Antibacterial Copper–Hydroxyapatite Composite Coatings via Electrochemical Synthesis
Abstract
Antibacterial copper-hydroxyapatite (Cu-HA) composite coatings on titanium were synthesized using a novel process consisting of two consecutive electrochemical reactions. In the first stage, HA nanocrystals were grown on titanium using cathodic electrolytic synthesis. The HA-coated titanium was then used as the cathode in a second reaction stage to electrochemically reduce Cu2+ ions in solution to metallic Cu nanoparticles. Reaction conditions were found that result in nano-scale Cu particles growing on the surface of the HA crystals. The two-stage synthesis allows facile control of copper content in the HA coatings. Antibacterial activity was measured by culturing Escherichia coli (Gram-negative) and Staphylococcus aureus (Gram-positive) in the presence of coatings having varying copper content. The coatings displayed copper concentration-dependent antibacterial activity against both types of bacteria, likely due to the slow release of copper ions from the coatings. Lastly, the observation of antibacterial activity from a relatively low loading of copper on the bioactive HA support suggests that multifunctional implant coatings can be developed to supplement or supplant prophylactic antibiotics used in implant surgery that are responsible for creating resistant bacteria strains.
- Authors:
-
[2];
[3]
- Univ. of Rochester, NY (United States). Dept. of Chemical Engineering
- Univ. of Rochester, NY (United States). Dept. of Dermatology
- Univ. of Rochester, NY (United States). Dept. of Chemical Engineering, and Lab. for Laser Energetics
- Publication Date:
- Research Org.:
- Univ. of Rochester, NY (United States). Lab. for Laser Energetics
- Sponsoring Org.:
- USDOE National Nuclear Security Administration (NNSA)
- OSTI Identifier:
- 1515003
- Report Number(s):
- 2018-310,1494
Journal ID: ISSN 0743-7463; 2018-310, 1494, 2454
- Grant/Contract Number:
- NA0003856
- Resource Type:
- Accepted Manuscript
- Journal Name:
- Langmuir
- Additional Journal Information:
- Journal Volume: 35; Journal Issue: 17; Journal ID: ISSN 0743-7463
- Publisher:
- American Chemical Society
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
Citation Formats
Ghosh, Rashmi, Swart, Oliver, Westgate, Sabrina, Miller, Benjamin L., and Yates, Matthew Z. Antibacterial Copper–Hydroxyapatite Composite Coatings via Electrochemical Synthesis. United States: N. p., 2019.
Web. doi:10.1021/acs.langmuir.9b00919.
Ghosh, Rashmi, Swart, Oliver, Westgate, Sabrina, Miller, Benjamin L., & Yates, Matthew Z. Antibacterial Copper–Hydroxyapatite Composite Coatings via Electrochemical Synthesis. United States. https://doi.org/10.1021/acs.langmuir.9b00919
Ghosh, Rashmi, Swart, Oliver, Westgate, Sabrina, Miller, Benjamin L., and Yates, Matthew Z. Fri .
"Antibacterial Copper–Hydroxyapatite Composite Coatings via Electrochemical Synthesis". United States. https://doi.org/10.1021/acs.langmuir.9b00919. https://www.osti.gov/servlets/purl/1515003.
@article{osti_1515003,
title = {Antibacterial Copper–Hydroxyapatite Composite Coatings via Electrochemical Synthesis},
author = {Ghosh, Rashmi and Swart, Oliver and Westgate, Sabrina and Miller, Benjamin L. and Yates, Matthew Z.},
abstractNote = {Antibacterial copper-hydroxyapatite (Cu-HA) composite coatings on titanium were synthesized using a novel process consisting of two consecutive electrochemical reactions. In the first stage, HA nanocrystals were grown on titanium using cathodic electrolytic synthesis. The HA-coated titanium was then used as the cathode in a second reaction stage to electrochemically reduce Cu2+ ions in solution to metallic Cu nanoparticles. Reaction conditions were found that result in nano-scale Cu particles growing on the surface of the HA crystals. The two-stage synthesis allows facile control of copper content in the HA coatings. Antibacterial activity was measured by culturing Escherichia coli (Gram-negative) and Staphylococcus aureus (Gram-positive) in the presence of coatings having varying copper content. The coatings displayed copper concentration-dependent antibacterial activity against both types of bacteria, likely due to the slow release of copper ions from the coatings. Lastly, the observation of antibacterial activity from a relatively low loading of copper on the bioactive HA support suggests that multifunctional implant coatings can be developed to supplement or supplant prophylactic antibiotics used in implant surgery that are responsible for creating resistant bacteria strains.},
doi = {10.1021/acs.langmuir.9b00919},
journal = {Langmuir},
number = 17,
volume = 35,
place = {United States},
year = {Fri Apr 05 00:00:00 EDT 2019},
month = {Fri Apr 05 00:00:00 EDT 2019}
}
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