Biocompatibility of NbTaTiVZr with Surface Modifications for Osteoblasts

Lin, Shih-Jie; Lin, Jia-An; Yu, Wei; Lee, Chanho; Hung, Chun-Yu; Poplawsky, Jonathan D.; Liaw, Peter K.; Chou, Yi-Chia

doi:10.1021/acsabm.1c01103

Title: Biocompatibility of NbTaTiVZr with Surface Modifications for Osteoblasts

Journal Article · 26 January 2022 · ACS Applied Bio Materials

DOI: https://doi.org/10.1021/acsabm.1c01103 · OSTI ID:1888905

Lin, Shih-Jie ^[1]; Lin, Jia-An ^[2]; Yu, Wei ^[2]; Lee, Chanho ^[3]; Hung, Chun-Yu ^[4];

^[5]; Liaw, Peter K. ^[6];

^[7]

Chang Gung Memorial Hospital, New Taipei City (Taiwan); National Tsing Hua University, Hsinchu (Taiwan)
National Yang Ming Chiao Tung University, Hsinchu (Taiwan)
University of Tennessee, Knoxville, TN (United States); Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
Chang Gung Memorial Hospital, Yunlin (Taiwan)
Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
University of Tennessee, Knoxville, TN (United States)
National Yang Ming Chiao Tung University, Hsinchu (Taiwan); National Taiwan University, Taipei (Taiwan)

Here, we report a potential biomedical material, NbTaTiVZr, and the impact of surface roughness on the osteoblast culture and later behavior based on in vitro tests of preosteoblasts. Cell activities such as adhesion, viability, and typical protein activity on NbTaTiVZr showed comparable results with that of commercially pure Ti (CP-Ti). In addition, NbTaTiVZr with a smooth surface exhibits better cell adhesion, viability, and typical protein activity which shows that surface modification can improve the biocompatibility of NbTaTiVZr. This supports the biological evidence and shows that NbTaTiVZr can potentially be evaluated as a biomedical material for clinical use.

View Accepted Manuscript (DOE)

Cite

Export

Save

Research Organization:: Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States); Los Alamos National Laboratory (LANL), Los Alamos, NM (United States)

Sponsoring Organization:: USDOE Office of Science (SC); Ministry of Science and Technology of Taiwan; Chang Gung Medical Foundation; National Yang Ming Chiao Tung University (NYCU); Ministry of Education (MOE) Taiwan; National Science Foundation (NSF); US Army Research Office

Grant/Contract Number:: AC05-00OR22725

OSTI ID:: 1888905

Journal Information:: ACS Applied Bio Materials, Journal Name: ACS Applied Bio Materials Journal Issue: 2 Vol. 5; ISSN 2576-6422

Publisher:: ACS PublicationsCopyright Statement

Country of Publication:: United States

Language:: English

References (32)

Nanostructured High-Entropy Alloys with Multiple Principal Elements: Novel Alloy Design Concepts and Outcomes Yeh, J.-W.; Chen, S.-K.; Lin, S.-J. Advanced Engineering Materials, Vol. 6, Issue 5, p. 299-303 https://doi.org/10.1002/adem.200300567	journal	May 2004
Solid-Solution Phase Formation Rules for Multi-component Alloys Zhang, Y.; Zhou, Y. J.; Lin, J. P. Advanced Engineering Materials, Vol. 10, Issue 6, p. 534-538 https://doi.org/10.1002/adem.200700240	journal	June 2008
Functionalized TiO ₂ Based Nanomaterials for Biomedical Applications Wu, Shuilin; Weng, Zhengyang; Liu, Xiangmei Advanced Functional Materials, Vol. 24, Issue 35 https://doi.org/10.1002/adfm.201400706	journal	July 2014
Ultrathin Diamond Nanofilms—Development, Challenges, and Applications Handschuh‐Wang, Stephan; Wang, Tao; Tang, Yongbing Small, Vol. 17, Issue 30 https://doi.org/10.1002/smll.202007529	journal	May 2021
Aging response of the young’s modulus and mechanical properties of Ti-29Nb-13Ta-4.6Zr for biomedical applications Hao, Y. L.; Yang, R.; Niinomi, M. Metallurgical and Materials Transactions A, Vol. 34, Issue 4 https://doi.org/10.1007/s11661-003-0230-x	journal	April 2003
Lattice distortion in a strong and ductile refractory high-entropy alloy Lee, Chanho; Song, Gian; Gao, Michael C. Acta Materialia, Vol. 160 https://doi.org/10.1016/j.actamat.2018.08.053	journal	November 2018
Responses of bone-forming cells on pre-immersed Zr-based bulk metallic glasses: Effects of composition and roughness Huang, L.; Cao, Z.; Meyer, H. M. Acta Biomaterialia, Vol. 7, Issue 1 https://doi.org/10.1016/j.actbio.2010.08.002	journal	January 2011
Analysis for determining surface free energy uncertainty by the Owen–Wendt method Rudawska, Anna; Jacniacka, Elżbieta International Journal of Adhesion and Adhesives, Vol. 29, Issue 4 https://doi.org/10.1016/j.ijadhadh.2008.09.008	journal	June 2009
Bio-corrosion behavior and in vitro biocompatibility of equimolar TiZrHfNbTa high-entropy alloy Yang, Wei; Liu, Ying; Pang, Shujie Intermetallics, Vol. 124 https://doi.org/10.1016/j.intermet.2020.106845	journal	September 2020
Microstructure and room temperature properties of a high-entropy TaNbHfZrTi alloy Senkov, O. N.; Scott, J. M.; Senkova, S. V. Journal of Alloys and Compounds, Vol. 509, Issue 20 https://doi.org/10.1016/j.jallcom.2011.02.171	journal	May 2011
Microstructures and mechanical properties of ductile NbTaTiV refractory high entropy alloy prepared by powder metallurgy Guo, Wenmin; Liu, Bin; Liu, Yong Journal of Alloys and Compounds, Vol. 776 https://doi.org/10.1016/j.jallcom.2018.10.230	journal	March 2019
Mechanical biocompatibilities of titanium alloys for biomedical applications Niinomi, Mitsuo Journal of the Mechanical Behavior of Biomedical Materials, Vol. 1, Issue 1 https://doi.org/10.1016/j.jmbbm.2007.07.001	journal	January 2008
Effect of lattice distortion on solid solution strengthening of BCC high-entropy alloys Wang, Zhipeng; Fang, Qihong; Li, Jia Journal of Materials Science & Technology, Vol. 34, Issue 2 https://doi.org/10.1016/j.jmst.2017.07.013	journal	February 2018
Microstructural development in equiatomic multicomponent alloys Cantor, B.; Chang, I. T. H.; Knight, P. Materials Science and Engineering: A, Vol. 375-377 https://doi.org/10.1016/j.msea.2003.10.257	journal	July 2004
In vitro responses of bone-forming MC3T3-E1 pre-osteoblasts to biodegradable Mg-based bulk metallic glasses Li, Haifei; He, Wei; Pang, Shujie Materials Science and Engineering: C, Vol. 68 https://doi.org/10.1016/j.msec.2016.06.022	journal	November 2016
TiZrNbTaMo high-entropy alloy designed for orthopedic implants: As-cast microstructure and mechanical properties Wang, Shao-Ping; Xu, Jian Materials Science and Engineering: C, Vol. 73 https://doi.org/10.1016/j.msec.2016.12.057	journal	April 2017
Ti based biomaterials, the ultimate choice for orthopaedic implants – A review Geetha, M.; Singh, A. K.; Asokamani, R. Progress in Materials Science, Vol. 54, Issue 3 https://doi.org/10.1016/j.pmatsci.2008.06.004	journal	May 2009
Microstructures and properties of high-entropy alloys Zhang, Yong; Zuo, Ting Ting; Tang, Zhi Progress in Materials Science, Vol. 61 https://doi.org/10.1016/j.pmatsci.2013.10.001	journal	April 2014
Novel TiNbTaZrMo high-entropy alloys for metallic biomaterials Todai, Mitsuharu; Nagase, Takeshi; Hori, Takao Scripta Materialia, Vol. 129 https://doi.org/10.1016/j.scriptamat.2016.10.028	journal	March 2017
Development of non-equiatomic Ti-Nb-Ta-Zr-Mo high-entropy alloys for metallic biomaterials Hori, Takao; Nagase, Takeshi; Todai, Mitsuharu Scripta Materialia, Vol. 172 https://doi.org/10.1016/j.scriptamat.2019.07.011	journal	November 2019
Engineering a Bioactive Hybrid Coating for In Vitro Corrosion Control of Magnesium and Its Alloy Rahman, Md. Mostafizur; Balu, Rajkamal; Abraham, Amanda ACS Applied Bio Materials, Vol. 4, Issue 7 https://doi.org/10.1021/acsabm.1c00366	journal	June 2021
Robust Biomimetic Hierarchical Diamond Architecture with a Self-Cleaning, Antibacterial, and Antibiofouling Surface Wang, Tao; Huang, Lei; Liu, Yuzhi ACS Applied Materials & Interfaces, Vol. 12, Issue 21 https://doi.org/10.1021/acsami.0c02460	journal	April 2020
An In Vitro Evaluation of the Hierarchical Micro/Nanoporous Structure of a Ti3Zr2Sn3Mo25Nb Alloy after Surface Dealloying Wang, Lan; Zhou, Wenhao; Yu, Zhentao ACS Applied Materials & Interfaces, Vol. 13, Issue 13 https://doi.org/10.1021/acsami.1c02140	journal	March 2021
Magnetic Field-Guided MoS₂/WS₂ Heterolayered Nanofilm Regulates Cell Behavior and Gene Expression Luo, Jiwei; Zhou, Qixing; Hu, Xiangang ACS Applied Nano Materials, Vol. 4, Issue 10 https://doi.org/10.1021/acsanm.1c02264	journal	October 2021
Fundamental electronic structure and multiatomic bonding in 13 biocompatible high-entropy alloys Ching, Wai-Yim; San, Saro; Brechtl, Jamieson npj Computational Materials, Vol. 6, Issue 1 https://doi.org/10.1038/s41524-020-0321-x	journal	May 2020
Formation, structure and properties of biocompatible TiZrHfNbTa high-entropy alloys Yuan, Yuan; Wu, Yuan; Yang, Zhi Materials Research Letters, Vol. 7, Issue 6 https://doi.org/10.1080/21663831.2019.1584592	journal	March 2019
Biomaterials in orthopaedics Navarro, M.; Michiardi, A.; Castaño, O. Journal of The Royal Society Interface, Vol. 5, Issue 27 https://doi.org/10.1098/rsif.2008.0151	journal	July 2008
Titanium-Based Biomaterials for Preventing Stress Shielding between Implant Devices and Bone Niinomi, M.; Nakai, M. International Journal of Biomaterials, Vol. 2011 https://doi.org/10.1155/2011/836587	journal	January 2011
Biologically and Mechanically Biocompatible Titanium Alloys Niinomi, Mitsuo MATERIALS TRANSACTIONS, Vol. 49, Issue 10 https://doi.org/10.2320/matertrans.L-MRA2008828	journal	January 2008
Wear and Mechanical Properties, and Cell Viability of Gas-Nitrided Beta-Type Ti-Nb-Ta-Zr System Alloy for Biomedical Applications Akahori, Toshikazu; Niinomi, Mitsuo; Nakai, Masaaki MATERIALS TRANSACTIONS, Vol. 49, Issue 1 https://doi.org/10.2320/matertrans.MRA2007210	journal	January 2008
Wear Characteristics of Surface Oxidation Treated New Biomedical β-type Titanium Alloy in Simulated Body Environment Niinomi, Mitsuo; Akahori, Toshikazu; Nakamura, Sei-ichiro Tetsu-to-Hagane, Vol. 88, Issue 9 https://doi.org/10.2355/tetsutohagane1955.88.9_567	journal	January 2002
Nanochannelar Topography Positively Modulates Osteoblast Differentiation and Inhibits Osteoclastogenesis Ion, Raluca; Mazare, Anca; Dumitriu, Cristina Coatings, Vol. 8, Issue 9 https://doi.org/10.3390/coatings8090294	journal	August 2018

Similar Records

Surface modification induced phase transformation and structure variation on the rapidly solidified recast layer of titanium

Journal Article · 2015 · Materials Characterization · OSTI ID:22476148

Tsai, Ming-Hung; Haung, Chiung-Fang; Shyu, Shih-Shiun; +4 more

In Vitro Fabrication and Biocompatibility Assay of a Biomimetic Osteoblastic Niche

Journal Article · 2019 · Applied Biochemistry and Biotechnology · OSTI ID:22927544

Song, Kedong; Kong, Qian; Li, Liying; +7 more

Use of green fluorescent fusion protein to track activation of the transcription factor osterix during early osteoblast differentiation

Journal Article · 2005 · Biochemical and Biophysical Research Communications · OSTI ID:20710899

Guangping, Tai; Christodoulou, Ioannis; Bishop, Anne E; +1 more

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
NbTaTiVZr
biocompatibility
biomedical material
in vitro test
surface modification

Title: Biocompatibility of NbTaTiVZr with Surface Modifications for Osteoblasts

Citation Formats

References (32)

Similar Records

Related Subjects