A trinuclear oxo-chromium(III) complex containing the natural flavonoid primuletin: Synthesis, characterization, and antiradical properties

Rocha, Reginaldo C.; Alexiou, Anamaria D.P.; Decandio, Carla C.; Almeida, Sabrina da N.; Ferreira, Marcelo J.P.; Romoff, Paulete

doi:10.3390/molecules20046310

Title: A trinuclear oxo-chromium(III) complex containing the natural flavonoid primuletin: Synthesis, characterization, and antiradical properties

Journal Article · Fri Apr 10 00:00:00 EDT 2015 · Molecules

DOI: https://doi.org/10.3390/molecules20046310 · OSTI ID:1208875

Rocha, Reginaldo C. ^[1]; Alexiou, Anamaria D.P. ^[2]; Decandio, Carla C. ^[2]; Almeida, Sabrina da N. ^[2]; Ferreira, Marcelo J.P. ^[3]; Romoff, Paulete ^[2]

Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
Univ. Presbiteriana Mackenzie, Sao Paulo (Brazil)
Univ. de Sao Paulo, Sao Paulo (Brazil)

A new trinuclear oxo-centered chromium(III) complex with formula [Cr₃O(CH₃CO₂)₆(L)(H₂O)₂] (L = 5-hydroxyflavone, known as primuletin) was synthetized and characterized by ESI mass spectrometry, thermogravimetry, and ¹H-NMR, UV-Vis, and FTIR spectroscopies. In agreement with the experimental results, DFT calculations indicated that the flavonoid ligand is coordinated to one of the three Cr(III) centers in an O,O-bidentate mode through the 5-hydroxy/4-keto groups. In a comparative study involving the uncoordinated primuletin and its corresponding complex, systematic reactions with the free radical 2,2-diphenyl-1-picrylhydrazyl (DPPH) showed that antiradical activity increases upon complexation.

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Research Organization:: Los Alamos National Laboratory (LANL), Los Alamos, NM (United States)

Sponsoring Organization:: USDOE

Grant/Contract Number:: AC52-06NA25396

OSTI ID:: 1208875

Journal Information:: Molecules, Journal Name: Molecules Journal Issue: 4 Vol. 20; ISSN MOLEFW; ISSN 1420-3049

Publisher:: MDPICopyright Statement

Country of Publication:: United States

Language:: English

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Determination of Anticancer Zn(II)–Rutin Complex Structures in Solution through Density Functional Theory Calculations of ¹H NMR and UV–VIS Spectra Da Silva, Haroldo C.; De Souza, Leonardo A.; Dos Santos, Hélio F. ACS Omega, Vol. 5, Issue 6 https://doi.org/10.1021/acsomega.9b04174	journal	February 2020
Metal-ligand coordination and antiradical activity of a trichromium(III) complex with the flavonoid naringenin Alexiou, Anamaria D. P.; Decandio, Carla C.; Almeida, Sabrina da N. Journal of Coordination Chemistry, Vol. 70, Issue 12 https://doi.org/10.1080/00958972.2017.1328735	journal	May 2017
Metal-ligand coordination and antiradical activity of a trichromium(III) complex with the flavonoid naringenin Alexiou, Anamaria D. P.; Decandio, Carla C.; Almeida, Sabrina Da N. Taylor & Francis https://doi.org/10.6084/m9.figshare.5182795	text	January 2017
Metal-ligand coordination and antiradical activity of a trichromium(III) complex with the flavonoid naringenin Alexiou, Anamaria D. P.; Decandio, Carla C.; Almeida, Sabrina Da N. Taylor & Francis https://doi.org/10.6084/m9.figshare.5182795.v1	text	January 2017

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37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
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Title: A trinuclear oxo-chromium(III) complex containing the natural flavonoid primuletin: Synthesis, characterization, and antiradical properties

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