Genomic Characterization of Newly Completed Genomes of Botulinum Neurotoxin-Producing Species from Argentina, Australia, and Africa
Abstract
Botulinum neurotoxin-producing clostridia are diverse in the types of toxins they produce as well as in their overall genomic composition. They are globally distributed, with prevalent species and toxin types found within distinct geographic regions, but related strains containing the same toxin types may also be located on distinct continents. The mechanisms behind the spread of these bacteria and the independent movements of their bont genes may be understood through examination of their genetic backgrounds. The generation of 15 complete genomic sequences from bacteria isolated in Argentina, Australia, and Africa allows for a thorough examination of genome features, including overall relationships, bont gene cluster locations and arrangements, and plasmid comparisons, in bacteria isolated from various areas in the southern hemisphere. Insights gained from these examinations provide an understanding of the mechanisms behind the independent movements of these elements among distinct species.
- Authors:
-
[2];
[2]
- Northern Arizona Univ., Flagstaff, AZ (United States)
- Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
- Univ. Nacional de Cuyo, Mendoza (Argentina)
- Publication Date:
- Research Org.:
- Los Alamos National Laboratory (LANL), Los Alamos, NM (United States)
- Sponsoring Org.:
- US Department of Homeland Security (DHS)
- OSTI Identifier:
- 1688743
- Report Number(s):
- LA-UR-19-26361
Journal ID: ISSN 1759-6653
- Grant/Contract Number:
- 89233218CNA000001; HSHQPM-15-X-00229
- Resource Type:
- Accepted Manuscript
- Journal Name:
- Genome Biology and Evolution
- Additional Journal Information:
- Journal Volume: 12; Journal Issue: 3; Journal ID: ISSN 1759-6653
- Publisher:
- Society for Molecular Biology and Evolution
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES; biological science; clostridia; botulinum neurotoxin producing; Argentina; Australia; Africa
Citation Formats
Smith, Theresa J., Xie, Gary, Williamson, Charles H. D., Hill, Karen K., Fernández, Rafael A., Sahl, Jason W., Keim, Paul, and Johnson, Shannon L. Genomic Characterization of Newly Completed Genomes of Botulinum Neurotoxin-Producing Species from Argentina, Australia, and Africa. United States: N. p., 2020.
Web. doi:10.1093/gbe/evaa043.
Smith, Theresa J., Xie, Gary, Williamson, Charles H. D., Hill, Karen K., Fernández, Rafael A., Sahl, Jason W., Keim, Paul, & Johnson, Shannon L. Genomic Characterization of Newly Completed Genomes of Botulinum Neurotoxin-Producing Species from Argentina, Australia, and Africa. United States. https://doi.org/10.1093/gbe/evaa043
Smith, Theresa J., Xie, Gary, Williamson, Charles H. D., Hill, Karen K., Fernández, Rafael A., Sahl, Jason W., Keim, Paul, and Johnson, Shannon L. Mon .
"Genomic Characterization of Newly Completed Genomes of Botulinum Neurotoxin-Producing Species from Argentina, Australia, and Africa". United States. https://doi.org/10.1093/gbe/evaa043. https://www.osti.gov/servlets/purl/1688743.
@article{osti_1688743,
title = {Genomic Characterization of Newly Completed Genomes of Botulinum Neurotoxin-Producing Species from Argentina, Australia, and Africa},
author = {Smith, Theresa J. and Xie, Gary and Williamson, Charles H. D. and Hill, Karen K. and Fernández, Rafael A. and Sahl, Jason W. and Keim, Paul and Johnson, Shannon L.},
abstractNote = {Botulinum neurotoxin-producing clostridia are diverse in the types of toxins they produce as well as in their overall genomic composition. They are globally distributed, with prevalent species and toxin types found within distinct geographic regions, but related strains containing the same toxin types may also be located on distinct continents. The mechanisms behind the spread of these bacteria and the independent movements of their bont genes may be understood through examination of their genetic backgrounds. The generation of 15 complete genomic sequences from bacteria isolated in Argentina, Australia, and Africa allows for a thorough examination of genome features, including overall relationships, bont gene cluster locations and arrangements, and plasmid comparisons, in bacteria isolated from various areas in the southern hemisphere. Insights gained from these examinations provide an understanding of the mechanisms behind the independent movements of these elements among distinct species.},
doi = {10.1093/gbe/evaa043},
journal = {Genome Biology and Evolution},
number = 3,
volume = 12,
place = {United States},
year = {Mon Apr 06 00:00:00 EDT 2020},
month = {Mon Apr 06 00:00:00 EDT 2020}
}
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