Viruses interact with hosts that span distantly related microbial domains in dense hydrothermal mats
Abstract
Abstract Many microbes in nature reside in dense, metabolically interdependent communities. We investigated the nature and extent of microbe-virus interactions in relation to microbial density and syntrophy by examining microbe-virus interactions in a biomass dense, deep-sea hydrothermal mat. Using metagenomic sequencing, we find numerous instances where phylogenetically distant (up to domain level) microbes encode CRISPR-based immunity against the same viruses in the mat. Evidence of viral interactions with hosts cross-cutting microbial domains is particularly striking between known syntrophic partners, for example those engaged in anaerobic methanotrophy. These patterns are corroborated by proximity-ligation-based (Hi-C) inference. Surveys of public datasets reveal additional viruses interacting with hosts across domains in diverse ecosystems known to harbour syntrophic biofilms. We propose that the entry of viral particles and/or DNA to non-primary host cells may be a common phenomenon in densely populated ecosystems, with eco-evolutionary implications for syntrophic microbes and CRISPR-mediated inter-population augmentation of resilience against viruses.
- Publication Date:
- Research Org.:
- Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States); USDOE Joint Genome Institute (JGI), Berkeley, CA (United States)
- Sponsoring Org.:
- USDOE; USDOE Office of Science (SC), Basic Energy Sciences (BES). Scientific User Facilities (SUF); Gordon and Betty Moore Foundation; National Science Foundation (NSF); National Aeronautics and Space Administration (NASA)
- OSTI Identifier:
- 1968630
- Alternate Identifier(s):
- OSTI ID: 2234130
- Grant/Contract Number:
- AC02-05CH11231; 9208; OCE-1635365; 80NSSC18K1140; 80NSSC19K1427
- Resource Type:
- Published Article
- Journal Name:
- Nature Microbiology
- Additional Journal Information:
- Journal Name: Nature Microbiology Journal Volume: 8 Journal Issue: 5; Journal ID: ISSN 2058-5276
- Publisher:
- Nature Publishing Group
- Country of Publication:
- United Kingdom
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES
Citation Formats
Hwang, Yunha, Roux, Simon, Coclet, Clément, Krause, Sebastian J. E., and Girguis, Peter R. Viruses interact with hosts that span distantly related microbial domains in dense hydrothermal mats. United Kingdom: N. p., 2023.
Web. doi:10.1038/s41564-023-01347-5.
Hwang, Yunha, Roux, Simon, Coclet, Clément, Krause, Sebastian J. E., & Girguis, Peter R. Viruses interact with hosts that span distantly related microbial domains in dense hydrothermal mats. United Kingdom. https://doi.org/10.1038/s41564-023-01347-5
Hwang, Yunha, Roux, Simon, Coclet, Clément, Krause, Sebastian J. E., and Girguis, Peter R. Thu .
"Viruses interact with hosts that span distantly related microbial domains in dense hydrothermal mats". United Kingdom. https://doi.org/10.1038/s41564-023-01347-5.
@article{osti_1968630,
title = {Viruses interact with hosts that span distantly related microbial domains in dense hydrothermal mats},
author = {Hwang, Yunha and Roux, Simon and Coclet, Clément and Krause, Sebastian J. E. and Girguis, Peter R.},
abstractNote = {Abstract Many microbes in nature reside in dense, metabolically interdependent communities. We investigated the nature and extent of microbe-virus interactions in relation to microbial density and syntrophy by examining microbe-virus interactions in a biomass dense, deep-sea hydrothermal mat. Using metagenomic sequencing, we find numerous instances where phylogenetically distant (up to domain level) microbes encode CRISPR-based immunity against the same viruses in the mat. Evidence of viral interactions with hosts cross-cutting microbial domains is particularly striking between known syntrophic partners, for example those engaged in anaerobic methanotrophy. These patterns are corroborated by proximity-ligation-based (Hi-C) inference. Surveys of public datasets reveal additional viruses interacting with hosts across domains in diverse ecosystems known to harbour syntrophic biofilms. We propose that the entry of viral particles and/or DNA to non-primary host cells may be a common phenomenon in densely populated ecosystems, with eco-evolutionary implications for syntrophic microbes and CRISPR-mediated inter-population augmentation of resilience against viruses.},
doi = {10.1038/s41564-023-01347-5},
journal = {Nature Microbiology},
number = 5,
volume = 8,
place = {United Kingdom},
year = {Thu Apr 06 00:00:00 EDT 2023},
month = {Thu Apr 06 00:00:00 EDT 2023}
}
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