Paclitaxel loading in cationic liposome vectors is enhanced by replacement of oleoyl with linoleoyl tails with distinct lipid shapes

Zhen, Yuhong; Ewert, Kai K.; Fisher, William S.; Steffes, Victoria M.; Li, Youli; Safinya, Cyrus R.

doi:10.1038/s41598-021-86484-9

Title: Paclitaxel loading in cationic liposome vectors is enhanced by replacement of oleoyl with linoleoyl tails with distinct lipid shapes

Journal Article · 30 March 2021 · Scientific Reports

DOI: https://doi.org/10.1038/s41598-021-86484-9 · OSTI ID:1773548

Zhen, Yuhong; Ewert, Kai K.; Fisher, William S.; Steffes, Victoria M.; Li, Youli; Safinya, Cyrus R.

Abstract Lipid carriers of hydrophobic paclitaxel (PTX) are used in clinical trials for cancer chemotherapy. Improving their loading capacity requires enhanced PTX solubilization. We compared the time-dependence of PTX membrane solubility as a function of PTX content in cationic liposomes (CLs) with lipid tails containing one (oleoyl; DOPC/DOTAP) or two (linoleoyl; DLinPC/newly synthesized DLinTAP) cis double bonds by using microscopy to generate kinetic phase diagrams. The DLin lipids displayed significantly increased PTX membrane solubility over DO lipids. Remarkably, 8 mol% PTX in DLinTAP/DLinPC CLs remained soluble for approximately as long as 3 mol% PTX (the solubility limit, which has been the focus of most previous studies and clinical trials) in DOTAP/DOPC CLs. The increase in solubility is likely caused by enhanced molecular affinity between lipid tails and PTX, rather than by the transition in membrane structure from bilayers to inverse cylindrical micelles observed with small-angle X-ray scattering. Importantly, the efficacy of PTX-loaded CLs against prostate cancer cells (their IC50 of PTX cytotoxicity) was unaffected by changing the lipid tails, and toxicity of the CL carrier was negligible. Moreover, efficacy was approximately doubled against melanoma cells for PTX-loaded DLinTAP/DLinPC over DOTAP/DOPC CLs. Our findings demonstrate the potential of chemical modifications of the lipid tails to increase the PTX membrane loading while maintaining (and in some cases even increasing) the efficacy of CLs. The increased PTX solubility will aid the development of liposomal PTX carriers that require significantly less lipid to deliver a given amount of PTX, reducing side effects and costs.

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Research Organization:: Univ. of California, Santa Barbara, CA (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Basic Energy Sciences (BES); USDOE Office of Science (SC), Basic Energy Sciences (BES). Materials Sciences & Engineering Division

Grant/Contract Number:: FG02-06ER46314

OSTI ID:: 1773548

Journal Information:: Scientific Reports, Journal Name: Scientific Reports Journal Issue: 1 Vol. 11; ISSN 2045-2322

Publisher:: Nature Publishing GroupCopyright Statement

Country of Publication:: United Kingdom

Language:: English

References (94)

Interaction of the anticancer agent Taxol? (paclitaxel) with phospholipid bilayers Bernsdorff, Corinna; Reszka, Regina; Winter, Roland Journal of Biomedical Materials Research, Vol. 46, Issue 2 https://doi.org/10.1002/(sici)1097-4636(199908)46:2<141::aid-jbm2>3.0.co;2-u	journal	August 1999
Neovascular targeting chemotherapy: Encapsulation of paclitaxel in cationic liposomes impairs functional tumor microvasculature Strieth, Sebastian; Eichhorn, Martin E.; Sauer, Birgitta International Journal of Cancer, Vol. 110, Issue 1 https://doi.org/10.1002/ijc.20083	journal	January 2004
Tumor-selective vessel occlusions by platelets after vascular targeting chemotherapy using paclitaxel encapsulated in cationic liposomes: Targeted Tumor-Selective Thromboses In Vivo Strieth, Sebastian; Nussbaum, Claudia F.; Eichhorn, Martin E. International Journal of Cancer, Vol. 122, Issue 2 https://doi.org/10.1002/ijc.23088	journal	October 2007
Vascular targeting by EndoTAG™-1 enhances therapeutic efficacy of conventional chemotherapy in lung and pancreatic cancer: Efficient Antitumoral Therapy by EndoTAG™-1 Eichhorn, Martin E.; Ischenko, Ivan; Luedemann, Siiri International Journal of Cancer, Vol. 126, Issue 5 https://doi.org/10.1002/ijc.24846	journal	August 2009
Influence of cationic lipids on the stability and membrane properties of paclitaxel‐containing liposomes Campbell, Robert B.; Balasubramanian, Sathyamangalam V.; Straubinger, Robert M. Journal of Pharmaceutical Sciences, Vol. 90, Issue 8 https://doi.org/10.1002/jps.1063	journal	August 2001
Fighting Cancer: From the Bench to Bedside Using Second Generation Cationic Liposomal Therapeutics Campbell, Robert B.; Ying, Bo; Kuesters, Geoffrey M. Journal of Pharmaceutical Sciences, Vol. 98, Issue 2 https://doi.org/10.1002/jps.21458	journal	February 2009
Liposomes with high encapsulation capacity for paclitaxel: Preparation, characterisation and in vivo anticancer effect**Štěpán Koudelka and Pavlína Turánek-Knötigová contributed equally to this work. Koudelka, Štěpán; Turánek-Knötigová, Pavlína; MaŠek, Josef Journal of Pharmaceutical Sciences, Vol. 99, Issue 5 https://doi.org/10.1002/jps.21992	journal	May 2010
Characterization of Cationic Liposome Formulations Designed to Exhibit Extended Plasma Residence Times and Tumor Vasculature Targeting Properties Ho, Emmanuel A.; Ramsay, Euan; Ginj, Mihaela Journal of Pharmaceutical Sciences, Vol. 99, Issue 6 https://doi.org/10.1002/jps.22043	journal	June 2010
Weekly paclitaxel as second-line chemotherapy for advanced or recurrent gastric cancer Hironaka, Shuichi; Zenda, Sadamoto; Boku, Narikazu Gastric Cancer, Vol. 9, Issue 1 https://doi.org/10.1007/s10120-005-0351-6	journal	February 2006
Paclitaxel chemotherapy for the treatment of gastric cancer Sakamoto, Junichi; Matsui, Takanori; Kodera, Yasuhiro Gastric Cancer, Vol. 12, Issue 2 https://doi.org/10.1007/s10120-009-0505-z	journal	June 2009
Antitumor Effect of Paclitaxel-Loaded PEGylated Immunoliposomes Against Human Breast Cancer Cells Yang, Tao; Choi, Min-Koo; Cui, Fu-De Pharmaceutical Research, Vol. 24, Issue 12 https://doi.org/10.1007/s11095-007-9425-y	journal	September 2007
Lipid nanoparticle delivery systems for siRNA-based therapeutics Wan, C.; Allen, T. M.; Cullis, P. R. Drug Delivery and Translational Research, Vol. 4, Issue 1 https://doi.org/10.1007/s13346-013-0161-z	journal	June 2013
Patisiran: First Global Approval Hoy, Sheridan M. Drugs, Vol. 78, Issue 15 https://doi.org/10.1007/s40265-018-0983-6	journal	September 2018
Interactions of mammalian cells with lipid dispersions containing novel metabolizable cationic amphiphiles Leventis, Rania; Silvius, John R. Biochimica et Biophysica Acta (BBA) - Biomembranes, Vol. 1023, Issue 1 https://doi.org/10.1016/0005-2736(90)90017-I	journal	March 1990
Paclitaxel-liposomes for intracavitary therapy of intraperitoneal P388 leukemia Sharma, Amarnath; Sharma, Uma S.; Straubinger, Robert M. Cancer Letters, Vol. 107, Issue 2 https://doi.org/10.1016/0304-3835(96)04380-7	journal	October 1996
Structure and design of polymeric surfactant-based drug delivery systems Torchilin, Vladimir P. Journal of Controlled Release, Vol. 73, Issue 2-3 https://doi.org/10.1016/S0168-3659(01)00299-1	journal	June 2001
Cremophor EL Gelderblom, H.; Verweij, J.; Nooter, K. European Journal of Cancer, Vol. 37, Issue 13 https://doi.org/10.1016/S0959-8049(01)00171-X	journal	September 2001
Liposomal drug delivery systems: From concept to clinical applications Allen, Theresa M.; Cullis, Pieter R. Advanced Drug Delivery Reviews, Vol. 65, Issue 1 https://doi.org/10.1016/j.addr.2012.09.037	journal	January 2013
Preclinical and clinical development of siRNA-based therapeutics Ozcan, Gulnihal; Ozpolat, Bulent; Coleman, Robert L. Advanced Drug Delivery Reviews, Vol. 87 https://doi.org/10.1016/j.addr.2015.01.007	journal	June 2015
Delivery of oligonucleotides with lipid nanoparticles Wang, Yuhua; Miao, Lei; Satterlee, Andrew Advanced Drug Delivery Reviews, Vol. 87 https://doi.org/10.1016/j.addr.2015.02.007	journal	June 2015
Co-delivery of drugs and plasmid DNA for cancer therapy Teo, Pei Yun; Cheng, Wei; Hedrick, James L. Advanced Drug Delivery Reviews, Vol. 98 https://doi.org/10.1016/j.addr.2015.10.014	journal	March 2016
The battle of “nano” paclitaxel Sofias, Alexandros Marios; Dunne, Michael; Storm, Gert Advanced Drug Delivery Reviews, Vol. 122 https://doi.org/10.1016/j.addr.2017.02.003	journal	December 2017
Remote loading of doxorubicin into liposomes driven by a transmembrane phosphate gradient Fritze, Andreas; Hens, Felicitas; Kimpfler, Andrea Biochimica et Biophysica Acta (BBA) - Biomembranes, Vol. 1758, Issue 10, p. 1633-1640 https://doi.org/10.1016/j.bbamem.2006.05.028	journal	October 2006
The systemic toxicity of positively charged lipid nanoparticles and the role of Toll-like receptor 4 in immune activation Kedmi, Ranit; Ben-Arie, Noa; Peer, Dan Biomaterials, Vol. 31, Issue 26 https://doi.org/10.1016/j.biomaterials.2010.05.027	journal	September 2010
Distinct solubility and cytotoxicity regimes of paclitaxel-loaded cationic liposomes at low and high drug content revealed by kinetic phase behavior and cancer cell viability studies Steffes, Victoria M.; Murali, Meena M.; Park, Yoonsang Biomaterials, Vol. 145 https://doi.org/10.1016/j.biomaterials.2017.08.026	journal	November 2017
Synthesis of linear and cyclic peptide–PEG–lipids for stabilization and targeting of cationic liposome–DNA complexes Ewert, Kai K.; Kotamraju, Venkata Ramana; Majzoub, Ramsey N. Bioorganic & Medicinal Chemistry Letters, Vol. 26, Issue 6 https://doi.org/10.1016/j.bmcl.2016.01.079	journal	March 2016
A critical review of lipid-based nanoparticles for taxane delivery Feng, Lan; Mumper, Russell J. Cancer Letters, Vol. 334, Issue 2 https://doi.org/10.1016/j.canlet.2012.07.006	journal	July 2013
Nanoparticle-siRNA: A potential cancer therapy? Young, Samuel Wang Sherng; Stenzel, Martina; Jia-Lin, Yang Critical Reviews in Oncology/Hematology, Vol. 98 https://doi.org/10.1016/j.critrevonc.2015.10.015	journal	February 2016
Development and characterization of a novel Cremophor® EL free liposome-based paclitaxel (LEP-ETU) formulation Zhang, J. Allen; Anyarambhatla, Gopal; Ma, Lan European Journal of Pharmaceutics and Biopharmaceutics, Vol. 59, Issue 1 https://doi.org/10.1016/j.ejpb.2004.06.009	journal	January 2005
Enhanced solubility and stability of PEGylated liposomal paclitaxel: In vitro and in vivo evaluation Yang, Tao; Cui, Fu-De; Choi, Min-Koo International Journal of Pharmaceutics, Vol. 338, Issue 1-2 https://doi.org/10.1016/j.ijpharm.2007.02.011	journal	June 2007
Paclitaxel: What has been done and the challenges remain ahead Bernabeu, Ezequiel; Cagel, Maximiliano; Lagomarsino, Eduardo International Journal of Pharmaceutics, Vol. 526, Issue 1-2 https://doi.org/10.1016/j.ijpharm.2017.05.016	journal	June 2017
Preparation and evaluation of paclitaxel-loaded PEGylated immunoliposome Yang, Tao; Choi, Min-Koo; Cui, Fu-De Journal of Controlled Release, Vol. 120, Issue 3 https://doi.org/10.1016/j.jconrel.2007.05.011	journal	July 2007
Non-viral is superior to viral gene delivery Li, Shyh-Dar; Huang, Leaf Journal of Controlled Release, Vol. 123, Issue 3 https://doi.org/10.1016/j.jconrel.2007.09.004	journal	November 2007
Improvement of drug safety by the use of lipid-based nanocarriers Lim, Sok Bee; Banerjee, Amrita; Önyüksel, Hayat Journal of Controlled Release, Vol. 163, Issue 1 https://doi.org/10.1016/j.jconrel.2012.06.002	journal	October 2012
Liposomal paclitaxel formulations Koudelka, Štěpán; Turánek, Jaroslav Journal of Controlled Release, Vol. 163, Issue 3 https://doi.org/10.1016/j.jconrel.2012.09.006	journal	November 2012
Non-viral gene therapy: Gains and challenges of non-invasive administration methods Foldvari, Marianna; Chen, Ding Wen; Nafissi, Nafiseh Journal of Controlled Release, Vol. 240 https://doi.org/10.1016/j.jconrel.2015.12.012	journal	October 2016
Preclinical development of drug delivery systems for paclitaxel-based cancer chemotherapy Wang, Feihu; Porter, Michael; Konstantopoulos, Alexandros Journal of Controlled Release, Vol. 267 https://doi.org/10.1016/j.jconrel.2017.09.026	journal	December 2017
RNAi and small interfering RNAs in human disease therapeutic applications Lares, Monica R.; Rossi, John J.; Ouellet, Dominique L. Trends in Biotechnology, Vol. 28, Issue 11 https://doi.org/10.1016/j.tibtech.2010.07.009	journal	November 2010
Paclitaxel Crystal Seeds with Different Intrinsic Properties and Their Impact on Dissolution of Paclitaxel-HPMCAS Amorphous Solid Dispersions Que, Chailu; Gao, Yi; Raina, Shweta A. Crystal Growth & Design, Vol. 18, Issue 3 https://doi.org/10.1021/acs.cgd.7b01521	journal	February 2018
Vectorization of Nucleic Acids for Therapeutic Approach: Tutorial Review Geinguenaud, Frederic; Guenin, Erwann; Lalatonne, Yoann ACS Chemical Biology, Vol. 11, Issue 5 https://doi.org/10.1021/acschembio.5b01053	journal	March 2016
Formation of Highly Structured Cubic Micellar Lipid Nanoparticles of Soy Phosphatidylcholine and Glycerol Dioleate and Their Degradation by Triacylglycerol Lipase Wadsäter, Maria; Barauskas, Justas; Nylander, Tommy ACS Applied Materials & Interfaces, Vol. 6, Issue 10 https://doi.org/10.1021/am501489e	journal	May 2014
Recent Advances in Nonviral Vectors for Gene Delivery Guo, Xia; Huang, Leaf Accounts of Chemical Research, Vol. 45, Issue 7 https://doi.org/10.1021/ar200151m	journal	August 2011
Taxol-Lipid Interactions: Taxol-Dependent Effects on the Physical Properties of Model Membranes Balasubramanian, Sathyamangalam V.; Straubinger, Robert M. Biochemistry, Vol. 33, Issue 30 https://doi.org/10.1021/bi00196a011	journal	August 1994
Plant antitumor agents. VI. Isolation and structure of taxol, a novel antileukemic and antitumor agent from Taxus brevifolia Wani, Mansukhlal C.; Taylor, Harold Lawrence; Wall, Monroe E. Journal of the American Chemical Society, Vol. 93, Issue 9 https://doi.org/10.1021/ja00738a045	journal	May 1971
A Columnar Phase of Dendritic Lipid−Based Cationic Liposome−DNA Complexes for Gene Delivery: Hexagonally Ordered Cylindrical Micelles Embedded in a DNA Honeycomb Lattice Ewert, Kai K.; Evans, Heather M.; Zidovska, Alexandra Journal of the American Chemical Society, Vol. 128, Issue 12 https://doi.org/10.1021/ja055907h	journal	March 2006
Highly Efficient Gene Silencing Activity of siRNA Embedded in a Nanostructured Gyroid Cubic Lipid Matrix Leal, Cecília; Bouxsein, Nathan F.; Ewert, Kai K. Journal of the American Chemical Society, Vol. 132, Issue 47 https://doi.org/10.1021/ja1059763	journal	December 2010
Emerging Frontiers in Drug Delivery Tibbitt, Mark W.; Dahlman, James E.; Langer, Robert Journal of the American Chemical Society, Vol. 138, Issue 3 https://doi.org/10.1021/jacs.5b09974	journal	January 2016
Nanogyroids Incorporating Multivalent Lipids: Enhanced Membrane Charge Density and Pore Forming Ability for Gene Silencing Leal, Cecília; Ewert, Kai K.; Shirazi, Rahau S. Langmuir, Vol. 27, Issue 12 https://doi.org/10.1021/la200679x	journal	June 2011
Mechanism of Macromolecular Structure Evolution in Self-Assembled Lipid Nanoparticles for siRNA Delivery Gindy, Marian E.; DiFelice, Katherine; Kumar, Varun Langmuir, Vol. 30, Issue 16 https://doi.org/10.1021/la500630h	journal	April 2014
Promotion of microtubule assembly in vitro by taxol Schiff, Peter B.; Fant, Jane; Horwitz, Susan B. Nature, Vol. 277, Issue 5698 https://doi.org/10.1038/277665a0	journal	February 1979
Liposomes derived from molecular vases Safinya, Cyrus R.; Ewert, Kai K. Nature, Vol. 489, Issue 7416 https://doi.org/10.1038/489372b	journal	September 2012
Nanotechnologies in delivery of mRNA therapeutics using nonviral vector-based delivery systems Guan, S.; Rosenecker, J. Gene Therapy, Vol. 24, Issue 3 https://doi.org/10.1038/gt.2017.5	journal	January 2017
Microtubules as a target for anticancer drugs Jordan, Mary Ann; Wilson, Leslie Nature Reviews Cancer, Vol. 4, Issue 4 https://doi.org/10.1038/nrc1317	journal	April 2004
RNA interference in the clinic: challenges and future directions Pecot, Chad V.; Calin, George A.; Coleman, Robert L. Nature Reviews Cancer, Vol. 11, Issue 1 https://doi.org/10.1038/nrc2966	journal	December 2010
MicroRNA therapeutics: towards a new era for the management of cancer and other diseases Rupaimoole, Rajesha; Slack, Frank J. Nature Reviews Drug Discovery, Vol. 16, Issue 3 https://doi.org/10.1038/nrd.2016.246	journal	February 2017
Delivery technologies for genome editing Yin, Hao; Kauffman, Kevin J.; Anderson, Daniel G. Nature Reviews Drug Discovery, Vol. 16, Issue 6 https://doi.org/10.1038/nrd.2016.280	journal	March 2017
Recent advances with liposomes as pharmaceutical carriers Torchilin, Vladimir P. Nature Reviews Drug Discovery, Vol. 4, Issue 2 https://doi.org/10.1038/nrd1632	journal	February 2005
Non-viral vectors for gene-based therapy Yin, Hao; Kanasty, Rosemary L.; Eltoukhy, Ahmed A. Nature Reviews Genetics, Vol. 15, Issue 8 https://doi.org/10.1038/nrg3763	journal	July 2014
Progress and challenges towards targeted delivery of cancer therapeutics Rosenblum, Daniel; Joshi, Nitin; Tao, Wei Nature Communications, Vol. 9, Issue 1 https://doi.org/10.1038/s41467-018-03705-y	journal	April 2018
Cationic liposome–nucleic acid complexes for gene delivery and gene silencing Safinya, Cyrus R.; Ewert, Kai K.; Majzoub, Ramsey N. New J. Chem., Vol. 38, Issue 11 https://doi.org/10.1039/c4nj01314j	journal	January 2014
Paclitaxel Encapsulated in Cationic Liposomes Diminishes Tumor Angiogenesis and Melanoma Growth in a “Humanized” SCID Mouse Model Kunstfeld, Rainer; Wickenhauser, Georg; Michaelis, Uwe Journal of Investigative Dermatology, Vol. 120, Issue 3 https://doi.org/10.1046/j.1523-1747.2003.12057.x	journal	March 2003
Paclitaxel (Taxol) Rowinsky, Eric K.; Donehower, Ross C. New England Journal of Medicine, Vol. 332, Issue 15 https://doi.org/10.1056/nejm199504133321507	journal	April 1995
Mechanism of mitotic block and inhibition of cell proliferation by taxol at low concentrations. Jordan, M. A.; Toso, R. J.; Thrower, D. Proceedings of the National Academy of Sciences, Vol. 90, Issue 20 https://doi.org/10.1073/pnas.90.20.9552	journal	October 1993
Taxol Suppresses Dynamics of Individual Microtubules in Living Human Tumor Cells Yvon, Anne-Marie C.; Wadsworth, Patricia; Jordan, Mary Ann Molecular Biology of the Cell, Vol. 10, Issue 4 https://doi.org/10.1091/mbc.10.4.947	journal	April 1999
How Taxol/paclitaxel kills cancer cells Weaver, Beth A. Molecular Biology of the Cell, Vol. 25, Issue 18 https://doi.org/10.1091/mbc.E14-04-0916	journal	September 2014
Vascular and pharmacokinetic effects of EndoTAG-1 in patients with advanced cancer and liver metastasis Fasol, U.; Frost, A.; Büchert, M. Annals of Oncology, Vol. 23, Issue 4 https://doi.org/10.1093/annonc/mdr300	journal	April 2012
A randomized controlled phase II trial of a novel composition of paclitaxel embedded into neutral and cationic lipids targeting tumor endothelial cells in advanced triple-negative breast cancer (TNBC) Awada, A.; Bondarenko, I. N.; Bonneterre, J. Annals of Oncology, Vol. 25, Issue 4 https://doi.org/10.1093/annonc/mdu025	journal	April 2014
A randomized, controlled phase III trial of nab-Paclitaxel versus dacarbazine in chemotherapy-naïve patients with metastatic melanoma Hersh, E. M.; Del Vecchio, M.; Brown, M. P. Annals of Oncology, Vol. 26, Issue 11 https://doi.org/10.1093/annonc/mdv324	journal	November 2015
Polyunsaturated Fatty Acid-Induced Cytotoxicity Against Tumor Cells and Its Relationship to Lipid Peroxidation Begin, M. E.; Ells, G.; Horrobin, D. F. JNCI Journal of the National Cancer Institute, Vol. 80, Issue 3 https://doi.org/10.1093/jnci/80.3.188	journal	April 1988
Cationic liposome–nucleic acid nanoparticle assemblies with applications in gene delivery and gene silencing Majzoub, Ramsey N.; Ewert, Kai K.; Safinya, Cyrus R. Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences, Vol. 374, Issue 2072 https://doi.org/10.1098/rsta.2015.0129	journal	July 2016
Two-Dimensional Smectic Ordering of Linear DNA Chains in Self-Assembled DNA-Cationic Liposome Mixtures Salditt, T.; Koltover, I.; Rädler, J. O. Physical Review Letters, Vol. 79, Issue 13 https://doi.org/10.1103/PhysRevLett.79.2582	journal	September 1997
Lipid-Based Drug Delivery Systems in Cancer Therapy: What Is Available and What Is Yet to Come Yingchoncharoen, Phatsapong; Kalinowski, Danuta S.; Richardson, Des R. Pharmacological Reviews, Vol. 68, Issue 3 https://doi.org/10.1124/pr.115.012070	journal	May 2016
Structure of DNA-Cationic Liposome Complexes: DNA Intercalation in Multilamellar Membranes in Distinct Interhelical Packing Regimes Radler, J. O. Science, Vol. 275, Issue 5301 https://doi.org/10.1126/science.275.5301.810	journal	February 1997
An Inverted Hexagonal Phase of Cationic Liposome-DNA Complexes Related to DNA Release and Delivery Koltover, I. Science, Vol. 281, Issue 5373 https://doi.org/10.1126/science.281.5373.78	journal	July 1998
A Liposomal Formulation Able to Incorporate a High Content of Paclitaxel and Exert Promising Anticancer Effect Kan, Pei; Tsao, Chih-Wan; Wang, Ae-June Journal of Drug Delivery, Vol. 2011 https://doi.org/10.1155/2011/629234	journal	October 2011
Cationic liposomes target angiogenic endothelial cells in tumors and chronic inflammation in mice. Thurston, G.; McLean, J. W.; Rizen, M. Journal of Clinical Investigation, Vol. 101, Issue 7 https://doi.org/10.1172/jci965	journal	April 1998
Pharmacology and Toxicology of Cremophor EL Diluent Dorr, Robert T. Annals of Pharmacotherapy, Vol. 28, Issue 5_suppl https://doi.org/10.1177/10600280940280S503	journal	May 1994
Abraxane® versus Taxol® for patients with advanced breast cancer: A prospective time and motion analysis from a Chinese health care perspective Dranitsaris, George; Yu, Bo; Wang, Leiping Journal of Oncology Pharmacy Practice, Vol. 22, Issue 2 https://doi.org/10.1177/1078155214556008	journal	October 2014
Hypersensitivity reactions from taxol. Weiss, R. B.; Donehower, R. C.; Wiernik, P. H. Journal of Clinical Oncology, Vol. 8, Issue 7 https://doi.org/10.1200/jco.1990.8.7.1263	journal	July 1990
Phase III Trial of Nanoparticle Albumin-Bound Paclitaxel Compared With Polyethylated Castor Oil–Based Paclitaxel in Women With Breast Cancer Gradishar, William J.; Tjulandin, Sergei; Davidson, Neville Journal of Clinical Oncology, Vol. 23, Issue 31 https://doi.org/10.1200/jco.2005.04.937	journal	November 2005
Randomized Phase III Trial of Paclitaxel Once Per Week Compared With Nanoparticle Albumin-Bound Nab-Paclitaxel Once Per Week or Ixabepilone With Bevacizumab As First-Line Chemotherapy for Locally Recurrent or Metastatic Breast Cancer: CALGB 40502/NCCTG N063H (Alliance) Rugo, Hope S.; Barry, William T.; Moreno-Aspitia, Alvaro Journal of Clinical Oncology, Vol. 33, Issue 21 https://doi.org/10.1200/jco.2014.59.5298	journal	July 2015
Pharmacokinetics of paclitaxel-containing liposomes in rats Fetterly, Gerald J.; Straubinger, Robert M. AAPS PharmSci, Vol. 5, Issue 4 https://doi.org/10.1208/ps050432	journal	December 2003
Paclitaxel in cancer therapy Markman, Maurie; Mekhail, Tarek M. Expert Opinion on Pharmacotherapy, Vol. 3, Issue 6 https://doi.org/10.1517/14656566.3.6.755	journal	June 2002
Paclitaxel for non-small cell lung cancer Ramalingam, Sakkaraiappan; Belani, Chandra P. Expert Opinion on Pharmacotherapy, Vol. 5, Issue 8 https://doi.org/10.1517/14656566.5.8.1771	journal	August 2004
Cationic lipid–DNA complexes for non-viral gene therapy: relating supramolecular structures to cellular pathways Ewert, Kai; Ahmad, Ayesha; Evans, Heather M. Expert Opinion on Biological Therapy, Vol. 5, Issue 1 https://doi.org/10.1517/14712598.5.1.33	journal	January 2005
Challenges in the pharmaceutical development of lipid-based short interfering ribonucleic acid therapeutics Gindy, Marian E.; Leone, Anthony M.; Cunningham, James J. Expert Opinion on Drug Delivery, Vol. 9, Issue 2 https://doi.org/10.1517/17425247.2012.642363	journal	January 2012
Endometrial Carcinoma: A Review of Chemotherapy, Drug Resistance, and the Search for New Agents Moxley, Katherine M.; McMeekin, D. Scott The Oncologist, Vol. 15, Issue 10 https://doi.org/10.1634/theoncologist.2010-0087	journal	October 2010
Development of paclitaxel-loaded liposomal nanocarrier stabilized by triglyceride incorporation Lim, Soo-Jeong; Hong, Soon-Seok; Choi, Ju Yeon International Journal of Nanomedicine, Vol. Volume 11 https://doi.org/10.2147/ijn.s113723	journal	January 2016
Docosahexaenoic acid liposomes for targeting chronic inflammatory diseases and cancer: an in vitro assessment Alaarg, Amr; Jordan, Nan; Verhoef, Johan International Journal of Nanomedicine, Vol. Volume 11 https://doi.org/10.2147/ijn.s115995	journal	January 2016
Optimization of drug loading to improve physical stability of paclitaxel-loaded long-circulating liposomes Kannan, Vinayagam; Balabathula, Pavan; Divi, Murali K. Journal of Liposome Research, Vol. 25, Issue 4 https://doi.org/10.3109/08982104.2014.995671	journal	December 2014
Advances and Challenges of Liposome Assisted Drug Delivery Sercombe, Lisa; Veerati, Tejaswi; Moheimani, Fatemeh Frontiers in Pharmacology, Vol. 6 https://doi.org/10.3389/fphar.2015.00286	journal	December 2015
Liposomal paclitaxel induces fewer hematopoietic and cardiovascular complications than bioequivalent doses of Taxol Huang, Shih-Ting; Wang, Yi‑Ping; Chen, Yen-Hui International Journal of Oncology https://doi.org/10.3892/ijo.2018.4449	journal	June 2018
Paclitaxel Nano-Delivery Systems: A Comprehensive Review Ma, Ping Journal of Nanomedicine & Nanotechnology, Vol. 04, Issue 02 https://doi.org/10.4172/2157-7439.1000164	journal	January 2013
Designing Paclitaxel Drug Delivery Systems Aimed at Improved Patient Outcomes: Current Status and Challenges Surapaneni, Madhu S.; Das, Sudip K.; Das, Nandita G. ISRN Pharmacology, Vol. 2012 https://doi.org/10.5402/2012/623139	journal	August 2012

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Title: Paclitaxel loading in cationic liposome vectors is enhanced by replacement of oleoyl with linoleoyl tails with distinct lipid shapes

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