Copper Capture in a Thioether-Functionalized Porous Polymer Applied to the Detection of Wilson’s Disease

Lee, Sumin; Barin, Gokhan; Ackerman, Cheri M.; Muchenditsi, Abigael; Xu, Jun; Reimer, Jeffrey A.; Lutsenko, Svetlana; Long, Jeffrey R.; Chang, Christopher J.

doi:10.1021/jacs.6b02515

Title: Copper Capture in a Thioether-Functionalized Porous Polymer Applied to the Detection of Wilson’s Disease

Journal Article · 10 June 2016 · Journal of the American Chemical Society

DOI: https://doi.org/10.1021/jacs.6b02515 · OSTI ID:1415261

Lee, Sumin ^[1]; Barin, Gokhan ^[1]; Ackerman, Cheri M. ^[1]; Muchenditsi, Abigael ^[2]; Xu, Jun ^[3]; Reimer, Jeffrey A. ^[4]; Lutsenko, Svetlana ^[2]; Long, Jeffrey R. ^[5]; Chang, Christopher J. ^[6]

Univ. of California, Berkeley, CA (United States). Dept. of Chemistry
Johns Hopkins Univ., Baltimore, MD (United States). School of Medicine and Dept. of Physiology
Univ. of California, Berkeley, CA (United States). Chemical and Biomolecular Engineering
Univ. of California, Berkeley, CA (United States). Chemical and Biomolecular Engineering; Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Materials Sciences Division
Univ. of California, Berkeley, CA (United States). Dept. of Chemistry and Chemical and Biomolecular Engineering; Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Materials Sciences Division
Univ. of California, Berkeley, CA (United States). Howard Hughes Medical Inst., Dept. of Chemistry and Dept. of Molecular and Cell Biology; Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Chemical Sciences Division

Copper is an essential nutrient for life, but at the same time, hyperaccumulation of this redox-active metal in biological fluids and tissues is a hallmark of pathologies such as Wilson's and Menkes diseases, various neurodegenerative diseases, and toxic environmental exposure. Diseases characterized by copper hyperaccumulation are currently challenging to identify due to costly diagnostic tools that involve extensive technical workup. Motivated to create simple yet highly selective and sensitive diagnostic tools, we have initiated a program to develop new materials that can enable monitoring of copper levels in biological fluid samples without complex and expensive instrumentation. We report the design, synthesis, and properties of PAF-1-SMe, a robust three-dimensional porous aromatic framework (PAF) densely functionalized with thioether groups for selective capture and concentration of copper from biofluids as well as aqueous samples. PAF-1-SMe exhibits a high selectivity for copper over other biologically relevant metals, with a saturation capacity reaching over 600 mg/g. Moreover, the combination of PAF-1-SMe as a material for capture and concentration of copper from biological samples with 8-hydroxyquinoline as a colorimetric indicator affords a method for identifying aberrant elevations of copper in urine samples from mice with Wilson's disease and also tracing exogenously added copper in serum. This divide-and-conquer sensing strategy, where functional and robust porous materials serve as molecular recognition elements that can be used to capture and concentrate analytes in conjunction with molecular indicators for signal readouts, establishes a valuable starting point for the use of porous polymeric materials in noninvasive diagnostic applications.

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Research Organization:: Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Basic Energy Sciences (BES); National Institutes of Health (NIH); Fannie and John Hertz Foundation

Grant/Contract Number:: AC02-05CH11231; GM79465; SC0001015; T32 GM066698

OSTI ID:: 1415261

Alternate ID(s):: OSTI ID: 1464138

Journal Information:: Journal of the American Chemical Society, Vol. 138, Issue 24; Related Information: © 2016 American Chemical Society.; ISSN 0002-7863

Publisher:: American Chemical Society (ACS)Copyright Statement

Country of Publication:: United States

Language:: English

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Cited by: 126 works

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