polymorphic DNA Origami Assemblies with Coiled‐Coil Patches and Patterns.  Germany.  https://doi.org/10.1002/advs.202307257

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                    Teng, Teng, Bernal‐Chanchavac, Julio, Stephanopoulos, Nicholas, and Castro, Carlos E. Fri .  
"Construction of Reconfigurable and Polymorphic DNA Origami Assemblies with Coiled‐Coil Patches and Patterns".  Germany.  https://doi.org/10.1002/advs.202307257.

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@article{osti_2322449,

  title        = {Construction of Reconfigurable and Polymorphic DNA Origami Assemblies with Coiled‐Coil Patches and Patterns},

  author       = {Teng, Teng and Bernal‐Chanchavac, Julio and Stephanopoulos, Nicholas and Castro, Carlos E.},

  abstractNote = {Abstract DNA origami nanodevices achieve programmable structure and tunable mechanical and dynamic properties by leveraging the sequence‐specific interactions of nucleic acids. Previous advances have also established DNA origami as a useful building block to make well‐defined micron‐scale structures through hierarchical self‐assembly, but these efforts have largely leveraged the structural features of DNA origami. The tunable dynamic and mechanical properties also provide an opportunity to make assemblies with adaptive structures and properties. Here the integration of DNA origami hinge nanodevices and coiled‐coil peptides are reported into hybrid reconfigurable assemblies. With the same dynamic device and peptide interaction, it is made multiple higher‐order assemblies (i.e., polymorphic assembly) by organizing clusters of peptides into patches or arranging single peptides into patterns on the surfaces of DNA origami to control the relative orientation of devices. The coiled‐coil interactions are used to construct circular and linear assemblies whose structure and mechanical properties can be modulated with DNA‐based reconfiguration. Reconfiguration of linear assemblies leads to micron scale motions and ≈2.5‐10‐fold increase in bending stiffness. The results provide a foundation for stimulus‐responsive hybrid assemblies that can adapt their structure and properties in response to nucleic acid, peptide, protein, or other triggers.},

  doi          = {10.1002/advs.202307257},

  journal      = {Advanced Science},

  number       = ,

  volume       = ,

  place        = {Germany},

  year         = {Fri Mar 08 00:00:00 EST 2024},

  month        = {Fri Mar 08 00:00:00 EST 2024}

}

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Title: Construction of Reconfigurable and Polymorphic DNA Origami Assemblies with Coiled‐Coil Patches and Patterns

Abstract

Citation Formats

Measuring molecular rupture forces between single actin filaments and actin-binding proteins journal, July 2008

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Bioactive Fibronectin-III10–DNA Origami Nanofibers Promote Cell Adhesion and Spreading journal, September 2022

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Concepts and Application of DNA Origami and DNA Self-Assembly: A Systematic Review journal, November 2021

Multi-micron crisscross structures grown from DNA-origami slats journal, December 2022

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The Beauty and Utility of DNA Origami
journal, March 2017

Design of Stimuli‐Responsive Peptides and Proteins
journal, December 2022

DNA origami tubes with reconfigurable cross-sections
journal, January 2023

Rational Design of a Reversible pH-Responsive Switch for Peptide Self-Assembly
journal, May 2006

A primer to scaffolded DNA origami
journal, February 2011

Self-assembly for the synthesis of functional biomaterials
journal, February 2013

Self‐Assembling Peptide‐Based Functional Biomaterials
journal, November 2022

DNA-Guided Plasmonic Helix with Switchable Chirality
journal, August 2018

DNA origami directed 3D nanoparticle superlattice via electrostatic assembly
journal, January 2019

Designing the Self-Assembly of Arbitrary Shapes Using Minimal Complexity Building Blocks
journal, February 2023

Hierarchical self-assembly of DNA into symmetric supramolecular polyhedra
journal, March 2008