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Title: Robust surface coating for a fast, facile fluorine-18 labeling of iron oxide nanoparticles for PET/MR dual-modality imaging

Abstract

Grafting a robust organic shell around inorganic nanoparticles can optimize their colloidal features to dramatically improve their physicochemical properties. Here, we have developed a polymer coating procedure for providing colloidal stability to the nanoparticles and, more importantly, for applying a fast, facile fluorine-18 labeling of iron oxide nanoparticles (IONPs) for positron emission tomography (PET)/magnetic resonance (MR) dual-modality imaging. The structure of the amphiphilic polymer is based on a backbone of polyacrylic acid, conjugated with multiple oleylamines to form a comb-like branched structure. The dense polymer shell provides high colloidal stability to the IONPs against harsh conditions such as high temperature, low pH value, and high ion strength. By incorporating a 1,4,7-triazacyclononane (NOTA) chelator to the comb-like amphiphilic polymer for the chelation of aluminum fluoride ions, we applied a one-step radiolabeling approach for a fast, facile radiofluorination of magnetic nanoparticles. The new strategy can significantly reduce the procedure time and radiation exposure. In conclusion, the PET/MR dual modality imaging was successfully achieved in living subjects by using 18F labeled magnetic nanoparticles.

Authors:
 [1];  [2];  [3];  [2];  [2];  [2];  [2];  [4];  [2]
+ Show Author Affiliations
  1. Huazhong Univ. of Science and Technology, Wuhan (China); Stanford Univ., Stanford, CA (United States)
  2. Stanford Univ., Stanford, CA (United States)
  3. Stanford Univ., Stanford, CA (United States); Affiliated Hospital of Qingdao Univ., Qingdao (China)
  4. Huazhong Univ. of Science and Technology, Wuhan (China)
Publication Date:
Research Org.:
Huazhong Univ. of Science and Technology, Wuhan (China)
Sponsoring Org.:
USDOE Office of Science (SC), Biological and Environmental Research (BER)
OSTI Identifier:
1437936
Grant/Contract Number:  
SC0008397
Resource Type:
Accepted Manuscript
Journal Name:
Nanoscale
Additional Journal Information:
Journal Volume: 8; Journal Issue: 47; Journal ID: ISSN 2040-3364
Publisher:
Royal Society of Chemistry
Country of Publication:
United States
Language:
English
Subject:
77 NANOSCIENCE AND NANOTECHNOLOGY

Citation Formats

Sun, Ziyan, Cheng, Kai, Wu, Fengyu, Liu, Hongguang, Ma, Xiaowei, Su, Xinhui, Liu, Yang, Xia, Liming, and Cheng, Zhen. Robust surface coating for a fast, facile fluorine-18 labeling of iron oxide nanoparticles for PET/MR dual-modality imaging. United States: N. p., 2016. Web. doi:10.1039/c6nr07298d.
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Sun, Ziyan, Cheng, Kai, Wu, Fengyu, Liu, Hongguang, Ma, Xiaowei, Su, Xinhui, Liu, Yang, Xia, Liming, & Cheng, Zhen. Robust surface coating for a fast, facile fluorine-18 labeling of iron oxide nanoparticles for PET/MR dual-modality imaging. United States. https://doi.org/10.1039/c6nr07298d
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Sun, Ziyan, Cheng, Kai, Wu, Fengyu, Liu, Hongguang, Ma, Xiaowei, Su, Xinhui, Liu, Yang, Xia, Liming, and Cheng, Zhen. Mon . "Robust surface coating for a fast, facile fluorine-18 labeling of iron oxide nanoparticles for PET/MR dual-modality imaging". United States. https://doi.org/10.1039/c6nr07298d. https://www.osti.gov/servlets/purl/1437936.
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@article{osti_1437936,
title = {Robust surface coating for a fast, facile fluorine-18 labeling of iron oxide nanoparticles for PET/MR dual-modality imaging},
author = {Sun, Ziyan and Cheng, Kai and Wu, Fengyu and Liu, Hongguang and Ma, Xiaowei and Su, Xinhui and Liu, Yang and Xia, Liming and Cheng, Zhen},
abstractNote = {Grafting a robust organic shell around inorganic nanoparticles can optimize their colloidal features to dramatically improve their physicochemical properties. Here, we have developed a polymer coating procedure for providing colloidal stability to the nanoparticles and, more importantly, for applying a fast, facile fluorine-18 labeling of iron oxide nanoparticles (IONPs) for positron emission tomography (PET)/magnetic resonance (MR) dual-modality imaging. The structure of the amphiphilic polymer is based on a backbone of polyacrylic acid, conjugated with multiple oleylamines to form a comb-like branched structure. The dense polymer shell provides high colloidal stability to the IONPs against harsh conditions such as high temperature, low pH value, and high ion strength. By incorporating a 1,4,7-triazacyclononane (NOTA) chelator to the comb-like amphiphilic polymer for the chelation of aluminum fluoride ions, we applied a one-step radiolabeling approach for a fast, facile radiofluorination of magnetic nanoparticles. The new strategy can significantly reduce the procedure time and radiation exposure. In conclusion, the PET/MR dual modality imaging was successfully achieved in living subjects by using 18F labeled magnetic nanoparticles.},
doi = {10.1039/c6nr07298d},
journal = {Nanoscale},
number = 47,
volume = 8,
place = {United States},
year = {Mon Oct 31 00:00:00 EDT 2016},
month = {Mon Oct 31 00:00:00 EDT 2016}
}
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Journal Article:
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Publisher's Version of Record
https://doi.org/10.1039/c6nr07298d
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Works referenced in this record:

Molecular imaging: current status and emerging strategies
journal, July 2010

A Novel Facile Method of Labeling Octreotide with 18F-Fluorine
journal, February 2010

Construction and Validation of Nano Gold Tripods for Molecular Imaging of Living Subjects
journal, February 2014

  • Cheng, Kai; Kothapalli, Sri-Rajasekhar; Liu, Hongguang
  • Journal of the American Chemical Society, Vol. 136, Issue 9
  • DOI: 10.1021/ja412001e

First 18F-labeled ligand for PET imaging of uPAR: In vivo studies in human prostate cancer xenografts
journal, July 2013

Optimized labeling of NOTA-conjugated octreotide with F-18
journal, October 2011

Cy5.5-labeled Affibody molecule for near-infrared fluorescent optical imaging of epidermal growth factor receptor positive tumors
journal, January 2010

  • Miao, Zheng; Ren, Gang; Liu, Hongguang
  • Journal of Biomedical Optics, Vol. 15, Issue 3
  • DOI: 10.1117/1.3432738

18 F-Labeled Modified Porous Silicon Particles for Investigation of Drug Delivery Carrier Distribution in Vivo with Positron Emission Tomography
journal, July 2011

  • Sarparanta, Mirkka; Mäkilä, Ermei; Heikkilä, Teemu
  • Molecular Pharmaceutics, Vol. 8, Issue 5
  • DOI: 10.1021/mp2001654

Size-Controlled Synthesis of Magnetite Nanoparticles
journal, July 2002

  • Sun, Shouheng; Zeng, Hao
  • Journal of the American Chemical Society, Vol. 124, Issue 28
  • DOI: 10.1021/ja026501x

PET/NIRF/MRI triple functional iron oxide nanoparticles
journal, April 2010

Multifunctional Nanoparticles for Dual Imaging
journal, April 2011

  • Ali, Z.; Abbasi, A. Z.; Zhang, F.
  • Analytical Chemistry, Vol. 83, Issue 8
  • DOI: 10.1021/ac103261y

18 F-Labeled Magnetic-Upconversion Nanophosphors via Rare-Earth Cation-Assisted Ligand Assembly
journal, March 2011

  • Liu, Qian; Sun, Yun; Li, Chenguang
  • ACS Nano, Vol. 5, Issue 4
  • DOI: 10.1021/nn200298y

In vivo integrity of polymer-coated gold nanoparticles
journal, June 2015

  • Kreyling, Wolfgang G.; Abdelmonem, Abuelmagd M.; Ali, Zulqurnain
  • Nature Nanotechnology, Vol. 10, Issue 7
  • DOI: 10.1038/nnano.2015.111

Small-Animal PET Imaging of Human Epidermal Growth Factor Receptor Positive Tumor with a 64 Cu Labeled Affibody Protein
journal, May 2010

  • Miao, Zheng; Ren, Gang; Liu, Hongguang
  • Bioconjugate Chemistry, Vol. 21, Issue 5
  • DOI: 10.1021/bc900515p

PET/MRI Dual-Modality Tumor Imaging Using Arginine-Glycine-Aspartic (RGD)-Conjugated Radiolabeled Iron Oxide Nanoparticles
journal, July 2008

Hybrid Nanotrimers for Dual T 1 and T 2 -Weighted Magnetic Resonance Imaging
journal, October 2014

  • Cheng, Kai; Yang, Meng; Zhang, Ruiping
  • ACS Nano, Vol. 8, Issue 10
  • DOI: 10.1021/nn500188y

Fluorine-18-labeled Gd3+/Yb3+/Er3+ co-doped NaYF4 nanophosphors for multimodality PET/MR/UCL imaging
journal, February 2011

Hybrid anisotropic nanostructures for dual-modal cancer imaging and image-guided chemo-thermo therapies
journal, October 2016

Positron Emission Tomography Imaging Using Radiolabeled Inorganic Nanomaterials
journal, January 2015

  • Sun, Xiaolian; Cai, Weibo; Chen, Xiaoyuan
  • Accounts of Chemical Research, Vol. 48, Issue 2
  • DOI: 10.1021/ar500362y

A Novel Method of 18F Radiolabeling for PET
journal, May 2009

One-step radiosynthesis of 18F-AlF-NOTA-RGD2 for tumor angiogenesis PET imaging
journal, May 2011

  • Liu, Shuanglong; Liu, Hongguang; Jiang, Han
  • European Journal of Nuclear Medicine and Molecular Imaging, Vol. 38, Issue 9
  • DOI: 10.1007/s00259-011-1847-4
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