Dye-Sensitized Core/Active Shell Upconversion Nanoparticles for Optogenetics and Bioimaging Applications
Abstract
A near-infrared (NIR) dye-sensitized upconversion nanoparticles (UCNPs) can broaden the absorption range and boost upconversion efficiency of UCNPs. We achieved significantly enhanced upconversion luminescence in dye-sensitized core/active shell UCNPs via the doping of ytterbium ions (Yb 3+ ) in the UCNP shell, which bridged the energy transfer from the dye to the UCNP core. As a result, we synergized the two most practical upconversion booster effectors (dye-sensitizing and core/shell enhancement) to amplify upconversion efficiency. We also demonstrated two biomedical applications using these UCNPs. By using dye-sensitized core/active shell UCNP embedded poly(methyl methacrylate) polymer implantable systems, we successfully shifted the optogenetic neuron excitation window to a biocompatible and deep tissue penetrable 800 nm wavelength. Furthermore, UCNPs were water-solubilized with Pluronic F127 with high upconversion efficiency and can be imaged in a mouse model.
- Authors:
-
- Univ. of Massachusetts Medical School, Worcester, MA (United States). Dept. of Biochemistry and Molecular Pharmacology; Dalian Univ. of Technology (People's Republic of China)
- Univ. of Massachusetts Medical School, Worcester, MA (United States). Dept. of Biochemistry and Molecular Pharmacology
- Univ. of Massachusetts Medical School, Worcester, MA (United States). Neurobiology Dept.
- Zhejiang Univ., Hangzhou (China).. Dept. of Materials Science and Engineering
- Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
- Univ. of Massachusetts, Amherst, MA (United States). Chemical Engineering Dept.
- Dalian Univ. of Technology (People's Republic of China). State Key Lab. of Fine Chemicals
- Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). The Molecular Foundry
- Publication Date:
- Research Org.:
- Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)
- Sponsoring Org.:
- USDOE Office of Science (SC), Basic Energy Sciences (BES); National Institutes of Health (NIH)
- OSTI Identifier:
- 1379046
- Grant/Contract Number:
- AC02-05CH11231; R01MH103133; RGY-0090/2014
- Resource Type:
- Accepted Manuscript
- Journal Name:
- ACS Nano
- Additional Journal Information:
- Journal Volume: 10; Journal Issue: 1; Journal ID: ISSN 1936-0851
- Publisher:
- American Chemical Society (ACS)
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 77 NANOSCIENCE AND NANOTECHNOLOGY; 37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY; bioimaging; core/active shell structure; dye-sensitizing; near-infrared; optogenetics; upconversion nanoparticles
Citation Formats
Wu, Xiang, Zhang, Yuanwei, Takle, Kendra, Bilsel, Osman, Li, Zhanjun, Lee, Hyungseok, Zhang, Zijiao, Li, Dongsheng, Fan, Wei, Duan, Chunying, Chan, Emory M., Lois, Carlos, Xiang, Yang, and Han, Gang. Dye-Sensitized Core/Active Shell Upconversion Nanoparticles for Optogenetics and Bioimaging Applications. United States: N. p., 2016.
Web. doi:10.1021/acsnano.5b06383.
Wu, Xiang, Zhang, Yuanwei, Takle, Kendra, Bilsel, Osman, Li, Zhanjun, Lee, Hyungseok, Zhang, Zijiao, Li, Dongsheng, Fan, Wei, Duan, Chunying, Chan, Emory M., Lois, Carlos, Xiang, Yang, & Han, Gang. Dye-Sensitized Core/Active Shell Upconversion Nanoparticles for Optogenetics and Bioimaging Applications. United States. https://doi.org/10.1021/acsnano.5b06383
Wu, Xiang, Zhang, Yuanwei, Takle, Kendra, Bilsel, Osman, Li, Zhanjun, Lee, Hyungseok, Zhang, Zijiao, Li, Dongsheng, Fan, Wei, Duan, Chunying, Chan, Emory M., Lois, Carlos, Xiang, Yang, and Han, Gang. Wed .
"Dye-Sensitized Core/Active Shell Upconversion Nanoparticles for Optogenetics and Bioimaging Applications". United States. https://doi.org/10.1021/acsnano.5b06383. https://www.osti.gov/servlets/purl/1379046.
@article{osti_1379046,
title = {Dye-Sensitized Core/Active Shell Upconversion Nanoparticles for Optogenetics and Bioimaging Applications},
author = {Wu, Xiang and Zhang, Yuanwei and Takle, Kendra and Bilsel, Osman and Li, Zhanjun and Lee, Hyungseok and Zhang, Zijiao and Li, Dongsheng and Fan, Wei and Duan, Chunying and Chan, Emory M. and Lois, Carlos and Xiang, Yang and Han, Gang},
abstractNote = {A near-infrared (NIR) dye-sensitized upconversion nanoparticles (UCNPs) can broaden the absorption range and boost upconversion efficiency of UCNPs. We achieved significantly enhanced upconversion luminescence in dye-sensitized core/active shell UCNPs via the doping of ytterbium ions (Yb 3+ ) in the UCNP shell, which bridged the energy transfer from the dye to the UCNP core. As a result, we synergized the two most practical upconversion booster effectors (dye-sensitizing and core/shell enhancement) to amplify upconversion efficiency. We also demonstrated two biomedical applications using these UCNPs. By using dye-sensitized core/active shell UCNP embedded poly(methyl methacrylate) polymer implantable systems, we successfully shifted the optogenetic neuron excitation window to a biocompatible and deep tissue penetrable 800 nm wavelength. Furthermore, UCNPs were water-solubilized with Pluronic F127 with high upconversion efficiency and can be imaged in a mouse model.},
doi = {10.1021/acsnano.5b06383},
journal = {ACS Nano},
number = 1,
volume = 10,
place = {United States},
year = {Wed Jan 06 00:00:00 EST 2016},
month = {Wed Jan 06 00:00:00 EST 2016}
}
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