Biology of extracellular vesicles secreted from senescent cells as senescence‐associated secretory phenotype factors
Abstract
The increase of the morbidity rate in age‐related diseases, such as cancer, Alzheimer’s disease, arteriosclerosis and pulmonary fibrosis, has become a profound social problem. Recent reports have pointed out that senescent cells accumulated in the body with aging might cause these aged‐related pathologies. Cellular senescence is known as an irreversible cell cycle arrest induced by various stresses, and can function as an important tumor suppression mechanism to exclude the premalignant cells. In contrast, senescent cells provoke the phenomenon, termed the senescence‐associated secretory phenotype, which causes the secretion of various inflammatory proteins, and it is at risk of facilitating chronic inflammation and oncogenic transformation to surrounding cells. We have previously reported that senescent cells secrete not only inflammatory proteins, but also extracellular vesicles (EV). EV include various cellular components, such as proteins, lipids and nucleic acids, which are proven to be important factors for cell‐to‐cell communication. Recent evidence suggests that EV secreted from senescent cells might contribute to tumorigenesis and age‐associated pathologies as new senescence‐associated secretory phenotype factors. In addition, we also showed that the EV secretion pathway is one of the essential defense mechanisms to maintain cellular homeostasis by excretion of intercellular toxic substances into extracellular space. Herein, this reviewmore »
- Authors:
-
[2]
- Project for Cellular Senescence The Cancer Institute, Japanese Foundation for Cancer Research Tokyo Japan
- Project for Cellular Senescence The Cancer Institute, Japanese Foundation for Cancer Research Tokyo Japan, Precursory Research for Embryonic Science and Technology (PRESTO), Japan Science and Technology Agency (JST) Saitama Japan, Advanced Research &, Development Programs for Medical Innovation (PRIME), Japan Agency for Medical Research and Development (AMED) Tokyo Japan
- Publication Date:
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1617051
- Resource Type:
- Publisher's Accepted Manuscript
- Journal Name:
- Geriatrics & Gerontology International
- Additional Journal Information:
- Journal Name: Geriatrics & Gerontology International Journal Volume: 20 Journal Issue: 6; Journal ID: ISSN 1444-1586
- Publisher:
- Wiley-Blackwell
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
Citation Formats
Misawa, Tomoka, Tanaka, Yoko, Okada, Ryo, and Takahashi, Akiko. Biology of extracellular vesicles secreted from senescent cells as senescence‐associated secretory phenotype factors. Country unknown/Code not available: N. p., 2020.
Web. doi:10.1111/ggi.13928.
Misawa, Tomoka, Tanaka, Yoko, Okada, Ryo, & Takahashi, Akiko. Biology of extracellular vesicles secreted from senescent cells as senescence‐associated secretory phenotype factors. Country unknown/Code not available. https://doi.org/10.1111/ggi.13928
Misawa, Tomoka, Tanaka, Yoko, Okada, Ryo, and Takahashi, Akiko. Fri .
"Biology of extracellular vesicles secreted from senescent cells as senescence‐associated secretory phenotype factors". Country unknown/Code not available. https://doi.org/10.1111/ggi.13928.
@article{osti_1617051,
title = {Biology of extracellular vesicles secreted from senescent cells as senescence‐associated secretory phenotype factors},
author = {Misawa, Tomoka and Tanaka, Yoko and Okada, Ryo and Takahashi, Akiko},
abstractNote = {The increase of the morbidity rate in age‐related diseases, such as cancer, Alzheimer’s disease, arteriosclerosis and pulmonary fibrosis, has become a profound social problem. Recent reports have pointed out that senescent cells accumulated in the body with aging might cause these aged‐related pathologies. Cellular senescence is known as an irreversible cell cycle arrest induced by various stresses, and can function as an important tumor suppression mechanism to exclude the premalignant cells. In contrast, senescent cells provoke the phenomenon, termed the senescence‐associated secretory phenotype, which causes the secretion of various inflammatory proteins, and it is at risk of facilitating chronic inflammation and oncogenic transformation to surrounding cells. We have previously reported that senescent cells secrete not only inflammatory proteins, but also extracellular vesicles (EV). EV include various cellular components, such as proteins, lipids and nucleic acids, which are proven to be important factors for cell‐to‐cell communication. Recent evidence suggests that EV secreted from senescent cells might contribute to tumorigenesis and age‐associated pathologies as new senescence‐associated secretory phenotype factors. In addition, we also showed that the EV secretion pathway is one of the essential defense mechanisms to maintain cellular homeostasis by excretion of intercellular toxic substances into extracellular space. Herein, this review shows the biological functions of EV secreted from senescent cells. Geriatr Gerontol Int 2020; ••: ••–•• .},
doi = {10.1111/ggi.13928},
journal = {Geriatrics & Gerontology International},
number = 6,
volume = 20,
place = {Country unknown/Code not available},
year = {Fri May 01 00:00:00 EDT 2020},
month = {Fri May 01 00:00:00 EDT 2020}
}
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