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Title: Tunable, Ultrafast Fiber-Laser between 1.15 μm and 1.35 μm for Harmonic Generation Microscopy in Human Skin

Abstract

We demonstrate a fiber-optic ultrafast tunable source for harmonic generation microscopy (HGM) in human skin. The source is based on a 31-MHz Er-fiber laser followed by self-phase modulation enabled spectral selection (SESS). The resulting pulses are tunable between 1.15 and 1.35 μm with up to >10-nJ pulse energy and ~100-fs pulse duration. Here we employ this source to drive a scanning microscope for HGM imaging of ex vivo human skin. A systematic investigation on imaging depth versus excitation wavelength reveals that excitation wavelengths in the 1.15-1.25 μm range exhibit low optical attenuation within the tissue and allows larger imaging depth for HGM in human skin. HGM driven by fiber-based SESS sources constitutes an enabling tool for noninvasive virtual skin biopsy in clinical applications.

Authors:
 [1];  [2];  [1];  [3];  [1];  [4]
  1. Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany). Center for Free-Electron Laser Science
  2. Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany). Center for Free-Electron Laser Science; Univ. of Hamburg (Germany). Dept. of Physics
  3. Skin Cancer Center Buxtehude, Buxtehude (Germany)
  4. Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany). Center for Free-Electron Laser Science; Chinese Academy of Sciences (CAS), Beijing (China). Inst. of Physics
Publication Date:
Research Org.:
SLAC National Accelerator Lab., Menlo Park, CA (United States)
Sponsoring Org.:
USDOE; Helmholtz Association
OSTI Identifier:
1475580
Grant/Contract Number:  
AC02-76SF00515; HCJRG 201; VH-NG-804; EXC 1074
Resource Type:
Accepted Manuscript
Journal Name:
IEEE Journal of Selected Topics in Quantum Electronics
Additional Journal Information:
Journal Volume: 25; Journal Issue: 1; Journal ID: ISSN 1077-260X
Publisher:
IEEE Lasers and Electro-optics Society
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES; Biomedical imaging; fiber lasers; nonlinear fiber optics; nonlinear optical microscopy; optical harmonic generation

Citation Formats

Chung, Hsiang-Yu, Liu, Wei, Cao, Qian, Greinert, Rudiger, Kartner, Franz X., and Chang, Guoqing. Tunable, Ultrafast Fiber-Laser between 1.15 μm and 1.35 μm for Harmonic Generation Microscopy in Human Skin. United States: N. p., 2018. Web. doi:10.1109/jstqe.2018.2864193.
Chung, Hsiang-Yu, Liu, Wei, Cao, Qian, Greinert, Rudiger, Kartner, Franz X., & Chang, Guoqing. Tunable, Ultrafast Fiber-Laser between 1.15 μm and 1.35 μm for Harmonic Generation Microscopy in Human Skin. United States. doi:10.1109/jstqe.2018.2864193.
Chung, Hsiang-Yu, Liu, Wei, Cao, Qian, Greinert, Rudiger, Kartner, Franz X., and Chang, Guoqing. Thu . "Tunable, Ultrafast Fiber-Laser between 1.15 μm and 1.35 μm for Harmonic Generation Microscopy in Human Skin". United States. doi:10.1109/jstqe.2018.2864193. https://www.osti.gov/servlets/purl/1475580.
@article{osti_1475580,
title = {Tunable, Ultrafast Fiber-Laser between 1.15 μm and 1.35 μm for Harmonic Generation Microscopy in Human Skin},
author = {Chung, Hsiang-Yu and Liu, Wei and Cao, Qian and Greinert, Rudiger and Kartner, Franz X. and Chang, Guoqing},
abstractNote = {We demonstrate a fiber-optic ultrafast tunable source for harmonic generation microscopy (HGM) in human skin. The source is based on a 31-MHz Er-fiber laser followed by self-phase modulation enabled spectral selection (SESS). The resulting pulses are tunable between 1.15 and 1.35 μm with up to >10-nJ pulse energy and ~100-fs pulse duration. Here we employ this source to drive a scanning microscope for HGM imaging of ex vivo human skin. A systematic investigation on imaging depth versus excitation wavelength reveals that excitation wavelengths in the 1.15-1.25 μm range exhibit low optical attenuation within the tissue and allows larger imaging depth for HGM in human skin. HGM driven by fiber-based SESS sources constitutes an enabling tool for noninvasive virtual skin biopsy in clinical applications.},
doi = {10.1109/jstqe.2018.2864193},
journal = {IEEE Journal of Selected Topics in Quantum Electronics},
number = 1,
volume = 25,
place = {United States},
year = {2018},
month = {8}
}

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