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Title: Upconverting nanoparticle micro-lightbulbs designed for deep tissue optical stimulation and imaging

Optical methods for imaging and stimulation of biological events based on the use of visible light are limited to the superficial layers of tissue due to the significant absorption and scattering of light. Here in this paper we demonstrate the design and implementation of passive micro-structured lightbulbs (MLBs) containing bright-emitting lanthanide-doped upconverting nanoparticles (UCNPs) for light delivery deep into the tissue. The MLBs are realized as cylindrical pillars made of Parylene C polymer that can be implanted deep into the tissue. The encapsulated UCNPs absorb near-infrared (NIR) light at λ = 980 nm, which undergoes much less absorption than the blue light in the brain tissue, and then locally emit blue light ( 1G 43H 6 and 1D 23F 4 transitions) that can be used for optogenetic excitation of neurons in the brain. The 3H 43H 6 transition will result in the emission of higher energy NIR photons at λ = 800 nm that can be used for imaging and tracking MLBs through thick tissue.
Authors:
 [1] ;  [2] ;  [3] ;  [4] ;  [3] ;  [4] ;  [5] ;  [6]
  1. Carnegie Mellon Univ., Pittsburgh, PA (United States). Electrical and Computer Engineering Dept.; Univ. of California, Berkeley, CA (United States). Dept. of Electrical Engineering and Computer Sciences
  2. Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Molecular Foundry; National Renewable Energy Lab. (NREL), Golden, CO (United States). Innovation and Entrepreneurship Center
  3. Univ. of California, San Francisco, CA (United States). Dept. of Psychiatry
  4. Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Molecular Foundry
  5. Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Molecular Foundry; Columbia Univ., New York, NY (United States). Dept. of Mechanical Engineering
  6. Univ. of California, Berkeley, CA (United States). Dept. of Electrical Engineering and Computer Sciences; Chan Zuckerberg Biohub, San Francisco, CA (United States)
Publication Date:
Report Number(s):
NREL/JA-6A60-72480
Journal ID: ISSN 2156-7085
Grant/Contract Number:
AC36-08GO28308; AC02-05CH11231
Type:
Published Article
Journal Name:
Biomedical Optics Express
Additional Journal Information:
Journal Volume: 9; Journal Issue: 9; Journal ID: ISSN 2156-7085
Publisher:
Optical Society of America
Research Org:
National Renewable Energy Lab. (NREL), Golden, CO (United States); Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
Sponsoring Org:
USDOE Office of Science (SC), Basic Energy Sciences (BES) (SC-22); Ministry of Science and ICT, South Korea
Country of Publication:
United States
Language:
English
Subject:
77 NANOSCIENCE AND NANOTECHNOLOGY; infrared devices; light; nanoparticles; polymeric implants
OSTI Identifier:
1465251
Alternate Identifier(s):
OSTI ID: 1474841; OSTI ID: 1477370

Chamanzar, Maysamreza, Garfield, David J., Iafrati, Jillian, Chan, Emory M., Sohal, Vikaas, Cohen, Bruce E., Schuck, P. James, and Maharbiz, Michel M.. Upconverting nanoparticle micro-lightbulbs designed for deep tissue optical stimulation and imaging. United States: N. p., Web. doi:10.1364/BOE.9.004359.
Chamanzar, Maysamreza, Garfield, David J., Iafrati, Jillian, Chan, Emory M., Sohal, Vikaas, Cohen, Bruce E., Schuck, P. James, & Maharbiz, Michel M.. Upconverting nanoparticle micro-lightbulbs designed for deep tissue optical stimulation and imaging. United States. doi:10.1364/BOE.9.004359.
Chamanzar, Maysamreza, Garfield, David J., Iafrati, Jillian, Chan, Emory M., Sohal, Vikaas, Cohen, Bruce E., Schuck, P. James, and Maharbiz, Michel M.. 2018. "Upconverting nanoparticle micro-lightbulbs designed for deep tissue optical stimulation and imaging". United States. doi:10.1364/BOE.9.004359.
@article{osti_1465251,
title = {Upconverting nanoparticle micro-lightbulbs designed for deep tissue optical stimulation and imaging},
author = {Chamanzar, Maysamreza and Garfield, David J. and Iafrati, Jillian and Chan, Emory M. and Sohal, Vikaas and Cohen, Bruce E. and Schuck, P. James and Maharbiz, Michel M.},
abstractNote = {Optical methods for imaging and stimulation of biological events based on the use of visible light are limited to the superficial layers of tissue due to the significant absorption and scattering of light. Here in this paper we demonstrate the design and implementation of passive micro-structured lightbulbs (MLBs) containing bright-emitting lanthanide-doped upconverting nanoparticles (UCNPs) for light delivery deep into the tissue. The MLBs are realized as cylindrical pillars made of Parylene C polymer that can be implanted deep into the tissue. The encapsulated UCNPs absorb near-infrared (NIR) light at λ = 980 nm, which undergoes much less absorption than the blue light in the brain tissue, and then locally emit blue light (1G4→3H6 and 1D2→3F4 transitions) that can be used for optogenetic excitation of neurons in the brain. The 3H4→3H6 transition will result in the emission of higher energy NIR photons at λ = 800 nm that can be used for imaging and tracking MLBs through thick tissue.},
doi = {10.1364/BOE.9.004359},
journal = {Biomedical Optics Express},
number = 9,
volume = 9,
place = {United States},
year = {2018},
month = {1}
}