Glove-based sensors for multimodal monitoring of natural sweat

Bariya, Mallika; Li, Lu; Ghattamaneni, Rahul; Ahn, Christine Heera; Nyein, Hnin Yin Yin; Tai, Li-Chia; Javey, Ali

doi:10.1126/sciadv.abb8308

Title: Glove-based sensors for multimodal monitoring of natural sweat

Abstract

Sweat sensors targeting exercise or chemically induced sweat have shown promise for noninvasive health monitoring. Natural thermoregulatory sweat is an attractive alternative as it can be accessed during routine and sedentary activity without impeding user lifestyles and potentially preserves correlations between sweat and blood biomarkers. We present simple glove-based sensors to accumulate natural sweat with minimal evaporation, capitalizing on high sweat gland densities to collect hundreds of microliters in just 30 min without active sweat stimulation. Sensing electrodes are patterned on nitrile gloves and finger cots for in situ detection of diverse biomarkers, including electrolytes and xenobiotics, and multiple gloves or cots are worn in sequence to track overarching analyte dynamics. Direct integration of sensors into gloves represents a simple and low-overhead scheme for natural sweat analysis, enabling sweat-based physiological monitoring to become practical and routine without requiring highly complex or miniaturized components for analyte collection and signal transduction.

Authors:

^[1]; Li, Lu ^[1];

^[2];

^[1];

^[1]

Univ. of California, Berkeley, CA (United States). Dept. of Electrical Engineering and Computer Sciences and Berkeley Sensor and Actuator Center; Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Materials Sciences Division
Univ. of California, Berkeley, CA (United States). Dept. of Electrical Engineering and Computer Sciences

Publication Date:: Fri Aug 28 00:00:00 EDT 2020

Research Org.:: Univ. of California, Berkeley, CA (United States)

Sponsoring Org.:: USDOE Office of Science (SC)

OSTI Identifier:: 1816091

Grant/Contract Number:: AC02-05CH11231

Resource Type:: Accepted Manuscript

Journal Name:: Science Advances

Additional Journal Information:: Journal Volume: 6; Journal Issue: 35; Journal ID: ISSN 2375-2548

Publisher:: AAAS

Country of Publication:: United States

Language:: English

Subject:: 42 ENGINEERING

Citation Formats


                    Bariya, Mallika, Li, Lu, Ghattamaneni, Rahul, Ahn, Christine Heera, Nyein, Hnin Yin Yin, Tai, Li-Chia, and Javey, Ali. Glove-based sensors for multimodal monitoring of natural sweat.  United States: N. p., 2020. 
Web.  doi:10.1126/sciadv.abb8308.

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                    Bariya, Mallika, Li, Lu, Ghattamaneni, Rahul, Ahn, Christine Heera, Nyein, Hnin Yin Yin, Tai, Li-Chia, & Javey, Ali. Glove-based sensors for multimodal monitoring of natural sweat.  United States.  https://doi.org/10.1126/sciadv.abb8308

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                    Bariya, Mallika, Li, Lu, Ghattamaneni, Rahul, Ahn, Christine Heera, Nyein, Hnin Yin Yin, Tai, Li-Chia, and Javey, Ali. Fri .  
"Glove-based sensors for multimodal monitoring of natural sweat".  United States.  https://doi.org/10.1126/sciadv.abb8308.  https://www.osti.gov/servlets/purl/1816091.

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@article{osti_1816091,

  title        = {Glove-based sensors for multimodal monitoring of natural sweat},

  author       = {Bariya, Mallika and Li, Lu and Ghattamaneni, Rahul and Ahn, Christine Heera and Nyein, Hnin Yin Yin and Tai, Li-Chia and Javey, Ali},

  abstractNote = {Sweat sensors targeting exercise or chemically induced sweat have shown promise for noninvasive health monitoring. Natural thermoregulatory sweat is an attractive alternative as it can be accessed during routine and sedentary activity without impeding user lifestyles and potentially preserves correlations between sweat and blood biomarkers. We present simple glove-based sensors to accumulate natural sweat with minimal evaporation, capitalizing on high sweat gland densities to collect hundreds of microliters in just 30 min without active sweat stimulation. Sensing electrodes are patterned on nitrile gloves and finger cots for in situ detection of diverse biomarkers, including electrolytes and xenobiotics, and multiple gloves or cots are worn in sequence to track overarching analyte dynamics. Direct integration of sensors into gloves represents a simple and low-overhead scheme for natural sweat analysis, enabling sweat-based physiological monitoring to become practical and routine without requiring highly complex or miniaturized components for analyte collection and signal transduction.},

  doi          = {10.1126/sciadv.abb8308},

  journal      = {Science Advances},

  number       = 35,

  volume       = 6,

  place        = {United States},

  year         = {Fri Aug 28 00:00:00 EDT 2020},

  month        = {Fri Aug 28 00:00:00 EDT 2020}

}

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Works referenced in this record:

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Similar Records

Title: Glove-based sensors for multimodal monitoring of natural sweat

Abstract

Citation Formats

The Excretion of Ascorbic acid and Dehydroascorbic acid in Sweat and Urine Under Different Environmental Conditions journal, November 1945

Wearable biosensors for healthcare monitoring journal, February 2019

A wearable patch for continuous monitoring of sweat electrolytes during exertion journal, January 2018

Mechanisms of reversible stretchability of thin metal films on elastomeric substrates journal, May 2006

Wearable Electrochemical Sensors and Biosensors: A Review journal, September 2012

The microfluidics of the eccrine sweat gland, including biomarker partitioning, transport, and biosensing implications journal, May 2015

Prolonged and localized sweat stimulation by iontophoretic delivery of the slowly-metabolized cholinergic agent carbachol journal, January 2018

Sweating-Physiology and Pathophysiology journal, December 1976

Excitation and depression of eccrine sweat glands by acetylcholine, acetyl-β-methylcholine and adrenaline journal, October 1959

The regional distribution of sweating journal, June 1945

Regional variations in transepidermal water loss, eccrine sweat gland density, sweat secretion rates and electrolyte composition in resting and exercising humans journal, February 2013

Simultaneous lancet-free monitoring of alcohol and glucose from low-volumes of perspired human sweat journal, April 2018

Enhancing glucose flux into sweat by increasing paracellular permeability of the sweat gland journal, July 2018

Fully integrated wearable sensor arrays for multiplexed in situ perspiration analysis journal, January 2016

Wearable sweat sensors journal, March 2018

Sweat Ethanol Concentrations are Highly Correlated with Co-Existing Blood Values in Humans journal, March 1999

A soft, wearable microfluidic device for the capture, storage, and colorimetric sensing of sweat journal, November 2016

Flexible thick-film glucose biosensor: Influence of mechanical bending on the performance journal, April 2010

Natural Perspiration Sampling and in Situ Electrochemical Analysis with Hydrogel Micropatches for User-Identifiable and Wireless Chemo/Biosensing journal, December 2019

A Bromphenol Blue Method for Visualizing Sweat at the Openings of the Sweat Ducts**From the Physiological Laboratory, Tohoku University School of Medicine, Sendai, Japan. journal, January 1961

Stretchable gold conductors embedded in PDMS and patterned by photolithography: fabrication and electromechanical characterization journal, April 2010

Noninvasive Alcohol Monitoring Using a Wearable Tattoo-Based Iontophoretic-Biosensing System journal, July 2016

Gender-linked differences in human skin journal, September 2009

Modified iodine-paper technique for the standardized determination of sweat gland activation journal, April 2012

Biomechanical performance of powder-free examination gloves journal, November 1999

Wearable Sweat Band for Noninvasive Levodopa Monitoring journal, August 2019

Neural control of sweat secretion: a review journal, April 2018

Methylxanthine Drug Monitoring with Wearable Sweat Sensors journal, April 2018

Complete validation of a continuous and blood-correlated sweat biosensing device with integrated sweat stimulation journal, January 2018

Epidermal Microfluidic Electrochemical Detection System: Enhanced Sweat Sampling and Metabolite Detection journal, December 2017

Autonomous sweat extraction and analysis applied to cystic fibrosis and glucose monitoring using a fully integrated wearable platform journal, April 2017

Effect of induced metabolic alkalosis on sweat composition in men: Alkalosis and sweat composition journal, January 2002

Acid-Base Balance in Sweat journal, August 1932

A novel non-invasive electrochemical biosensing device for in situ determination of the alcohol content in blood by monitoring ethanol in sweat journal, January 2014

A laser-engraved wearable sensor for sensitive detection of uric acid and tyrosine in sweat journal, November 2019

Vitamin C Pharmacokinetics: Implications for Oral and Intravenous Use journal, April 2004

Regional and correlative sweat analysis using high-throughput microfluidic sensing patches toward decoding sweat journal, August 2019

Battery-free, skin-interfaced microfluidic/electronic systems for simultaneous electrochemical, colorimetric, and volumetric analysis of sweat journal, January 2019

Porous Enzymatic Membrane for Nanotextured Glucose Sweat Sensors with High Stability toward Reliable Noninvasive Health Monitoring journal, June 2019

Accessing analytes in biofluids for peripheral biochemical monitoring journal, February 2019

Wearable Microsensor Array for Multiplexed Heavy Metal Monitoring of Body Fluids journal, May 2016

Integrated sudomotor axon reflex sweat stimulation for continuous sweat analyte analysis with individuals at rest journal, January 2017

A Wearable Electrochemical Platform for Noninvasive Simultaneous Monitoring of Ca 2+ and pH journal, July 2016

Wearable/disposable sweat-based glucose monitoring device with multistage transdermal drug delivery module journal, March 2017

Flexible thick-film electrochemical sensors: Impact of mechanical bending and stress on the electrochemical behavior journal, March 2009

The Excretion of Ascorbic acid and Dehydroascorbic acid in Sweat and Urine Under Different Environmental Conditions
journal, November 1945

Wearable biosensors for healthcare monitoring
journal, February 2019

A wearable patch for continuous monitoring of sweat electrolytes during exertion
journal, January 2018

Mechanisms of reversible stretchability of thin metal films on elastomeric substrates
journal, May 2006

Wearable Electrochemical Sensors and Biosensors: A Review
journal, September 2012

The microfluidics of the eccrine sweat gland, including biomarker partitioning, transport, and biosensing implications
journal, May 2015

Prolonged and localized sweat stimulation by iontophoretic delivery of the slowly-metabolized cholinergic agent carbachol
journal, January 2018

Sweating-Physiology and Pathophysiology
journal, December 1976

Excitation and depression of eccrine sweat glands by acetylcholine, acetyl-β-methylcholine and adrenaline
journal, October 1959

The regional distribution of sweating
journal, June 1945

Regional variations in transepidermal water loss, eccrine sweat gland density, sweat secretion rates and electrolyte composition in resting and exercising humans
journal, February 2013

Simultaneous lancet-free monitoring of alcohol and glucose from low-volumes of perspired human sweat
journal, April 2018

Enhancing glucose flux into sweat by increasing paracellular permeability of the sweat gland
journal, July 2018

Fully integrated wearable sensor arrays for multiplexed in situ perspiration analysis
journal, January 2016

Wearable sweat sensors
journal, March 2018

Sweat Ethanol Concentrations are Highly Correlated with Co-Existing Blood Values in Humans
journal, March 1999

A soft, wearable microfluidic device for the capture, storage, and colorimetric sensing of sweat
journal, November 2016

Flexible thick-film glucose biosensor: Influence of mechanical bending on the performance
journal, April 2010

Natural Perspiration Sampling and in Situ Electrochemical Analysis with Hydrogel Micropatches for User-Identifiable and Wireless Chemo/Biosensing
journal, December 2019

A Bromphenol Blue Method for Visualizing Sweat at the Openings of the Sweat Ducts**From the Physiological Laboratory, Tohoku University School of Medicine, Sendai, Japan.
journal, January 1961

Stretchable gold conductors embedded in PDMS and patterned by photolithography: fabrication and electromechanical characterization
journal, April 2010

Noninvasive Alcohol Monitoring Using a Wearable Tattoo-Based Iontophoretic-Biosensing System
journal, July 2016

Gender-linked differences in human skin
journal, September 2009

Modified iodine-paper technique for the standardized determination of sweat gland activation
journal, April 2012

Biomechanical performance of powder-free examination gloves
journal, November 1999

Wearable Sweat Band for Noninvasive Levodopa Monitoring
journal, August 2019

Neural control of sweat secretion: a review
journal, April 2018

Methylxanthine Drug Monitoring with Wearable Sweat Sensors
journal, April 2018

Complete validation of a continuous and blood-correlated sweat biosensing device with integrated sweat stimulation
journal, January 2018

Epidermal Microfluidic Electrochemical Detection System: Enhanced Sweat Sampling and Metabolite Detection
journal, December 2017

Autonomous sweat extraction and analysis applied to cystic fibrosis and glucose monitoring using a fully integrated wearable platform
journal, April 2017

Effect of induced metabolic alkalosis on sweat composition in men: Alkalosis and sweat composition
journal, January 2002

Acid-Base Balance in Sweat
journal, August 1932

A novel non-invasive electrochemical biosensing device for in situ determination of the alcohol content in blood by monitoring ethanol in sweat
journal, January 2014

A laser-engraved wearable sensor for sensitive detection of uric acid and tyrosine in sweat
journal, November 2019

Vitamin C Pharmacokinetics: Implications for Oral and Intravenous Use
journal, April 2004

Regional and correlative sweat analysis using high-throughput microfluidic sensing patches toward decoding sweat
journal, August 2019

Battery-free, skin-interfaced microfluidic/electronic systems for simultaneous electrochemical, colorimetric, and volumetric analysis of sweat
journal, January 2019

Porous Enzymatic Membrane for Nanotextured Glucose Sweat Sensors with High Stability toward Reliable Noninvasive Health Monitoring
journal, June 2019

Accessing analytes in biofluids for peripheral biochemical monitoring
journal, February 2019

Wearable Microsensor Array for Multiplexed Heavy Metal Monitoring of Body Fluids
journal, May 2016

Integrated sudomotor axon reflex sweat stimulation for continuous sweat analyte analysis with individuals at rest
journal, January 2017

A Wearable Electrochemical Platform for Noninvasive Simultaneous Monitoring of Ca ²⁺ and pH
journal, July 2016

Wearable/disposable sweat-based glucose monitoring device with multistage transdermal drug delivery module
journal, March 2017

Flexible thick-film electrochemical sensors: Impact of mechanical bending and stress on the electrochemical behavior
journal, March 2009