Codelivery of Paclitaxel and Parthenolide in Discoidal Bicelles for a Synergistic Anticancer Effect: Structure Matters
Abstract
Nanotechnology has long been used to improve the tumor targeting of chemotherapeutics. The structure of these nanocarriers greatly affects their efficacy and toxicity. Herein, structurally stable nanodiscoidal phospholipid bicelles, which are capable of encapsulating anticancer drugs, paclitaxel (PTX) and parthenolide (PTL), are designed. This nanodiscoidal bicelle structure is shown previously to exhibit longer blood circulation, deeper tumor penetration, and increased tumor cell uptake compared with spherical particles of similar compositions. Structural characterization and loading capacity of the PTX‐ and PTL‐ loaded nanodiscs are conducted along with an investigation into the cytotoxicity of the bicelles based on the drug‐to‐lipid ratios of both drugs loaded separately and in combination. A significant synergistic effect between both loaded drugs is also observed in A549 lung cancer and drug‐resistant MDA‐MB‐231 cell lines. An in vivo study using mice bearing subcutaneous A549 tumors shows a long circulation time of the intravenously injected DiR‐loaded bicelles and significant antitumor efficacy of the PTX‐ and PTL‐loaded bicelles. This efficacious self‐assembled nanoparticle system displays great potential as a nanoplatform to codeliver multiple therapeutics or diagnostics for improving cancer therapy.
- Authors:
-
[1];
[6]
- Department of Biomedical Engineering University of Connecticut Storrs CT 06269 USA, Polymer Program Institute of Materials Sciences University of Connecticut 191 Auditorium Road Storrs CT 06269 USA, Encapsulate, University of Connecticut Technology Incubation Program Farmington CT 06032
- School of Pharmacy University of Connecticut Storrs CT 06269 USA
- Department of Biomedical Engineering University of Connecticut Storrs CT 06269 USA, Encapsulate, University of Connecticut Technology Incubation Program Farmington CT 06032
- Department of Chemical and Bimolecular Engineering University of Connecticut Storrs CT 06269 USA
- Polymer Program Institute of Materials Sciences University of Connecticut 191 Auditorium Road Storrs CT 06269 USA, School of Pharmacy University of Connecticut Storrs CT 06269 USA
- Department of Biomedical Engineering University of Connecticut Storrs CT 06269 USA, Polymer Program Institute of Materials Sciences University of Connecticut 191 Auditorium Road Storrs CT 06269 USA, Department of Chemical and Bimolecular Engineering University of Connecticut Storrs CT 06269 USA
- Publication Date:
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1832035
- Alternate Identifier(s):
- OSTI ID: 1832038
- Resource Type:
- Published Article
- Journal Name:
- Advanced NanoBiomed Research
- Additional Journal Information:
- Journal Name: Advanced NanoBiomed Research Journal Volume: 2 Journal Issue: 1; Journal ID: ISSN 2699-9307
- Publisher:
- Wiley Blackwell (John Wiley & Sons)
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
Citation Formats
Rad, Armin Tahmasbi, Hargrove, Derek, Daneshmandi, Leila, Ramsdell, Amanda, Lu, Xiuling, and Nieh, Mu-Ping. Codelivery of Paclitaxel and Parthenolide in Discoidal Bicelles for a Synergistic Anticancer Effect: Structure Matters. Country unknown/Code not available: N. p., 2021.
Web. doi:10.1002/anbr.202100080.
Rad, Armin Tahmasbi, Hargrove, Derek, Daneshmandi, Leila, Ramsdell, Amanda, Lu, Xiuling, & Nieh, Mu-Ping. Codelivery of Paclitaxel and Parthenolide in Discoidal Bicelles for a Synergistic Anticancer Effect: Structure Matters. Country unknown/Code not available. https://doi.org/10.1002/anbr.202100080
Rad, Armin Tahmasbi, Hargrove, Derek, Daneshmandi, Leila, Ramsdell, Amanda, Lu, Xiuling, and Nieh, Mu-Ping. Sat .
"Codelivery of Paclitaxel and Parthenolide in Discoidal Bicelles for a Synergistic Anticancer Effect: Structure Matters". Country unknown/Code not available. https://doi.org/10.1002/anbr.202100080.
@article{osti_1832035,
title = {Codelivery of Paclitaxel and Parthenolide in Discoidal Bicelles for a Synergistic Anticancer Effect: Structure Matters},
author = {Rad, Armin Tahmasbi and Hargrove, Derek and Daneshmandi, Leila and Ramsdell, Amanda and Lu, Xiuling and Nieh, Mu-Ping},
abstractNote = {Nanotechnology has long been used to improve the tumor targeting of chemotherapeutics. The structure of these nanocarriers greatly affects their efficacy and toxicity. Herein, structurally stable nanodiscoidal phospholipid bicelles, which are capable of encapsulating anticancer drugs, paclitaxel (PTX) and parthenolide (PTL), are designed. This nanodiscoidal bicelle structure is shown previously to exhibit longer blood circulation, deeper tumor penetration, and increased tumor cell uptake compared with spherical particles of similar compositions. Structural characterization and loading capacity of the PTX‐ and PTL‐ loaded nanodiscs are conducted along with an investigation into the cytotoxicity of the bicelles based on the drug‐to‐lipid ratios of both drugs loaded separately and in combination. A significant synergistic effect between both loaded drugs is also observed in A549 lung cancer and drug‐resistant MDA‐MB‐231 cell lines. An in vivo study using mice bearing subcutaneous A549 tumors shows a long circulation time of the intravenously injected DiR‐loaded bicelles and significant antitumor efficacy of the PTX‐ and PTL‐loaded bicelles. This efficacious self‐assembled nanoparticle system displays great potential as a nanoplatform to codeliver multiple therapeutics or diagnostics for improving cancer therapy.},
doi = {10.1002/anbr.202100080},
journal = {Advanced NanoBiomed Research},
number = 1,
volume = 2,
place = {Country unknown/Code not available},
year = {Sat Nov 20 00:00:00 EST 2021},
month = {Sat Nov 20 00:00:00 EST 2021}
}
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