Extraction chromatography of 225Ac and lanthanides on N,N-dioctyldiglycolamic acid /1-butyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide solvent impregnated resin

Friend, Mitchell Thomas; Parker, Tracey Gannon; Mastren, Tara; Mocko, Veronika; Brugh, Mark; Birnbaum, Eva R.; Fassbender, Michael Ernst

doi:10.1016/j.chroma.2020.461219

Title: Extraction chromatography of ²²⁵Ac and lanthanides on N,N-dioctyldiglycolamic acid /1-butyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide solvent impregnated resin

Abstract

The alpha-emitter ²²⁵Ac (t_1/2 = 9.92 d) is currently under development for targeted alpha-particle therapy of cancer, and accelerator production of ²²⁵Ac via proton irradiation of thorium targets requires robust separations of ²²⁵Ac from chemically similar fission product lanthanides. Additionally, the lanthanide elements represent critical components in modern technologies, and radiolanthanides such as ¹⁴⁰Nd (t_1/2 = 3.37 d) also have potential application in the field of nuclear medicine. The ionic liquid, 1-butyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide ([Bmim][NTf₂]), combined with the diglycolamide extractant, N,N-dioctyldiglycolamic acid (DODGAA), was adsorbed on macroporous resin support to produce a solvent impregnated resin (SIR) that was investigated for separations of ²²⁵Ac and lanthanides. The equilibrium distribution coefficients (Kd) of the rare earth elements (Sc(III), Y(III), Ln(III)), ²²⁵Ac(III), Th(IV), and U(VI) on the prepared DODGAA/[Bmim][NTf₂]-SIR were determined from batch adsorption experiments in HCl and HNO₃ media. The DODGAA/[Bmim][NTf2]-SIR exhibited preferential uptake of the heavier lanthanide elements while allowing for the separation of the lighter lanthanides. Column separations utilizing the DODGAA/[Bmim][NTf₂]-SIR were effective at separating the lighter lanthanides from each other, and separating ²²⁵Ac from a mixture of lanthanides, ²¹³Bi, and ²²⁵Ra without the need for additional complexing agents.

Authors:

^[1]; Parker, Tracey Gannon ^[1];

^[2];

^[1]; Brugh, Mark ^[1];

^[1];

^[1]

Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Univ. of Utah, Salt Lake City, UT (United States)

Publication Date:: 2020-05-23

Research Org.:: Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

Sponsoring Org.:: USDOE Office of Science (SC). Nuclear Physics (NP) (SC-26); USDOE

OSTI Identifier:: 1631575

Alternate Identifier(s):: OSTI ID: 1775849

Report Number(s):: LA-UR-20-21569
Journal ID: ISSN 0021-9673

Grant/Contract Number:: 89233218CNA000001

Resource Type:: Accepted Manuscript

Journal Name:: Journal of Chromatography

Additional Journal Information:: Journal Volume: 1624; Journal Issue: C; Journal ID: ISSN 0021-9673

Publisher:: Elsevier

Country of Publication:: United States

Language:: English

Subject:: 37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY

Citation Formats


                    Friend, Mitchell Thomas, Parker, Tracey Gannon, Mastren, Tara, Mocko, Veronika, Brugh, Mark, Birnbaum, Eva R., and Fassbender, Michael Ernst. Extraction chromatography of 225Ac and lanthanides on N,N-dioctyldiglycolamic acid /1-butyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide solvent impregnated resin.  United States: N. p., 2020. 
Web.  doi:10.1016/j.chroma.2020.461219.

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                    Friend, Mitchell Thomas, Parker, Tracey Gannon, Mastren, Tara, Mocko, Veronika, Brugh, Mark, Birnbaum, Eva R., & Fassbender, Michael Ernst. Extraction chromatography of 225Ac and lanthanides on N,N-dioctyldiglycolamic acid /1-butyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide solvent impregnated resin.  United States.  https://doi.org/10.1016/j.chroma.2020.461219

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                    Friend, Mitchell Thomas, Parker, Tracey Gannon, Mastren, Tara, Mocko, Veronika, Brugh, Mark, Birnbaum, Eva R., and Fassbender, Michael Ernst. Sat .  
"Extraction chromatography of 225Ac and lanthanides on N,N-dioctyldiglycolamic acid /1-butyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide solvent impregnated resin".  United States.  https://doi.org/10.1016/j.chroma.2020.461219.  https://www.osti.gov/servlets/purl/1631575.

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@article{osti_1631575,

  title        = {Extraction chromatography of 225Ac and lanthanides on N,N-dioctyldiglycolamic acid /1-butyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide solvent impregnated resin},

  author       = {Friend, Mitchell Thomas and Parker, Tracey Gannon and Mastren, Tara and Mocko, Veronika and Brugh, Mark and Birnbaum, Eva R. and Fassbender, Michael Ernst},

  abstractNote = {The alpha-emitter 225Ac (t1/2 = 9.92 d) is currently under development for targeted alpha-particle therapy of cancer, and accelerator production of 225Ac via proton irradiation of thorium targets requires robust separations of 225Ac from chemically similar fission product lanthanides. Additionally, the lanthanide elements represent critical components in modern technologies, and radiolanthanides such as 140Nd (t1/2 = 3.37 d) also have potential application in the field of nuclear medicine. The ionic liquid, 1-butyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide ([Bmim][NTf2]), combined with the diglycolamide extractant, N,N-dioctyldiglycolamic acid (DODGAA), was adsorbed on macroporous resin support to produce a solvent impregnated resin (SIR) that was investigated for separations of 225Ac and lanthanides. The equilibrium distribution coefficients (Kd) of the rare earth elements (Sc(III), Y(III), Ln(III)), 225Ac(III), Th(IV), and U(VI) on the prepared DODGAA/[Bmim][NTf2]-SIR were determined from batch adsorption experiments in HCl and HNO3 media. The DODGAA/[Bmim][NTf2]-SIR exhibited preferential uptake of the heavier lanthanide elements while allowing for the separation of the lighter lanthanides. Column separations utilizing the DODGAA/[Bmim][NTf2]-SIR were effective at separating the lighter lanthanides from each other, and separating 225Ac from a mixture of lanthanides, 213Bi, and 225Ra without the need for additional complexing agents.},

  doi          = {10.1016/j.chroma.2020.461219},

  journal      = {Journal of Chromatography},

  number       = C,

  volume       = 1624,

  place        = {United States},

  year         = {2020},

  month        = {5}

}

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https://doi.org/10.1016/j.chroma.2020.461219

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Title: Extraction chromatography of 225Ac and lanthanides on N,N-dioctyldiglycolamic acid /1-butyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide solvent impregnated resin

Abstract

Citation Formats

An Overview of Targeted Alpha Therapy with 225 Actinium and 213 Bismuth journal, October 2018

Production of Ac-225 from Th-229 for Targeted α Therapy journal, October 2005

Therapeutic Radionuclides: Biophysical and Radiobiologic Principles journal, September 2008

Alpha-Emitters and Targeted Alpha Therapy in Oncology: from Basic Science to Clinical Investigations journal, February 2018

Present and Future Prospects of Radiation Therapy Using α-Emitting Nuclides journal, January 2018

225Ac-PSMA-617 for PSMA-Targeted -Radiation Therapy of Metastatic Castration-Resistant Prostate Cancer journal, July 2016

Production of actinium-225 for alpha particle mediated radioimmunotherapy journal, May 2005

Ac, La, and Ce radioimpurities in 225Ac produced in 40–200 MeV proton irradiations of thorium journal, January 2014

Proton-induced cross sections relevant to production of 225Ac and 223Ra in natural thorium targets below 200MeV journal, November 2012

Large scale accelerator production of 225Ac: Effective cross sections for 78–192 MeV protons incident on 232Th targets journal, December 2016

Application of ion exchange and extraction chromatography to the separation of actinium from proton-irradiated thorium metal for analytical purposes journal, February 2015

Selective separation of radium and actinium from bulk thorium target material on strong acid cation exchange resin from sulfate media journal, October 2018

An Improved Method for the Production of Ac‐225/Bi‐213 from Th‐229 for Targeted Alpha Therapy journal, April 2007

Radiometric evaluation of diglycolamide resins for the chromatographic separation of actinium from fission product lanthanides journal, December 2017

Benefiting from the Unique Properties of Lanthanide Ions journal, January 2006

Lanthanide-Based Luminescent Hybrid Materials journal, September 2009

Nuclear forensic analysis of an unknown uranium ore concentrate sample seized in a criminal investigation in Australia journal, July 2014

Application of radioisotopes in the field of nuclear medicine: I. Lanthanide series elements journal, November 1999

Experimental measurements and nuclear model calculations on the excitation functions of natCe(3He, xn) and 141Pr(p, xn) reactions with special reference to production of the therapeutic radionuclide 140Nd journal, January 2005

Extraction of Rare Earths in Ionic Liquids Via Competitive Ligand Complexation between TODGA and DTPA journal, September 2018

Application of a functionalized ionic liquid extractant tributylmethylammonium dibutyldiglycolamate ([A336][BDGA]) in light rare earth extraction and separation journal, August 2018

Application of ionic liquids in the preparation of extraction chromatographic materials for metal ion separations: Progress and prospects journal, May 2017

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The solid–liquid extraction of yttrium from rare earths by solvent (ionic liquid) impreganated resin coupled with complexing method journal, October 2008

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Synthesis and Characterization of the Actinium Aquo Ion journal, February 2017

Revised effective ionic radii and systematic studies of interatomic distances in halides and chalcogenides journal, September 1976

Production and Radiochemical Separation of the Auger Electron Emitter 140 Nd journal, January 2000

A 140Nd/140Pr radionuclide generator based on physico-chemical transitions in 140Pr complexes after electron capture decay of 140Nd-DOTA journal, January 2007

Glacial-interglacial circulation changes inferred from 231 Pa/ 230 Th sedimentary record in the North Atlantic region : MOC CHANGES INFERRED FROM Pa/Th RECORDS journal, May 2009

Determination of the age of highly enriched uranium journal, October 2002

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Distribution coefficients of 60 elements on TODGA resin: Application to Ca, Lu, Hf, U and Th isotope geochemistry journal, May 2010

Title: Extraction chromatography of ²²⁵Ac and lanthanides on N,N-dioctyldiglycolamic acid /1-butyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide solvent impregnated resin

An Overview of Targeted Alpha Therapy with ²²⁵ Actinium and ²¹³ Bismuth
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Therapeutic Radionuclides: Biophysical and Radiobiologic Principles
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Alpha-Emitters and Targeted Alpha Therapy in Oncology: from Basic Science to Clinical Investigations
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Present and Future Prospects of Radiation Therapy Using α-Emitting Nuclides
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journal, May 2005

Ac, La, and Ce radioimpurities in 225Ac produced in 40–200 MeV proton irradiations of thorium
journal, January 2014

Proton-induced cross sections relevant to production of 225Ac and 223Ra in natural thorium targets below 200MeV
journal, November 2012

Large scale accelerator production of 225Ac: Effective cross sections for 78–192 MeV protons incident on 232Th targets
journal, December 2016

Application of ion exchange and extraction chromatography to the separation of actinium from proton-irradiated thorium metal for analytical purposes
journal, February 2015

Selective separation of radium and actinium from bulk thorium target material on strong acid cation exchange resin from sulfate media
journal, October 2018

An Improved Method for the Production of Ac‐225/Bi‐213 from Th‐229 for Targeted Alpha Therapy
journal, April 2007

Radiometric evaluation of diglycolamide resins for the chromatographic separation of actinium from fission product lanthanides
journal, December 2017

Benefiting from the Unique Properties of Lanthanide Ions
journal, January 2006

Lanthanide-Based Luminescent Hybrid Materials
journal, September 2009

Nuclear forensic analysis of an unknown uranium ore concentrate sample seized in a criminal investigation in Australia
journal, July 2014

Application of radioisotopes in the field of nuclear medicine: I. Lanthanide series elements
journal, November 1999

Experimental measurements and nuclear model calculations on the excitation functions of natCe(3He, xn) and 141Pr(p, xn) reactions with special reference to production of the therapeutic radionuclide 140Nd
journal, January 2005

Extraction of Rare Earths in Ionic Liquids Via Competitive Ligand Complexation between TODGA and DTPA
journal, September 2018

Application of a functionalized ionic liquid extractant tributylmethylammonium dibutyldiglycolamate ([A336][BDGA]) in light rare earth extraction and separation
journal, August 2018

Application of ionic liquids in the preparation of extraction chromatographic materials for metal ion separations: Progress and prospects
journal, May 2017

Solvent-impregnated resins (SIRs) – Methods of preparation and their applications
journal, August 2010

The solid–liquid extraction of yttrium from rare earths by solvent (ionic liquid) impreganated resin coupled with complexing method
journal, October 2008

Use of extraction chromatography in the recycling of critical metals from thin film leach solutions
journal, March 2017

Solvent extraction-separation of La(III), Eu(III) and Er(III) ions from aqueous chloride medium using carbamoyl-carboxylic acid extractants
journal, January 2016

Synthesis and Characterization of the Actinium Aquo Ion
journal, February 2017

Revised effective ionic radii and systematic studies of interatomic distances in halides and chalcogenides
journal, September 1976

Production and Radiochemical Separation of the Auger Electron Emitter ¹⁴⁰ Nd
journal, January 2000

A 140Nd/140Pr radionuclide generator based on physico-chemical transitions in 140Pr complexes after electron capture decay of 140Nd-DOTA
journal, January 2007

Glacial-interglacial circulation changes inferred from ²³¹ Pa/ ²³⁰ Th sedimentary record in the North Atlantic region : MOC CHANGES INFERRED FROM Pa/Th RECORDS
journal, May 2009

Determination of the age of highly enriched uranium
journal, October 2002

A method for dating small amounts of uranium
journal, September 2012

Distribution coefficients of 60 elements on TODGA resin: Application to Ca, Lu, Hf, U and Th isotope geochemistry
journal, May 2010