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Title: Accelerated Chemical Reactions and Organic Synthesis in Leidenfrost Droplets

Abstract

Abstract Leidenfrost levitated droplets can be used to accelerate chemical reactions in processes that appear similar to reaction acceleration in charged microdroplets produced by electrospray ionization. Reaction acceleration in Leidenfrost droplets is demonstrated for a base‐catalyzed Claisen–Schmidt condensation, hydrazone formation from precharged and neutral ketones, and for the Katritzky pyrylium into pyridinium conversion under various reaction conditions. Comparisons with bulk reactions gave intermediate acceleration factors (2–50). By keeping the volume of the Leidenfrost droplets constant, it was shown that interfacial effects contribute to acceleration; this was confirmed by decreased reaction rates in the presence of a surfactant. The ability to multiplex Leidenfrost microreactors, to extract product into an immiscible solvent during reaction, and to use Leidenfrost droplets as reaction vessels to synthesize milligram quantities of product is also demonstrated.

Authors:
 [1];  [1];  [2];  [1]
  1. Department of Chemistry Purdue University 560 Oval Drive West Lafayette IN USA
  2. Department of Chemistry Purdue University 560 Oval Drive West Lafayette IN USA, Laboratory of Neuroscience University of Lille 1 France
Publication Date:
Sponsoring Org.:
USDOE
OSTI Identifier:
1401698
Grant/Contract Number:  
FG02-06ER15807
Resource Type:
Publisher's Accepted Manuscript
Journal Name:
Angewandte Chemie (International Edition)
Additional Journal Information:
Journal Name: Angewandte Chemie (International Edition) Journal Volume: 55 Journal Issue: 35; Journal ID: ISSN 1433-7851
Publisher:
Wiley Blackwell (John Wiley & Sons)
Country of Publication:
Germany
Language:
English

Citation Formats

Bain, Ryan M., Pulliam, Christopher J., Thery, Fabien, and Cooks, R. Graham. Accelerated Chemical Reactions and Organic Synthesis in Leidenfrost Droplets. Germany: N. p., 2016. Web. doi:10.1002/anie.201605899.
Bain, Ryan M., Pulliam, Christopher J., Thery, Fabien, & Cooks, R. Graham. Accelerated Chemical Reactions and Organic Synthesis in Leidenfrost Droplets. Germany. https://doi.org/10.1002/anie.201605899
Bain, Ryan M., Pulliam, Christopher J., Thery, Fabien, and Cooks, R. Graham. Thu . "Accelerated Chemical Reactions and Organic Synthesis in Leidenfrost Droplets". Germany. https://doi.org/10.1002/anie.201605899.
@article{osti_1401698,
title = {Accelerated Chemical Reactions and Organic Synthesis in Leidenfrost Droplets},
author = {Bain, Ryan M. and Pulliam, Christopher J. and Thery, Fabien and Cooks, R. Graham},
abstractNote = {Abstract Leidenfrost levitated droplets can be used to accelerate chemical reactions in processes that appear similar to reaction acceleration in charged microdroplets produced by electrospray ionization. Reaction acceleration in Leidenfrost droplets is demonstrated for a base‐catalyzed Claisen–Schmidt condensation, hydrazone formation from precharged and neutral ketones, and for the Katritzky pyrylium into pyridinium conversion under various reaction conditions. Comparisons with bulk reactions gave intermediate acceleration factors (2–50). By keeping the volume of the Leidenfrost droplets constant, it was shown that interfacial effects contribute to acceleration; this was confirmed by decreased reaction rates in the presence of a surfactant. The ability to multiplex Leidenfrost microreactors, to extract product into an immiscible solvent during reaction, and to use Leidenfrost droplets as reaction vessels to synthesize milligram quantities of product is also demonstrated.},
doi = {10.1002/anie.201605899},
journal = {Angewandte Chemie (International Edition)},
number = 35,
volume = 55,
place = {Germany},
year = {Thu Jul 28 00:00:00 EDT 2016},
month = {Thu Jul 28 00:00:00 EDT 2016}
}

Journal Article:
Free Publicly Available Full Text
Publisher's Version of Record
https://doi.org/10.1002/anie.201605899

Citation Metrics:
Cited by: 85 works
Citation information provided by
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