In situ, in vivo, and in operando imaging and spectroscopy of liquids using microfluidics in vacuum

Yu, Xiao-Ying

doi:10.1116/1.5144499

Title: In situ, in vivo, and in operando imaging and spectroscopy of liquids using microfluidics in vacuum

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Abstract

This review offers a succinct overview of the development of a vacuum compatible microfluidic reactor, system for analysis at the liquid vacuum interface (SALVI), and its diverse applications in in situ, in vivo, and in operando imaging of liquid surfaces as well as the air-liquid (a-l), liquid-liquid (l-l), and solid-liquid (s-l) interfaces in the past decade. SALVI is one of the first microfluidics-based reactors that has enabled direct analysis of volatile liquids in vacuum surface tools such as scanning electron microscopy (SEM) and time-of-flight secondary ion mass spectrometry (ToF-SIMS). Its integration into ambient and vacuum spectroscopy and microscopy is illustrated. Several applications are highlighted including 1) imaging nano particles in liquid using in situ SEM; 2) mapping the evolving l-l interface using in situ x-ray absorption spectroscopy (XAS) and ToF-SIMS; 3) following complex air-liquid interfacial oxidation reaction products using in situ ToF-SIMS; 4) capturing biological interfaces of cells and microbes via in vivo multimodal and correlative imaging; and 5) monitoring the dynamic solid electrode and liquid electrolyte interface using in operando molecular imaging . Finally, outlook and recommendations are presented. Besides showing the holistic information volume obtained by real-time multiplexed imaging, this review intends to convey the importance of toolmore »« less

Authors:

^[1]

Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

Publication Date:: Fri Jun 19 00:00:00 EDT 2020

Research Org.:: Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

Sponsoring Org.:: USDOE

OSTI Identifier:: 1647584

Alternate Identifier(s):: OSTI ID: 1633932

Report Number(s):: PNNL-SA-150221
Journal ID: ISSN 0734-2101

Grant/Contract Number:: AC05-76RL01830; 60410

Resource Type:: Accepted Manuscript

Journal Name:: Journal of Vacuum Science and Technology A

Additional Journal Information:: Journal Volume: 38; Journal Issue: 4; Journal ID: ISSN 0734-2101

Publisher:: American Vacuum Society / AIP

Country of Publication:: United States

Language:: English

Subject:: 42 ENGINEERING; microfluidics; SALVI; in situ; in vivo; in operando; chemical imaging; air-liquid interface; liquid-liquid interface

Citation Formats


                    Yu, Xiao-Ying. In situ, in vivo, and in operando imaging and spectroscopy of liquids using microfluidics in vacuum.  United States: N. p., 2020. 
Web.  doi:10.1116/1.5144499.

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                    Yu, Xiao-Ying. In situ, in vivo, and in operando imaging and spectroscopy of liquids using microfluidics in vacuum.  United States.  https://doi.org/10.1116/1.5144499

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                    Yu, Xiao-Ying. Fri .  
"In situ, in vivo, and in operando imaging and spectroscopy of liquids using microfluidics in vacuum".  United States.  https://doi.org/10.1116/1.5144499.  https://www.osti.gov/servlets/purl/1647584.

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@article{osti_1647584,

  title        = {In situ, in vivo, and in operando imaging and spectroscopy of liquids using microfluidics in vacuum},

  author       = {Yu, Xiao-Ying},

  abstractNote = {This review offers a succinct overview of the development of a vacuum compatible microfluidic reactor, system for analysis at the liquid vacuum interface (SALVI), and its diverse applications in in situ, in vivo, and in operando imaging of liquid surfaces as well as the air-liquid (a-l), liquid-liquid (l-l), and solid-liquid (s-l) interfaces in the past decade. SALVI is one of the first microfluidics-based reactors that has enabled direct analysis of volatile liquids in vacuum surface tools such as scanning electron microscopy (SEM) and time-of-flight secondary ion mass spectrometry (ToF-SIMS). Its integration into ambient and vacuum spectroscopy and microscopy is illustrated. Several applications are highlighted including 1) imaging nano particles in liquid using in situ SEM; 2) mapping the evolving l-l interface using in situ x-ray absorption spectroscopy (XAS) and ToF-SIMS; 3) following complex air-liquid interfacial oxidation reaction products using in situ ToF-SIMS; 4) capturing biological interfaces of cells and microbes via in vivo multimodal and correlative imaging; and 5) monitoring the dynamic solid electrode and liquid electrolyte interface using in operando molecular imaging . Finally, outlook and recommendations are presented. Besides showing the holistic information volume obtained by real-time multiplexed imaging, this review intends to convey the importance of tool development in revolutionizing surface and interface analysis using vacuum platforms previously limited to solid surfaces. Microfluidics is manifested to be not limited to ambient conditions in many examples in this review. Moreover, fundamental interfacial phenomena underpinning mass and charge transfer can now be pursued in real time via innovated chemical imaging and spectroscopy.},

  doi          = {10.1116/1.5144499},

  journal      = {Journal of Vacuum Science and Technology A},

  number       = 4,

  volume       = 38,

  place        = {United States},

  year         = {Fri Jun 19 00:00:00 EDT 2020},

  month        = {Fri Jun 19 00:00:00 EDT 2020}

}

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