Tunable, Ultrafast Fiber-Laser between 1.15 μm and 1.35 μm for Harmonic Generation Microscopy in Human Skin

Chung, Hsiang-Yu; Liu, Wei; Cao, Qian; Greinert, Rudiger; Kartner, Franz X.; Chang, Guoqing

doi:10.1109/jstqe.2018.2864193

Title: Tunable, Ultrafast Fiber-Laser between 1.15 μm and 1.35 μm for Harmonic Generation Microscopy in Human Skin

Abstract

We demonstrate a fiber-optic ultrafast tunable source for harmonic generation microscopy (HGM) in human skin. The source is based on a 31-MHz Er-fiber laser followed by self-phase modulation enabled spectral selection (SESS). The resulting pulses are tunable between 1.15 and 1.35 μm with up to >10-nJ pulse energy and ~100-fs pulse duration. Here we employ this source to drive a scanning microscope for HGM imaging of ex vivo human skin. A systematic investigation on imaging depth versus excitation wavelength reveals that excitation wavelengths in the 1.15-1.25 μm range exhibit low optical attenuation within the tissue and allows larger imaging depth for HGM in human skin. HGM driven by fiber-based SESS sources constitutes an enabling tool for noninvasive virtual skin biopsy in clinical applications.

Authors:

Chung, Hsiang-Yu ^[1]; Liu, Wei ^[2]; Cao, Qian ^[1]; Greinert, Rudiger ^[3]; Kartner, Franz X. ^[1]; Chang, Guoqing ^[4]

Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany). Center for Free-Electron Laser Science
Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany). Center for Free-Electron Laser Science; Univ. of Hamburg (Germany). Dept. of Physics
Skin Cancer Center Buxtehude, Buxtehude (Germany)
Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany). Center for Free-Electron Laser Science; Chinese Academy of Sciences (CAS), Beijing (China). Inst. of Physics

Publication Date:: Thu Aug 09 00:00:00 EDT 2018

Research Org.:: SLAC National Accelerator Lab., Menlo Park, CA (United States)

Sponsoring Org.:: USDOE; Helmholtz Association

OSTI Identifier:: 1475580

Grant/Contract Number:: AC02-76SF00515; HCJRG 201; VH-NG-804; EXC 1074

Resource Type:: Accepted Manuscript

Journal Name:: IEEE Journal of Selected Topics in Quantum Electronics

Additional Journal Information:: Journal Volume: 25; Journal Issue: 1; Journal ID: ISSN 1077-260X

Publisher:: IEEE Lasers and Electro-optics Society

Country of Publication:: United States

Language:: English

Subject:: 60 APPLIED LIFE SCIENCES; Biomedical imaging; fiber lasers; nonlinear fiber optics; nonlinear optical microscopy; optical harmonic generation

Citation Formats


                    Chung, Hsiang-Yu, Liu, Wei, Cao, Qian, Greinert, Rudiger, Kartner, Franz X., and Chang, Guoqing. Tunable, Ultrafast Fiber-Laser between 1.15 μm and 1.35 μm for Harmonic Generation Microscopy in Human Skin.  United States: N. p., 2018. 
Web.  doi:10.1109/jstqe.2018.2864193.

Copy to clipboard


                    Chung, Hsiang-Yu, Liu, Wei, Cao, Qian, Greinert, Rudiger, Kartner, Franz X., & Chang, Guoqing. Tunable, Ultrafast Fiber-Laser between 1.15 μm and 1.35 μm for Harmonic Generation Microscopy in Human Skin.  United States.  https://doi.org/10.1109/jstqe.2018.2864193

Copy to clipboard


                    Chung, Hsiang-Yu, Liu, Wei, Cao, Qian, Greinert, Rudiger, Kartner, Franz X., and Chang, Guoqing. Thu .  
"Tunable, Ultrafast Fiber-Laser between 1.15 μm and 1.35 μm for Harmonic Generation Microscopy in Human Skin".  United States.  https://doi.org/10.1109/jstqe.2018.2864193.  https://www.osti.gov/servlets/purl/1475580.

Copy to clipboard


                    
@article{osti_1475580,

  title        = {Tunable, Ultrafast Fiber-Laser between 1.15 μm and 1.35 μm for Harmonic Generation Microscopy in Human Skin},

  author       = {Chung, Hsiang-Yu and Liu, Wei and Cao, Qian and Greinert, Rudiger and Kartner, Franz X. and Chang, Guoqing},

  abstractNote = {We demonstrate a fiber-optic ultrafast tunable source for harmonic generation microscopy (HGM) in human skin. The source is based on a 31-MHz Er-fiber laser followed by self-phase modulation enabled spectral selection (SESS). The resulting pulses are tunable between 1.15 and 1.35 μm with up to >10-nJ pulse energy and ~100-fs pulse duration. Here we employ this source to drive a scanning microscope for HGM imaging of ex vivo human skin. A systematic investigation on imaging depth versus excitation wavelength reveals that excitation wavelengths in the 1.15-1.25 μm range exhibit low optical attenuation within the tissue and allows larger imaging depth for HGM in human skin. HGM driven by fiber-based SESS sources constitutes an enabling tool for noninvasive virtual skin biopsy in clinical applications.},

  doi          = {10.1109/jstqe.2018.2864193},

  journal      = {IEEE Journal of Selected Topics in Quantum Electronics},

  number       = 1,

  volume       = 25,

  place        = {United States},

  year         = {Thu Aug 09 00:00:00 EDT 2018},

  month        = {Thu Aug 09 00:00:00 EDT 2018}

}

Copy to clipboard

Journal Article:

Free Publicly Available Full Text

Accepted Manuscript (DOE)

Publisher's Version of Record

https://doi.org/10.1109/jstqe.2018.2864193

Other availability

Search WorldCat to find libraries that may hold this journal

Citation Metrics:

Cited by: 4 works

Citation information provided by
Web of Science

Figures / Tables:

Figure 1: Schematic setup of the fiber-based SESS source for HGM. ISO: isolator, WDM: wavelength-division multiplexing, EDF: erbium-doped fiber, EYDF: erbium ytterbium co-doped fiber, L: lens, LPF: long pass filter, HWP: half-wave plate, M: mirror, PBS: polarization beam splitter, DM: dichroic mirror, BPF: bandpass filter, PMT: photomultiplier tube.

All figures and tables (7 total)

Save / Share:

Export Metadata

Save to My Library

Figures / Tables found in this record:

Figures/Tables have been extracted from DOE-funded journal article accepted manuscripts.

Similar Records in DOE PAGES and OSTI.GOV collections:

High-average-power, 2-μm femtosecond optical parametric oscillator synchronously pumped by a thin-disk, mode-locked laser

Journal Article Petersen, T. ; Zuegel, J. D. ; Bromage, J. - Optics Express

A high-energy, extended-cavity femtosecond BiBO optical parametric oscillator synchronously pumped by a 1.0-ps, 1030-nm Yb:YAG, thin-disk pump laser is presented. The oscillator operated near degeneracy in a noncollinear interaction geometry, producing signal wavelength tunability from 1.99 to 2.20 μm. The signal pulses have an average power exceeding 2 W, producing 455-fs pulses at 7.08 MHz with energies up to 350 nJ, showing increased potential for tunable sources of scalable ultrafast pulses in the infrared.
Cited by 14
https://doi.org/10.1364/OE.25.008840

Full Text Available
Compact, ultrastable, high repetition-rate 2 μm and 3 μm fiber laser for seeding mid-IR OPCPA

Journal Article Hettel, W. ; Golba, G. ; Morrill, D. ; ... - Optics Express

We report a compact and reliable ultrafast fiber laser system optimized for seeding a high energy, 2 μ m pumped, 3 μ m wavelength optical parametric chirped pulse amplification to drive soft X-ray high harmonics. The system delivers 100 MHz narrowband 2 μ m pulses with >1 nJ energy, synchronized with ultra-broadband optical pulses with a ∼1 μ m FWHM spectrum centered at 3 μ m with 39 pJ pulse energy. The 2 μ m and 3 μ m pulses are derived from a single 1.5 μ m fiber oscillator, fully fiber integrated with free-space downconversion for the 3 μmore »« less
https://doi.org/10.1364/OE.508127
Volumetric cutaneous microangiography of human skin in vivo by VCSEL swept-source optical coherence tomography

Journal Article Choi, Woo June ; Wang, R K - Quantum Electronics (Woodbury, N.Y.)

We demonstrate volumetric cutaneous microangiography of the human skin in vivo that utilises 1.3-μm high-speed sweptsource optical coherence tomography (SS-OCT). The swept source is based on a micro-electro-mechanical (MEMS)-tunable vertical cavity surface emission laser (VCSEL) that is advantageous in terms of long coherence length over 50 mm and 100 nm spectral bandwidth, which enables the visualisation of microstructures within a few mm from the skin surface. We show that the skin microvasculature can be delineated in 3D SS-OCT images using ultrahigh-sensitive optical microangiography (UHS-OMAG) with a correlation mapping mask, providing a contrast enhanced blood perfusion map with capillary flow sensitivity.more »« less
https://doi.org/10.1070/QE2014V044N08ABEH015542
Study on harmonic generation regimes of Raman dissipative solitons in an external fibre cavity in a spectral region of 1.3 μm

Journal Article Kharenko, D. S. ; Efremov, V. D. ; Babin, S.A., E-mail: kharenko@iae.nsk.su - Quantum Electronics (Woodbury, N.Y.)

We have studied the harmonic generation regimes in a pulsed SRS laser with synchronous pumping. The use of phosphosilicate polarisation-maintaining fibre made it possible to obtain stable generation of Raman dissipative solitons (RDS’s) with a wavelength of 1.3 μm, and a fold increase in the length of the external cavity relative to that of the pump laser cavity by a dispersion-shifted fibre allowed us to raise the threshold for the transition to noise-like pulses and to increase the RDS energy up to 2.5 nJ with an estimated duration of a transform-limited pulse of about 200 fs. (paper)
https://doi.org/10.1070/QEL17020
Q-switched Erbium-doped fiber laser at 1600 nm for photoacoustic imaging application

Journal Article Piao, Zhonglie ; Beckman Laser Institute, Department of Biomedical Engineering, University of California, Irvine, California 92612 ; Zeng, Lvming ; ... - Applied Physics Letters

We present a nanosecond Q-switched Erbium-doped fiber (EDF) laser system operating at 1600 nm with a tunable repetition rate from 100 kHz to 1 MHz. A compact fiber coupled, acousto-optic modulator-based EDF ring cavity was used to generate a nanosecond seed laser at 1600 nm, and a double-cladding EDF based power amplifier was applied to achieve the maximum average power of 250 mW. In addition, 12 ns laser pulses with the maximum pulse energy of 2.4 μJ were obtained at 100 kHz. Furthermore, the Stokes shift by Raman scattering over a 25 km long fiber was measured, indicating that the laser can be potentially used to generate the highmore »« less
https://doi.org/10.1063/1.4945711

Similar Records