Copper-containing glass ceramic with high antimicrobial efficacy

Gross, Timothy M.; Lahiri, Joydeep; Golas, Avantika; Luo, Jian; Verrier, Florence; Kurzejewski, Jackie L.; Baker, David E.; Wang, Jie; Novak, Paul F.; Snyder, Michael J.

doi:10.1038/s41467-019-09946-9

Title: Copper-containing glass ceramic with high antimicrobial efficacy

Abstract

Hospital acquired infections (HAIs) and the emergence of antibiotic resistant strains are major threats to human health. Copper is well known for its high antimicrobial efficacy, including the ability to kill superbugs and the notorious ESKAPE group of pathogens. We sought a material that maintains the antimicrobial efficacy of copper while minimizing the downsides – cost, appearance and metallic properties – that limit application. Here we describe a copper-glass ceramic powder as an additive for antimicrobial surfaces; its mechanism is based on the controlled release of copper (I) ions (Cu¹⁺) from cuprite nanocrystals that form in situ in the water labile phase of the biphasic glass ceramic. Latex paints containing copper-glass ceramic powder exhibit ≥99.9% reduction in S. aureus, P. aeruginosa, K. aerogenes and E. Coli colony counts when evaluated by the US EPA test method for efficacy of copper-alloy surfaces as sanitizer, approaching that of benchmark metallic copper.

Authors:

Gross, Timothy M. ^[1]; Lahiri, Joydeep ^[1];

^[1]; Luo, Jian ^[1]; Verrier, Florence ^[1]; Kurzejewski, Jackie L. ^[1]; Baker, David E. ^[1]; Wang, Jie ^[2]; Novak, Paul F. ^[1]; Snyder, Michael J. ^[1]

Corning Incorporated, Corning, NY (United States)
Argonne National Lab. (ANL), Argonne, IL (United States)

Publication Date:: Tue Apr 30 00:00:00 EDT 2019

Research Org.:: Argonne National Laboratory (ANL), Argonne, IL (United States)

Sponsoring Org.:: USDOE; Corning Incorporated, Corning, NY (United States)

OSTI Identifier:: 1557606

Grant/Contract Number:: AC02-06CH11357

Resource Type:: Accepted Manuscript

Journal Name:: Nature Communications

Additional Journal Information:: Journal Volume: 10; Journal Issue: 1; Journal ID: ISSN 2041-1723

Publisher:: Nature Publishing Group

Country of Publication:: United States

Language:: English

Subject:: 36 MATERIALS SCIENCE

Citation Formats


                    Gross, Timothy M., Lahiri, Joydeep, Golas, Avantika, Luo, Jian, Verrier, Florence, Kurzejewski, Jackie L., Baker, David E., Wang, Jie, Novak, Paul F., and Snyder, Michael J. Copper-containing glass ceramic with high antimicrobial efficacy.  United States: N. p., 2019. 
Web.  doi:10.1038/s41467-019-09946-9.

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                    Gross, Timothy M., Lahiri, Joydeep, Golas, Avantika, Luo, Jian, Verrier, Florence, Kurzejewski, Jackie L., Baker, David E., Wang, Jie, Novak, Paul F., & Snyder, Michael J. Copper-containing glass ceramic with high antimicrobial efficacy.  United States.  https://doi.org/10.1038/s41467-019-09946-9

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                    Gross, Timothy M., Lahiri, Joydeep, Golas, Avantika, Luo, Jian, Verrier, Florence, Kurzejewski, Jackie L., Baker, David E., Wang, Jie, Novak, Paul F., and Snyder, Michael J. Tue .  
"Copper-containing glass ceramic with high antimicrobial efficacy".  United States.  https://doi.org/10.1038/s41467-019-09946-9.  https://www.osti.gov/servlets/purl/1557606.

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@article{osti_1557606,

  title        = {Copper-containing glass ceramic with high antimicrobial efficacy},

  author       = {Gross, Timothy M. and Lahiri, Joydeep and Golas, Avantika and Luo, Jian and Verrier, Florence and Kurzejewski, Jackie L. and Baker, David E. and Wang, Jie and Novak, Paul F. and Snyder, Michael J.},

  abstractNote = {Hospital acquired infections (HAIs) and the emergence of antibiotic resistant strains are major threats to human health. Copper is well known for its high antimicrobial efficacy, including the ability to kill superbugs and the notorious ESKAPE group of pathogens. We sought a material that maintains the antimicrobial efficacy of copper while minimizing the downsides – cost, appearance and metallic properties – that limit application. Here we describe a copper-glass ceramic powder as an additive for antimicrobial surfaces; its mechanism is based on the controlled release of copper (I) ions (Cu1+) from cuprite nanocrystals that form in situ in the water labile phase of the biphasic glass ceramic. Latex paints containing copper-glass ceramic powder exhibit ≥99.9% reduction in S. aureus, P. aeruginosa, K. aerogenes and E. Coli colony counts when evaluated by the US EPA test method for efficacy of copper-alloy surfaces as sanitizer, approaching that of benchmark metallic copper.},

  doi          = {10.1038/s41467-019-09946-9},

  journal      = {Nature Communications},

  number       = 1,

  volume       = 10,

  place        = {United States},

  year         = {Tue Apr 30 00:00:00 EDT 2019},

  month        = {Tue Apr 30 00:00:00 EDT 2019}

}

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https://doi.org/10.1038/s41467-019-09946-9

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Cited by: 45 works

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Doremus, R. H.
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Langmuir, Vol. 29, Issue 52
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Formation of copper nanocrystals in alkali-lime silica glass by means of different reducing agents
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Works referencing / citing this record:

The Effects of Copper Addition on The Structure and Antibacterial Properties of Biomedical Glasses
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Mojtabavi, Leyla; Razavi, Amir
European Chemical Bulletin, Vol. 9, Issue 1
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journal, December 2019

Montazerian, Maziar; Zanotto, Edgar D.; Mauro, John C.
International Materials Reviews, Vol. 65, Issue 5
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Similar Records

Title: Copper-containing glass ceramic with high antimicrobial efficacy

Abstract

Citation Formats

Contact killing and antimicrobial properties of copper journal, February 2018

Exchange and Diffusion of Ions in Glass journal, August 1964

Contact killing and antimicrobial properties of copper journal, February 2018

Highly efficient antiviral and antibacterial activities of solid-state cuprous compounds journal, October 2012

Fatigue limit and crack arrest in alkali-containing silicate glasses journal, October 1991

Low expansion copper aluminosilicate glasses journal, January 1979

Few-layer bismuth selenide cathode for low-temperature quasi-solid-state aqueous zinc metal batteries journal, February 2022

Airborne allergic contact dermatitis caused by isothiazolinones in water-based paints: a retrospective study of 44 cases: AIRBORNE ALLERGIC CONTACT DERMATITIS CAUSED BY PAINTS journal, April 2017

Fatigue limit and crack arrest in alkali-containing silicate glasses journal, January 1991

Revised effective ionic radii and systematic studies of interatomic distances in halides and chalcogenides journal, September 1976

Horizontal Transfer of Antibiotic Resistance Genes on Abiotic Touch Surfaces: Implications for Public Health journal, November 2012

Thermal Expansion of Substituted Copper Aluminosilicate Glasses journal, January 1983

Hydronium Ions in Soda-lime Silicate Glass Surfaces journal, December 2012

Origins and Evolution of Antibiotic Resistance journal, August 2010

Copper Surfaces Reduce the Rate of Healthcare-Acquired Infections in the Intensive Care Unit journal, May 2013

Interdiffusion of hydrogen and alkali ions in a glass surface journal, December 1975

Low expansion copper aluminosilicate glasses journal, January 1979

Dissolution behavior of Na2O–FeO–Fe2O3–P2O5 glasses journal, May 2017

Clinical relevance of the ESKAPE pathogens journal, March 2013

A New Self-Consistent Empirical Interatomic Potential Model for Oxides, Silicates, and Silica-Based Glasses journal, June 2006

Formation of copper nanocrystals in alkali-lime silica glass by means of different reducing agents journal, October 2004

A facile synthesis of Cu 2 O / SiO 2 and Cu / SiO 2 core–shell octahedral nanocomposites journal, July 2008

Rapid in situ assessment of Cu-ion mediated effects and antibacterial efficacy of copper surfaces journal, May 2018

A unified formulation of the constant temperature molecular dynamics methods journal, July 1984

Copper Reduction and Contact Killing of Bacteria by Iron Surfaces journal, July 2015

Deploy vaccines to fight superbugs journal, December 2017

Copper Surfaces Reduce the Rate of Healthcare-Acquired Infections in the Intensive Care Unit journal, May 2013

Interdiffusion of hydrogen and alkali ions in a glass surface journal, December 1975

Role of Copper Oxides in Contact Killing of Bacteria journal, December 2013

Thermal Expansion of Substituted Copper Aluminosilicate Glasses journal, January 1983

Permeation of Gaseous Oxygen through Vitreous Silica journal, August 1961

Preparation, application and testing of permanent antibacterial and antiviral coatings journal, September 2007

Preparation, application and testing of permanent antibacterial and antiviral coatings journal, September 2007

Hydration of soda-lime glass journal, June 1979

Amorphization-induced surface electronic states modulation of cobaltous oxide nanosheets for lithium-sulfur batteries journal, May 2021

A facile synthesis of Cu 2 O / SiO 2 and Cu / SiO 2 core–shell octahedral nanocomposites journal, July 2008

Role of Copper Oxides in Contact Killing of Bacteria journal, December 2013

Formation of copper nanocrystals in alkali-lime silica glass by means of different reducing agents journal, October 2004

The molecular mechanisms of copper and silver ion disinfection of bacteria and viruses journal, January 1989

Permeation of Gaseous Oxygen through Vitreous Silica journal, August 1961

Dissolution behavior of Na2O–FeO–Fe2O3–P2O5 glasses journal, May 2017

Welcome to the Glass Age journal, October 2016

Metallic Copper as an Antimicrobial Surface journal, December 2010

Effects of temperature and humidity on the efficacy of methicillin-resistant Staphylococcus aureus challenged antimicrobial materials containing silver and copper journal, August 2009

Clinical relevance of the ESKAPE pathogens journal, March 2013

Visualization and analysis of atomistic simulation data with OVITO–the Open Visualization Tool journal, December 2009

The Effects of Copper Addition on The Structure and Antibacterial Properties of Biomedical Glasses journal, December 2019

Model-driven design of bioactive glasses: from molecular dynamics through machine learning journal, December 2019

Contact killing and antimicrobial properties of copper
journal, February 2018

Exchange and Diffusion of Ions in Glass
journal, August 1964

Contact killing and antimicrobial properties of copper
journal, February 2018

Highly efficient antiviral and antibacterial activities of solid-state cuprous compounds
journal, October 2012

Fatigue limit and crack arrest in alkali-containing silicate glasses
journal, October 1991

Low expansion copper aluminosilicate glasses
journal, January 1979

Few-layer bismuth selenide cathode for low-temperature quasi-solid-state aqueous zinc metal batteries
journal, February 2022

Airborne allergic contact dermatitis caused by isothiazolinones in water-based paints: a retrospective study of 44 cases: AIRBORNE ALLERGIC CONTACT DERMATITIS CAUSED BY PAINTS
journal, April 2017

Fatigue limit and crack arrest in alkali-containing silicate glasses
journal, January 1991

Revised effective ionic radii and systematic studies of interatomic distances in halides and chalcogenides
journal, September 1976

Horizontal Transfer of Antibiotic Resistance Genes on Abiotic Touch Surfaces: Implications for Public Health
journal, November 2012

Thermal Expansion of Substituted Copper Aluminosilicate Glasses
journal, January 1983

Hydronium Ions in Soda-lime Silicate Glass Surfaces
journal, December 2012

Origins and Evolution of Antibiotic Resistance
journal, August 2010

Copper Surfaces Reduce the Rate of Healthcare-Acquired Infections in the Intensive Care Unit
journal, May 2013

Interdiffusion of hydrogen and alkali ions in a glass surface
journal, December 1975

Low expansion copper aluminosilicate glasses
journal, January 1979

Dissolution behavior of Na2O–FeO–Fe2O3–P2O5 glasses
journal, May 2017

Clinical relevance of the ESKAPE pathogens
journal, March 2013

A New Self-Consistent Empirical Interatomic Potential Model for Oxides, Silicates, and Silica-Based Glasses
journal, June 2006

Formation of copper nanocrystals in alkali-lime silica glass by means of different reducing agents
journal, October 2004

A facile synthesis of Cu ₂ O / SiO ₂ and Cu / SiO ₂ core–shell octahedral nanocomposites
journal, July 2008

Rapid in situ assessment of Cu-ion mediated effects and antibacterial efficacy of copper surfaces
journal, May 2018

A unified formulation of the constant temperature molecular dynamics methods
journal, July 1984

Copper Reduction and Contact Killing of Bacteria by Iron Surfaces
journal, July 2015

Deploy vaccines to fight superbugs
journal, December 2017

Copper Surfaces Reduce the Rate of Healthcare-Acquired Infections in the Intensive Care Unit
journal, May 2013

Interdiffusion of hydrogen and alkali ions in a glass surface
journal, December 1975

Role of Copper Oxides in Contact Killing of Bacteria
journal, December 2013

Thermal Expansion of Substituted Copper Aluminosilicate Glasses
journal, January 1983

Permeation of Gaseous Oxygen through Vitreous Silica
journal, August 1961

Preparation, application and testing of permanent antibacterial and antiviral coatings
journal, September 2007

Preparation, application and testing of permanent antibacterial and antiviral coatings
journal, September 2007

Hydration of soda-lime glass
journal, June 1979

Amorphization-induced surface electronic states modulation of cobaltous oxide nanosheets for lithium-sulfur batteries
journal, May 2021

A facile synthesis of Cu ₂ O / SiO ₂ and Cu / SiO ₂ core–shell octahedral nanocomposites
journal, July 2008

Role of Copper Oxides in Contact Killing of Bacteria
journal, December 2013

Formation of copper nanocrystals in alkali-lime silica glass by means of different reducing agents
journal, October 2004

The molecular mechanisms of copper and silver ion disinfection of bacteria and viruses
journal, January 1989

Permeation of Gaseous Oxygen through Vitreous Silica
journal, August 1961

Dissolution behavior of Na2O–FeO–Fe2O3–P2O5 glasses
journal, May 2017

Welcome to the Glass Age
journal, October 2016

Metallic Copper as an Antimicrobial Surface
journal, December 2010

Effects of temperature and humidity on the efficacy of methicillin-resistant Staphylococcus aureus challenged antimicrobial materials containing silver and copper
journal, August 2009

Clinical relevance of the ESKAPE pathogens
journal, March 2013

Visualization and analysis of atomistic simulation data with OVITO–the Open Visualization Tool
journal, December 2009

The Effects of Copper Addition on The Structure and Antibacterial Properties of Biomedical Glasses
journal, December 2019

Model-driven design of bioactive glasses: from molecular dynamics through machine learning
journal, December 2019