A Wearable Electrochemical Platform for Noninvasive Simultaneous Monitoring of Ca2+ and pH
Abstract
Homeostasis of ionized calcium in biofluids is critical for human biological functions and organ systems. Measurement of ionized calcium for clinical applications is not easily accessible due to its strict procedures and dependence on pH. pH balance in body fluids greatly affects metabolic reactions and biological transport systems. Here, we demonstrate a wearable electrochemical device for continuous monitoring of ionized calcium and pH of body fluids using a disposable and flexible array of Ca2+ and pH sensors that interfaces with a flexible printed circuit board. This platform enables real-time quantitative analysis of these sensing elements in body fluids such as sweat, urine, and tears. Accuracy of Ca2+ concentration and pH measured by the wearable sensors is validated through inductively coupled plasma-mass spectrometry technique and a commercial pH meter, respectively. Our results show that the wearable sensors have high repeatability and selectivity to the target ions. Real-time on-body assessment of sweat is also performed, and our results indicate that calcium concentration increases with decreasing pH. Finally, this platform can be used in noninvasive continuous analysis of ionized calcium and pH in body fluids for disease diagnosis such as primary hyperparathyroidism and kidney stones.
- Authors:
-
- Univ. of California, Berkeley, CA (United States); Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Materials Sciences Division
- Univ. of California, Berkeley, CA (United States)
- Univ. of California, Berkeley, CA (United States); Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Materials Sciences Division; Stanford School of Medicine, Palo Alto, CA (United States)
- Stanford School of Medicine, Palo Alto, CA (United States)
- Publication Date:
- Research Org.:
- Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)
- Sponsoring Org.:
- National Science Foundation (NSF)
- OSTI Identifier:
- 1580044
- Grant/Contract Number:
- AC02-05CH11231
- Resource Type:
- Accepted Manuscript
- Journal Name:
- ACS Nano
- Additional Journal Information:
- Journal Volume: 10; Journal Issue: 7; Journal ID: ISSN 1936-0851
- Publisher:
- American Chemical Society (ACS)
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 47 OTHER INSTRUMENTATION; wearable biosensors; flexible electronics; multiplexed sensing; system integration; in situ analysis
Citation Formats
Nyein, Hnin Yin Yin, Gao, Wei, Shahpar, Ziba, Emaminejad, Sam, Challa, Samyuktha, Chen, Kevin, Fahad, Hossain M., Tai, Li-Chia, Ota, Hiroki, Davis, Ronald W., and Javey, Ali. A Wearable Electrochemical Platform for Noninvasive Simultaneous Monitoring of Ca2+ and pH. United States: N. p., 2016.
Web. doi:10.1021/acsnano.6b04005.
Nyein, Hnin Yin Yin, Gao, Wei, Shahpar, Ziba, Emaminejad, Sam, Challa, Samyuktha, Chen, Kevin, Fahad, Hossain M., Tai, Li-Chia, Ota, Hiroki, Davis, Ronald W., & Javey, Ali. A Wearable Electrochemical Platform for Noninvasive Simultaneous Monitoring of Ca2+ and pH. United States. https://doi.org/10.1021/acsnano.6b04005
Nyein, Hnin Yin Yin, Gao, Wei, Shahpar, Ziba, Emaminejad, Sam, Challa, Samyuktha, Chen, Kevin, Fahad, Hossain M., Tai, Li-Chia, Ota, Hiroki, Davis, Ronald W., and Javey, Ali. Tue .
"A Wearable Electrochemical Platform for Noninvasive Simultaneous Monitoring of Ca2+ and pH". United States. https://doi.org/10.1021/acsnano.6b04005. https://www.osti.gov/servlets/purl/1580044.
@article{osti_1580044,
title = {A Wearable Electrochemical Platform for Noninvasive Simultaneous Monitoring of Ca2+ and pH},
author = {Nyein, Hnin Yin Yin and Gao, Wei and Shahpar, Ziba and Emaminejad, Sam and Challa, Samyuktha and Chen, Kevin and Fahad, Hossain M. and Tai, Li-Chia and Ota, Hiroki and Davis, Ronald W. and Javey, Ali},
abstractNote = {Homeostasis of ionized calcium in biofluids is critical for human biological functions and organ systems. Measurement of ionized calcium for clinical applications is not easily accessible due to its strict procedures and dependence on pH. pH balance in body fluids greatly affects metabolic reactions and biological transport systems. Here, we demonstrate a wearable electrochemical device for continuous monitoring of ionized calcium and pH of body fluids using a disposable and flexible array of Ca2+ and pH sensors that interfaces with a flexible printed circuit board. This platform enables real-time quantitative analysis of these sensing elements in body fluids such as sweat, urine, and tears. Accuracy of Ca2+ concentration and pH measured by the wearable sensors is validated through inductively coupled plasma-mass spectrometry technique and a commercial pH meter, respectively. Our results show that the wearable sensors have high repeatability and selectivity to the target ions. Real-time on-body assessment of sweat is also performed, and our results indicate that calcium concentration increases with decreasing pH. Finally, this platform can be used in noninvasive continuous analysis of ionized calcium and pH in body fluids for disease diagnosis such as primary hyperparathyroidism and kidney stones.},
doi = {10.1021/acsnano.6b04005},
journal = {ACS Nano},
number = 7,
volume = 10,
place = {United States},
year = {Tue Jul 05 00:00:00 EDT 2016},
month = {Tue Jul 05 00:00:00 EDT 2016}
}
Web of Science
Works referenced in this record:
Ionized Calcium in Body Fluids
journal, January 1981
- Robertson, W. G.; Marshall, R. W.; Bowers, George N.
- CRC Critical Reviews in Clinical Laboratory Sciences, Vol. 15, Issue 2
Metabolic consequences of acid-base disorders
journal, May 1972
- Relman, Arnold S.
- Kidney International, Vol. 1, Issue 5
Metabolic Basis for Low Urine pH in Type 2 Diabetes
journal, April 2010
- Maalouf, Naim M.; Cameron, Mary Ann; Moe, Orson W.
- Clinical Journal of the American Society of Nephrology, Vol. 5, Issue 7
The pH of the Skin Surface and Its Impact on the Barrier Function
journal, January 2006
- Schmid-Wendtner, M. -H.; Korting, H. C.
- Skin Pharmacology and Physiology, Vol. 19, Issue 6
Wearable Chemical Sensors: Present Challenges and Future Prospects
journal, March 2016
- Bandodkar, Amay J.; Jeerapan, Itthipon; Wang, Joseph
- ACS Sensors, Vol. 1, Issue 5
Epidermal Electronics
journal, August 2011
- Kim, D.-H.; Lu, N.; Ma, R.
- Science, Vol. 333, Issue 6044, p. 838-843
User-interactive electronic skin for instantaneous pressure visualization
journal, July 2013
- Wang, Chuan; Hwang, David; Yu, Zhibin
- Nature Materials, Vol. 12, Issue 10, p. 899-904
Flexible polymer transistors with high pressure sensitivity for application in electronic skin and health monitoring
journal, May 2013
- Schwartz, Gregor; Tee, Benjamin C. -K.; Mei, Jianguo
- Nature Communications, Vol. 4, Issue 1
Soft Microfluidic Assemblies of Sensors, Circuits, and Radios for the Skin
journal, April 2014
- Xu, Sheng; Zhang, Yihui; Jia, Lin
- Science, Vol. 344, Issue 6179
An ultra-lightweight design for imperceptible plastic electronics
journal, July 2013
- Kaltenbrunner, Martin; Sekitani, Tsuyoshi; Reeder, Jonathan
- Nature, Vol. 499, Issue 7459
A skin-inspired organic digital mechanoreceptor
journal, October 2015
- Tee, B. C. - K.; Chortos, A.; Berndt, A.
- Science, Vol. 350, Issue 6258
Toward Flexible and Wearable Human-Interactive Health-Monitoring Devices
journal, November 2014
- Takei, Kuniharu; Honda, Wataru; Harada, Shingo
- Advanced Healthcare Materials, Vol. 4, Issue 4
Printed Carbon Nanotube Electronics and Sensor Systems
journal, February 2016
- Chen, Kevin; Gao, Wei; Emaminejad, Sam
- Advanced Materials, Vol. 28, Issue 22
Stretchable, Wireless Sensors and Functional Substrates for Epidermal Characterization of Sweat
journal, April 2014
- Huang, Xian; Liu, Yuhao; Chen, Kaile
- Small, Vol. 10, Issue 15
Real-time sweat pH monitoring based on a wearable chemical barcode micro-fluidic platform incorporating ionic liquids
journal, August 2012
- Curto, Vincenzo F.; Fay, Cormac; Coyle, Shirley
- Sensors and Actuators B: Chemical, Vol. 171-172
The microfluidics of the eccrine sweat gland, including biomarker partitioning, transport, and biosensing implications
journal, May 2015
- Sonner, Z.; Wilder, E.; Heikenfeld, J.
- Biomicrofluidics, Vol. 9, Issue 3
Tattoo-based potentiometric ion-selective sensors for epidermal pH monitoring
journal, January 2013
- Bandodkar, Amay J.; Hung, Vinci W. S.; Jia, Wenzhao
- The Analyst, Vol. 138, Issue 1
Epidermal tattoo potentiometric sodium sensors with wireless signal transduction for continuous non-invasive sweat monitoring
journal, April 2014
- Bandodkar, Amay J.; Molinnus, Denise; Mirza, Omar
- Biosensors and Bioelectronics, Vol. 54
Electrochemical Tattoo Biosensors for Real-Time Noninvasive Lactate Monitoring in Human Perspiration
journal, July 2013
- Jia, Wenzhao; Bandodkar, Amay J.; Valdés-Ramírez, Gabriela
- Analytical Chemistry, Vol. 85, Issue 14, p. 6553-6560
Adhesive RFID Sensor Patch for Monitoring of Sweat Electrolytes
journal, June 2015
- Rose, Daniel P.; Ratterman, Michael E.; Griffin, Daniel K.
- IEEE Transactions on Biomedical Engineering, Vol. 62, Issue 6
A wearable electrochemical sensor for the real-time measurement of sweat sodium concentration
journal, January 2010
- Schazmann, Benjamin; Morris, Deirdre; Slater, Conor
- Analytical Methods, Vol. 2, Issue 4
Wearable temporary tattoo sensor for real-time trace metal monitoring in human sweat
journal, February 2015
- Kim, Jayoung; de Araujo, William R.; Samek, Izabela A.
- Electrochemistry Communications, Vol. 51
Wearable Microsensor Array for Multiplexed Heavy Metal Monitoring of Body Fluids
journal, May 2016
- Gao, Wei; Nyein, Hnin Y. Y.; Shahpar, Ziba
- ACS Sensors, Vol. 1, Issue 7
A graphene-based electrochemical device with thermoresponsive microneedles for diabetes monitoring and therapy
journal, March 2016
- Lee, Hyunjae; Choi, Tae Kyu; Lee, Young Bum
- Nature Nanotechnology, Vol. 11, Issue 6
Fluorescent Fiber-Optic Calcium Sensor for Physiological Measurements
journal, January 1996
- Shortreed, Michael; Kopelman, Raoul; Kuhn, Michael
- Analytical Chemistry, Vol. 68, Issue 8
An Optical Submicrometer Calcium Sensor with Conductance Sensing Capability
journal, January 1997
- Shalom, S.; Strinkovski, A.; Peleg, G.
- Analytical Biochemistry, Vol. 244, Issue 2
Carrier-Based Ion-Selective Electrodes and Bulk Optodes. 2. Ionophores for Potentiometric and Optical Sensors
journal, June 1998
- Bühlmann, Philippe; Pretsch, Ernö; Bakker, Eric
- Chemical Reviews, Vol. 98, Issue 4
The Ionophore ETH 129 as Ca2+ Translocator in Artificial and Natural Membranes
journal, April 1993
- Prestipino, G.; Falugi, C.; Falchetto, R.
- Analytical Biochemistry, Vol. 210, Issue 1
Calcium ion-selective electrodes under galvanostatic current control
journal, July 2005
- Bedlechowicz, Iwona; Sokalski, Tomasz; Lewenstam, Andrzej
- Sensors and Actuators B: Chemical, Vol. 108, Issue 1-2
Calcium-selective electrode based on polyaniline functionalized with bis[4-(1,1,3,3-tetramethylbutyl)phenyl]phosphate
journal, June 2001
- Lindfors, Tom; Ivaska, Ari
- Analytica Chimica Acta, Vol. 437, Issue 2
Fully integrated wearable sensor arrays for multiplexed in situ perspiration analysis
journal, January 2016
- Gao, Wei; Emaminejad, Sam; Nyein, Hnin Yin Yin
- Nature, Vol. 529, Issue 7587
Advanced Bioelectronic Materials
book, October 2015
- Tiwari, Ashutosh; Patra, Hirak K.; Turner, Anthony P. F.
- Scrivener Publishing LLC
A reference electrode based on polyvinyl butyral (PVB) polymer for decentralized chemical measurements
journal, April 2014
- Guinovart, Tomàs; Crespo, Gastón A.; Rius, F. Xavier
- Analytica Chimica Acta, Vol. 821
Exercise-Induced Trace Mineral Element Concentration in Regional Versus Whole-Body Wash-Down Sweat
journal, June 2011
- Baker, Lindsay B.; Stofan, John R.; Lukaski, Henry C.
- International Journal of Sport Nutrition and Exercise Metabolism, Vol. 21, Issue 3
The calcium hypothesis of Cystic Fibrosis
journal, October 1984
- Katz, Sidney; Schöni, Martin H.; Bridges, Michael A.
- Cell Calcium, Vol. 5, Issue 5
Sweat composition in exercise and in heat
journal, December 1982
- Verde, T.; Shephard, R. J.; Corey, P.
- Journal of Applied Physiology, Vol. 53, Issue 6
Whole body sweat collection in humans: an improved method with preliminary data on electrolyte content
journal, January 1997
- Shirreffs, S. M.; Maughan, R. J.
- Journal of Applied Physiology, Vol. 82, Issue 1
Calcium ion-selective electrode in which a membrane contacts graphite directly
journal, March 1973
- Ansaldi, Anthony.; Epstein, S. I.
- Analytical Chemistry, Vol. 45, Issue 3
Interference by polyamines in the measurement of magnesium ion at physiological pH with the divalent cation-selective electrode
journal, November 1974
- Kent, Patricia; Bunce, S. C.; Bailey, R. A.
- Analytical Biochemistry, Vol. 62, Issue 1
A comparative review of cutaneous pH
journal, December 2002
- Matousek, Jennifer L.; Campbell, Karen L.
- Veterinary Dermatology, Vol. 13, Issue 6
Microfabricated Liquid Junction Ag/AgCl Reference Electrode and Its Application to a One-Chip Potentiometric Sensor
journal, October 1999
- Suzuki, Hiroaki; Shiroishi, Hisanori; Sasaki, Satoshi
- Analytical Chemistry, Vol. 71, Issue 22
Clinical Skin Temperature Measurement to Predict Incipient Pressure Ulcers
journal, January 2001
- Sprigle, Stephen; Linden, Maureen; McKenna, Diane
- Advances in Skin & Wound Care, Vol. 14, Issue 3
Works referencing / citing this record:
Engineering Precision Medicine
journal, October 2018
- Sun, Wujin; Lee, Junmin; Zhang, Shiming
- Advanced Science, Vol. 6, Issue 1
Dermal Tattoo Biosensors for Colorimetric Metabolite Detection
journal, July 2019
- Yetisen, Ali K.; Moreddu, Rosalia; Seifi, Sarah
- Angewandte Chemie, Vol. 131, Issue 31
Wearable flexible sweat sensors for healthcare monitoring: a review
journal, October 2019
- Chung, Michael; Fortunato, Giuseppino; Radacsi, Norbert
- Journal of The Royal Society Interface, Vol. 16, Issue 159
Design of a smart sensor mesh for the measurement of pH in ostomy applications
journal, April 2019
- McLister, Anna; Casimero, Charnete; McConville, Aaron
- Journal of Materials Science, Vol. 54, Issue 14
Thin, Soft, Skin-Mounted Microfluidic Networks with Capillary Bursting Valves for Chrono-Sampling of Sweat
journal, January 2017
- Choi, Jungil; Kang, Daeshik; Han, Seungyong
- Advanced Healthcare Materials, Vol. 6, Issue 5
Toothed Substrate Design to Improve Stretchability of Serpentine Interconnect for Stretchable Electronics
journal, August 2018
- Zhao, Qian; Liang, Ziwei; Lu, Bingwei
- Advanced Materials Technologies, Vol. 3, Issue 11
Potentiometric performance of flexible pH sensor based on polyaniline nanofiber arrays
journal, March 2019
- Park, Hong Jun; Yoon, Jo Hee; Lee, Kyoung G.
- Nano Convergence, Vol. 6, Issue 1
Disposable Sensors in Diagnostics, Food, and Environmental Monitoring
journal, May 2019
- Dincer, Can; Bruch, Richard; Costa‐Rama, Estefanía
- Advanced Materials
Optimized Potentiometric Assay for Non-invasive Investigation of Skin Antioxidant Activity
journal, August 2018
- Brainina, Khiena Z.; Markina, Maria G.; Stozhko, Natalia Yu.
- Electroanalysis, Vol. 30, Issue 10
A wearable, cotton thread/paper-based microfluidic device coupled with smartphone for sweat glucose sensing
journal, April 2019
- Xiao, Gang; He, Jing; Chen, Xiaodie
- Cellulose, Vol. 26, Issue 7
Flexible, Stretchable Sensors for Wearable Health Monitoring: Sensing Mechanisms, Materials, Fabrication Strategies and Features
journal, February 2018
- Liu, Yan; Wang, Hai; Zhao, Wei
- Sensors, Vol. 18, Issue 2
A multifunctional wearable sensor based on a graphene/inverse opal cellulose film for simultaneous, in situ monitoring of human motion and sweat
journal, January 2018
- Xu, Hua; Lu, Yi Fei; Xiang, Jian Xin
- Nanoscale, Vol. 10, Issue 4
CdSSe nanowire-chip based wearable sweat sensor
journal, March 2019
- Zhang, Min; Guo, Shuai; Weller, Dieter
- Journal of Nanobiotechnology, Vol. 17, Issue 1
Construction of a flexible electrochemiluminescence platform for sweat detection
journal, January 2019
- Chen, Miao-Miao; Cheng, Shi-Bo; Ji, Kailun
- Chemical Science, Vol. 10, Issue 25
Autonomous sweat extraction and analysis applied to cystic fibrosis and glucose monitoring using a fully integrated wearable platform
journal, April 2017
- Emaminejad, Sam; Gao, Wei; Wu, Eric
- Proceedings of the National Academy of Sciences, Vol. 114, Issue 18
Flexible Hybrid Sensors for Health Monitoring: Materials and Mechanisms to Render Wearability
journal, July 2019
- Gao, Yuji; Yu, Longteng; Yeo, Joo Chuan
- Advanced Materials
Cyber–Physiochemical Interfaces
journal, January 2020
- Wang, Ting; Wang, Ming; Yang, Le
- Advanced Materials, Vol. 32, Issue 8
Advanced Carbon for Flexible and Wearable Electronics
journal, October 2018
- Wang, Chunya; Xia, Kailun; Wang, Huimin
- Advanced Materials, Vol. 31, Issue 9
Impedance Matching Effect between a Triboelectric Nanogenerator and a Piezoresistive Pressure Sensor Induced Self-Powered Weighing
journal, April 2018
- Xie, Xinkai; Wen, Zhen; Shen, Qingqing
- Advanced Materials Technologies, Vol. 3, Issue 6
Wearable sensors for monitoring the physiological and biochemical profile of the athlete
journal, July 2019
- Seshadri, Dhruv R.; Li, Ryan T.; Voos, James E.
- npj Digital Medicine, Vol. 2, Issue 1
Functional nanostructures for enzyme based biosensors: properties, fabrication and applications
journal, January 2016
- Othman, Ali; Karimi, Anahita; Andreescu, Silvana
- Journal of Materials Chemistry B, Vol. 4, Issue 45
Recent Advances in Wearable Transdermal Delivery Systems
journal, January 2018
- Amjadi, Morteza; Sheykhansari, Sahar; Nelson, Bradley J.
- Advanced Materials, Vol. 30, Issue 7
Porous Enzymatic Membrane for Nanotextured Glucose Sweat Sensors with High Stability toward Reliable Noninvasive Health Monitoring
journal, June 2019
- Lin, Yuanjing; Bariya, Mallika; Nyein, Hnin Yin Yin
- Advanced Functional Materials, Vol. 29, Issue 33
A Mediator‐Free Electroenzymatic Sensing Methodology to Mitigate Ionic and Electroactive Interferents' Effects for Reliable Wearable Metabolite and Nutrient Monitoring
journal, December 2019
- Cheng, Xuanbing; Wang, Bo; Zhao, Yichao
- Advanced Functional Materials, Vol. 30, Issue 10
Recent applications of paper‐based point‐of‐care devices for biomarker detection
journal, October 2019
- Suntornsuk, Worapot; Suntornsuk, Leena
- ELECTROPHORESIS, Vol. 41, Issue 5-6
Top-down fabrication meets bottom-up synthesis for nanoelectronic barcoding of microparticles
journal, January 2017
- Xie, Pengfei; Cao, Xinnan; Lin, Zhongtian
- Lab on a Chip, Vol. 17, Issue 11
Palladium/palladium oxide coated electrospun fibers for wearable sweat pH-sensors
journal, June 2019
- Diculescu, Victor C.; Beregoi, Mihaela; Evanghelidis, Alexandru
- Scientific Reports, Vol. 9, Issue 1
Wearable/disposable sweat-based glucose monitoring device with multistage transdermal drug delivery module
journal, March 2017
- Lee, Hyunjae; Song, Changyeong; Hong, Yong Seok
- Science Advances, Vol. 3, Issue 3
Methylxanthine Drug Monitoring with Wearable Sweat Sensors
journal, April 2018
- Tai, Li-Chia; Gao, Wei; Chao, Minghan
- Advanced Materials, Vol. 30, Issue 23
Ultra-highly sensitive, low hysteretic and flexible pressure sensor based on porous MWCNTs/Ecoflex elastomer composites
journal, October 2018
- Wen, Zheng; Yang, Jiahao; Ding, Huizhen
- Journal of Materials Science: Materials in Electronics, Vol. 29, Issue 24
Wearable sweat sensors
journal, March 2018
- Bariya, Mallika; Nyein, Hnin Yin Yin; Javey, Ali
- Nature Electronics, Vol. 1, Issue 3
Fast Procedures for the Electrodeposition of Platinum Nanostructures on Miniaturized Electrodes for Improved Ion Sensing
journal, May 2019
- Criscuolo, Francesca; Taurino, Irene; Dam, Van
- Sensors, Vol. 19, Issue 10
Soft, skin-mounted microfluidic systems for measuring secretory fluidic pressures generated at the surface of the skin by eccrine sweat glands
journal, January 2017
- Choi, Jungil; Xue, Yeguang; Xia, Wei
- Lab on a Chip, Vol. 17, Issue 15
A Protocol to Characterize pH Sensing Materials and Systems
journal, September 2018
- Ghoneim, Mohamed T.; Sadraei, Atieh; de Souza, Pedro
- Small Methods, Vol. 3, Issue 2
Infrared Skin‐Like Active Stretchable Electronics Based on Organic–Inorganic Composite Structures for Promotion of Cutaneous Wound Healing
journal, May 2019
- Zhang, Lijuan; Jiang, Xiaoxiao; Jiang, Wei
- Advanced Materials Technologies, Vol. 4, Issue 8
Flexible Sensing Electronics for Wearable/Attachable Health Monitoring
journal, March 2017
- Wang, Xuewen; Liu, Zheng; Zhang, Ting
- Small, Vol. 13, Issue 25
Imperceptible electrooculography graphene sensor system for human–robot interface
journal, July 2018
- Ameri, Shideh Kabiri; Kim, Myungsoo; Kuang, Irene Agnes
- npj 2D Materials and Applications, Vol. 2, Issue 1
Three-dimensional paper-based microfluidic electrochemical integrated devices (3D-PMED) for wearable electrochemical glucose detection
journal, January 2019
- Cao, Qingpeng; Liang, Bo; Tu, Tingting
- RSC Advances, Vol. 9, Issue 10
Super-Absorbent Polymer Valves and Colorimetric Chemistries for Time-Sequenced Discrete Sampling and Chloride Analysis of Sweat via Skin-Mounted Soft Microfluidics
journal, February 2018
- Kim, Sung Bong; Zhang, Yi; Won, Sang Min
- Small, Vol. 14, Issue 12
Wearable Potentiometric Sensors for Medical Applications
journal, January 2019
- Cuartero, María; Parrilla, Marc; Crespo, Gaston
- Sensors, Vol. 19, Issue 2
Advanced electronic skin devices for healthcare applications
journal, January 2019
- Ma, Zhong; Li, Sheng; Wang, Huiting
- Journal of Materials Chemistry B, Vol. 7, Issue 2
A Four-Channel Electrical Impedance Spectroscopy Module for Cortisol Biosensing in Sweat-Based Wearable Applications
journal, February 2018
- Sankhala, Devangsingh; Muthukumar, Sriram; Prasad, Shalini
- SLAS TECHNOLOGY: Translating Life Sciences Innovation, Vol. 23, Issue 6
A fluorescent wearable platform for sweat Cl − analysis and logic smart-device fabrication based on color adjustable lanthanide MOFs
journal, January 2018
- Xu, Xiao-Yu; Yan, Bing
- Journal of Materials Chemistry C, Vol. 6, Issue 7
Edible Electrochemistry: Food Materials Based Electrochemical Sensors
journal, August 2017
- Kim, Jayoung; Jeerapan, Itthipon; Ciui, Bianca
- Advanced Healthcare Materials, Vol. 6, Issue 22
Wearable Wireless Tyrosinase Bandage and Microneedle Sensors: Toward Melanoma Screening
journal, January 2018
- Ciui, Bianca; Martin, Aida; Mishra, Rupesh K.
- Advanced Healthcare Materials, Vol. 7, Issue 7
Soft Elastomers with Ionic Liquid-Filled Cavities as Strain Isolating Substrates for Wearable Electronics
journal, December 2016
- Ma, Yinji; Pharr, Matt; Wang, Liang
- Small, Vol. 13, Issue 9
Weaving Sensing Fibers into Electrochemical Fabric for Real-Time Health Monitoring
journal, September 2018
- Wang, Lie; Wang, Liyuan; Zhang, Ye
- Advanced Functional Materials, Vol. 28, Issue 42
Wearable physiological systems and technologies for metabolic monitoring
journal, March 2018
- Gao, Wei; Brooks, George A.; Klonoff, David C.
- Journal of Applied Physiology, Vol. 124, Issue 3
Battery‐Free and Wireless Epidermal Electrochemical System with All‐Printed Stretchable Electrode Array for Multiplexed In Situ Sweat Analysis
journal, February 2019
- Xu, Gang; Cheng, Chen; Liu, Zhaoyang
- Advanced Materials Technologies, Vol. 4, Issue 7
A wearable pH sensor with high sensitivity based on a flexible charge-coupled device
journal, November 2018
- Nakata, Shogo; Shiomi, Mao; Fujita, Yusuke
- Nature Electronics, Vol. 1, Issue 11
Stretchable gold fiber-based wearable electrochemical sensor toward pH monitoring
journal, January 2020
- Wang, Ren; Zhai, Qingfeng; Zhao, Yunmeng
- Journal of Materials Chemistry B, Vol. 8, Issue 16
Sensors Based on Bio and Biomimetic Receptors in Medical Diagnostic, Environment, and Food Analysis
journal, April 2018
- Kozitsina, Alisa; Svalova, Tatiana; Malysheva, Natalia
- Biosensors, Vol. 8, Issue 2
Recent Developments in Printing Flexible and Wearable Sensing Electronics for Healthcare Applications
journal, March 2019
- Khan, Saleem; Ali, Shawkat; Bermak, Amine
- Sensors, Vol. 19, Issue 5
Soft, Skin-Interfaced Microfluidic Systems with Wireless, Battery-Free Electronics for Digital, Real-Time Tracking of Sweat Loss and Electrolyte Composition
journal, October 2018
- Kim, Sung Bong; Lee, KunHyuck; Raj, Milan S.
- Small, Vol. 14, Issue 45
Wearable sensors: modalities, challenges, and prospects
journal, January 2018
- Heikenfeld, J.; Jajack, A.; Rogers, J.
- Lab on a Chip, Vol. 18, Issue 2
Plasmonic colored nanopaper: a potential preventive healthcare tool against threats emerging from uncontrolled UV exposure
journal, September 2019
- Francisco-Aldana, Leydi; Morales-Narváez, Eden
- Journal of Physics: Photonics, Vol. 1, Issue 4
Soft, skin-interfaced microfluidic systems with integrated enzymatic assays for measuring the concentration of ammonia and ethanol in sweat
journal, January 2020
- Kim, Sung Bong; Koo, Jahyun; Yoon, Jangryeol
- Lab on a Chip, Vol. 20, Issue 1
Flexible Electrochemical Bioelectronics: The Rise of In Situ Bioanalysis
journal, August 2019
- Yu, You; Nyein, Hnin Yin Yin; Gao, Wei
- Advanced Materials, Vol. 32, Issue 15
Skin-interfaced systems for sweat collection and analytics
journal, February 2018
- Choi, Jungil; Ghaffari, Roozbeh; Baker, Lindsay B.
- Science Advances, Vol. 4, Issue 2
Wearable Sensing Systems with Mechanically Soft Assemblies of Nanoscale Materials
journal, June 2017
- Lee, Youngsik; Kim, Jaemin; Joo, Hyunwoo
- Advanced Materials Technologies, Vol. 2, Issue 9
Multifunctional Skin-Inspired Flexible Sensor Systems for Wearable Electronics
journal, January 2019
- Xu, Kaichen; Lu, Yuyao; Takei, Kuniharu
- Advanced Materials Technologies, Vol. 4, Issue 3
Multifunctional Wearable System that Integrates Sweat-Based Sensing and Vital-Sign Monitoring to Estimate Pre-/Post-Exercise Glucose Levels
journal, October 2018
- Hong, Yongseok Joseph; Lee, Hyunjae; Kim, Jaemin
- Advanced Functional Materials, Vol. 28, Issue 47
A multi-modal sweat sensing patch for cross-verification of sweat rate, total ionic charge, and Na + concentration
journal, January 2019
- Yuan, Zhen; Hou, Lei; Bariya, Mallika
- Lab on a Chip, Vol. 19, Issue 19
Dermal Tattoo Biosensors for Colorimetric Metabolite Detection
journal, July 2019
- Yetisen, Ali K.; Moreddu, Rosalia; Seifi, Sarah
- Angewandte Chemie International Edition, Vol. 58, Issue 31
Wearable Potentiometric Sensors for Medical Applications
journalarticle, January 2019
- Cuartero, Maria; Parrilla, Marc; Crespo, Gaston A.
- Zenodo
Wearable Potentiometric Sensors for Medical Applications
journalarticle, January 2019
- Cuartero, Maria; Parrilla, Marc; Crespo, Gaston A.
- Zenodo
Engineering Precision Medicine
journal, October 2018
- Sun, Wujin; Lee, Junmin; Zhang, Shiming
- Advanced Science, Vol. 6, Issue 1
Effect of heat-treatment on the pH sensitivity of stainless-steel electrodes as pH sensors
journal, March 2019
- Hashimoto, Tadanori; Kitabayashi, Hiroki; Ito, Kenta
- Heliyon, Vol. 5, Issue 3
From Point-of-Care Testing to eHealth Diagnostic Devices (eDiagnostics)
journal, November 2018
- Christodouleas, Dionysios C.; Kaur, Balwinder; Chorti, Parthena
- ACS Central Science, Vol. 4, Issue 12
Palladium/palladium oxide coated electrospun fibers for wearable sweat pH-sensors
journal, June 2019
- Diculescu, Victor C.; Beregoi, Mihaela; Evanghelidis, Alexandru
- Scientific Reports, Vol. 9, Issue 1
Wearable sensors for monitoring the physiological and biochemical profile of the athlete
journal, July 2019
- Seshadri, Dhruv R.; Li, Ryan T.; Voos, James E.
- npj Digital Medicine, Vol. 2, Issue 1
Skin-interfaced systems for sweat collection and analytics
journal, February 2018
- Choi, Jungil; Ghaffari, Roozbeh; Baker, Lindsay B.
- Science Advances, Vol. 4, Issue 2
Potentiometric performance of flexible pH sensor based on polyaniline nanofiber arrays
journal, March 2019
- Park, Hong Jun; Yoon, Jo Hee; Lee, Kyoung G.
- Nano Convergence, Vol. 6, Issue 1
Sensors Based on Bio and Biomimetic Receptors in Medical Diagnostic, Environment, and Food Analysis
journal, April 2018
- Kozitsina, Alisa; Svalova, Tatiana; Malysheva, Natalia
- Biosensors, Vol. 8, Issue 2
Highly Sensitive Biosensors Based on Biomolecules and Functional Nanomaterials Depending on the Types of Nanomaterials: A Perspective Review
journal, January 2020
- Yoon, Jinho; Shin, Minkyu; Lee, Taek
- Materials, Vol. 13, Issue 2
Fully-Polymeric pH Sensor Realized by Means of a Single-Step Soft Embossing Technique
journal, May 2017
- Fanzio, Paola; Chang, Chi-Tung; Skolimowski, Maciej
- Sensors, Vol. 17, Issue 5
Flexible, Stretchable Sensors for Wearable Health Monitoring: Sensing Mechanisms, Materials, Fabrication Strategies and Features
journal, February 2018
- Liu, Yan; Wang, Hai; Zhao, Wei
- Sensors, Vol. 18, Issue 2
Fast Procedures for the Electrodeposition of Platinum Nanostructures on Miniaturized Electrodes for Improved Ion Sensing
journal, May 2019
- Criscuolo, Francesca; Taurino, Irene; Dam, Van
- Sensors, Vol. 19, Issue 10
Wearable Potentiometric Sensors for Medical Applications
journalarticle, January 2019
- Cuartero, Maria; Parrilla, Marc; Crespo, Gaston A.
- Zenodo