Evidence of Recent Genomic Evolution in Gonococcal Strains With Decreased Susceptibility to Cephalosporins or Azithromycin in the United States, 2014–2016

Thomas, Jesse C.; Seby, Sandra; Abrams, A. Jeanine; Cartee, Jack; Lucking, Sean; Vidyaprakash, Eshaw; Schmerer, Matthew; Pham, Cau D.; Hong, Jaeyoung; Torrone, Elizabeth; Cyr, Sancta St; Shafer, William M.; Bernstein, Kyle; Kersh, Ellen N.; Gernert, Kim M.; Weinstock, Hillard; Dominguez, Catherine; Hun, Sopheay; Kneupper, Katie

doi:10.1093/infdis/jiz079

Title: Evidence of Recent Genomic Evolution in Gonococcal Strains With Decreased Susceptibility to Cephalosporins or Azithromycin in the United States, 2014–2016

Authors:

Thomas, Jesse C. ^[1]; Seby, Sandra ^[1]; Abrams, A. Jeanine ^[1]; Cartee, Jack ^[1]; Lucking, Sean ^[1]; Vidyaprakash, Eshaw ^[1]; Schmerer, Matthew ^[1]; Pham, Cau D. ^[1]; Hong, Jaeyoung ^[1]; Torrone, Elizabeth ^[1]; Cyr, Sancta St ^[1]; Shafer, William M. ^[2]; Bernstein, Kyle ^[1]; Kersh, Ellen N. ^[1]; Gernert, Kim M. ^[1]; Antimicrobial-Resistant Neisseria gonorrhoeae Working Group; Weinstock, Hillard; Dominguez, Catherine; Hun, Sopheay; Kneupper, Katie

Division of STD Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia
Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia, Emory Antibiotic Resistance Center, Emory University School of Medicine, Atlanta, Georgia, Laboratories of Bacterial Pathogenesis, Veterans Affairs Medical Center, Decatur, Georgia

Publication Date:: Thu Feb 21 00:00:00 EST 2019

Sponsoring Org.:: USDOE

OSTI Identifier:: 1527039

Alternate Identifier(s):: OSTI ID: 1508174

Resource Type:: Published Article

Journal Name:: Journal of Infectious Diseases

Additional Journal Information:: Journal Name: Journal of Infectious Diseases Journal Volume: 220 Journal Issue: 2; Journal ID: ISSN 0022-1899

Publisher:: Oxford University Press

Country of Publication:: United States

Language:: English

Citation Formats


                    Thomas, Jesse C., Seby, Sandra, Abrams, A. Jeanine, Cartee, Jack, Lucking, Sean, Vidyaprakash, Eshaw, Schmerer, Matthew, Pham, Cau D., Hong, Jaeyoung, Torrone, Elizabeth, Cyr, Sancta St, Shafer, William M., Bernstein, Kyle, Kersh, Ellen N., Gernert, Kim M., Antimicrobial-Resistant Neisseria gonorrhoeae Working Group, Weinstock, Hillard, Dominguez, Catherine, Hun, Sopheay, and Kneupper, Katie. Evidence of Recent Genomic Evolution in Gonococcal Strains With Decreased Susceptibility to Cephalosporins or Azithromycin in the United States, 2014–2016.  United States: N. p., 2019. 
Web.  doi:10.1093/infdis/jiz079.

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                    Thomas, Jesse C., Seby, Sandra, Abrams, A. Jeanine, Cartee, Jack, Lucking, Sean, Vidyaprakash, Eshaw, Schmerer, Matthew, Pham, Cau D., Hong, Jaeyoung, Torrone, Elizabeth, Cyr, Sancta St, Shafer, William M., Bernstein, Kyle, Kersh, Ellen N., Gernert, Kim M., Antimicrobial-Resistant Neisseria gonorrhoeae Working Group, Weinstock, Hillard, Dominguez, Catherine, Hun, Sopheay, & Kneupper, Katie. Evidence of Recent Genomic Evolution in Gonococcal Strains With Decreased Susceptibility to Cephalosporins or Azithromycin in the United States, 2014–2016.  United States.  https://doi.org/10.1093/infdis/jiz079

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                    Thomas, Jesse C., Seby, Sandra, Abrams, A. Jeanine, Cartee, Jack, Lucking, Sean, Vidyaprakash, Eshaw, Schmerer, Matthew, Pham, Cau D., Hong, Jaeyoung, Torrone, Elizabeth, Cyr, Sancta St, Shafer, William M., Bernstein, Kyle, Kersh, Ellen N., Gernert, Kim M., Antimicrobial-Resistant Neisseria gonorrhoeae Working Group, Weinstock, Hillard, Dominguez, Catherine, Hun, Sopheay, and Kneupper, Katie. Thu .  
"Evidence of Recent Genomic Evolution in Gonococcal Strains With Decreased Susceptibility to Cephalosporins or Azithromycin in the United States, 2014–2016".  United States.  https://doi.org/10.1093/infdis/jiz079.

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@article{osti_1527039,

  title        = {Evidence of Recent Genomic Evolution in Gonococcal Strains With Decreased Susceptibility to Cephalosporins or Azithromycin in the United States, 2014–2016},

  author       = {Thomas, Jesse C. and Seby, Sandra and Abrams, A. Jeanine and Cartee, Jack and Lucking, Sean and Vidyaprakash, Eshaw and Schmerer, Matthew and Pham, Cau D. and Hong, Jaeyoung and Torrone, Elizabeth and Cyr, Sancta St and Shafer, William M. and Bernstein, Kyle and Kersh, Ellen N. and Gernert, Kim M. and Antimicrobial-Resistant Neisseria gonorrhoeae Working Group and Weinstock, Hillard and Dominguez, Catherine and Hun, Sopheay and Kneupper, Katie},

  abstractNote = {},

  doi          = {10.1093/infdis/jiz079},

  journal      = {Journal of Infectious Diseases},

  number       = 2,

  volume       = 220,

  place        = {United States},

  year         = {Thu Feb 21 00:00:00 EST 2019},

  month        = {Thu Feb 21 00:00:00 EST 2019}

}

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Title: Evidence of Recent Genomic Evolution in Gonococcal Strains With Decreased Susceptibility to Cephalosporins or Azithromycin in the United States, 2014–2016

Citation Formats

Genomic Epidemiology of Gonococcal Resistance to Extended-Spectrum Cephalosporins, Macrolides, and Fluoroquinolones in the United States, 2000–2013 journal, September 2016

Genomic epidemiology of Neisseria gonorrhoeae with reduced susceptibility to cefixime in the USA: a retrospective observational study journal, March 2014

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Clinically relevant mutations that cause derepression of the Neisseria gonorrhoeae MtrC-MtrD-MtrE Efflux pump system confer different levels of antimicrobial resistance and in vivo fitness journal, October 2008

Mixed gonococcal infections in a high-risk population, Sydney, Australia 2015: implications for antimicrobial resistance surveillance? journal, October 2016

Genomic Epidemiology and Molecular Resistance Mechanisms of Azithromycin-Resistant Neisseria gonorrhoeae in Canada from 1997 to 2014 journal, March 2016

Azithromycin Resistance and Decreased Ceftriaxone Susceptibility in Neisseria gonorrhoeae, Hawaii, USA journal, May 2017

The MtrR repressor binds the DNA sequence between the mtrR and mtrC genes of Neisseria gonorrhoeae. journal, July 1997

Neisseria gonorrhoeae Antimicrobial Susceptibility Surveillance — The Gonococcal Isolate Surveillance Project, 27 Sites, United States, 2014 journal, July 2016

Molecular Analysis of Antimicrobial Resistance Mechanisms in Neisseria gonorrhoeae Isolates from Ontario, Canada journal, November 2010

A Case of Decreased Susceptibility to Ceftriaxone in Neisseria gonorrhoeae in the Absence of a Mosaic Penicillin-Binding Protein 2 (penA) Allele journal, January 2017

Genomic analyses of Neisseria gonorrhoeae reveal an association of the gonococcal genetic island with antimicrobial resistance journal, December 2016

Control of gdhR Expression in Neisseria gonorrhoeae via Autoregulation and a Master Repressor (MtrR) of a Drug Efflux Pump Operon journal, April 2017

Azithromycin Resistance through Interspecific Acquisition of an Epistasis-Dependent Efflux Pump Component and Transcriptional Regulator in Neisseria gonorrhoeae journal, August 2018

The Harvest suite for rapid core-genome alignment and visualization of thousands of intraspecific microbial genomes journal, November 2014

Is Neisseria gonorrhoeae Initiating a Future Era of Untreatable Gonorrhea?: Detailed Characterization of the First Strain with High-Level Resistance to Ceftriaxone journal, May 2011

Whole-genome sequencing to determine transmission of Neisseria gonorrhoeae : an observational study journal, November 2016

Resistance to β-Lactams in Neisseria ssp Due to Chromosomally Encoded Penicillin-Binding Proteins journal, September 2016

High-Level Cefixime- and Ceftriaxone-Resistant Neisseria gonorrhoeae in France: Novel penA Mosaic Allele in a Successful International Clone Causes Treatment Failure journal, December 2011

Mechanistic Basis for Decreased Antimicrobial Susceptibility in a Clinical Isolate of Neisseria gonorrhoeae Possessing a Mosaic-Like mtr Efflux Pump Locus journal, November 2018

Diversity of penA Alterations and Subtypes in Neisseria gonorrhoeae Strains from Sydney, Australia, That Are Less Susceptible to Ceftriaxone journal, June 2007

Alanine 501 Mutations in Penicillin-Binding Protein 2 from Neisseria gonorrhoeae : Structure, Mechanism, and Effects on Cephalosporin Resistance and Biological Fitness journal, February 2017

Informed and automated k-mer size selection for genome assembly journal, June 2013

Neisseria gonorrhoeae 23S rRNA A2059G mutation is the only determinant necessary for high-level azithromycin resistance and improves in vivo biological fitness journal, October 2018

Estimating the prevalence of mixed-type gonococcal infections in Queensland, Australia journal, January 2015

Using Crude Whole-Genome Assemblies of Neisseria gonorrhoeae as a Platform for Strain Analysis: Clonal Spread of Gonorrhea Infection in Saskatchewan, Canada journal, July 2014

Impact of Fluoroquinolone Resistance Mutations on Gonococcal Fitness and In Vivo Selection for Compensatory Mutations journal, April 2012

Unique combined penA/mtrR/porB mutations and NG-MAST strain types associated with ceftriaxone and cefixime MIC increases in a ‘susceptible’ Neisseria gonorrhoeae population journal, February 2014

Azithromycin-resistant Neisseria gonorrhoeae spreading amongst men who have sex with men (MSM) and heterosexuals in New South Wales, Australia, 2017 journal, January 2018

RAxML-VI-HPC: maximum likelihood-based phylogenetic analyses with thousands of taxa and mixed models journal, August 2006

New Ceftriaxone- and Multidrug-Resistant Neisseria gonorrhoeae Strain with a Novel Mosaic penA Gene Isolated in Japan journal, April 2016

Sustained transmission of high-level azithromycin-resistant Neisseria gonorrhoeae in England: an observational study journal, May 2018

Novel penA mutations identified in Neisseria gonorrhoeae with decreased susceptibility to ceftriaxone isolated between 2000 and 2014 in Japan journal, May 2016

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Statistical notes for clinical researchers: Chi-squared test and Fisher's exact test journal, January 2017

High-Level Azithromycin Resistance Occurs in Neisseria gonorrhoeae as a Result of a Single Point Mutation in the 23S rRNA Genes journal, June 2010

Genomic Epidemiology of Gonococcal Resistance to Extended-Spectrum Cephalosporins, Macrolides, and Fluoroquinolones in the United States, 2000–2013
journal, September 2016

Genomic epidemiology of Neisseria gonorrhoeae with reduced susceptibility to cefixime in the USA: a retrospective observational study
journal, March 2014

Spread of a Chromosomal Cefixime-Resistant penA Gene among Different Neisseria gonorrhoeae Lineages
journal, December 2009

SPAdes: A New Genome Assembly Algorithm and Its Applications to Single-Cell Sequencing
journal, May 2012

Clinically relevant mutations that cause derepression of the Neisseria gonorrhoeae MtrC-MtrD-MtrE Efflux pump system confer different levels of antimicrobial resistance and in vivo fitness
journal, October 2008

Mixed gonococcal infections in a high-risk population, Sydney, Australia 2015: implications for antimicrobial resistance surveillance?
journal, October 2016

Genomic Epidemiology and Molecular Resistance Mechanisms of Azithromycin-Resistant Neisseria gonorrhoeae in Canada from 1997 to 2014
journal, March 2016

Azithromycin Resistance and Decreased Ceftriaxone Susceptibility in Neisseria gonorrhoeae, Hawaii, USA
journal, May 2017

The MtrR repressor binds the DNA sequence between the mtrR and mtrC genes of Neisseria gonorrhoeae.
journal, July 1997

Neisseria gonorrhoeae Antimicrobial Susceptibility Surveillance — The Gonococcal Isolate Surveillance Project, 27 Sites, United States, 2014
journal, July 2016

Molecular Analysis of Antimicrobial Resistance Mechanisms in Neisseria gonorrhoeae Isolates from Ontario, Canada
journal, November 2010

A Case of Decreased Susceptibility to Ceftriaxone in Neisseria gonorrhoeae in the Absence of a Mosaic Penicillin-Binding Protein 2 (penA) Allele
journal, January 2017

Genomic analyses of Neisseria gonorrhoeae reveal an association of the gonococcal genetic island with antimicrobial resistance
journal, December 2016

Control of gdhR Expression in Neisseria gonorrhoeae via Autoregulation and a Master Repressor (MtrR) of a Drug Efflux Pump Operon
journal, April 2017

Azithromycin Resistance through Interspecific Acquisition of an Epistasis-Dependent Efflux Pump Component and Transcriptional Regulator in Neisseria gonorrhoeae
journal, August 2018

The Harvest suite for rapid core-genome alignment and visualization of thousands of intraspecific microbial genomes
journal, November 2014

Is Neisseria gonorrhoeae Initiating a Future Era of Untreatable Gonorrhea?: Detailed Characterization of the First Strain with High-Level Resistance to Ceftriaxone
journal, May 2011

Whole-genome sequencing to determine transmission of Neisseria gonorrhoeae : an observational study
journal, November 2016

Resistance to β-Lactams in Neisseria ssp Due to Chromosomally Encoded Penicillin-Binding Proteins
journal, September 2016

High-Level Cefixime- and Ceftriaxone-Resistant Neisseria gonorrhoeae in France: Novel penA Mosaic Allele in a Successful International Clone Causes Treatment Failure
journal, December 2011

Mechanistic Basis for Decreased Antimicrobial Susceptibility in a Clinical Isolate of Neisseria gonorrhoeae Possessing a Mosaic-Like mtr Efflux Pump Locus
journal, November 2018

Diversity of penA Alterations and Subtypes in Neisseria gonorrhoeae Strains from Sydney, Australia, That Are Less Susceptible to Ceftriaxone
journal, June 2007

Alanine 501 Mutations in Penicillin-Binding Protein 2 from Neisseria gonorrhoeae : Structure, Mechanism, and Effects on Cephalosporin Resistance and Biological Fitness
journal, February 2017

Informed and automated k-mer size selection for genome assembly
journal, June 2013

Neisseria gonorrhoeae 23S rRNA A2059G mutation is the only determinant necessary for high-level azithromycin resistance and improves in vivo biological fitness
journal, October 2018

Estimating the prevalence of mixed-type gonococcal infections in Queensland, Australia
journal, January 2015

Using Crude Whole-Genome Assemblies of Neisseria gonorrhoeae as a Platform for Strain Analysis: Clonal Spread of Gonorrhea Infection in Saskatchewan, Canada
journal, July 2014

Impact of Fluoroquinolone Resistance Mutations on Gonococcal Fitness and In Vivo Selection for Compensatory Mutations
journal, April 2012

Unique combined penA/mtrR/porB mutations and NG-MAST strain types associated with ceftriaxone and cefixime MIC increases in a ‘susceptible’ Neisseria gonorrhoeae population
journal, February 2014

Azithromycin-resistant Neisseria gonorrhoeae spreading amongst men who have sex with men (MSM) and heterosexuals in New South Wales, Australia, 2017
journal, January 2018

RAxML-VI-HPC: maximum likelihood-based phylogenetic analyses with thousands of taxa and mixed models
journal, August 2006

New Ceftriaxone- and Multidrug-Resistant Neisseria gonorrhoeae Strain with a Novel Mosaic penA Gene Isolated in Japan
journal, April 2016

Sustained transmission of high-level azithromycin-resistant Neisseria gonorrhoeae in England: an observational study
journal, May 2018

Novel penA mutations identified in Neisseria gonorrhoeae with decreased susceptibility to ceftriaxone isolated between 2000 and 2014 in Japan
journal, May 2016

Kraken: ultrafast metagenomic sequence classification using exact alignments
journal, January 2014

Antimicrobial Resistance in Neisseria gonorrhoeae in the 21st Century: Past, Evolution, and Future
journal, June 2014

Statistical notes for clinical researchers: Chi-squared test and Fisher's exact test
journal, January 2017

High-Level Azithromycin Resistance Occurs in Neisseria gonorrhoeae as a Result of a Single Point Mutation in the 23S rRNA Genes
journal, June 2010