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Title: Copper-containing glass ceramic with high antimicrobial efficacy

Abstract

Hospital acquired infections (HAIs) and the emergence of antibiotic resistant strains are major threats to human health. Copper is well known for its high antimicrobial efficacy, including the ability to kill superbugs and the notorious ESKAPE group of pathogens. We sought a material that maintains the antimicrobial efficacy of copper while minimizing the downsides – cost, appearance and metallic properties – that limit application. Here we describe a copper-glass ceramic powder as an additive for antimicrobial surfaces; its mechanism is based on the controlled release of copper (I) ions (Cu 1+) from cuprite nanocrystals that form in situ in the water labile phase of the biphasic glass ceramic. Latex paints containing copper-glass ceramic powder exhibit ≥99.9% reduction in S. aureus, P. aeruginosa, K. aerogenes and E. Coli colony counts when evaluated by the US EPA test method for efficacy of copper-alloy surfaces as sanitizer, approaching that of benchmark metallic copper.

Authors:
 [1];  [1]; ORCiD logo [1];  [1];  [1];  [1];  [1];  [2];  [1];  [1]
  1. Corning Incorporated, Corning, NY (United States)
  2. Argonne National Lab. (ANL), Argonne, IL (United States)
Publication Date:
Research Org.:
Argonne National Lab. (ANL), Argonne, IL (United States)
Sponsoring Org.:
USDOE; Corning Incorporated, Corning, NY (United States)
OSTI Identifier:
1557606
Grant/Contract Number:  
AC02-06CH11357
Resource Type:
Accepted Manuscript
Journal Name:
Nature Communications
Additional Journal Information:
Journal Volume: 10; Journal Issue: 1; Journal ID: ISSN 2041-1723
Publisher:
Nature Publishing Group
Country of Publication:
United States
Language:
English
Subject:
36 MATERIALS SCIENCE

Citation Formats

Gross, Timothy M., Lahiri, Joydeep, Golas, Avantika, Luo, Jian, Verrier, Florence, Kurzejewski, Jackie L., Baker, David E., Wang, Jie, Novak, Paul F., and Snyder, Michael J. Copper-containing glass ceramic with high antimicrobial efficacy. United States: N. p., 2019. Web. doi:10.1038/s41467-019-09946-9.
Gross, Timothy M., Lahiri, Joydeep, Golas, Avantika, Luo, Jian, Verrier, Florence, Kurzejewski, Jackie L., Baker, David E., Wang, Jie, Novak, Paul F., & Snyder, Michael J. Copper-containing glass ceramic with high antimicrobial efficacy. United States. doi:10.1038/s41467-019-09946-9.
Gross, Timothy M., Lahiri, Joydeep, Golas, Avantika, Luo, Jian, Verrier, Florence, Kurzejewski, Jackie L., Baker, David E., Wang, Jie, Novak, Paul F., and Snyder, Michael J. Tue . "Copper-containing glass ceramic with high antimicrobial efficacy". United States. doi:10.1038/s41467-019-09946-9. https://www.osti.gov/servlets/purl/1557606.
@article{osti_1557606,
title = {Copper-containing glass ceramic with high antimicrobial efficacy},
author = {Gross, Timothy M. and Lahiri, Joydeep and Golas, Avantika and Luo, Jian and Verrier, Florence and Kurzejewski, Jackie L. and Baker, David E. and Wang, Jie and Novak, Paul F. and Snyder, Michael J.},
abstractNote = {Hospital acquired infections (HAIs) and the emergence of antibiotic resistant strains are major threats to human health. Copper is well known for its high antimicrobial efficacy, including the ability to kill superbugs and the notorious ESKAPE group of pathogens. We sought a material that maintains the antimicrobial efficacy of copper while minimizing the downsides – cost, appearance and metallic properties – that limit application. Here we describe a copper-glass ceramic powder as an additive for antimicrobial surfaces; its mechanism is based on the controlled release of copper (I) ions (Cu1+) from cuprite nanocrystals that form in situ in the water labile phase of the biphasic glass ceramic. Latex paints containing copper-glass ceramic powder exhibit ≥99.9% reduction in S. aureus, P. aeruginosa, K. aerogenes and E. Coli colony counts when evaluated by the US EPA test method for efficacy of copper-alloy surfaces as sanitizer, approaching that of benchmark metallic copper.},
doi = {10.1038/s41467-019-09946-9},
journal = {Nature Communications},
number = 1,
volume = 10,
place = {United States},
year = {2019},
month = {4}
}

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Works referenced in this record:

Contact killing and antimicrobial properties of copper
journal, February 2018

  • Vincent, M.; Duval, R. E.; Hartemann, P.
  • Journal of Applied Microbiology, Vol. 124, Issue 5
  • DOI: 10.1111/jam.13681

Exchange and Diffusion of Ions in Glass
journal, August 1964


Highly efficient antiviral and antibacterial activities of solid-state cuprous compounds
journal, October 2012


Fatigue limit and crack arrest in alkali-containing silicate glasses
journal, October 1991

  • Gehrke, E.; Ullner, Ch.; Hähnert, M.
  • Journal of Materials Science, Vol. 26, Issue 20
  • DOI: 10.1007/BF02403942

Preparation, application and testing of permanent antibacterial and antiviral coatings
journal, September 2007

  • Haldar, Jayanta; Weight, Alisha K.; Klibanov, Alexander M.
  • Nature Protocols, Vol. 2, Issue 10
  • DOI: 10.1038/nprot.2007.353

Hydration of soda-lime glass
journal, June 1979


Revised effective ionic radii and systematic studies of interatomic distances in halides and chalcogenides
journal, September 1976


Horizontal Transfer of Antibiotic Resistance Genes on Abiotic Touch Surfaces: Implications for Public Health
journal, November 2012

  • Warnes, Sarah L.; Highmore, Callum J.; Keevil, C. William
  • mBio, Vol. 3, Issue 6
  • DOI: 10.1128/mBio.00489-12

Thermal Expansion of Substituted Copper Aluminosilicate Glasses
journal, January 1983


Role of Copper Oxides in Contact Killing of Bacteria
journal, December 2013

  • Hans, Michael; Erbe, Andreas; Mathews, Salima
  • Langmuir, Vol. 29, Issue 52
  • DOI: 10.1021/la404091z

Formation of copper nanocrystals in alkali-lime silica glass by means of different reducing agents
journal, October 2004


Origins and Evolution of Antibiotic Resistance
journal, August 2010

  • Davies, J.; Davies, D.
  • Microbiology and Molecular Biology Reviews, Vol. 74, Issue 3
  • DOI: 10.1128/MMBR.00016-10

Copper Surfaces Reduce the Rate of Healthcare-Acquired Infections in the Intensive Care Unit
journal, May 2013

  • Salgado, Cassandra D.; Sepkowitz, Kent A.; John, Joseph F.
  • Infection Control & Hospital Epidemiology, Vol. 34, Issue 5
  • DOI: 10.1086/670207

The molecular mechanisms of copper and silver ion disinfection of bacteria and viruses
journal, January 1989

  • Thurman, Robert B.; Gerba, Charles P.; Bitton, Gabriel
  • Critical Reviews in Environmental Control, Vol. 18, Issue 4
  • DOI: 10.1080/10643388909388351

Interdiffusion of hydrogen and alkali ions in a glass surface
journal, December 1975


Permeation of Gaseous Oxygen through Vitreous Silica
journal, August 1961


Low expansion copper aluminosilicate glasses
journal, January 1979


Dissolution behavior of Na2O–FeO–Fe2O3–P2O5 glasses
journal, May 2017


A New Self-Consistent Empirical Interatomic Potential Model for Oxides, Silicates, and Silica-Based Glasses
journal, June 2006

  • Pedone, Alfonso; Malavasi, Gianluca; Menziani, M. Cristina
  • The Journal of Physical Chemistry B, Vol. 110, Issue 24
  • DOI: 10.1021/jp0611018

Welcome to the Glass Age
journal, October 2016

  • Morse, David L.; Evenson, Jeffrey W.
  • International Journal of Applied Glass Science, Vol. 7, Issue 4
  • DOI: 10.1111/ijag.12242

A facile synthesis of Cu 2 O / SiO 2 and Cu / SiO 2 core–shell octahedral nanocomposites
journal, July 2008


Metallic Copper as an Antimicrobial Surface
journal, December 2010

  • Grass, Gregor; Rensing, Christopher; Solioz, Marc
  • Applied and Environmental Microbiology, Vol. 77, Issue 5
  • DOI: 10.1128/AEM.02766-10

Rapid in situ assessment of Cu-ion mediated effects and antibacterial efficacy of copper surfaces
journal, May 2018


A unified formulation of the constant temperature molecular dynamics methods
journal, July 1984

  • Nosé, Shuichi
  • The Journal of Chemical Physics, Vol. 81, Issue 1
  • DOI: 10.1063/1.447334

Copper Reduction and Contact Killing of Bacteria by Iron Surfaces
journal, July 2015

  • Mathews, Salima; Kumar, Ranjeet; Solioz, Marc
  • Applied and Environmental Microbiology, Vol. 81, Issue 18
  • DOI: 10.1128/AEM.01725-15

Deploy vaccines to fight superbugs
journal, December 2017


Clinical relevance of the ESKAPE pathogens
journal, March 2013

  • Pendleton, Jack N.; Gorman, Sean P.; Gilmore, Brendan F.
  • Expert Review of Anti-infective Therapy, Vol. 11, Issue 3
  • DOI: 10.1586/eri.13.12