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This content will become publicly available on August 21, 2018

Title: Adsorption and Recovery of Polyphenolic Flavonoids Using TiO 2-Functionalized Mesoporous Silica Nanoparticles

Exploiting specific interactions with titania (TiO 2) has been proposed for the separation and recovery of a broad range of biomolecules and natural products, including therapeutic polyphenolic flavonoids which are susceptible to degradation, such as quercetin. Functionalizing mesoporous silica with TiO 2 has many potential advantages over bulk and mesoporous TiO 2 as an adsorbent for natural products, including robust synthetic approaches leading to high surface area, stable separation platforms. Here, TiO 2 surface functionalized mesoporous silica nanoparticles (MSNPs) are synthesized and characterized as a function of TiO 2 content (up to 636 mg TiO2/g). The adsorption isotherms of two polyphenolic flavonoids, quercetin and rutin, were determined (0.05-10 mg/ml in ethanol), and a 100-fold increase in the adsorption capacity was observed relative to functionalized nonporous particles with similar TiO 2 surface coverage. An optimum extent of functionalization (approximately 440 mg TiO 2/g particles) is interpreted from characterization techniques including grazing incidence x-ray scattering (GIXS), high resolution transmission electron microscopy (HRTEM) and nitrogen adsorption, which examined the interplay between the extent of TiO 2 functionalization and the accessibility of the porous structures. The recovery of flavonoids is demonstrated using ligand displacement in ethanolic citric acid solution (20% w/v), in which greatermore » than 90% recovery can be achieved in a multistep extraction process. The radical scavenging activity (RSA) of the recovered and particle-bound quercetin as measured by 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assay demonstrates greater than 80% retention of antioxidant activity by both particle-bound and recovered quercetin. In conclusion, these mesoporous titanosilicate materials can serve as a synthetic platform to isolate, recover, and potentially deliver degradation-sensitive natural products to biological systems.« less
Authors:
 [1] ;  [1] ;  [1] ;  [1] ;  [2] ;  [3] ; ORCiD logo [1] ; ORCiD logo [1]
  1. Univ. of Kentucky, Lexington, KY (United States)
  2. Argonne National Lab. (ANL), Argonne, IL (United States)
  3. Naprogenix Inc., Lexington, KY (United States)
Publication Date:
Grant/Contract Number:
AC02-06CH11357
Type:
Accepted Manuscript
Journal Name:
ACS Applied Materials and Interfaces
Additional Journal Information:
Journal Volume: 9; Journal Issue: 37; Journal ID: ISSN 1944-8244
Publisher:
American Chemical Society (ACS)
Research Org:
Argonne National Lab. (ANL), Argonne, IL (United States)
Sponsoring Org:
National Institutes of Health (NIH); USDOE Office of Science (SC), Basic Energy Sciences (BES) (SC-22), Scientific User Facilities Division
Country of Publication:
United States
Language:
English
Subject:
36 MATERIALS SCIENCE; adsorption; flavonoid; functionalization; silica nanoparticles; stability
OSTI Identifier:
1395148