Uniform, Large-Area, Highly Ordered Peptoid Monolayer and Bilayer Films for Sensing Applications
Abstract
The production of atomically defined, uniform, large-area 2D materials remains as a challenge in materials chemistry. Many methods to produce 2D nanomaterials suffer from limited lateral film dimensions, lack of film uniformity, or limited chemical diversity. These issues have hindered the application of these materials to sensing applications, which require large-area uniform films to achieve reliable and consistent signals. Furthermore, the development of a 2D material system that is biocompatible and readily chemically tunable has been a fundamental challenge. Here, we report a simple, robust method for the production of large-area, uniform, and highly tunable monolayer and bilayer films, from sequence-defined peptoid polymers, and their application as highly selective molecular recognition elements in sensor production. Monolayers and bilayer films were produced on the centimeter scale using Langmuir-Blodgett methods and exhibited a high degree of uniformity and ordering as evidenced by atomic force microscopy, electron diffraction, and grazing incidence X-ray scattering. We further demonstrated the utility of these films in sensing applications by employing the biolayer interferometry technique to detect the specific binding of the pathogen derived proteins, shiga toxin and anthrax protective antigen, to peptoid-coated sensors.
- Authors:
-
[2];
[3];
[1]
- Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
- Univ. of California, San Francisco, CA (United States)
- Chan Zuckerberg Biohub, San Francisco, CA (United States); Univ. of California, San Francisco, CA (United States)
- Publication Date:
- Research Org.:
- Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
- Sponsoring Org.:
- USDOE Office of Science (SC), Basic Energy Sciences (BES)
- OSTI Identifier:
- 1779229
- Grant/Contract Number:
- AC02-05CH11231
- Resource Type:
- Accepted Manuscript
- Journal Name:
- Langmuir
- Additional Journal Information:
- Journal Volume: 35; Journal Issue: 42; Journal ID: ISSN 0743-7463
- Publisher:
- American Chemical Society
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY; Vesicles; Thin films; Two dimensional materials; Monolayers; Deposition
Citation Formats
Murray, Daniel J., Kim, Jae Hong, Grzincic, Elissa M., Kim, Samuel C., Abate, Adam R., and Zuckermann, Ronald N. Uniform, Large-Area, Highly Ordered Peptoid Monolayer and Bilayer Films for Sensing Applications. United States: N. p., 2019.
Web. doi:10.1021/acs.langmuir.9b02557.
Murray, Daniel J., Kim, Jae Hong, Grzincic, Elissa M., Kim, Samuel C., Abate, Adam R., & Zuckermann, Ronald N. Uniform, Large-Area, Highly Ordered Peptoid Monolayer and Bilayer Films for Sensing Applications. United States. https://doi.org/10.1021/acs.langmuir.9b02557
Murray, Daniel J., Kim, Jae Hong, Grzincic, Elissa M., Kim, Samuel C., Abate, Adam R., and Zuckermann, Ronald N. Fri .
"Uniform, Large-Area, Highly Ordered Peptoid Monolayer and Bilayer Films for Sensing Applications". United States. https://doi.org/10.1021/acs.langmuir.9b02557. https://www.osti.gov/servlets/purl/1779229.
@article{osti_1779229,
title = {Uniform, Large-Area, Highly Ordered Peptoid Monolayer and Bilayer Films for Sensing Applications},
author = {Murray, Daniel J. and Kim, Jae Hong and Grzincic, Elissa M. and Kim, Samuel C. and Abate, Adam R. and Zuckermann, Ronald N.},
abstractNote = {The production of atomically defined, uniform, large-area 2D materials remains as a challenge in materials chemistry. Many methods to produce 2D nanomaterials suffer from limited lateral film dimensions, lack of film uniformity, or limited chemical diversity. These issues have hindered the application of these materials to sensing applications, which require large-area uniform films to achieve reliable and consistent signals. Furthermore, the development of a 2D material system that is biocompatible and readily chemically tunable has been a fundamental challenge. Here, we report a simple, robust method for the production of large-area, uniform, and highly tunable monolayer and bilayer films, from sequence-defined peptoid polymers, and their application as highly selective molecular recognition elements in sensor production. Monolayers and bilayer films were produced on the centimeter scale using Langmuir-Blodgett methods and exhibited a high degree of uniformity and ordering as evidenced by atomic force microscopy, electron diffraction, and grazing incidence X-ray scattering. We further demonstrated the utility of these films in sensing applications by employing the biolayer interferometry technique to detect the specific binding of the pathogen derived proteins, shiga toxin and anthrax protective antigen, to peptoid-coated sensors.},
doi = {10.1021/acs.langmuir.9b02557},
journal = {Langmuir},
number = 42,
volume = 35,
place = {United States},
year = {Fri Oct 11 00:00:00 EDT 2019},
month = {Fri Oct 11 00:00:00 EDT 2019}
}
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