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Title: Nutritional interventions and the IL‐6 response to exercise

Authors:
 [1];  [2];  [2]
  1. Military Nutrition DivisionU.S. Army Research Institute of Environmental Medicine (USARIEM) Natick Massachusetts USA, Oak Ridge Institute for Science and Education Belcamp Maryland USA
  2. Military Nutrition DivisionU.S. Army Research Institute of Environmental Medicine (USARIEM) Natick Massachusetts USA
Publication Date:
Sponsoring Org.:
USDOE
OSTI Identifier:
1602606
Resource Type:
Publisher's Accepted Manuscript
Journal Name:
FASEB Journal
Additional Journal Information:
[Journal Name: FASEB Journal Journal Volume: 31 Journal Issue: 9]; Journal ID: ISSN 0892-6638
Publisher:
FASEB
Country of Publication:
United States
Language:
English

Citation Formats

Hennigar, Stephen R., McClung, James P., and Pasiakos, Stefan M. Nutritional interventions and the IL‐6 response to exercise. United States: N. p., 2017. Web. doi:10.1096/fj.201700080R.
Hennigar, Stephen R., McClung, James P., & Pasiakos, Stefan M. Nutritional interventions and the IL‐6 response to exercise. United States. doi:10.1096/fj.201700080R.
Hennigar, Stephen R., McClung, James P., and Pasiakos, Stefan M. Tue . "Nutritional interventions and the IL‐6 response to exercise". United States. doi:10.1096/fj.201700080R.
@article{osti_1602606,
title = {Nutritional interventions and the IL‐6 response to exercise},
author = {Hennigar, Stephen R. and McClung, James P. and Pasiakos, Stefan M.},
abstractNote = {},
doi = {10.1096/fj.201700080R},
journal = {FASEB Journal},
number = [9],
volume = [31],
place = {United States},
year = {2017},
month = {9}
}

Journal Article:
Free Publicly Available Full Text
Publisher's Version of Record
DOI: 10.1096/fj.201700080R

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Works referenced in this record:

The effects of carbohydrate ingestion during endurance running on post-exercise inflammation and hepcidin levels
journal, September 2011

  • Sim, Marc; Dawson, Brian; Landers, Grant
  • European Journal of Applied Physiology, Vol. 112, Issue 5
  • DOI: 10.1007/s00421-011-2156-0

From cytokine to myokine: the emerging role of interleukin-6 in metabolic regulation
journal, March 2014

  • Pal, Martin; Febbraio, Mark A.; Whitham, Martin
  • Immunology and Cell Biology, Vol. 92, Issue 4
  • DOI: 10.1038/icb.2014.16

Effects of endotoxin on zinc metabolism in human volunteers
journal, June 1997

  • Gaetke, L. M.; McClain, C. J.; Talwalkar, R. T.
  • American Journal of Physiology-Endocrinology and Metabolism, Vol. 272, Issue 6
  • DOI: 10.1152/ajpendo.1997.272.6.E952

Cellular Catabolism of the Iron-Regulatory Peptide Hormone Hepcidin
journal, March 2013


Prolonged vitamin C supplementation and recovery from eccentric exercise
journal, June 2004

  • Thompson, D.; Hill, J.; Hurst, T.
  • European Journal of Applied Physiology, Vol. 92, Issue 1-2
  • DOI: 10.1007/s00421-004-1064-y

Influence of Vitamin C Supplementation on Cytokine Changes Following an Ultramarathon
journal, November 2000

  • Nieman, David C.; Peters, Edith M.; Henson, Dru A.
  • Journal of Interferon & Cytokine Research, Vol. 20, Issue 11
  • DOI: 10.1089/10799900050198480

Muscle-derived interleukin-6: possible biological effects
journal, October 2001


Control of endothelial leukocyte adhesion molecules by fatty acids
journal, March 1996


Interleukin-6 Is a Novel Factor Mediating Glucose Homeostasis During Skeletal Muscle Contraction
journal, June 2004


Docosahexaenoic Acid Affects Markers of Inflammation and Muscle Damage After Eccentric Exercise
journal, January 2014

  • DiLorenzo, Frank M.; Drager, Christopher J.; Rankin, Janet W.
  • Journal of Strength and Conditioning Research, Vol. 28, Issue 10
  • DOI: 10.1519/JSC.0000000000000617

Immune Responses to Strenuous Exercise and Carbohydrate Intake in Boys and Men
journal, August 2004


Influence of carbohydrate ingestion on immune changes after 2 h of intensive resistance training
journal, April 2004


Pro- and anti-inflammatory cytokine balance in strenuous exercise in humans
journal, February 1999


Longitudinal decrements in iron status during military training in female soldiers
journal, January 2009

  • McClung, James P.; Karl, J. Philip; Cable, Sonya J.
  • British Journal of Nutrition, Vol. 102, Issue 04
  • DOI: 10.1017/S0007114509220873

Carbohydrate ingestion attenuates the increase in plasma interleukin-6, but not skeletal muscle interleukin-6 mRNA, during exercise in humans
journal, June 2001


Antioxidant supplementation prevents exercise-induced lipid peroxidation, but not inflammation, in ultramarathon runners
journal, May 2004


Seven days of high carbohydrate ingestion does not attenuate post-exercise IL-6 and hepcidin levels
journal, July 2016

  • Badenhorst, Claire E.; Dawson, Brian; Cox, Gregory R.
  • European Journal of Applied Physiology, Vol. 116, Issue 9
  • DOI: 10.1007/s00421-016-3426-7

Interleukin-6 myokine signaling in skeletal muscle: a double-edged sword?
journal, June 2013

  • Muñoz-Cánoves, Pura; Scheele, Camilla; Pedersen, Bente K.
  • FEBS Journal, Vol. 280, Issue 17
  • DOI: 10.1111/febs.12338

Enhanced plasma IL-6 and IL-1ra responses to repeated vs. single bouts of prolonged cycling in elite athletes
journal, June 2002


N-3 polyunsaturated fatty acids do not affect cytokine response to strenuous exercise
journal, December 2000


Soy and the exercise-induced inflammatory response in postmenopausal women
journal, June 2010

  • Beavers, Kristen M.; Serra, Monica C.; Beavers, Daniel P.
  • Applied Physiology, Nutrition, and Metabolism, Vol. 35, Issue 3
  • DOI: 10.1139/H10-015

Dose-Dependent Effects of Recombinant Human Interleukin-6 on Glucose Regulation
journal, December 1997

  • Tsigos, Constantine; Papanicolaou, Dimitris A.; Kyrou, Ioannis
  • The Journal of Clinical Endocrinology & Metabolism, Vol. 82, Issue 12
  • DOI: 10.1210/jcem.82.12.4422

Effect of Pre-exercise Carbohydrate Ingestion on Plasma Cytokine, Stress Hormone, and Neutrophil Degranulation Responses to Continuous, High-Intensity Exercise
journal, December 2003

  • Lancaster, Graeme I.; Jentjens, Roy L. P. G.; Moseley, Luke
  • International Journal of Sport Nutrition and Exercise Metabolism, Vol. 13, Issue 4
  • DOI: 10.1123/ijsnem.13.4.436

Muscle Cytokine mRNA Changes after 2.5 h of Cycling: Influence of Carbohydrate
journal, January 2005


Effects of Graded Carbohydrate Supplementation on the Immune Response in Cycling
journal, January 2006


Interleukin-6 production in human subcutaneous abdominal adipose tissue: the effect of exercise
journal, August 2002


Randomized, double-blind, placebo-controlled trial of iron supplementation in female soldiers during military training: effects on iron status, physical performance, and mood
journal, May 2009

  • McClung, James P.; Karl, J. Philip; Cable, Sonya J.
  • The American Journal of Clinical Nutrition, Vol. 90, Issue 1
  • DOI: 10.3945/ajcn.2009.27774

Interleukin-6 production in contracting human skeletal muscle is influenced by pre-exercise muscle glycogen content
journal, December 2001


Pre-Exercise Carbohydrate Status and Immune Responses to Prolonged Cycling: II. Effect on Plasma Cytokine Concentration
journal, December 2001

  • Bishop, Nicolette C.; Walsh, Neil P.; Haines, Donna L.
  • International Journal of Sport Nutrition and Exercise Metabolism, Vol. 11, Issue 4
  • DOI: 10.1123/ijsnem.11.4.503

Effect of post-exercise protein–leucine feeding on neutrophil function, immunomodulatory plasma metabolites and cortisol during a 6-day block of intense cycling
journal, April 2013

  • Nelson, Andre R.; Jackson, Lara; Clarke, Jim
  • European Journal of Applied Physiology, Vol. 113, Issue 9
  • DOI: 10.1007/s00421-013-2650-7

Prolonged Vitamin C Supplementation and Recovery from Demanding Exercise
journal, December 2001

  • Thompson, Dylan; Williams, Clyde; McGregor, Stephen J.
  • International Journal of Sport Nutrition and Exercise Metabolism, Vol. 11, Issue 4
  • DOI: 10.1123/ijsnem.11.4.466

The effect of carbohydrate ingestion on plasma interleukin-6, hepcidin and iron concentrations following prolonged exercise
journal, February 2011


IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin
journal, May 2004

  • Nemeth, Elizabeta; Rivera, Seth; Gabayan, Victoria
  • Journal of Clinical Investigation, Vol. 113, Issue 9, p. 1271-1276
  • DOI: 10.1172/JCI200420945

Role of vitamin C and E supplementation on IL-6 in response to training
journal, March 2012


Effect of prolonged, submaximal exercise and carbohydrate ingestion on monocyte intracellular cytokine production in humans
journal, November 2000


Effect of Carbohydrate Intake during Recovery from Eccentric Exercise on Interleukin-6 and Muscle-Damage Markers
journal, December 2007

  • Miles, Mary P.; Pearson, Sherri D.; Andring, Jan M.
  • International Journal of Sport Nutrition and Exercise Metabolism, Vol. 17, Issue 6
  • DOI: 10.1123/ijsnem.17.6.507

Prolonged submaximal eccentric exercise is associated with increased levels of plasma IL-6
journal, July 1997

  • Rohde, T.; MacLean, D. A.; Richter, E. A.
  • American Journal of Physiology-Endocrinology and Metabolism, Vol. 273, Issue 1
  • DOI: 10.1152/ajpendo.1997.273.1.E85

The anti-inflammatory effect of exercise
journal, April 2005


Influence of vitamin C supplementation on oxidative and immune changes after an ultramarathon
journal, May 2002


Plasma/Serum Zinc Status During Aerobic Exercise Recovery: A Systematic Review and Meta-Analysis
journal, June 2016


Exercise Metabolism and the Molecular Regulation of Skeletal Muscle Adaptation
journal, February 2013


The effects of carbohydrate supplementation during the second of two prolonged cycling bouts on immunoendocrine responses
journal, September 2005


Some aspects of the acute phase response after a marathon race, and the effects of glutamine supplementation
journal, December 1996

  • Castell, L. M.; Poortmans, J. R.; Leclercq, R.
  • European Journal of Applied Physiology, Vol. 75, Issue 1
  • DOI: 10.1007/s004210050125

Acute dietary carbohydrate manipulation and the subsequent inflammatory and hepcidin responses to exercise
journal, September 2015

  • Badenhorst, Claire E.; Dawson, Brian; Cox, Gregory R.
  • European Journal of Applied Physiology, Vol. 115, Issue 12
  • DOI: 10.1007/s00421-015-3252-3

The molecular basis of hepcidin-resistant hereditary hemochromatosis
journal, July 2009


Effects of a 7-day military training exercise on inflammatory biomarkers, serum hepcidin, and iron status
journal, November 2013


Post-exercise vitamin C supplementation and recovery from demanding exercise
journal, May 2003

  • Thompson, D.; Williams, C.; Garcia-Roves, P.
  • European Journal of Applied Physiology, Vol. 89, Issue 3
  • DOI: 10.1007/s00421-003-0816-4

Effect of Dietary Fat Intake and Exercise on Inflammatory Mediators of the Immune System in Sedentary Men and Women
journal, August 2004

  • Meksawan, Kulwara; Venkatraman, Jaya T.; Awad, Atif B.
  • Journal of the American College of Nutrition, Vol. 23, Issue 4
  • DOI: 10.1080/07315724.2004.10719376

Exercise and the Immune System: Regulation, Integration, and Adaptation
journal, July 2000


Zinc Transporter ZIP14 Functions in Hepatic Zinc, Iron and Glucose Homeostasis during the Innate Immune Response (Endotoxemia)
journal, October 2012


n-3 Polyunsaturated Fatty Acids Do Not Alter Immune and Inflammation Measures in Endurance Athletes
journal, October 2009

  • Nieman, David C.; Henson, Dru A.; McAnulty, Steven R.
  • International Journal of Sport Nutrition and Exercise Metabolism, Vol. 19, Issue 5
  • DOI: 10.1123/ijsnem.19.5.536

Influence of Acute Vitamin C and/or Carbohydrate Ingestion on Hormonal, Cytokine, and Immune Responses to Prolonged Exercise
journal, October 2005

  • Davison, Glen; Gleeson, Michael
  • International Journal of Sport Nutrition and Exercise Metabolism, Vol. 15, Issue 5
  • DOI: 10.1123/ijsnem.15.5.465

Glucose Ingestion Attenuates Interleukin-6 Release from Contracting Skeletal Muscle in Humans
journal, June 2003


A trauma-like elevation of plasma cytokines in humans in response to treadmill running
journal, December 1998


Timing of post-exercise carbohydrate ingestion: influence on IL-6 and hepcidin responses
journal, June 2015

  • Badenhorst, Claire E.; Dawson, Brian; Cox, Gregory R.
  • European Journal of Applied Physiology, Vol. 115, Issue 10
  • DOI: 10.1007/s00421-015-3202-0

Interleukin-6 regulates the zinc transporter Zip14 in liver and contributes to the hypozincemia of the acute-phase response
journal, April 2005

  • Liuzzi, J. P.; Lichten, L. A.; Rivera, S.
  • Proceedings of the National Academy of Sciences, Vol. 102, Issue 19
  • DOI: 10.1073/pnas.0502257102

Effects of Exercise on Hepcidin Response and Iron Metabolism during Recovery
journal, December 2009

  • Peeling, Peter; Dawson, Brian; Goodman, Carmel
  • International Journal of Sport Nutrition and Exercise Metabolism, Vol. 19, Issue 6
  • DOI: 10.1123/ijsnem.19.6.583

Cytokine changes after a marathon race
journal, July 2001


Effect of a carbohydrate-protein multi-ingredient supplement on intermittent sprint performance and muscle damage in recreational athletes
journal, October 2014

  • Naclerio, Fernando; Larumbe-Zabala, Eneko; Cooper, Robert
  • Applied Physiology, Nutrition, and Metabolism, Vol. 39, Issue 10
  • DOI: 10.1139/apnm-2013-0556

Interleukin-6 release from human skeletal muscle during exercise: relation to AMPK activity
journal, December 2003

  • MacDonald, Christopher; Wojtaszewski, Jørgen F. P.; Pedersen, Bente Klarlund
  • Journal of Applied Physiology, Vol. 95, Issue 6
  • DOI: 10.1152/japplphysiol.00242.2003

Post-Exercise Skeletal Muscle Glycogen Related to Plasma Cytokines and Muscle IL-6 Protein Content, but not Muscle Cytokine mRNA Expression
journal, September 2015

  • Nieman, David C.; Zwetsloot, Kevin A.; Meaney, Mary Pat
  • Frontiers in Nutrition, Vol. 2
  • DOI: 10.3389/fnut.2015.00027

Carbohydrate and the cytokine response to 2.5 h of running
journal, May 1997

  • Nehlsen-Cannarella, S. L.; Fagoaga, O. R.; Nieman, D. C.
  • Journal of Applied Physiology, Vol. 82, Issue 5
  • DOI: 10.1152/jappl.1997.82.5.1662

IL-6 enhances plasma IL-1ra, IL-10, and cortisol in humans
journal, August 2003

  • Steensberg, Adam; Fischer, Christian P.; Keller, Charlotte
  • American Journal of Physiology-Endocrinology and Metabolism, Vol. 285, Issue 2
  • DOI: 10.1152/ajpendo.00074.2003

Transcriptional activation of the IL‐6 gene in human contracting skeletal muscle: influence of muscle glycogen content
journal, October 2001

  • Keller, Charlotte; Steensberg, Adam; Pilegaard, Henriette
  • The FASEB Journal, Vol. 15, Issue 14
  • DOI: 10.1096/fj.01-0507fje

Anti-inflammatory effects of a special carbohydrate–whey protein cake after exhaustive cycling in humans
journal, November 2013

  • Kerasioti, Efthalia; Stagos, Dimitrios; Jamurtas, Athanasios
  • Food and Chemical Toxicology, Vol. 61
  • DOI: 10.1016/j.fct.2013.01.023

Muscle‐derived interleukin‐6: mechanisms for activation and possible biological roles
journal, September 2002

  • Febbraio, Mark A.; Pedersen, Bente Klarlund
  • The FASEB Journal, Vol. 16, Issue 11
  • DOI: 10.1096/fj.01-0876rev

Effects of exercise mode, energy, and macronutrient interventions on inflammation during military training
journal, June 2016

  • Pasiakos, Stefan M.; Margolis, Lee M.; Murphy, Nancy E.
  • Physiological Reports, Vol. 4, Issue 11
  • DOI: 10.14814/phy2.12820

Effect of dietary protein content during recovery from high-intensity cycling on subsequent performance and markers of stress, inflammation, and muscle damage in well-trained men
journal, February 2008

  • Rowlands, David S.; Rössler, Karin; Thorp, Rhys M.
  • Applied Physiology, Nutrition, and Metabolism, Vol. 33, Issue 1
  • DOI: 10.1139/H07-136

Pre-Exercise Carbohydrate Status Influences Carbohydrate-Mediated Attenuation of Post-Exercise Cytokine Responses
journal, July 2008

  • Cox, A.; Pyne, D.; Cox, G.
  • International Journal of Sports Medicine, Vol. 29, Issue 12
  • DOI: 10.1055/s-2008-1038753

Hepcidin-Induced Endocytosis of Ferroportin Is Dependent on Ferroportin Ubiquitination
journal, June 2012


The effects of fish oil and isoflavones on delayed onset muscle soreness
journal, January 2002


A Dietary Supplement Attenuates IL-6 and CRP after Eccentric Exercise in Untrained Males
journal, January 2003


Interleukin-6 contributes to hepcidin mRNA increase in response to exercise
journal, May 2012


Interleukin-6 and the acute phase response
journal, February 1990

  • Heinrich, P. C.; Castell, J. V.; Andus, T.
  • Biochemical Journal, Vol. 265, Issue 3
  • DOI: 10.1042/bj2650621

Exercise-Induced Muscle Damage in Humans
journal, January 2002

  • Clarkson, Priscilla M.; Hubal, Monica J.
  • American Journal of Physical Medicine & Rehabilitation, Vol. 81, Issue Supplement
  • DOI: 10.1097/00002060-200211001-00007

Behavioral Data and Methodology Issues in Studies of Zinc Nutrition in Humans
journal, February 2000


Influence of Chronic Dietary Carbohydrate Supplementation on Plasma Cytokine Responses to Exercise
journal, February 2010

  • Cox, A.; Pyne, D.; Cox, G.
  • International Journal of Sports Medicine, Vol. 31, Issue 03
  • DOI: 10.1055/s-0029-1243645

Vitamin C supplementation does not influence plasma and blood mononuclear cell IL-6 and IL-10 levels after exercise
journal, May 2014


Elevated hepcidin serum level in response to inflammatory and iron signals in exercising athletes is independent of moderate supplementation with vitamin C and E
journal, August 2015

  • Díaz, Víctor; Peinado, Ana B.; Barba-Moreno, Laura
  • Physiological Reports, Vol. 3, Issue 8
  • DOI: 10.14814/phy2.12475

Cycling Time Trial Performance May Be Impaired by Whey Protein and L-Alanine Intake During Prolonged Exercise
journal, October 2014

  • Schroer, Adam B.; Saunders, Michael J.; Baur, Daniel A.
  • International Journal of Sport Nutrition and Exercise Metabolism, Vol. 24, Issue 5
  • DOI: 10.1123/ijsnem.2013-0173

Carbohydrate ingestion influences skeletal muscle cytokine mRNA and plasma cytokine levels after a 3-h run
journal, May 2003


Influence of mode and carbohydrate on the cytokine response to heavy exertion
journal, January 1998

  • Nieman, David C.; Nehlsen-Cannarella, Sandra L.; Fagoaga, Omar R.
  • Medicine & Science in Sports & Exercise, Vol. 30, Issue 5
  • DOI: 10.1097/00005768-199805000-00005

Hepcidin Attenuates Zinc Efflux in Caco-2 Cells
journal, September 2016

  • Hennigar, Stephen R.; McClung, James P.
  • The Journal of Nutrition, Vol. 146, Issue 11
  • DOI: 10.3945/jn.116.237081

IL-6 Gene Expression in Human Adipose Tissue in Response to Exercise - Effect of Carbohydrate Ingestion
journal, August 2003


Effects of Carbohydrate Ingestion on Acute Leukocyte, Cortisol, and Interleukin-6 Response in High-Intensity Long-Distance Running
journal, January 2014

  • Ihalainen, Johanna K.; Vuorimaa, Timo; Puurtinen, Risto
  • Journal of Strength and Conditioning Research, Vol. 28, Issue 10
  • DOI: 10.1519/JSC.0000000000000470

Polyphenols in Exercise Performance and Prevention of Exercise-Induced Muscle Damage
journal, January 2013

  • Malaguti, Marco; Angeloni, Cristina; Hrelia, Silvana
  • Oxidative Medicine and Cellular Longevity, Vol. 2013
  • DOI: 10.1155/2013/825928

Exercise and IL‐6 infusion inhibit endotoxin‐induced TNF‐α production in humans
journal, March 2003

  • Starkie, Rebecca; Ostrowski, Sisse Rye; Jauffred, Sune
  • The FASEB Journal, Vol. 17, Issue 8
  • DOI: 10.1096/fj.02-0670fje

Antioxidants attenuate the plasma cytokine response to exercise in humans
journal, March 2003

  • Vassilakopoulos, Theodoros; Karatza, Maria-Helena; Katsaounou, Paraskevi
  • Journal of Applied Physiology, Vol. 94, Issue 3
  • DOI: 10.1152/japplphysiol.00735.2002

Immediate Effects of Aerobic Exercise on Plasma/Serum Zinc Levels: A Meta-analysis
journal, January 2016


Low dietary zinc decreases erythrocyte carbonic anhydrase activities and impairs cardiorespiratory function in men during exercise
journal, May 2005


Omega-3 Fatty Acids Supplementation Attenuates Inflammatory Markers After Eccentric Exercise in Untrained Men
journal, January 2011

  • Tartibian, Bakhtyar; Maleki, Behzad Hajizadeh; Abbasi, Asghar
  • Clinical Journal of Sport Medicine, Vol. 21, Issue 2
  • DOI: 10.1097/JSM.0b013e31820f8c2f

Glutamine supplementation further enhances exercise-induced plasma IL-6
journal, July 2003


Time-course analysis of hepcidin, serum iron, and plasma cytokine levels in humans injected with LPS
journal, September 2005