skip to main content
DOE PAGES title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Hydroxyapatite Nanocrystal Deposited Titanium Dioxide Nanotubes Loaded with Antibiotics for Combining Biocompatibility and Antibacterial Properties

Abstract

Hydroxyapatite (HA)/nanotubular titanium dioxide (TiO 2) composite coatings loaded with antibiotics were developed here to combine biocompatibility and antibacterial property. TiO 2 nanotubes were first fabricated on Ti plates using anodization techniques. Then HA nanocrystals were synthesized on the TiO 2 nanotubes by electrochemical deposition, followed by loading of a model drug compound, streptomycin. The streptomycin release profile of the composite coating was investigated. Bacterial tests demonstrate that the streptomycin-loaded composite coatings were highly effective in inhibiting bacterial growth. Simulated body fluid (SBF) experiments indicated that the composite coatings possessed good osseointegration capability.

Authors:
 [1];  [2];  [2]
  1. Univ. of Rochester, NY (United States). Materials Science Program
  2. Univ. of Rochester, NY (United States). Dept. of Chemical Engineering
Publication Date:
Research Org.:
Univ. of Rochester, NY (United States)
Sponsoring Org.:
USDOE National Nuclear Security Administration (NNSA); National Science Foundation (NSF)
OSTI Identifier:
1494560
Grant/Contract Number:  
NA0001944; CMMI-0856128; IIP-1343083; CHE-1427882
Resource Type:
Accepted Manuscript
Journal Name:
MRS Advances
Additional Journal Information:
Journal Volume: 3; Journal Issue: 30; Journal ID: ISSN 2059-8521
Publisher:
Materials Research Society (MRS)
Country of Publication:
United States
Language:
English
Subject:
36 MATERIALS SCIENCE; 37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY; 59 BASIC BIOLOGICAL SCIENCES; biomaterial; coating; electrochemical synthesis

Citation Formats

Zhang, Xuefei, Zhang, Yuan, and Yates, Matthew Z. Hydroxyapatite Nanocrystal Deposited Titanium Dioxide Nanotubes Loaded with Antibiotics for Combining Biocompatibility and Antibacterial Properties. United States: N. p., 2018. Web. doi:10.1557/adv.2018.114.
Zhang, Xuefei, Zhang, Yuan, & Yates, Matthew Z. Hydroxyapatite Nanocrystal Deposited Titanium Dioxide Nanotubes Loaded with Antibiotics for Combining Biocompatibility and Antibacterial Properties. United States. doi:10.1557/adv.2018.114.
Zhang, Xuefei, Zhang, Yuan, and Yates, Matthew Z. Sun . "Hydroxyapatite Nanocrystal Deposited Titanium Dioxide Nanotubes Loaded with Antibiotics for Combining Biocompatibility and Antibacterial Properties". United States. doi:10.1557/adv.2018.114. https://www.osti.gov/servlets/purl/1494560.
@article{osti_1494560,
title = {Hydroxyapatite Nanocrystal Deposited Titanium Dioxide Nanotubes Loaded with Antibiotics for Combining Biocompatibility and Antibacterial Properties},
author = {Zhang, Xuefei and Zhang, Yuan and Yates, Matthew Z.},
abstractNote = {Hydroxyapatite (HA)/nanotubular titanium dioxide (TiO2) composite coatings loaded with antibiotics were developed here to combine biocompatibility and antibacterial property. TiO2 nanotubes were first fabricated on Ti plates using anodization techniques. Then HA nanocrystals were synthesized on the TiO2 nanotubes by electrochemical deposition, followed by loading of a model drug compound, streptomycin. The streptomycin release profile of the composite coating was investigated. Bacterial tests demonstrate that the streptomycin-loaded composite coatings were highly effective in inhibiting bacterial growth. Simulated body fluid (SBF) experiments indicated that the composite coatings possessed good osseointegration capability.},
doi = {10.1557/adv.2018.114},
journal = {MRS Advances},
number = 30,
volume = 3,
place = {United States},
year = {2018},
month = {1}
}

Journal Article:
Free Publicly Available Full Text
Publisher's Version of Record

Save / Share: