Multifunctional Magnetic and Upconverting Nanobeads as Dual Modal Imaging Tools

Materia, Maria Elena; Pernia Leal, Manuel; Scotto, Marco; Balakrishnan, Preethi Bala; Kumar Avugadda, Sahitya; García-Martín, María L.; Cohen, Bruce E.; Chan, Emory M.; Pellegrino, Teresa

doi:10.1021/acs.bioconjchem.7b00432

Title: Multifunctional Magnetic and Upconverting Nanobeads as Dual Modal Imaging Tools

Abstract

We report the fabrication of aqueous multimodal imaging nanocomposites based on superparamagnetic nanoparticles (MNPs) and two different sizes of photoluminescent upconverting nanoparticles (UCNPs). The controlled and simultaneous incorporation of both types of nanoparticles (NPs) was obtained by controlling the solvent composition and the addition rate of the destabilizing solvent. The magnetic properties of the MNPs remained unaltered after their encapsulation into the polymeric beads as shown by the T2 relaxivity measurements. The UCNPs maintain photoluminescent properties even when embedded with the MNPs into the polymer bead. Moreover, the light emitted by the magnetic and upconverting nanobeads (MUCNBs) under NIR excitation (λexc = 980 nm) was clearly observed through different thicknesses of agarose gel or through a mouse skin layer. The comparison with magnetic and luminescent nanobeads based on red-emitting quantum dots (QDs) demonstrated that while the QD-based beads show significant autofluorescence background from the skin, the signal obtained by the MUCNBs allows a decrease in this background. In summary, these results indicate that MUCNBs are good magnetic and optical probes for in vivo multimodal imaging sensors.

Authors:

Materia, Maria Elena ^[1]; Pernia Leal, Manuel ^[2]; Scotto, Marco ^[1]; Balakrishnan, Preethi Bala ^[1]; Kumar Avugadda, Sahitya ^[1]; García-Martín, María L. ^[3];

^[4]; Chan, Emory M. ^[4];

^[1]

Istituto Italiano di Tecnologia, Via Morego 30, 16163 Genova, Italy
Istituto Italiano di Tecnologia, Via Morego 30, 16163 Genova, Italy, BIONAND, Andalusian Centre for Nanomedicine and Biotechnology (Junta de Andalucía-Universidad de Málaga), 29590 Málaga, Spain
BIONAND, Andalusian Centre for Nanomedicine and Biotechnology (Junta de Andalucía-Universidad de Málaga), 29590 Málaga, Spain
The Molecular Foundry, Lawrence Berkeley National Laboratory, Berkeley, California 94720, United States

Publication Date:: Mon Sep 25 00:00:00 EDT 2017

Research Org.:: Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)

Sponsoring Org.:: USDOE Office of Science (SC), Basic Energy Sciences (BES)

OSTI Identifier:: 1464277

Alternate Identifier(s):: OSTI ID: 1507995; OSTI ID: 1630602

Grant/Contract Number:: AC02-05CH11231

Resource Type:: Published Article

Journal Name:: Bioconjugate Chemistry

Additional Journal Information:: Journal Name: Bioconjugate Chemistry Journal Volume: 28 Journal Issue: 11; Journal ID: ISSN 1043-1802

Publisher:: American Chemical Society

Country of Publication:: United States

Language:: English

Subject:: 60 APPLIED LIFE SCIENCES

Citation Formats


                    Materia, Maria Elena, Pernia Leal, Manuel, Scotto, Marco, Balakrishnan, Preethi Bala, Kumar Avugadda, Sahitya, García-Martín, María L., Cohen, Bruce E., Chan, Emory M., and Pellegrino, Teresa. Multifunctional Magnetic and Upconverting Nanobeads as Dual Modal Imaging Tools.  United States: N. p., 2017. 
Web.  doi:10.1021/acs.bioconjchem.7b00432.

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                    Materia, Maria Elena, Pernia Leal, Manuel, Scotto, Marco, Balakrishnan, Preethi Bala, Kumar Avugadda, Sahitya, García-Martín, María L., Cohen, Bruce E., Chan, Emory M., & Pellegrino, Teresa. Multifunctional Magnetic and Upconverting Nanobeads as Dual Modal Imaging Tools.  United States.  https://doi.org/10.1021/acs.bioconjchem.7b00432

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                    Materia, Maria Elena, Pernia Leal, Manuel, Scotto, Marco, Balakrishnan, Preethi Bala, Kumar Avugadda, Sahitya, García-Martín, María L., Cohen, Bruce E., Chan, Emory M., and Pellegrino, Teresa. Mon .  
"Multifunctional Magnetic and Upconverting Nanobeads as Dual Modal Imaging Tools".  United States.  https://doi.org/10.1021/acs.bioconjchem.7b00432.

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@article{osti_1464277,

  title        = {Multifunctional Magnetic and Upconverting Nanobeads as Dual Modal Imaging Tools},

  author       = {Materia, Maria Elena and Pernia Leal, Manuel and Scotto, Marco and Balakrishnan, Preethi Bala and Kumar Avugadda, Sahitya and García-Martín, María L. and Cohen, Bruce E. and Chan, Emory M. and Pellegrino, Teresa},

  abstractNote = {We report the fabrication of aqueous multimodal imaging nanocomposites based on superparamagnetic nanoparticles (MNPs) and two different sizes of photoluminescent upconverting nanoparticles (UCNPs). The controlled and simultaneous incorporation of both types of nanoparticles (NPs) was obtained by controlling the solvent composition and the addition rate of the destabilizing solvent. The magnetic properties of the MNPs remained unaltered after their encapsulation into the polymeric beads as shown by the T2 relaxivity measurements. The UCNPs maintain photoluminescent properties even when embedded with the MNPs into the polymer bead. Moreover, the light emitted by the magnetic and upconverting nanobeads (MUCNBs) under NIR excitation (λexc = 980 nm) was clearly observed through different thicknesses of agarose gel or through a mouse skin layer. The comparison with magnetic and luminescent nanobeads based on red-emitting quantum dots (QDs) demonstrated that while the QD-based beads show significant autofluorescence background from the skin, the signal obtained by the MUCNBs allows a decrease in this background. In summary, these results indicate that MUCNBs are good magnetic and optical probes for in vivo multimodal imaging sensors.},

  doi          = {10.1021/acs.bioconjchem.7b00432},

  journal      = {Bioconjugate Chemistry},

  number       = 11,

  volume       = 28,

  place        = {United States},

  year         = {Mon Sep 25 00:00:00 EDT 2017},

  month        = {Mon Sep 25 00:00:00 EDT 2017}

}

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https://doi.org/10.1021/acs.bioconjchem.7b00432

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Cited by: 13 works

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Figure 1: Scheme for synthesis of MUCNBs (A); TEM images of 23 nm UCNPs (B), 15 nm IONPs (C), 6 nm UCNPs (D), and MUCNBs with 15 nm IONPs and 23 nm UCNPs (E) or 6 nm UCNPs (F).

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Works referencing / citing this record:

A water-soluble, upconverting Sr ₂ Yb _0.3 Gd _0.7 F ₇ :Er ³⁺ /Tm ³⁺ @PSI _oAm bio-probe for in vivo trimodality imaging
journal, January 2018

Xiang, Li-Jun; Zhu, Xiao-Jiao; Zhang, Hui-Hui
Nanoscale, Vol. 10, Issue 30
DOI: 10.1039/c8nr03220c

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Figures/Tables have been extracted from DOE-funded journal article accepted manuscripts.

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Title: Multifunctional Magnetic and Upconverting Nanobeads as Dual Modal Imaging Tools

Abstract

Citation Formats

Figures / Tables:

A water-soluble, upconverting Sr 2 Yb 0.3 Gd 0.7 F 7 :Er 3+ /Tm 3+ @PSI oAm bio-probe for in vivo trimodality imaging journal, January 2018

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