Extracellular vesicles in β cell biology: Role of lipids in vesicle biogenesis, cargo, and intercellular signaling
Abstract
Background: Type 1 diabetes (T1D) is a complex autoimmune disorder whose pathogenesis involves an intricate interplay between ß cells of the pancreatic islet, other islet cells, and cells of the immune system. Direct intercellular communication within the islet occurs via cell surface proteins and indirect intercellular communication has traditionally been as occurring via secreted proteins (e.g., endocrine hormones and cytokines). However, recent literature suggests that extracellular vesicles (EVs) secreted by ß cells constitute an additional and biologically important mechanism for transmitting signals to adjacent ß cells or immune cells. Scope of Review: This review summarizes the general mechanisms of EV formation, with a particular focus on how lipids and lipid signaling pathways influence their formation and cargo. We review the implications of EV release from ß cells for T1D pathogenesis, how EVs and their cargo might be leveraged as biomarkers of the early events leading to T1D, and how EVs might be engineered as a therapeutic candidate to counter T1D outcomes. Major Conclusions: Islet ß cells have been viewed as initiators and propagators of the cellular circuit giving rise to autoimmunity in T1D. In this context, emerging literature suggests that EVs may represent a conduit for communication that holds moremore »
- Authors:
-
[3];
[5];
[2]
- Baylor College of Medicine, Houston, TX (United States)
- Univ. of Chicago, IL (United States)
- Univ. of Florida, Gainesville, FL (United States)
- Univ. of Alabama, Birmingham, AL (United States)
- Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
- Indiana University School of Medicine, Indianapolis IN (United States)
- Publication Date:
- Research Org.:
- Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
- Sponsoring Org.:
- USDOE; National Institutes of Health (NIH)
- OSTI Identifier:
- 1886837
- Report Number(s):
- PNNL-SA-173821
Journal ID: ISSN 2212-8778
- Grant/Contract Number:
- AC05-76RL01830; U01 DK122786; P30 DK020595; P30 DK097512
- Resource Type:
- Accepted Manuscript
- Journal Name:
- Molecular Metabolism
- Additional Journal Information:
- Journal Volume: 63; Journal ID: ISSN 2212-8778
- Publisher:
- Elsevier
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 60 APPLIED LIFE SCIENCES; 59 BASIC BIOLOGICAL SCIENCES; 37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY; islet; diabetes; extracellular vesicles; lipids
Citation Formats
Aguirre, Rebecca Schneider, Kulkarni, Abhishek A., Becker, Matthew W., Lei, Xiaoyong, Sarkar, Soumyadeep, Ramanadham, Sasanka, Phelps, Edward A., Nakayasu, Ernesto S., Sims, Emily K., and Mirmira, Raghavendra G. Extracellular vesicles in β cell biology: Role of lipids in vesicle biogenesis, cargo, and intercellular signaling. United States: N. p., 2022.
Web. doi:10.1016/j.molmet.2022.101545.
Aguirre, Rebecca Schneider, Kulkarni, Abhishek A., Becker, Matthew W., Lei, Xiaoyong, Sarkar, Soumyadeep, Ramanadham, Sasanka, Phelps, Edward A., Nakayasu, Ernesto S., Sims, Emily K., & Mirmira, Raghavendra G. Extracellular vesicles in β cell biology: Role of lipids in vesicle biogenesis, cargo, and intercellular signaling. United States. https://doi.org/10.1016/j.molmet.2022.101545
Aguirre, Rebecca Schneider, Kulkarni, Abhishek A., Becker, Matthew W., Lei, Xiaoyong, Sarkar, Soumyadeep, Ramanadham, Sasanka, Phelps, Edward A., Nakayasu, Ernesto S., Sims, Emily K., and Mirmira, Raghavendra G. Fri .
"Extracellular vesicles in β cell biology: Role of lipids in vesicle biogenesis, cargo, and intercellular signaling". United States. https://doi.org/10.1016/j.molmet.2022.101545. https://www.osti.gov/servlets/purl/1886837.
@article{osti_1886837,
title = {Extracellular vesicles in β cell biology: Role of lipids in vesicle biogenesis, cargo, and intercellular signaling},
author = {Aguirre, Rebecca Schneider and Kulkarni, Abhishek A. and Becker, Matthew W. and Lei, Xiaoyong and Sarkar, Soumyadeep and Ramanadham, Sasanka and Phelps, Edward A. and Nakayasu, Ernesto S. and Sims, Emily K. and Mirmira, Raghavendra G.},
abstractNote = {Background: Type 1 diabetes (T1D) is a complex autoimmune disorder whose pathogenesis involves an intricate interplay between ß cells of the pancreatic islet, other islet cells, and cells of the immune system. Direct intercellular communication within the islet occurs via cell surface proteins and indirect intercellular communication has traditionally been as occurring via secreted proteins (e.g., endocrine hormones and cytokines). However, recent literature suggests that extracellular vesicles (EVs) secreted by ß cells constitute an additional and biologically important mechanism for transmitting signals to adjacent ß cells or immune cells. Scope of Review: This review summarizes the general mechanisms of EV formation, with a particular focus on how lipids and lipid signaling pathways influence their formation and cargo. We review the implications of EV release from ß cells for T1D pathogenesis, how EVs and their cargo might be leveraged as biomarkers of the early events leading to T1D, and how EVs might be engineered as a therapeutic candidate to counter T1D outcomes. Major Conclusions: Islet ß cells have been viewed as initiators and propagators of the cellular circuit giving rise to autoimmunity in T1D. In this context, emerging literature suggests that EVs may represent a conduit for communication that holds more comprehensive messaging about the ß cells from which they arise. As the field of EV biology advances, it opens the possibility that intervening with EV formation and cargo loading could be a novel disease-modifying approach in T1D.},
doi = {10.1016/j.molmet.2022.101545},
journal = {Molecular Metabolism},
number = ,
volume = 63,
place = {United States},
year = {Fri Jul 08 00:00:00 EDT 2022},
month = {Fri Jul 08 00:00:00 EDT 2022}
}
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