Copper Capture in a Thioether-Functionalized Porous Polymer Applied to the Detection of Wilson’s Disease
Abstract
Copper is an essential nutrient for life, but at the same time, hyperaccumulation of this redox-active metal in biological fluids and tissues is a hallmark of pathologies such as Wilson's and Menkes diseases, various neurodegenerative diseases, and toxic environmental exposure. Diseases characterized by copper hyperaccumulation are currently challenging to identify due to costly diagnostic tools that involve extensive technical workup. Motivated to create simple yet highly selective and sensitive diagnostic tools, we have initiated a program to develop new materials that can enable monitoring of copper levels in biological fluid samples without complex and expensive instrumentation. We report the design, synthesis, and properties of PAF-1-SMe, a robust three-dimensional porous aromatic framework (PAF) densely functionalized with thioether groups for selective capture and concentration of copper from biofluids as well as aqueous samples. PAF-1-SMe exhibits a high selectivity for copper over other biologically relevant metals, with a saturation capacity reaching over 600 mg/g. Moreover, the combination of PAF-1-SMe as a material for capture and concentration of copper from biological samples with 8-hydroxyquinoline as a colorimetric indicator affords a method for identifying aberrant elevations of copper in urine samples from mice with Wilson's disease and also tracing exogenously added copper in serum. Thismore »
- Authors:
-
- Department of Physiology, Johns Hopkins University, School of Medicine, Baltimore, Maryland 21205, United States
- Publication Date:
- Research Org.:
- Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)
- Sponsoring Org.:
- USDOE Office of Science (SC), Basic Energy Sciences (BES); National Institutes of Health (NIH); Fannie and John Hertz Foundation
- OSTI Identifier:
- 1415261
- Alternate Identifier(s):
- OSTI ID: 1464138
- Grant/Contract Number:
- AC02-05CH11231; GM79465; SC0001015; T32 GM066698
- Resource Type:
- Published Article
- Journal Name:
- Journal of the American Chemical Society
- Additional Journal Information:
- Journal Name: Journal of the American Chemical Society Journal Volume: 138 Journal Issue: 24; Journal ID: ISSN 0002-7863
- Publisher:
- American Chemical Society (ACS)
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 36 MATERIALS SCIENCE; 59 BASIC BIOLOGICAL SCIENCES
Citation Formats
Lee, Sumin, Barin, Gokhan, Ackerman, Cheri M., Muchenditsi, Abigael, Xu, Jun, Reimer, Jeffrey A., Lutsenko, Svetlana, Long, Jeffrey R., and Chang, Christopher J. Copper Capture in a Thioether-Functionalized Porous Polymer Applied to the Detection of Wilson’s Disease. United States: N. p., 2016.
Web. doi:10.1021/jacs.6b02515.
Lee, Sumin, Barin, Gokhan, Ackerman, Cheri M., Muchenditsi, Abigael, Xu, Jun, Reimer, Jeffrey A., Lutsenko, Svetlana, Long, Jeffrey R., & Chang, Christopher J. Copper Capture in a Thioether-Functionalized Porous Polymer Applied to the Detection of Wilson’s Disease. United States. https://doi.org/10.1021/jacs.6b02515
Lee, Sumin, Barin, Gokhan, Ackerman, Cheri M., Muchenditsi, Abigael, Xu, Jun, Reimer, Jeffrey A., Lutsenko, Svetlana, Long, Jeffrey R., and Chang, Christopher J. Fri .
"Copper Capture in a Thioether-Functionalized Porous Polymer Applied to the Detection of Wilson’s Disease". United States. https://doi.org/10.1021/jacs.6b02515.
@article{osti_1415261,
title = {Copper Capture in a Thioether-Functionalized Porous Polymer Applied to the Detection of Wilson’s Disease},
author = {Lee, Sumin and Barin, Gokhan and Ackerman, Cheri M. and Muchenditsi, Abigael and Xu, Jun and Reimer, Jeffrey A. and Lutsenko, Svetlana and Long, Jeffrey R. and Chang, Christopher J.},
abstractNote = {Copper is an essential nutrient for life, but at the same time, hyperaccumulation of this redox-active metal in biological fluids and tissues is a hallmark of pathologies such as Wilson's and Menkes diseases, various neurodegenerative diseases, and toxic environmental exposure. Diseases characterized by copper hyperaccumulation are currently challenging to identify due to costly diagnostic tools that involve extensive technical workup. Motivated to create simple yet highly selective and sensitive diagnostic tools, we have initiated a program to develop new materials that can enable monitoring of copper levels in biological fluid samples without complex and expensive instrumentation. We report the design, synthesis, and properties of PAF-1-SMe, a robust three-dimensional porous aromatic framework (PAF) densely functionalized with thioether groups for selective capture and concentration of copper from biofluids as well as aqueous samples. PAF-1-SMe exhibits a high selectivity for copper over other biologically relevant metals, with a saturation capacity reaching over 600 mg/g. Moreover, the combination of PAF-1-SMe as a material for capture and concentration of copper from biological samples with 8-hydroxyquinoline as a colorimetric indicator affords a method for identifying aberrant elevations of copper in urine samples from mice with Wilson's disease and also tracing exogenously added copper in serum. This divide-and-conquer sensing strategy, where functional and robust porous materials serve as molecular recognition elements that can be used to capture and concentrate analytes in conjunction with molecular indicators for signal readouts, establishes a valuable starting point for the use of porous polymeric materials in noninvasive diagnostic applications.},
doi = {10.1021/jacs.6b02515},
journal = {Journal of the American Chemical Society},
number = 24,
volume = 138,
place = {United States},
year = {2016},
month = {6}
}
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Works referenced in this record:
Photonic Nanosensor for Colorimetric Detection of Metal Ions
journal, February 2015
- Yetisen, Ali K.; Montelongo, Yunuen; Qasim, Malik M.
- Analytical Chemistry, Vol. 87, Issue 10
Determination of iron, cobalt, copper, zinc, rubidium, molybdenum, and cesium in human serum by inductively coupled plasma mass spectrometry
journal, September 1989
- Vanhoe, Hans.; Vandecasteele, Carlo.; Versieck, Jacques.
- Analytical Chemistry, Vol. 61, Issue 17
Introduction of π-Complexation into Porous Aromatic Framework for Highly Selective Adsorption of Ethylene over Ethane
journal, June 2014
- Li, Baiyan; Zhang, Yiming; Krishna, Rajamani
- Journal of the American Chemical Society, Vol. 136, Issue 24
Urinary Copper Elevation in a Mouse Model of Wilson's Disease Is a Regulated Process to Specifically Decrease the Hepatic Copper Load
journal, June 2012
- Gray, Lawrence W.; Peng, Fangyu; Molloy, Shannon A.
- PLoS ONE, Vol. 7, Issue 6
Phosphoric Acid Loaded Azo (−N═N−) Based Covalent Organic Framework for Proton Conduction
journal, April 2014
- Chandra, Suman; Kundu, Tanay; Kandambeth, Sharath
- Journal of the American Chemical Society, Vol. 136, Issue 18
Clinical presentation, diagnosis and long-term outcome of Wilson's disease: a cohort study
journal, January 2007
- Merle, U.; Schaefer, M.; Ferenci, P.
- Gut, Vol. 56, Issue 1
A place for thioether chemistry in cellular copper ion recognition and trafficking
journal, March 2008
- Davis, Anna V.; O'Halloran, Thomas V.
- Nature Chemical Biology, Vol. 4, Issue 3
Metal–organic framework materials as catalysts
journal, January 2009
- Lee, JeongYong; Farha, Omar K.; Roberts, John
- Chemical Society Reviews, Vol. 38, Issue 5, p. 1450-1459
Optical Cu2+ probe bearing an 8-hydroxyquinoline subunit: High sensitivity and large fluorescence enhancement
journal, May 2012
- Zhu, Hao; Fan, Jiangli; Lu, Jing
- Talanta, Vol. 93
Synthesis and properties of a copper selective chelating resin containing a salicylaldoxime group
journal, September 1997
- Ebraheem, Kais A. K.; Hamdi, Suhaila T.
- Reactive and Functional Polymers, Vol. 34, Issue 1
Creation of a new type of ion exchange material for rapid, high-capacity, reversible and selective ion exchange without swelling and entrainment
journal, January 2016
- Li, Baiyan; Zhang, Yiming; Ma, Dingxuan
- Chemical Science, Vol. 7, Issue 3
Regional distribution of mutations of the ATP7B gene in patients with Wilson disease: impact on genetic testing
journal, June 2006
- Ferenci, Peter
- Human Genetics, Vol. 120, Issue 2
Binding and uptake of copper from ceruloplasmin
journal, September 1986
- Orena, Stephen J.; Goode, Christina A.; Linder, Maria C.
- Biochemical and Biophysical Research Communications, Vol. 139, Issue 2
Wilson disease
journal, October 2010
- Huster, Dominik
- Best Practice & Research Clinical Gastroenterology, Vol. 24, Issue 5
Metal–Organic Frameworks (MOFs)
journal, January 2014
- Zhou, Hong-Cai “Joe”; Kitagawa, Susumu
- Chem. Soc. Rev., Vol. 43, Issue 16
A copper-activated magnetic resonance imaging contrast agent with improved turn-on relaxivity response and anion compatibility
journal, January 2010
- Que, Emily L.; Gianolio, Eliana; Baker, Suzanne L.
- Dalton Trans., Vol. 39, Issue 2
Recognition- and Reactivity-Based Fluorescent Probes for Studying Transition Metal Signaling in Living Systems
journal, July 2015
- Aron, Allegra T.; Ramos-Torres, Karla M.; Cotruvo, Joseph A.
- Accounts of Chemical Research, Vol. 48, Issue 8
Significance of copper determination in late onset of Wilson's disease
journal, January 2007
- Lech, Teresa; Hydzik, Piotr; Kosowski, Bogdan
- Clinical Toxicology, Vol. 45, Issue 6
Sorption of Trace Heavy Metals by Thiol Containing Chelating Resins
journal, January 2000
- Saha, B.; Iglesias, M.; dimming, I. W.
- Solvent Extraction and Ion Exchange, Vol. 18, Issue 1
Preparation and use of Coppersensor-1, a synthetic fluorophore for live-cell copper imaging
journal, July 2006
- Miller, Evan W.; Zeng, Li; Domaille, Dylan W.
- Nature Protocols, Vol. 1, Issue 2
Post-metalation of porous aromatic frameworks for highly efficient carbon capture from CO 2 + N 2 and CH 4 + N 2 mixtures
journal, January 2014
- Ma, Heping; Ren, Hao; Zou, Xiaoqin
- Polym. Chem., Vol. 5, Issue 1
A Targetable Fluorescent Sensor Reveals That Copper-Deficient SCO1 and SCO2 Patient Cells Prioritize Mitochondrial Copper Homeostasis
journal, June 2011
- Dodani, Sheel C.; Leary, Scot C.; Cobine, Paul A.
- Journal of the American Chemical Society, Vol. 133, Issue 22
Ammonia Capture in Porous Organic Polymers Densely Functionalized with Brønsted Acid Groups
journal, January 2014
- Van Humbeck, Jeffrey F.; McDonald, Thomas M.; Jing, Xiaofei
- Journal of the American Chemical Society, Vol. 136, Issue 6, p. 2432-2440
Wilson's disease
journal, February 2007
- Ala, Aftab; Walker, Ann P.; Ashkan, Keyoumars
- The Lancet, Vol. 369, Issue 9559
Porous, Crystalline, Covalent Organic Frameworks
journal, November 2005
- Côté, Adrien P.; Benin, Annabelle I.; Ockwig, Nathan W.
- Science, Vol. 310, Issue 5751, p. 1166-1170
Selective gas adsorption and separation in metal–organic frameworks
journal, January 2009
- Li, Jian-Rong; Kuppler, Ryan J.; Zhou, Hong-Cai
- Chemical Society Reviews, Vol. 38, Issue 5, p. 1477-1504
Subcellular metal imaging identifies dynamic sites of Cu accumulation in Chlamydomonas
journal, October 2014
- Hong-Hermesdorf, Anne; Miethke, Marcus; Gallaher, Sean D.
- Nature Chemical Biology, Vol. 10, Issue 12
Consequences of Copper Accumulation in the Livers of the Atp7b−/− (Wilson Disease Gene) Knockout Mice
journal, February 2006
- Huster, Dominik; Finegold, Milton J.; Morgan, Clinton T.
- The American Journal of Pathology, Vol. 168, Issue 2
Hydrothermally Stable Thioether-Bridged Mesoporous Materials with Void Defects in the Pore Walls
journal, August 2005
- Liu, J.; Yang, J.; Yang, Q.
- Advanced Functional Materials, Vol. 15, Issue 8
Mercury nano-trap for effective and efficient removal of mercury(II) from aqueous solution
journal, November 2014
- Li, Baiyan; Zhang, Yiming; Ma, Dingxuan
- Nature Communications, Vol. 5, Issue 1
Synthetic fluorescent sensors for studying the cell biology of metals
journal, February 2008
- Domaille, Dylan W.; Que, Emily L.; Chang, Christopher J.
- Nature Chemical Biology, Vol. 4, Issue 3
A Selective Turn-On Fluorescent Sensor for Imaging Copper in Living Cells
journal, January 2006
- Zeng, Li; Miller, Evan W.; Pralle, Arnd
- Journal of the American Chemical Society, Vol. 128, Issue 1
Copper is required for oncogenic BRAF signalling and tumorigenesis
journal, April 2014
- Brady, Donita C.; Crowe, Matthew S.; Turski, Michelle L.
- Nature, Vol. 509, Issue 7501
A Smart Magnetic Resonance Contrast Agent for Selective Copper Sensing
journal, December 2006
- Que, Emily L.; Chang, Christopher J.
- Journal of the American Chemical Society, Vol. 128, Issue 50
Three-Dimensional Framework with Channeling Cavities for Small Molecules:{[M2(4, 4′-bpy)3(NO3)4]·xH2O}n(M Co, Ni, Zn)
journal, September 1997
- Kondo, Mitsuru; Yoshitomi, Tomomichi; Matsuzaka, Hiroyuki
- Angewandte Chemie International Edition in English, Vol. 36, Issue 16
Lithiated Porous Aromatic Frameworks with Exceptional Gas Storage Capacity
journal, June 2012
- Konstas, Kristina; Taylor, James W.; Thornton, Aaron W.
- Angewandte Chemie International Edition, Vol. 51, Issue 27
Thioether-Based Fluorescent Covalent Organic Framework for Selective Detection and Facile Removal of Mercury(II)
journal, February 2016
- Ding, San-Yuan; Dong, Ming; Wang, Ya-Wen
- Journal of the American Chemical Society, Vol. 138, Issue 9
Oriented 2D Covalent Organic Framework Thin Films on Single-Layer Graphene
journal, April 2011
- Colson, J. W.; Woll, A. R.; Mukherjee, A.
- Science, Vol. 332, Issue 6026
Convenient Detection of Pd(II) by a Metal–Organic Framework with Sulfur and Olefin Functions
journal, May 2013
- He, Jun; Zha, Meiqin; Cui, Jieshun
- Journal of the American Chemical Society, Vol. 135, Issue 21
Removal of zinc, copper and lead by natural zeolite—a comparison of adsorption isotherms
journal, April 2004
- Perić, J.; Trgo, M.; Vukojević Medvidović, N.
- Water Research, Vol. 38, Issue 7
Removal of pollutants from acid mine wastewater using metallurgical by-product slags
journal, November 2004
- Feng, D.; van Deventer, J. S. J.; Aldrich, C.
- Separation and Purification Technology, Vol. 40, Issue 1
Colorimetric sensing of Cu2+ using a cyclodextrin–dye rotaxane
journal, September 2010
- Park, Jong S.; Jeong, Sooyeon; Dho, Seongkook
- Dyes and Pigments, Vol. 87, Issue 1
Rapid removal of organic micropollutants from water by a porous β-cyclodextrin polymer
journal, December 2015
- Alsbaiee, Alaaeddin; Smith, Brian J.; Xiao, Leilei
- Nature, Vol. 529, Issue 7585
Targeted Synthesis of a Porous Aromatic Framework with High Stability and Exceptionally High Surface Area
journal, November 2009
- Ben, Teng; Ren, Hao; Ma, Shengqian
- Angewandte Chemie International Edition, Vol. 48, Issue 50, p. 9457-9460
Association of Zinc, Copper and Magnesium with bone mineral density in Iranian postmenopausal women – a case control study
journal, March 2014
- Razmandeh, Rezvan; Nasli-Esfahani, Ensieh; Heydarpour, Reza
- Journal of Diabetes & Metabolic Disorders, Vol. 13, Issue 1
Visualizing Ascorbate-Triggered Release of Labile Copper within Living Cells using a Ratiometric Fluorescent Sensor
journal, February 2010
- Domaille, Dylan W.; Zeng, Li; Chang, Christopher J.
- Journal of the American Chemical Society, Vol. 132, Issue 4
Comparative Genomic Analyses of Copper Transporters and Cuproproteomes Reveal Evolutionary Dynamics of Copper Utilization and Its Link to Oxygen
journal, January 2008
- Ridge, Perry G.; Zhang, Yan; Gladyshev, Vadim N.
- PLoS ONE, Vol. 3, Issue 1
Systematic Design of Pore Size and Functionality in Isoreticular MOFs and Their Application in Methane Storage
journal, January 2002
- Eddaoudi, Mohamed; Kim, Jaheon; Rosi, Nathaniel
- Science, Vol. 295, Issue 5554, p. 469-472
Comparison of the influence of saturated nitrogen and sulfur donor atoms on the properties of copper(II/I)-macrocyclic polyamino polythiaether ligand complexes: redox potentials and protonation and stability constants of CuIL species and new structural data
journal, January 1992
- Bernardo, M. Margarida; Heeg, Mary Jane; Schroeder, Ronald R.
- Inorganic Chemistry, Vol. 31, Issue 2
Near-infrared fluorescent sensor for in vivo copper imaging in a murine Wilson disease model
journal, January 2012
- Hirayama, T.; Van de Bittner, G. C.; Gray, L. W.
- Proceedings of the National Academy of Sciences, Vol. 109, Issue 7
Carbon Dioxide Capture in Metal–Organic Frameworks
journal, September 2011
- Sumida, Kenji; Rogow, David L.; Mason, Jarad A.
- Chemical Reviews, Vol. 112, Issue 2, p. 724-781
Porous aromatic frameworks: Synthesis, structure and functions
journal, January 2013
- Ben, Teng; Qiu, Shilun
- CrystEngComm, Vol. 15, Issue 1
Topological Transformation of Thioether-Bridged Organosilicas into Nanostructured Functional Materials
journal, June 2012
- Kim, Jung Ho; Fang, Baizeng; Song, Min Young
- Chemistry of Materials, Vol. 24, Issue 12
Synthetic fluorescent probes for studying copper in biological systems
journal, January 2015
- Cotruvo, Jr., Joseph A.; Aron, Allegra T.; Ramos-Torres, Karla M.
- Chemical Society Reviews, Vol. 44, Issue 13
Protection by desferrioxamine and other hydroxamic acids against tetrachlorohydroquinone-induced cyto- and genotoxicity in human fibroblasts
journal, March 2000
- Witte, Irene; Zhu, Ben-Zhan; Lueken, Aloys
- Free Radical Biology and Medicine, Vol. 28, Issue 5
Calcium-dependent copper redistributions in neuronal cells revealed by a fluorescent copper sensor and X-ray fluorescence microscopy
journal, March 2011
- Dodani, S. C.; Domaille, D. W.; Nam, C. I.
- Proceedings of the National Academy of Sciences, Vol. 108, Issue 15
Copper-Responsive Magnetic Resonance Imaging Contrast Agents
journal, June 2009
- Que, Emily L.; Gianolio, Eliana; Baker, Suzanne L.
- Journal of the American Chemical Society, Vol. 131, Issue 24
The pattern of urinary copper excretion and its response to treatment in patients with Wilson's disease
journal, May 2011
- Walshe, J. M.
- QJM, Vol. 104, Issue 9
Sulfur-Functionalized Mesoporous Carbon
journal, October 2007
- Shin, Y.; Fryxell, G. E.; Um, W.
- Advanced Functional Materials, Vol. 17, Issue 15
Evaluating metal–organic frameworks for post-combustion carbon dioxide capture via temperature swing adsorption
journal, January 2011
- Mason, Jarad A.; Sumida, Kenji; Herm, Zoey R.
- Energy & Environmental Science, Vol. 4, Issue 8, p. 3030-3040
Conjugated Microporous Poly(aryleneethynylene) Networks
journal, September 2007
- Jiang, Jia-Xing; Su, Fabing; Trewin, Abbie
- Angewandte Chemie International Edition, Vol. 46, Issue 45
Covalent organic frameworks
journal, January 2012
- Feng, Xiao; Ding, Xuesong; Jiang, Donglin
- Chemical Society Reviews, Vol. 41, Issue 18
Tailoring Physical Aging in Super Glassy Polymers with Functionalized Porous Aromatic Frameworks for CO 2 Capture
journal, June 2015
- Lau, Cher Hon; Konstas, Kristina; Doherty, Cara M.
- Chemistry of Materials, Vol. 27, Issue 13
ATP7A-related copper transport diseases—emerging concepts and future trends
journal, January 2011
- Kaler, Stephen G.
- Nature Reviews Neurology, Vol. 7, Issue 1
Enhanced Ionic Recognition by a Functionalized Mesoporous Sol-Gel: Synthesis and Metal ion Selectivity of Diaminoethane Derivative
journal, November 2001
- Burleigh, M.; Dai, S.; Barnes, C.
- Separation Science and Technology, Vol. 36, Issue 15
Robust Superhydrophobic Bridged Silsesquioxane Aerogels with Tunable Performances and Their Applications
journal, January 2015
- Wang, Zhen; Wang, Dong; Qian, Zhenchao
- ACS Applied Materials & Interfaces, Vol. 7, Issue 3
Metals in Neurobiology: Probing Their Chemistry and Biology with Molecular Imaging
journal, May 2008
- Que, Emily L.; Domaille, Dylan W.; Chang, Christopher J.
- Chemical Reviews, Vol. 108, Issue 5
Structural Biology of Copper Trafficking
journal, October 2009
- Boal, Amie K.; Rosenzweig, Amy C.
- Chemical Reviews, Vol. 109, Issue 10
Uptake and desorption of copper ion using functionalized polymer coated silica gel in aqueous environment
journal, October 2007
- Kumar, G. Pramod; Kumar, P. Albino; Chakraborty, Saswati
- Separation and Purification Technology, Vol. 57, Issue 1
Sulfonate-Grafted Porous Polymer Networks for Preferential CO2 Adsorption at Low Pressure
journal, November 2011
- Lu, Weigang; Yuan, Daqiang; Sculley, Julian
- Journal of the American Chemical Society, Vol. 133, Issue 45, p. 18126-18129
Reducing Effect of Ingesting Tannic Acid on the Absorption of Iron, but Not of Zinc, Copper and Manganese by Rats
journal, January 2004
- Afsana, Kaosar; Shiga, Kazuki; Ishizuka, Satoshi
- Bioscience, Biotechnology, and Biochemistry, Vol. 68, Issue 3
Systems biology approach to Wilson’s disease
journal, March 2011
- Burkhead, Jason L.; Gray, Lawrence W.; Lutsenko, Svetlana
- BioMetals, Vol. 24, Issue 3
Serum ceruloplasmin protein expression and activity increases in iron-deficient rats and is further enhanced by higher dietary copper intake
journal, September 2011
- Ranganathan, Perungavur N.; Lu, Yan; Jiang, Lingli
- Blood, Vol. 118, Issue 11
A Comparative Study of the Removal of Heavy Metal Ions from Water Using a Silica−Polyamine Composite and a Polystyrene Chelator Resin
journal, November 1999
- Beatty, Susan T.; Fischer, Robert J.; Hagers, Dana L.
- Industrial & Engineering Chemistry Research, Vol. 38, Issue 11
Growing honeycombs on graphene
journal, June 2011
- Dogru, Mirjam; Bein, Thomas
- Nature Nanotechnology, Vol. 6, Issue 6
Design and synthesis of an exceptionally stable and highly porous metal-organic framework
journal, November 1999
- Li, Hailian; Eddaoudi, Mohamed; M., O'Keeffe
- Nature, Vol. 402, Issue 6759, p. 276-279
A cell-permeable gadolinium contrast agent for magnetic resonance imaging of copper in a Menkes disease model
journal, January 2012
- Que, Emily L.; New, Elizabeth J.; Chang, Christopher J.
- Chemical Science, Vol. 3, Issue 6
A comparison between the chelating properties of some dihydroxamic acids, desferrioxamine B and acetohydroxamic acid
journal, July 1999
- Farkas, Etelka; Enyedy, Éva A.; Csóka, Hajnalka
- Polyhedron, Vol. 18, Issue 18
Polyamine-Tethered Porous Polymer Networks for Carbon Dioxide Capture from Flue Gas
journal, June 2012
- Lu, Weigang; Sculley, Julian P.; Yuan, Daqiang
- Angewandte Chemie International Edition, Vol. 51, Issue 30, p. 7480-7484
Heavy metal adsorbents prepared from the modification of cellulose: A review
journal, October 2008
- O’Connell, David William; Birkinshaw, Colin; O’Dwyer, Thomas Francis
- Bioresource Technology, Vol. 99, Issue 15
Preparation and characterization of hydroxamic acid derivative and its metal complexes derived from cellulose
journal, November 1990
- Maekawa, Eiichi; Koshijima, Tetsuo
- Journal of Applied Polymer Science, Vol. 40, Issue 910
Copper is an endogenous modulator of neural circuit spontaneous activity
journal, November 2014
- Dodani, Sheel C.; Firl, Alana; Chan, Jefferson
- Proceedings of the National Academy of Sciences, Vol. 111, Issue 46