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Title: A multi-modal sweat sensing patch for cross-verification of sweat rate, total ionic charge, and Na+ concentration

Abstract

Sweat sensors introduced in recent years have targeted a variety of sweat features and biomarkers for non-invasive health monitoring. Amongst these targets, reliable monitoring of sweat rate is crucial due to its modulation of sweat analyte concentrations and its intrinsic significance to numerous medical and physiological health conditions. In this paper, we present a sweat rate sensor structure comprising of electrodes with interdigitated fingers in a microfluidic channel. Each time the accumulating sweat impinges on an electrode finger, the sensor reports a jump in admittance that can be simply and efficiently counted to estimate sweat rate, overcoming selectivity limitations of previously reported sweat rate sensors. We further integrate an impedimetric sensor for measuring total ionic charge concentration and an electrochemical Na+ sensor, together creating a multi-modal system for analyzing fluid and electrolyte secretion. We demonstrate how low analyte diffusion rates through this microfluidic device allow for multi-purpose sensor function, including utilizing the sweat rate sensor signal to corroborate total ionic sensor measurements. This cross-verification capability ensures data integrity in real time, satisfying a vital consideration for personalized healthcare technologies. We use the presented patch for continuous analysis of sweat rate, total ionic charge concentration, and Na+ concentration during exercise, whilemore » demonstrating how multi-modal cross-verification brings new trust to sensor readings.« less

Authors:
 [1];  [1]; ORCiD logo [1];  [1];  [1];  [1];  [1];  [1]
  1. Univ. of California, Berkeley, CA (United States). Dept. of Electrical Engineering and Computer Sciences and Berkeley Sensor and Actuator Center; Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Materials Sciences Division
Publication Date:
Research Org.:
Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
Sponsoring Org.:
USDOE Office of Science (SC), Basic Energy Sciences (BES). Materials Sciences & Engineering Division; National Science Foundation (NSF)
OSTI Identifier:
1638996
Grant/Contract Number:  
AC02-05CH11231
Resource Type:
Accepted Manuscript
Journal Name:
Lab on a chip (Print)
Additional Journal Information:
Journal Name: Lab on a chip (Print); Journal Volume: 19; Journal Issue: 19; Journal ID: ISSN 1473-0197
Publisher:
Royal Society of Chemistry
Country of Publication:
United States
Language:
English
Subject:
47 OTHER INSTRUMENTATION

Citation Formats

Yuan, Zhen, Hou, Lei, Bariya, Mallika, Nyein, Hnin Yin Yin, Tai, Li-Chia, Ji, Wenbo, Li, Lu, and Javey, Ali. A multi-modal sweat sensing patch for cross-verification of sweat rate, total ionic charge, and Na+ concentration. United States: N. p., 2019. Web. https://doi.org/10.1039/c9lc00598f.
Yuan, Zhen, Hou, Lei, Bariya, Mallika, Nyein, Hnin Yin Yin, Tai, Li-Chia, Ji, Wenbo, Li, Lu, & Javey, Ali. A multi-modal sweat sensing patch for cross-verification of sweat rate, total ionic charge, and Na+ concentration. United States. https://doi.org/10.1039/c9lc00598f
Yuan, Zhen, Hou, Lei, Bariya, Mallika, Nyein, Hnin Yin Yin, Tai, Li-Chia, Ji, Wenbo, Li, Lu, and Javey, Ali. Mon . "A multi-modal sweat sensing patch for cross-verification of sweat rate, total ionic charge, and Na+ concentration". United States. https://doi.org/10.1039/c9lc00598f. https://www.osti.gov/servlets/purl/1638996.
@article{osti_1638996,
title = {A multi-modal sweat sensing patch for cross-verification of sweat rate, total ionic charge, and Na+ concentration},
author = {Yuan, Zhen and Hou, Lei and Bariya, Mallika and Nyein, Hnin Yin Yin and Tai, Li-Chia and Ji, Wenbo and Li, Lu and Javey, Ali},
abstractNote = {Sweat sensors introduced in recent years have targeted a variety of sweat features and biomarkers for non-invasive health monitoring. Amongst these targets, reliable monitoring of sweat rate is crucial due to its modulation of sweat analyte concentrations and its intrinsic significance to numerous medical and physiological health conditions. In this paper, we present a sweat rate sensor structure comprising of electrodes with interdigitated fingers in a microfluidic channel. Each time the accumulating sweat impinges on an electrode finger, the sensor reports a jump in admittance that can be simply and efficiently counted to estimate sweat rate, overcoming selectivity limitations of previously reported sweat rate sensors. We further integrate an impedimetric sensor for measuring total ionic charge concentration and an electrochemical Na+ sensor, together creating a multi-modal system for analyzing fluid and electrolyte secretion. We demonstrate how low analyte diffusion rates through this microfluidic device allow for multi-purpose sensor function, including utilizing the sweat rate sensor signal to corroborate total ionic sensor measurements. This cross-verification capability ensures data integrity in real time, satisfying a vital consideration for personalized healthcare technologies. We use the presented patch for continuous analysis of sweat rate, total ionic charge concentration, and Na+ concentration during exercise, while demonstrating how multi-modal cross-verification brings new trust to sensor readings.},
doi = {10.1039/c9lc00598f},
journal = {Lab on a chip (Print)},
number = 19,
volume = 19,
place = {United States},
year = {2019},
month = {8}
}

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Cited by: 6 works
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    Works referencing / citing this record:

    Ultra-simple wearable local sweat volume monitoring patch based on swellable hydrogels
    journal, January 2020

    • Zhao, F. J.; Bonmarin, M.; Chen, Z. C.
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