Search Menu
DOE PAGES title logo U.S. Department of Energy
Office of Scientific and Technical Information
Search Scholarly Publications

Title: Biocompatibility of NbTaTiVZr with Surface Modifications for Osteoblasts

Abstract

Here, we report a potential biomedical material, NbTaTiVZr, and the impact of surface roughness on the osteoblast culture and later behavior based on in vitro tests of preosteoblasts. Cell activities such as adhesion, viability, and typical protein activity on NbTaTiVZr showed comparable results with that of commercially pure Ti (CP-Ti). In addition, NbTaTiVZr with a smooth surface exhibits better cell adhesion, viability, and typical protein activity which shows that surface modification can improve the biocompatibility of NbTaTiVZr. This supports the biological evidence and shows that NbTaTiVZr can potentially be evaluated as a biomedical material for clinical use.

Authors:
 [1];  [2];  [2];  [3];  [4]; ORCiD logo [5];  [6]; ORCiD logo [7]
+ Show Author Affiliations
  1. Chang Gung Memorial Hospital, New Taipei City (Taiwan); National Tsing Hua University, Hsinchu (Taiwan)
  2. National Yang Ming Chiao Tung University, Hsinchu (Taiwan)
  3. University of Tennessee, Knoxville, TN (United States); Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
  4. Chang Gung Memorial Hospital, Yunlin (Taiwan)
  5. Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
  6. University of Tennessee, Knoxville, TN (United States)
  7. National Yang Ming Chiao Tung University, Hsinchu (Taiwan); National Taiwan University, Taipei (Taiwan)
Publication Date:
Research Org.:
Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
Sponsoring Org.:
USDOE Office of Science (SC); Ministry of Science and Technology of Taiwan; Chang Gung Medical Foundation; National Yang Ming Chiao Tung University (NYCU); Ministry of Education (MOE) Taiwan; National Science Foundation (NSF); US Army Research Office
OSTI Identifier:
1888905
Grant/Contract Number:  
AC05-00OR22725; MOST-110-2636-M-009-008; CMRPG3J1131; CMRPVVK0141; DMR-1611180; DMR-1809640; W(11NF-13-1-0438; W911NF-19-2-0049
Resource Type:
Accepted Manuscript
Journal Name:
ACS Applied Bio Materials
Additional Journal Information:
Journal Volume: 5; Journal Issue: 2; Journal ID: ISSN 2576-6422
Publisher:
ACS Publications
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; biomedical material; NbTaTiVZr; surface modification; in vitro test; biocompatibility

Citation Formats

Lin, Shih-Jie, Lin, Jia-An, Yu, Wei, Lee, Chanho, Hung, Chun-Yu, Poplawsky, Jonathan D., Liaw, Peter K., and Chou, Yi-Chia. Biocompatibility of NbTaTiVZr with Surface Modifications for Osteoblasts. United States: N. p., 2022. Web. doi:10.1021/acsabm.1c01103.
Copy to clipboard
Lin, Shih-Jie, Lin, Jia-An, Yu, Wei, Lee, Chanho, Hung, Chun-Yu, Poplawsky, Jonathan D., Liaw, Peter K., & Chou, Yi-Chia. Biocompatibility of NbTaTiVZr with Surface Modifications for Osteoblasts. United States. https://doi.org/10.1021/acsabm.1c01103
Copy to clipboard
Lin, Shih-Jie, Lin, Jia-An, Yu, Wei, Lee, Chanho, Hung, Chun-Yu, Poplawsky, Jonathan D., Liaw, Peter K., and Chou, Yi-Chia. Wed . "Biocompatibility of NbTaTiVZr with Surface Modifications for Osteoblasts". United States. https://doi.org/10.1021/acsabm.1c01103. https://www.osti.gov/servlets/purl/1888905.
Copy to clipboard
@article{osti_1888905,
title = {Biocompatibility of NbTaTiVZr with Surface Modifications for Osteoblasts},
author = {Lin, Shih-Jie and Lin, Jia-An and Yu, Wei and Lee, Chanho and Hung, Chun-Yu and Poplawsky, Jonathan D. and Liaw, Peter K. and Chou, Yi-Chia},
abstractNote = {Here, we report a potential biomedical material, NbTaTiVZr, and the impact of surface roughness on the osteoblast culture and later behavior based on in vitro tests of preosteoblasts. Cell activities such as adhesion, viability, and typical protein activity on NbTaTiVZr showed comparable results with that of commercially pure Ti (CP-Ti). In addition, NbTaTiVZr with a smooth surface exhibits better cell adhesion, viability, and typical protein activity which shows that surface modification can improve the biocompatibility of NbTaTiVZr. This supports the biological evidence and shows that NbTaTiVZr can potentially be evaluated as a biomedical material for clinical use.},
doi = {10.1021/acsabm.1c01103},
journal = {ACS Applied Bio Materials},
number = 2,
volume = 5,
place = {United States},
year = {Wed Jan 26 00:00:00 EST 2022},
month = {Wed Jan 26 00:00:00 EST 2022}
}
Copy to clipboard
Journal Article:
Free Publicly Available Full Text
Publisher's Version of Record
https://doi.org/10.1021/acsabm.1c01103
Copyright Statement
Other availability
Search WorldCat Search WorldCat to find libraries that may hold this journal
Save / Share:
Export Metadata
Save to My Library
You must Sign In or Create an Account in order to save documents to your library.

Works referenced in this record:

Lattice distortion in a strong and ductile refractory high-entropy alloy
journal, November 2018

Analysis for determining surface free energy uncertainty by the Owen–Wendt method
journal, June 2009

An In Vitro Evaluation of the Hierarchical Micro/Nanoporous Structure of a Ti3Zr2Sn3Mo25Nb Alloy after Surface Dealloying
journal, March 2021

  • Wang, Lan; Zhou, Wenhao; Yu, Zhentao
  • ACS Applied Materials & Interfaces, Vol. 13, Issue 13
  • DOI: 10.1021/acsami.1c02140

Novel TiNbTaZrMo high-entropy alloys for metallic biomaterials
journal, March 2017

Microstructural development in equiatomic multicomponent alloys
journal, July 2004

Formation, structure and properties of biocompatible TiZrHfNbTa high-entropy alloys
journal, March 2019

Robust Biomimetic Hierarchical Diamond Architecture with a Self-Cleaning, Antibacterial, and Antibiofouling Surface
journal, April 2020

  • Wang, Tao; Huang, Lei; Liu, Yuzhi
  • ACS Applied Materials & Interfaces, Vol. 12, Issue 21
  • DOI: 10.1021/acsami.0c02460

Magnetic Field-Guided MoS2/WS2 Heterolayered Nanofilm Regulates Cell Behavior and Gene Expression
journal, October 2021

  • Luo, Jiwei; Zhou, Qixing; Hu, Xiangang
  • ACS Applied Nano Materials, Vol. 4, Issue 10
  • DOI: 10.1021/acsanm.1c02264

Microstructure and room temperature properties of a high-entropy TaNbHfZrTi alloy
journal, May 2011

Effect of lattice distortion on solid solution strengthening of BCC high-entropy alloys
journal, February 2018

  • Wang, Zhipeng; Fang, Qihong; Li, Jia
  • Journal of Materials Science & Technology, Vol. 34, Issue 2
  • DOI: 10.1016/j.jmst.2017.07.013

Microstructures and mechanical properties of ductile NbTaTiV refractory high entropy alloy prepared by powder metallurgy
journal, March 2019

Biologically and Mechanically Biocompatible Titanium Alloys
journal, January 2008

Fundamental electronic structure and multiatomic bonding in 13 biocompatible high-entropy alloys
journal, May 2020

Nanostructured High-Entropy Alloys with Multiple Principal Elements: Novel Alloy Design Concepts and Outcomes
journal, May 2004

  • Yeh, J.-W.; Chen, S.-K.; Lin, S.-J.
  • Advanced Engineering Materials, Vol. 6, Issue 5, p. 299-303
  • DOI: 10.1002/adem.200300567

Microstructures and properties of high-entropy alloys
journal, April 2014

Biomaterials in orthopaedics
journal, July 2008

  • Navarro, M.; Michiardi, A.; Castaño, O.
  • Journal of The Royal Society Interface, Vol. 5, Issue 27
  • DOI: 10.1098/rsif.2008.0151

Wear Characteristics of Surface Oxidation Treated New Biomedical β-type Titanium Alloy in Simulated Body Environment
journal, January 2002

In vitro responses of bone-forming MC3T3-E1 pre-osteoblasts to biodegradable Mg-based bulk metallic glasses
journal, November 2016

Solid-Solution Phase Formation Rules for Multi-component Alloys
journal, June 2008

  • Zhang, Y.; Zhou, Y. J.; Lin, J. P.
  • Advanced Engineering Materials, Vol. 10, Issue 6, p. 534-538
  • DOI: 10.1002/adem.200700240

Wear and Mechanical Properties, and Cell Viability of Gas-Nitrided Beta-Type Ti-Nb-Ta-Zr System Alloy for Biomedical Applications
journal, January 2008

TiZrNbTaMo high-entropy alloy designed for orthopedic implants: As-cast microstructure and mechanical properties
journal, April 2017

Ti based biomaterials, the ultimate choice for orthopaedic implants – A review
journal, May 2009

Functionalized TiO 2 Based Nanomaterials for Biomedical Applications
journal, July 2014

  • Wu, Shuilin; Weng, Zhengyang; Liu, Xiangmei
  • Advanced Functional Materials, Vol. 24, Issue 35
  • DOI: 10.1002/adfm.201400706

Engineering a Bioactive Hybrid Coating for In Vitro Corrosion Control of Magnesium and Its Alloy
journal, June 2021

  • Rahman, Md. Mostafizur; Balu, Rajkamal; Abraham, Amanda
  • ACS Applied Bio Materials, Vol. 4, Issue 7
  • DOI: 10.1021/acsabm.1c00366

Responses of bone-forming cells on pre-immersed Zr-based bulk metallic glasses: Effects of composition and roughness
journal, January 2011

Aging response of the young’s modulus and mechanical properties of Ti-29Nb-13Ta-4.6Zr for biomedical applications
journal, April 2003

  • Hao, Y. L.; Yang, R.; Niinomi, M.
  • Metallurgical and Materials Transactions A, Vol. 34, Issue 4
  • DOI: 10.1007/s11661-003-0230-x

Titanium-Based Biomaterials for Preventing Stress Shielding between Implant Devices and Bone
journal, January 2011

  • Niinomi, M.; Nakai, M.
  • International Journal of Biomaterials, Vol. 2011
  • DOI: 10.1155/2011/836587

Nanochannelar Topography Positively Modulates Osteoblast Differentiation and Inhibits Osteoclastogenesis
journal, August 2018

Mechanical biocompatibilities of titanium alloys for biomedical applications
journal, January 2008

Ultrathin Diamond Nanofilms—Development, Challenges, and Applications
journal, May 2021

Development of non-equiatomic Ti-Nb-Ta-Zr-Mo high-entropy alloys for metallic biomaterials
journal, November 2019

Bio-corrosion behavior and in vitro biocompatibility of equimolar TiZrHfNbTa high-entropy alloy
journal, September 2020

    Sort by:
    [ × clear filter / sort ]

    Similar Records in DOE PAGES and OSTI.GOV collections: