Methylxanthine Drug Monitoring with Wearable Sweat Sensors
Abstract
Drug monitoring plays crucial roles in doping control and precision medicine. It helps physicians tailor drug dosage for optimal benefits, track patients' compliance to prescriptions, and understand the complex pharmacokinetics of drugs. Conventional drug tests rely on invasive blood draws. While urine and sweat are attractive alternative biofluids, the state-of-the-art methods require separate sample collection and processing steps and fail to provide real-time information. In this paper, a wearable platform equipped with an electrochemical differential pulse voltammetry sensing module for drug monitoring is presented. A methylxanthine drug, caffeine, is selected to demonstrate the platform's functionalities. Sweat caffeine levels are monitored under various conditions, such as drug doses and measurement time after drug intake. Elevated sweat caffeine levels upon increasing dosage and confirmable caffeine physiological trends are observed. This work leverages a wearable sweat sensing platform toward noninvasive and continuous point-of-care drug monitoring and management.
- Authors:
-
[1];
- Univ. of California, Berkeley, CA (United States). Dept. of Electrical Engineering and Computer Sciences and Berkeley Sensor and Actuator Center; Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Materials Sciences Division
- Sunchon National Univ., Suncheon (South Korea). Department of Printed Electronics Engineering
- Publication Date:
- Research Org.:
- Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)
- Sponsoring Org.:
- USDOE Office of Science (SC), Basic Energy Sciences (BES). Materials Sciences & Engineering Division; National Science Foundation (NSF); Ministry of Food and Drug Safety in the Republic of Korea
- OSTI Identifier:
- 1638977
- Alternate Identifier(s):
- OSTI ID: 1433448
- Grant/Contract Number:
- AC02-05CH11231; 16163KKMFDS001
- Resource Type:
- Accepted Manuscript
- Journal Name:
- Advanced Materials
- Additional Journal Information:
- Journal Volume: 30; Journal Issue: 23; Journal ID: ISSN 0935-9648
- Publisher:
- Wiley
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 60 APPLIED LIFE SCIENCES; 47 OTHER INSTRUMENTATION; drug monitoring; wearable biosensors; electrochemical sensors; flexible electronics
Citation Formats
Tai, Li-Chia, Gao, Wei, Chao, Minghan, Bariya, Mallika, Ngo, Quynh P., Shahpar, Ziba, Nyein, Hnin Y. Y., Park, Hyejin, Sun, Junfeng, Jung, Younsu, Wu, Eric, Fahad, Hossain M., Lien, Der-Hsien, Ota, Hiroki, Cho, Gyoujin, and Javey, Ali. Methylxanthine Drug Monitoring with Wearable Sweat Sensors. United States: N. p., 2018.
Web. doi:10.1002/adma.201707442.
Tai, Li-Chia, Gao, Wei, Chao, Minghan, Bariya, Mallika, Ngo, Quynh P., Shahpar, Ziba, Nyein, Hnin Y. Y., Park, Hyejin, Sun, Junfeng, Jung, Younsu, Wu, Eric, Fahad, Hossain M., Lien, Der-Hsien, Ota, Hiroki, Cho, Gyoujin, & Javey, Ali. Methylxanthine Drug Monitoring with Wearable Sweat Sensors. United States. https://doi.org/10.1002/adma.201707442
Tai, Li-Chia, Gao, Wei, Chao, Minghan, Bariya, Mallika, Ngo, Quynh P., Shahpar, Ziba, Nyein, Hnin Y. Y., Park, Hyejin, Sun, Junfeng, Jung, Younsu, Wu, Eric, Fahad, Hossain M., Lien, Der-Hsien, Ota, Hiroki, Cho, Gyoujin, and Javey, Ali. Mon .
"Methylxanthine Drug Monitoring with Wearable Sweat Sensors". United States. https://doi.org/10.1002/adma.201707442. https://www.osti.gov/servlets/purl/1638977.
@article{osti_1638977,
title = {Methylxanthine Drug Monitoring with Wearable Sweat Sensors},
author = {Tai, Li-Chia and Gao, Wei and Chao, Minghan and Bariya, Mallika and Ngo, Quynh P. and Shahpar, Ziba and Nyein, Hnin Y. Y. and Park, Hyejin and Sun, Junfeng and Jung, Younsu and Wu, Eric and Fahad, Hossain M. and Lien, Der-Hsien and Ota, Hiroki and Cho, Gyoujin and Javey, Ali},
abstractNote = {Drug monitoring plays crucial roles in doping control and precision medicine. It helps physicians tailor drug dosage for optimal benefits, track patients' compliance to prescriptions, and understand the complex pharmacokinetics of drugs. Conventional drug tests rely on invasive blood draws. While urine and sweat are attractive alternative biofluids, the state-of-the-art methods require separate sample collection and processing steps and fail to provide real-time information. In this paper, a wearable platform equipped with an electrochemical differential pulse voltammetry sensing module for drug monitoring is presented. A methylxanthine drug, caffeine, is selected to demonstrate the platform's functionalities. Sweat caffeine levels are monitored under various conditions, such as drug doses and measurement time after drug intake. Elevated sweat caffeine levels upon increasing dosage and confirmable caffeine physiological trends are observed. This work leverages a wearable sweat sensing platform toward noninvasive and continuous point-of-care drug monitoring and management.},
doi = {10.1002/adma.201707442},
journal = {Advanced Materials},
number = 23,
volume = 30,
place = {United States},
year = {Mon Apr 16 00:00:00 EDT 2018},
month = {Mon Apr 16 00:00:00 EDT 2018}
}
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