Accelerated reactions in field desorption mass spectrometry
Abstract
Abstract Field desorption mass spectrometry under ambient conditions is used to study solution‐phase organic reactions in micro‐volumes. Reagent solution is transferred onto the microdendrites of the field emitter, and reaction products are examined online by mass spectrometry. Three reactions, hydrazone formation by phenyl hydrazine and indoline‐2,3‐dione, the Katritzky reaction between a pyrylium salt and anisidine, and the Hantzsch synthesis of 1,4‐dihydropyridine, were investigated, and reaction acceleration was observed to different extents. The increase in rate relative to the corresponding bulk reactions is attributed to solvent evaporation (simple concentration effect) and to the increase of surface‐to‐volume ratio (enhanced interfacial reactions). A distinguishing feature of this method of reaction acceleration, relative to that based on nano electrospray ionization, is the observation of radical cations and the formation of radical cation products. The study also breaks new ground in using field emitters at atmospheric pressure.
- Publication Date:
- Research Org.:
- Purdue Univ., West Lafayette, IN (United States)
- Sponsoring Org.:
- USDOE Office of Science (SC)
- OSTI Identifier:
- 1609706
- Alternate Identifier(s):
- OSTI ID: 1464841
- Grant/Contract Number:
- FG02-06ER15807; DE‐FG‐02‐06ER15807
- Resource Type:
- Accepted Manuscript
- Journal Name:
- Journal of Mass Spectrometry
- Additional Journal Information:
- Journal Volume: 53; Journal Issue: 10; Journal ID: ISSN 1076-5174
- Publisher:
- Wiley
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY; Biochemistry & Molecular Biology; Chemistry; Spectroscopy
Citation Formats
Chen, Xingshuo, and Cooks, R. Graham. Accelerated reactions in field desorption mass spectrometry. United States: N. p., 2018.
Web. doi:10.1002/jms.4254.
Chen, Xingshuo, & Cooks, R. Graham. Accelerated reactions in field desorption mass spectrometry. United States. https://doi.org/10.1002/jms.4254
Chen, Xingshuo, and Cooks, R. Graham. Sat .
"Accelerated reactions in field desorption mass spectrometry". United States. https://doi.org/10.1002/jms.4254. https://www.osti.gov/servlets/purl/1609706.
@article{osti_1609706,
title = {Accelerated reactions in field desorption mass spectrometry},
author = {Chen, Xingshuo and Cooks, R. Graham},
abstractNote = {Abstract Field desorption mass spectrometry under ambient conditions is used to study solution‐phase organic reactions in micro‐volumes. Reagent solution is transferred onto the microdendrites of the field emitter, and reaction products are examined online by mass spectrometry. Three reactions, hydrazone formation by phenyl hydrazine and indoline‐2,3‐dione, the Katritzky reaction between a pyrylium salt and anisidine, and the Hantzsch synthesis of 1,4‐dihydropyridine, were investigated, and reaction acceleration was observed to different extents. The increase in rate relative to the corresponding bulk reactions is attributed to solvent evaporation (simple concentration effect) and to the increase of surface‐to‐volume ratio (enhanced interfacial reactions). A distinguishing feature of this method of reaction acceleration, relative to that based on nano electrospray ionization, is the observation of radical cations and the formation of radical cation products. The study also breaks new ground in using field emitters at atmospheric pressure.},
doi = {10.1002/jms.4254},
journal = {Journal of Mass Spectrometry},
number = 10,
volume = 53,
place = {United States},
year = {Sat Jun 23 00:00:00 EDT 2018},
month = {Sat Jun 23 00:00:00 EDT 2018}
}
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