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Title: A nanocomposite of Au-AgI core/shell dimer as a dual-modality contrast agent for x-ray computed tomography and photoacoustic imaging

Abstract

Purpose: To develop a core/shell nanodimer of gold (core) and silver iodine (shell) as a dual-modal contrast-enhancing agent for biomarker targeted x-ray computed tomography (CT) and photoacoustic imaging (PAI) applications. Methods: The gold and silver iodine core/shell nanodimer (Au/AgICSD) was prepared by fusing together components of gold, silver, and iodine. The physicochemical properties of Au/AgICSD were then characterized using different optical and imaging techniques (e.g., HR- transmission electron microscope, scanning transmission electron microscope, x-ray photoelectron spectroscopy, energy-dispersive x-ray spectroscopy, Z-potential, and UV-vis). The CT and PAI contrast-enhancing effects were tested and then compared with a clinically used CT contrast agent and Au nanoparticles. To confer biocompatibility and the capability for efficient biomarker targeting, the surface of the Au/AgICSD nanodimer was modified with the amphiphilic diblock polymer and then functionalized with transferrin for targeting transferrin receptor that is overexpressed in various cancer cells. Cytotoxicity of the prepared Au/AgICSD nanodimer was also tested with both normal and cancer cell lines. Results: The characterizations of prepared Au/AgI core/shell nanostructure confirmed the formation of Au/AgICSD nanodimers. Au/AgICSD nanodimer is stable in physiological conditions for in vivo applications. Au/AgICSD nanodimer exhibited higher contrast enhancement in both CT and PAI for dual-modality imaging. Moreover, transferrin functionalizedmore » Au/AgICSD nanodimer showed specific binding to the tumor cells that have a high level of expression of the transferrin receptor. Conclusions: The developed Au/AgICSD nanodimer can be used as a potential biomarker targeted dual-modal contrast agent for both or combined CT and PAI molecular imaging.« less

Authors:
; ; ;  [1]; ;  [2]; ;  [3];  [4]
  1. Department of Radiology and Imaging Sciences and Center for Systems Imaging, Emory University School of Medicine, Atlanta, Georgia 30322 (United States)
  2. Department of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, Georgia 30322 (United States)
  3. Department of Biomedical Engineering, University of Michigan School of Medicine, Ann Arbor, Michigan 48109 (United States)
  4. Department of Surgery, Emory University School of Medicine, Atlanta, Georgia 30322 (United States)
Publication Date:
OSTI Identifier:
22579839
Resource Type:
Journal Article
Journal Name:
Medical Physics
Additional Journal Information:
Journal Volume: 43; Journal Issue: 1; Other Information: (c) 2016 American Association of Physicists in Medicine; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0094-2405
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; 61 RADIATION PROTECTION AND DOSIMETRY; BIOLOGICAL MARKERS; BIOMEDICAL RADIOGRAPHY; COMPUTERIZED TOMOGRAPHY; CONTRAST MEDIA; DIMERS; IN VIVO; NANOCOMPOSITES; NANOPARTICLES; NANOSTRUCTURES; NEOPLASMS; POLYMERS; RECEPTORS; TOXICITY; TRANSFERRIN; TRANSMISSION ELECTRON MICROSCOPY; TUMOR CELLS; X-RAY PHOTOELECTRON SPECTROSCOPY; X-RAY SPECTROSCOPY

Citation Formats

Orza, Anamaria, Wu, Hui, Li, Yuancheng, Mao, Hui, E-mail: hmao@emory.edu, E-mail: Xiangyang.Tang@emory.edu, Yang, Yi, Tang, Xiangyang, E-mail: hmao@emory.edu, E-mail: Xiangyang.Tang@emory.edu, Feng, Ting, Wang, Xueding, and Yang, Lily. A nanocomposite of Au-AgI core/shell dimer as a dual-modality contrast agent for x-ray computed tomography and photoacoustic imaging. United States: N. p., 2016. Web. doi:10.1118/1.4939062.
Orza, Anamaria, Wu, Hui, Li, Yuancheng, Mao, Hui, E-mail: hmao@emory.edu, E-mail: Xiangyang.Tang@emory.edu, Yang, Yi, Tang, Xiangyang, E-mail: hmao@emory.edu, E-mail: Xiangyang.Tang@emory.edu, Feng, Ting, Wang, Xueding, & Yang, Lily. A nanocomposite of Au-AgI core/shell dimer as a dual-modality contrast agent for x-ray computed tomography and photoacoustic imaging. United States. doi:10.1118/1.4939062.
Orza, Anamaria, Wu, Hui, Li, Yuancheng, Mao, Hui, E-mail: hmao@emory.edu, E-mail: Xiangyang.Tang@emory.edu, Yang, Yi, Tang, Xiangyang, E-mail: hmao@emory.edu, E-mail: Xiangyang.Tang@emory.edu, Feng, Ting, Wang, Xueding, and Yang, Lily. Fri . "A nanocomposite of Au-AgI core/shell dimer as a dual-modality contrast agent for x-ray computed tomography and photoacoustic imaging". United States. doi:10.1118/1.4939062.
@article{osti_22579839,
title = {A nanocomposite of Au-AgI core/shell dimer as a dual-modality contrast agent for x-ray computed tomography and photoacoustic imaging},
author = {Orza, Anamaria and Wu, Hui and Li, Yuancheng and Mao, Hui, E-mail: hmao@emory.edu, E-mail: Xiangyang.Tang@emory.edu and Yang, Yi and Tang, Xiangyang, E-mail: hmao@emory.edu, E-mail: Xiangyang.Tang@emory.edu and Feng, Ting and Wang, Xueding and Yang, Lily},
abstractNote = {Purpose: To develop a core/shell nanodimer of gold (core) and silver iodine (shell) as a dual-modal contrast-enhancing agent for biomarker targeted x-ray computed tomography (CT) and photoacoustic imaging (PAI) applications. Methods: The gold and silver iodine core/shell nanodimer (Au/AgICSD) was prepared by fusing together components of gold, silver, and iodine. The physicochemical properties of Au/AgICSD were then characterized using different optical and imaging techniques (e.g., HR- transmission electron microscope, scanning transmission electron microscope, x-ray photoelectron spectroscopy, energy-dispersive x-ray spectroscopy, Z-potential, and UV-vis). The CT and PAI contrast-enhancing effects were tested and then compared with a clinically used CT contrast agent and Au nanoparticles. To confer biocompatibility and the capability for efficient biomarker targeting, the surface of the Au/AgICSD nanodimer was modified with the amphiphilic diblock polymer and then functionalized with transferrin for targeting transferrin receptor that is overexpressed in various cancer cells. Cytotoxicity of the prepared Au/AgICSD nanodimer was also tested with both normal and cancer cell lines. Results: The characterizations of prepared Au/AgI core/shell nanostructure confirmed the formation of Au/AgICSD nanodimers. Au/AgICSD nanodimer is stable in physiological conditions for in vivo applications. Au/AgICSD nanodimer exhibited higher contrast enhancement in both CT and PAI for dual-modality imaging. Moreover, transferrin functionalized Au/AgICSD nanodimer showed specific binding to the tumor cells that have a high level of expression of the transferrin receptor. Conclusions: The developed Au/AgICSD nanodimer can be used as a potential biomarker targeted dual-modal contrast agent for both or combined CT and PAI molecular imaging.},
doi = {10.1118/1.4939062},
journal = {Medical Physics},
issn = {0094-2405},
number = 1,
volume = 43,
place = {United States},
year = {2016},
month = {1}
}