Smart Self‐Assembly Amphiphilic Cyclopeptide‐Dye for Near‐Infrared Window‐II Imaging
Abstract
Abstract Development of novel nanomaterials for disease theranostics represents an important direction in chemistry and precision medicine. Fluorescent molecular probes in the second near‐infrared window (NIR‐II, 1000–1700 nm) show high promise because of their exceptional high detection sensitivity, resolution, and deep imaging depth. Here, a sharp pH‐sensitive self‐assembling cyclopeptide‐dye, SIMM1000, as a smart nanoprobe for NIR‐II imaging of diseases in living animals, is reported. This small molecule assembled nanoprobe exhibits smart properties by responding to a sharp decrease of pH in the tumor microenvironment (pH 7.0 to 6.8), aggregating from small nanoprobe (80 nm at pH 7.0) into large nanoparticles (>500 nm at pH 6.8) with ≈20–30 times enhanced fluorescence compared with the non‐self‐assembled CH‐4T. It yields micrometer‐scale resolution in blood vessel imaging and high contrast and resolution in bone and tumor imaging in mice. Because of its self‐aggregation in acidic tumor microenvironments in situ, SIMM1000 exhibits high tumor accumulation and extremely long tumor retention (>19 days), while being excretable from normal tissues and safe. This smart self‐assembling small molecule strategy can shift the paradigm of designing new nanomaterials for molecular imaging and drug development.
- Authors:
-
[1];
[2]
- Center for Molecular Imaging Research Shanghai Institute of Materia Medica Chinese Academy of Sciences Shanghai 201203 China
- Molecular Imaging Program at Stanford (MIPS) Bio‐X Program and Department of Radiology Canary Center at Stanford for Cancer Early Detection Stanford University Stanford CA 94305–5344 USA
- Division of Oncology Departments of Medicine and Pathology Stanford University School of Medicine Stanford CA 94305 USA
- CAS Key Laboratory of Molecular Imaging The State Key Laboratory of Management and Control for Complex Systems Beijing Key Laboratory of Molecular Imaging Institute of Automation Chinese Academy of Sciences Beijing 100190 China
- Publication Date:
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1804182
- Grant/Contract Number:
- DE‐SC0008397
- Resource Type:
- Publisher's Accepted Manuscript
- Journal Name:
- Advanced Materials
- Additional Journal Information:
- Journal Name: Advanced Materials Journal Volume: 33 Journal Issue: 16; Journal ID: ISSN 0935-9648
- Publisher:
- Wiley Blackwell (John Wiley & Sons)
- Country of Publication:
- Germany
- Language:
- English
Citation Formats
Chen, Hao, Shou, Kangquan, Chen, Si, Qu, Chunrong, Wang, Zhiming, Jiang, Lei, Zhu, Mark, Ding, Bingbing, Qian, Kun, Ji, Aiyan, Lou, Hongyue, Tong, Ling, Hsu, Alexander, Wang, Yuebing, Felsher, Dean W., Hu, Zhenhua, Tian, Jie, and Cheng, Zhen. Smart Self‐Assembly Amphiphilic Cyclopeptide‐Dye for Near‐Infrared Window‐II Imaging. Germany: N. p., 2021.
Web. doi:10.1002/adma.202006902.
Chen, Hao, Shou, Kangquan, Chen, Si, Qu, Chunrong, Wang, Zhiming, Jiang, Lei, Zhu, Mark, Ding, Bingbing, Qian, Kun, Ji, Aiyan, Lou, Hongyue, Tong, Ling, Hsu, Alexander, Wang, Yuebing, Felsher, Dean W., Hu, Zhenhua, Tian, Jie, & Cheng, Zhen. Smart Self‐Assembly Amphiphilic Cyclopeptide‐Dye for Near‐Infrared Window‐II Imaging. Germany. https://doi.org/10.1002/adma.202006902
Chen, Hao, Shou, Kangquan, Chen, Si, Qu, Chunrong, Wang, Zhiming, Jiang, Lei, Zhu, Mark, Ding, Bingbing, Qian, Kun, Ji, Aiyan, Lou, Hongyue, Tong, Ling, Hsu, Alexander, Wang, Yuebing, Felsher, Dean W., Hu, Zhenhua, Tian, Jie, and Cheng, Zhen. Fri .
"Smart Self‐Assembly Amphiphilic Cyclopeptide‐Dye for Near‐Infrared Window‐II Imaging". Germany. https://doi.org/10.1002/adma.202006902.
@article{osti_1804182,
title = {Smart Self‐Assembly Amphiphilic Cyclopeptide‐Dye for Near‐Infrared Window‐II Imaging},
author = {Chen, Hao and Shou, Kangquan and Chen, Si and Qu, Chunrong and Wang, Zhiming and Jiang, Lei and Zhu, Mark and Ding, Bingbing and Qian, Kun and Ji, Aiyan and Lou, Hongyue and Tong, Ling and Hsu, Alexander and Wang, Yuebing and Felsher, Dean W. and Hu, Zhenhua and Tian, Jie and Cheng, Zhen},
abstractNote = {Abstract Development of novel nanomaterials for disease theranostics represents an important direction in chemistry and precision medicine. Fluorescent molecular probes in the second near‐infrared window (NIR‐II, 1000–1700 nm) show high promise because of their exceptional high detection sensitivity, resolution, and deep imaging depth. Here, a sharp pH‐sensitive self‐assembling cyclopeptide‐dye, SIMM1000, as a smart nanoprobe for NIR‐II imaging of diseases in living animals, is reported. This small molecule assembled nanoprobe exhibits smart properties by responding to a sharp decrease of pH in the tumor microenvironment (pH 7.0 to 6.8), aggregating from small nanoprobe (80 nm at pH 7.0) into large nanoparticles (>500 nm at pH 6.8) with ≈20–30 times enhanced fluorescence compared with the non‐self‐assembled CH‐4T. It yields micrometer‐scale resolution in blood vessel imaging and high contrast and resolution in bone and tumor imaging in mice. Because of its self‐aggregation in acidic tumor microenvironments in situ, SIMM1000 exhibits high tumor accumulation and extremely long tumor retention (>19 days), while being excretable from normal tissues and safe. This smart self‐assembling small molecule strategy can shift the paradigm of designing new nanomaterials for molecular imaging and drug development.},
doi = {10.1002/adma.202006902},
journal = {Advanced Materials},
number = 16,
volume = 33,
place = {Germany},
year = {Fri Mar 12 00:00:00 EST 2021},
month = {Fri Mar 12 00:00:00 EST 2021}
}
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