Hydroxyapatite Nanocrystal Deposited Titanium Dioxide Nanotubes Loaded with Antibiotics for Combining Biocompatibility and Antibacterial Properties

Zhang, Xuefei; Zhang, Yuan; Yates, Matthew Z.

doi:10.1557/adv.2018.114

Title: Hydroxyapatite Nanocrystal Deposited Titanium Dioxide Nanotubes Loaded with Antibiotics for Combining Biocompatibility and Antibacterial Properties

Abstract

Hydroxyapatite (HA)/nanotubular titanium dioxide (TiO₂) composite coatings loaded with antibiotics were developed here to combine biocompatibility and antibacterial property. TiO₂ nanotubes were first fabricated on Ti plates using anodization techniques. Then HA nanocrystals were synthesized on the TiO₂ nanotubes by electrochemical deposition, followed by loading of a model drug compound, streptomycin. The streptomycin release profile of the composite coating was investigated. Bacterial tests demonstrate that the streptomycin-loaded composite coatings were highly effective in inhibiting bacterial growth. Simulated body fluid (SBF) experiments indicated that the composite coatings possessed good osseointegration capability.

Authors:

Zhang, Xuefei ^[1]; Zhang, Yuan ^[2]; Yates, Matthew Z. ^[2]

Univ. of Rochester, NY (United States). Materials Science Program
Univ. of Rochester, NY (United States). Dept. of Chemical Engineering

Publication Date:: 2018-01-28

Research Org.:: Univ. of Rochester, NY (United States)

Sponsoring Org.:: USDOE National Nuclear Security Administration (NNSA); National Science Foundation (NSF)

OSTI Identifier:: 1494560

Grant/Contract Number:: NA0001944; CMMI-0856128; IIP-1343083; CHE-1427882

Resource Type:: Accepted Manuscript

Journal Name:: MRS Advances

Additional Journal Information:: Journal Volume: 3; Journal Issue: 30; Journal ID: ISSN 2059-8521

Publisher:: Materials Research Society (MRS)

Country of Publication:: United States

Language:: English

Subject:: 36 MATERIALS SCIENCE; 37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY; 59 BASIC BIOLOGICAL SCIENCES; biomaterial; coating; electrochemical synthesis

Citation Formats


                    Zhang, Xuefei, Zhang, Yuan, and Yates, Matthew Z. Hydroxyapatite Nanocrystal Deposited Titanium Dioxide Nanotubes Loaded with Antibiotics for Combining Biocompatibility and Antibacterial Properties.  United States: N. p., 2018. 
Web.  doi:10.1557/adv.2018.114.

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                    Zhang, Xuefei, Zhang, Yuan, & Yates, Matthew Z. Hydroxyapatite Nanocrystal Deposited Titanium Dioxide Nanotubes Loaded with Antibiotics for Combining Biocompatibility and Antibacterial Properties.  United States.  https://doi.org/10.1557/adv.2018.114

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                    Zhang, Xuefei, Zhang, Yuan, and Yates, Matthew Z. Sun .  
"Hydroxyapatite Nanocrystal Deposited Titanium Dioxide Nanotubes Loaded with Antibiotics for Combining Biocompatibility and Antibacterial Properties".  United States.  https://doi.org/10.1557/adv.2018.114.  https://www.osti.gov/servlets/purl/1494560.

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@article{osti_1494560,

  title        = {Hydroxyapatite Nanocrystal Deposited Titanium Dioxide Nanotubes Loaded with Antibiotics for Combining Biocompatibility and Antibacterial Properties},

  author       = {Zhang, Xuefei and Zhang, Yuan and Yates, Matthew Z.},

  abstractNote = {Hydroxyapatite (HA)/nanotubular titanium dioxide (TiO2) composite coatings loaded with antibiotics were developed here to combine biocompatibility and antibacterial property. TiO2 nanotubes were first fabricated on Ti plates using anodization techniques. Then HA nanocrystals were synthesized on the TiO2 nanotubes by electrochemical deposition, followed by loading of a model drug compound, streptomycin. The streptomycin release profile of the composite coating was investigated. Bacterial tests demonstrate that the streptomycin-loaded composite coatings were highly effective in inhibiting bacterial growth. Simulated body fluid (SBF) experiments indicated that the composite coatings possessed good osseointegration capability.},

  doi          = {10.1557/adv.2018.114},

  journal      = {MRS Advances},

  number       = 30,

  volume       = 3,

  place        = {United States},

  year         = {2018},

  month        = {1}

}

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Journal Article:

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https://doi.org/10.1557/adv.2018.114

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Figures / Tables:

Figure 1: SEM images of (a) top-view of the synthesized TiO₂ nanotubes, (b) top-view of rod-like HA nanocrystals electrochemically deposited on nanotubular TiO₂, and (c) side-view of the HA/nanotubular TiO₂ composite coating. (d) EDS spectra of the composite coating.

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