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Title: Enzymatically Powered Surface-Associated Self-Motile Protocells

 [1];  [1];  [1];  [1]; ORCiD logo [2]
  1. Department of Chemical and Biomolecular Engineering, School of Engineering and Applied Science, University of Pennsylvania, 220 South 33rd Street, 311A Towne Building Philadelphia PA 19104-6315 USA
  2. Department of Chemical and Biomolecular Engineering, School of Engineering and Applied Science, University of Pennsylvania, 220 South 33rd Street, 311A Towne Building Philadelphia PA 19104-6315 USA, Department of Bioengineering, School of Engineering and Applied Science, University of Pennsylvania, 210 South 33rd Street, Suite 240 Skirkanich Hall Philadelphia PA 19104-6321 USA
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Journal Name: Small Journal Volume: 14 Journal Issue: 36; Journal ID: ISSN 1613-6810
Wiley Blackwell (John Wiley & Sons)
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Jang, Woo-Sik, Kim, Hyun Ji, Gao, Chen, Lee, Daeyeon, and Hammer, Daniel A. Enzymatically Powered Surface-Associated Self-Motile Protocells. Germany: N. p., 2018. Web. doi:10.1002/smll.201801715.
Jang, Woo-Sik, Kim, Hyun Ji, Gao, Chen, Lee, Daeyeon, & Hammer, Daniel A. Enzymatically Powered Surface-Associated Self-Motile Protocells. Germany. doi:
Jang, Woo-Sik, Kim, Hyun Ji, Gao, Chen, Lee, Daeyeon, and Hammer, Daniel A. Thu . "Enzymatically Powered Surface-Associated Self-Motile Protocells". Germany. doi:
title = {Enzymatically Powered Surface-Associated Self-Motile Protocells},
author = {Jang, Woo-Sik and Kim, Hyun Ji and Gao, Chen and Lee, Daeyeon and Hammer, Daniel A.},
abstractNote = {},
doi = {10.1002/smll.201801715},
journal = {Small},
number = 36,
volume = 14,
place = {Germany},
year = {2018},
month = {8}

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Works referenced in this record:

Propulsion of a Molecular Machine by Asymmetric Distribution of Reaction Products
journal, June 2005

Effect of M1–M2 Polarization on the Motility and Traction Stresses of Primary Human Macrophages
journal, April 2016

  • Hind, Laurel E.; Lurier, Emily B.; Dembo, Micah
  • Cellular and Molecular Bioengineering, Vol. 9, Issue 3
  • DOI: 10.1007/s12195-016-0435-x

Chemotactic synthetic vesicles: Design and applications in blood-brain barrier crossing
journal, August 2017

  • Joseph, Adrian; Contini, Claudia; Cecchin, Denis
  • Science Advances, Vol. 3, Issue 8
  • DOI: 10.1126/sciadv.1700362

Catalytic Nanomotors:  Autonomous Movement of Striped Nanorods
journal, October 2004

  • Paxton, Walter F.; Kistler, Kevin C.; Olmeda, Christine C.
  • Journal of the American Chemical Society, Vol. 126, Issue 41
  • DOI: 10.1021/ja047697z

The Effect of Polymer Chain Length and Surface Density on the Adhesiveness of Functionalized Polymersomes
journal, June 2004

  • Lin, John J.; Silas, James A.; Bermudez, Harry
  • Langmuir, Vol. 20, Issue 13
  • DOI: 10.1021/la036417a

Protein Expression, Aggregation, and Triggered Release from Polymersomes as Artificial Cell-like Structures
journal, May 2012

  • Martino, Chiara; Kim, Shin-Hyun; Horsfall, Louise
  • Angewandte Chemie International Edition, Vol. 51, Issue 26
  • DOI: 10.1002/anie.201201443

Motility of Catalytic Nanoparticles through Self-Generated Forces
journal, November 2005

  • Paxton, Walter F.; Sen, Ayusman; Mallouk, Thomas E.
  • Chemistry - A European Journal, Vol. 11, Issue 22
  • DOI: 10.1002/chem.200500167

Enzymatically triggered rupture of polymersomes
journal, January 2016

  • Jang, Woo-Sik; Park, Seung Chul; Reed, Ellen H.
  • Soft Matter, Vol. 12, Issue 4
  • DOI: 10.1039/C5SM01881A

Catalytically Induced Electrokinetics for Motors and Micropumps
journal, November 2006

  • Paxton, Walter F.; Baker, Paul T.; Kline, Timothy R.
  • Journal of the American Chemical Society, Vol. 128, Issue 46
  • DOI: 10.1021/ja0643164

Substrate Catalysis Enhances Single-Enzyme Diffusion
journal, February 2010

  • Muddana, Hari S.; Sengupta, Samudra; Mallouk, Thomas E.
  • Journal of the American Chemical Society, Vol. 132, Issue 7
  • DOI: 10.1021/ja908773a

Autonomous movement of platinum-loaded stomatocytes
journal, February 2012

  • Wilson, Daniela A.; Nolte, Roeland J. M.; van Hest, Jan C. M.
  • Nature Chemistry, Vol. 4, Issue 4
  • DOI: 10.1038/nchem.1281

Impulsive Enzymes: A New Force in Mechanobiology
journal, January 2015

  • Butler, Peter J.; Dey, Krishna K.; Sen, Ayusman
  • Cellular and Molecular Bioengineering, Vol. 8, Issue 1
  • DOI: 10.1007/s12195-014-0376-1

Harnessing surface-bound enzymatic reactions to organize microcapsules in solution
journal, March 2016

The Role of Cell Contraction and Adhesion in Dictyostelium Motility
journal, July 2010

  • Buenemann, Mathias; Levine, Herbert; Rappel, Wouter-Jan
  • Biophysical Journal, Vol. 99, Issue 1
  • DOI: 10.1016/j.bpj.2010.03.057

Rapid Fabrication of Bimetallic Spherical Motors
journal, August 2010

  • Wheat, Philip M.; Marine, Nathan A.; Moran, Jeffrey L.
  • Langmuir, Vol. 26, Issue 16
  • DOI: 10.1021/la102218w

Enhanced Diffusion of Enzymes that Catalyze Exothermic Reactions
journal, September 2015

Self-Propelling Nanomotors in the Presence of Strong Brownian Forces
journal, April 2014

  • Lee, Tung-Chun; Alarcón-Correa, Mariana; Miksch, Cornelia
  • Nano Letters, Vol. 14, Issue 5
  • DOI: 10.1021/nl500068n

Adhesion of Antibody-Functionalized Polymersomes
journal, April 2006

  • Lin, John J.; Ghoroghchian, P. Peter; Zhang, Ying
  • Langmuir, Vol. 22, Issue 9
  • DOI: 10.1021/la052445c

The heat released during catalytic turnover enhances the diffusion of an enzyme
journal, December 2014

  • Riedel, Clement; Gabizon, Ronen; Wilson, Christian A. M.
  • Nature, Vol. 517, Issue 7533
  • DOI: 10.1038/nature14043

The Effect of Stabilizer on the Mechanical Response of Double-Emulsion-Templated Polymersomes
journal, December 2014

  • Jang, Woo-Sik; Park, Seung Chul; Kim, Miju
  • Macromolecular Rapid Communications, Vol. 36, Issue 4
  • DOI: 10.1002/marc.201400472

Convective flow reversal in self-powered enzyme micropumps
journal, February 2016

  • Ortiz-Rivera, Isamar; Shum, Henry; Agrawal, Arjun
  • Proceedings of the National Academy of Sciences, Vol. 113, Issue 10
  • DOI: 10.1073/pnas.1517908113

Micromotors Powered by Enzyme Catalysis
journal, November 2015

Polymersomes: Tough Vesicles Made from Diblock Copolymers
journal, May 1999

Self-assembly and properties of diblock copolymers by coarse-grain molecular dynamics
journal, August 2004

  • Srinivas, Goundla; Discher, Dennis E.; Klein, Michael L.
  • Nature Materials, Vol. 3, Issue 9
  • DOI: 10.1038/nmat1185

Actin Flows Mediate a Universal Coupling between Cell Speed and Cell Persistence
journal, April 2015

Macrophage motility is driven by frontal-towing with a force magnitude dependent on substrate stiffness
journal, January 2015

  • Hind, Laurel E.; Dembo, Micah; Hammer, Daniel A.
  • Integrative Biology, Vol. 7, Issue 4
  • DOI: 10.1039/C4IB00260A

Dendritic Cells Distinguish Individual Chemokine Signals through CCR7 and CXCR4
journal, November 2010

  • Ricart, Brendon G.; John, Beena; Lee, Dooyoung
  • The Journal of Immunology, Vol. 186, Issue 1
  • DOI: 10.4049/jimmunol.1002358

Mechanical Response of a Small Swimmer Driven by Conformational Transitions
journal, January 2008

Harnessing catalytic pumps for directional delivery of microparticles in microchambers
journal, February 2017

  • Das, Sambeeta; Shklyaev, Oleg E.; Altemose, Alicia
  • Nature Communications, Vol. 8, Issue 1
  • DOI: 10.1038/ncomms14384

Synthesis and Characterization of Model Polyalkane−Poly(ethylene oxide) Block Copolymers
journal, January 1996

  • Hillmyer, Marc A.; Bates, Frank S.
  • Macromolecules, Vol. 29, Issue 22
  • DOI: 10.1021/ma960774t

Exothermicity Is Not a Necessary Condition for Enhanced Diffusion of Enzymes
journal, June 2017

Hemostatic, inflammatory, and fibroblast responses are blunted in mice lacking gelsolin
journal, April 1995

Chemically Propelled Molecules and Machines
journal, May 2017

  • Dey, Krishna Kanti; Sen, Ayusman
  • Journal of the American Chemical Society, Vol. 139, Issue 23
  • DOI: 10.1021/jacs.7b02347

Molecular Weight Dependence of Polymersome Membrane Structure, Elasticity, and Stability
journal, October 2002

  • Bermudez, Harry; Brannan, Aaron K.; Hammer, Daniel A.
  • Macromolecules, Vol. 35, Issue 21
  • DOI: 10.1021/ma020669l

Rapid rotation of flagellar bundles in swimming bacteria
journal, February 1987

  • Lowe, Graeme; Meister, Markus; Berg, Howard C.
  • Nature, Vol. 325, Issue 6105
  • DOI: 10.1038/325637a0

Collective cell durotaxis emerges from long-range intercellular force transmission
journal, September 2016

Ligand density elicits a phenotypic switch in human neutrophils
journal, January 2014

  • Henry, Steven J.; Crocker, John C.; Hammer, Daniel A.
  • Integrative Biology, Vol. 6, Issue 3
  • DOI: 10.1039/c3ib40225h

Identification of Splenic Reservoir Monocytes and Their Deployment to Inflammatory Sites
journal, July 2009

Enzyme Molecules as Nanomotors
journal, January 2013

  • Sengupta, Samudra; Dey, Krishna K.; Muddana, Hari S.
  • Journal of the American Chemical Society, Vol. 135, Issue 4
  • DOI: 10.1021/ja3091615

Solutal and thermal buoyancy effects in self-powered phosphatase micropumps
journal, January 2017

  • Valdez, Lyanne; Shum, Henry; Ortiz-Rivera, Isamar
  • Soft Matter, Vol. 13, Issue 15
  • DOI: 10.1039/C7SM00022G

Motile Human Neutrophils Sense Ligand Density Over Their Entire Contact Area
journal, July 2015

  • Henry, Steven J.; Crocker, John C.; Hammer, Daniel A.
  • Annals of Biomedical Engineering, Vol. 44, Issue 4
  • DOI: 10.1007/s10439-015-1408-2

Energy landscapes of receptor–ligand bonds explored with dynamic force spectroscopy
journal, January 1999

  • Merkel, R.; Nassoy, P.; Leung, A.
  • Nature, Vol. 397, Issue 6714
  • DOI: 10.1038/16219

Giant Vesicles:  Imitating the Cytological Processes of Cell Membranes
journal, December 1998

  • Menger, Fredric M.; Angelova, Miglena I.
  • Accounts of Chemical Research, Vol. 31, Issue 12
  • DOI: 10.1021/ar970103v

Bioelectrochemical Propulsion
journal, August 2005

  • Mano, Nicolas; Heller, Adam
  • Journal of the American Chemical Society, Vol. 127, Issue 33
  • DOI: 10.1021/ja053937e