Amplifying the Red-Emission of Upconverting Nanoparticles for Biocompatible Clinically Used Prodrug-Induced Photodynamic Therapy
Abstract
A class of biocompatible upconverting nanoparticles (UCNPs) with largely amplified red-emissions was developed. The optimal UCNP shows a high absolute upconversion quantum yield of 3.2% in red-emission, which is 15-fold stronger than the known optimal β-phase core/shell UCNPs. When conjugated to aminolevulinic acid, a clinically used photodynamic therapy (PDT) prodrug, significant PDT effect in tumor was demonstrated in a deep-tissue (>1.2 cm) setting in vivo at a biocompatible laser power density. Furthermore, we show that our UCNP–PDT system with NIR irradiation outperforms clinically used red light irradiation in a deep tumor setting in vivo. This study marks a major step forward in photodynamic therapy utilizing UCNPs to effectively access deep-set tumors.Lastly, it also provides an opportunity for the wide application of upconverting red radiation in photonics and biophotonics.
- Authors:
-
- Univ. of Massachusetts, Amherst, MA (United States)
- Univ. of Massachusetts, Amherst, MA (United States); Dalian Univ. of Technology, Dalian (China)
- Soochow Univ., Suzhou, Jiangsu (China)
- Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Molecular Foundry
- Dalian Univ. of Technology, Dalian (China)
- Publication Date:
- Research Org.:
- Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)
- Sponsoring Org.:
- USDOE Office of Science (SC), Basic Energy Sciences (BES)
- OSTI Identifier:
- 1257361
- Grant/Contract Number:
- AC02-05CH11231; R01MH103133; RGY0090/2014
- Resource Type:
- Accepted Manuscript
- Journal Name:
- ACS Nano
- Additional Journal Information:
- Journal Volume: 8; Journal Issue: 10; Journal ID: ISSN 1936-0851
- Publisher:
- American Chemical Society
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 77 NANOSCIENCE AND NANOTECHNOLOGY; upconverting; nanoparticles; red-emission; prodrug; photodynamic therapy
Citation Formats
Punjabi, Amol, Wu, Xiang, Tokatli-Apollon, Amira, El-Rifai, Mahmoud, Lee, Hyungseok, Zhang, Yuanwei, Wang, Chao, Liu, Zhuang, Chan, Emory M., Duan, Chunying, and Han, Gang. Amplifying the Red-Emission of Upconverting Nanoparticles for Biocompatible Clinically Used Prodrug-Induced Photodynamic Therapy. United States: N. p., 2014.
Web. doi:10.1021/nn505051d.
Punjabi, Amol, Wu, Xiang, Tokatli-Apollon, Amira, El-Rifai, Mahmoud, Lee, Hyungseok, Zhang, Yuanwei, Wang, Chao, Liu, Zhuang, Chan, Emory M., Duan, Chunying, & Han, Gang. Amplifying the Red-Emission of Upconverting Nanoparticles for Biocompatible Clinically Used Prodrug-Induced Photodynamic Therapy. United States. https://doi.org/10.1021/nn505051d
Punjabi, Amol, Wu, Xiang, Tokatli-Apollon, Amira, El-Rifai, Mahmoud, Lee, Hyungseok, Zhang, Yuanwei, Wang, Chao, Liu, Zhuang, Chan, Emory M., Duan, Chunying, and Han, Gang. Thu .
"Amplifying the Red-Emission of Upconverting Nanoparticles for Biocompatible Clinically Used Prodrug-Induced Photodynamic Therapy". United States. https://doi.org/10.1021/nn505051d. https://www.osti.gov/servlets/purl/1257361.
@article{osti_1257361,
title = {Amplifying the Red-Emission of Upconverting Nanoparticles for Biocompatible Clinically Used Prodrug-Induced Photodynamic Therapy},
author = {Punjabi, Amol and Wu, Xiang and Tokatli-Apollon, Amira and El-Rifai, Mahmoud and Lee, Hyungseok and Zhang, Yuanwei and Wang, Chao and Liu, Zhuang and Chan, Emory M. and Duan, Chunying and Han, Gang},
abstractNote = {A class of biocompatible upconverting nanoparticles (UCNPs) with largely amplified red-emissions was developed. The optimal UCNP shows a high absolute upconversion quantum yield of 3.2% in red-emission, which is 15-fold stronger than the known optimal β-phase core/shell UCNPs. When conjugated to aminolevulinic acid, a clinically used photodynamic therapy (PDT) prodrug, significant PDT effect in tumor was demonstrated in a deep-tissue (>1.2 cm) setting in vivo at a biocompatible laser power density. Furthermore, we show that our UCNP–PDT system with NIR irradiation outperforms clinically used red light irradiation in a deep tumor setting in vivo. This study marks a major step forward in photodynamic therapy utilizing UCNPs to effectively access deep-set tumors.Lastly, it also provides an opportunity for the wide application of upconverting red radiation in photonics and biophotonics.},
doi = {10.1021/nn505051d},
journal = {ACS Nano},
number = 10,
volume = 8,
place = {United States},
year = {Thu Sep 25 00:00:00 EDT 2014},
month = {Thu Sep 25 00:00:00 EDT 2014}
}
Free Publicly Available Full Text
Publisher's Version of Record
Other availability
Search WorldCat to find libraries that may hold this journal
Cited by: 227 works
Citation information provided by
Web of Science
Web of Science
Save to My Library
You must Sign In or Create an Account in order to save documents to your library.
Works referenced in this record:
Nanoparticles in photodynamic therapy: An emerging paradigm
journal, December 2008
- Chatterjee, Dev Kumar; Fong, Li Shan; Zhang, Yong
- Advanced Drug Delivery Reviews, Vol. 60, Issue 15
Photodynamic therapy for cancer
journal, May 2003
- Dolmans, Dennis E. J. G. J.; Fukumura, Dai; Jain, Rakesh K.
- Nature Reviews Cancer, Vol. 3, Issue 5
Activatable Photosensitizers for Imaging and Therapy
journal, May 2010
- Lovell, Jonathan F.; Liu, Tracy W. B.; Chen, Juan
- Chemical Reviews, Vol. 110, Issue 5
Basic principles of photodynamic therapy
journal, February 2001
- Macdonald, Ian J.; Dougherty, Thomas J.
- Journal of Porphyrins and Phthalocyanines, Vol. 05, Issue 02
Phase I clinical trial of the use of zinc phthalocyanine tetrasulfonate as a photosensitizer for photodynamic therapy in dogs
journal, April 2007
- Borgatti-Jeffreys, Antonella; Hooser, Stephen B.; Miller, Margaret A.
- American Journal of Veterinary Research, Vol. 68, Issue 4
Photodynamic Therapy
journal, June 1998
- Dougherty, T. J.; Gomer, C. J.; Henderson, B. W.
- JNCI Journal of the National Cancer Institute, Vol. 90, Issue 12
A Review of Progress in Clinical Photodynamic Therapy
journal, June 2005
- Huang, Zheng
- Technology in Cancer Research & Treatment, Vol. 4, Issue 3
5-Aminolevulinic Acid-Based Photodynamic Therapy: Principles and Experimental Research
journal, February 1997
- Peng, Qian; Berg, Kristian; Moan, Johan
- Photochemistry and Photobiology, Vol. 65, Issue 2
5-Aminolevulinic acid-based photodynamic therapy: Clinical research and future challenges
journal, June 1997
- Peng, Qian; Warloe, Trond; Berg, Kristian
- Cancer, Vol. 79, Issue 12
Review of photodynamic therapy in actinic keratosis and basal cell carcinoma
journal, January 2008
- Larko, Olle
- Therapeutics and Clinical Risk Management, Vol. Volume 4
Photosensitization of Singlet Oxygen via Two-Photon-Excited Fluorescence Resonance Energy Transfer in a Water-Soluble Dendrimer
journal, April 2005
- Oar, Michael A.; Serin, Jason M.; Dichtel, William R.
- Chemistry of Materials, Vol. 17, Issue 9
Nanomaterials and singlet oxygen photosensitizers: potential applications in photodynamic therapy
journal, January 2004
- Wang, Shizhong; Gao, Ruomei; Zhou, Feimeng
- Journal of Materials Chemistry, Vol. 14, Issue 4
Upconverting Nanoparticles
journal, May 2011
- Haase, Markus; Schäfer, Helmut
- Angewandte Chemie International Edition, Vol. 50, Issue 26
Upconversion-Nanophosphor-Based Functional Nanocomposites
journal, August 2013
- Feng, Wei; Han, Chunmiao; Li, Fuyou
- Advanced Materials, Vol. 25, Issue 37
Upconversion nanoparticles in biological labeling, imaging, and therapy
journal, January 2010
- Wang, Feng; Banerjee, Debapriya; Liu, Yongsheng
- The Analyst, Vol. 135, Issue 8
Recent advances in the chemistry of lanthanide-doped upconversion nanocrystals
journal, January 2009
- Wang, Feng; Liu, Xiaogang
- Chemical Society Reviews, Vol. 38, Issue 4
Near-infrared light induced in vivo photodynamic therapy of cancer based on upconversion nanoparticles
journal, September 2011
- Wang, Chao; Tao, Huiquan; Cheng, Liang
- Biomaterials, Vol. 32, Issue 26
In vivo photodynamic therapy using upconversion nanoparticles as remote-controlled nanotransducers
journal, September 2012
- Idris, Niagara Muhammad; Gnanasammandhan, Muthu Kumara; Zhang, Jing
- Nature Medicine, Vol. 18, Issue 10
Upconverting nanoparticles as nanotransducers for photodynamic therapy in cancer cells
journal, February 2008
- Chatterjee, Dev K.; Yong, Zhang
- Nanomedicine, Vol. 3, Issue 1
Covalently Assembled NIR Nanoplatform for Simultaneous Fluorescence Imaging and Photodynamic Therapy of Cancer Cells
journal, April 2012
- Liu, Kai; Liu, Xiaomin; Zeng, Qinghui
- ACS Nano, Vol. 6, Issue 5
Pegylated Composite Nanoparticles Containing Upconverting Phosphors and meso-Tetraphenyl porphine (TPP) for Photodynamic Therapy
journal, May 2011
- Shan, Jingning; Budijono, Stephanie J.; Hu, Guohong
- Advanced Functional Materials, Vol. 21, Issue 13
Mesoporous-Silica-Coated Up-Conversion Fluorescent Nanoparticles for Photodynamic Therapy
journal, October 2009
- Qian, Hai Sheng; Guo, Hui Chen; Ho, Paul Chi-Lui
- Small, Vol. 5, Issue 20
Drug delivery with upconversion nanoparticles for multi-functional targeted cancer cell imaging and therapy
journal, February 2011
- Wang, Chao; Cheng, Liang; Liu, Zhuang
- Biomaterials, Vol. 32, Issue 4
Red-Emitting Upconverting Nanoparticles for Photodynamic Therapy in Cancer Cells Under Near-Infrared Excitation
journal, December 2012
- Tian, Gan; Ren, Wenlu; Yan, Liang
- Small, Vol. 9, Issue 11
Mn2+ Dopant-Controlled Synthesis of NaYF4:Yb/Er Upconversion Nanoparticles for in vivo Imaging and Drug Delivery
journal, January 2012
- Tian, Gan; Gu, Zhanjun; Zhou, Liangjun
- Advanced Materials, Vol. 24, Issue 9
Lanthanide-Doped Na x ScF 3+ x Nanocrystals: Crystal Structure Evolution and Multicolor Tuning
journal, May 2012
- Teng, Xue; Zhu, Yihan; Wei, Wei
- Journal of the American Chemical Society, Vol. 134, Issue 20
Orthorhombic KSc2F7:Yb/Er nanorods: controlled synthesis and strong red upconversion emission
journal, January 2013
- Ding, Yujie; Teng, Xue; Zhu, Hao
- Nanoscale, Vol. 5, Issue 23
Absolute quantum yield measurements of colloidal NaYF4: Er3+, Yb3+ upconverting nanoparticles
journal, January 2010
- Boyer, John-Christopher; van Veggel, Frank C. J. M.
- Nanoscale, Vol. 2, Issue 8
Hexagonal Sodium Yttrium Fluoride Based Green and Blue Emitting Upconversion Phosphors
journal, April 2004
- Krämer, Karl W.; Biner, Daniel; Frei, Gabriela
- Chemistry of Materials, Vol. 16, Issue 7
Rare-Earth Nanoparticles with Enhanced Upconversion Emission and Suppressed Rare-Earth-Ion Leakage
journal, April 2012
- Wang, Ye-Fu; Sun, Ling-Dong; Xiao, Jia-Wen
- Chemistry - A European Journal, Vol. 18, Issue 18
(α-NaYbF 4 :Tm 3+ )/CaF 2 Core/Shell Nanoparticles with Efficient Near-Infrared to Near-Infrared Upconversion for High-Contrast Deep Tissue Bioimaging
journal, August 2012
- Chen, Guanying; Shen, Jie; Ohulchanskyy, Tymish Y.
- ACS Nano, Vol. 6, Issue 9
Triple-functional core–shell structured upconversion luminescent nanoparticles covalently grafted with photosensitizer for luminescent, magnetic resonance imaging and photodynamic therapy in vitro
journal, January 2012
- Qiao, Xiao-Fei; Zhou, Jia-Cai; Xiao, Jia-Wen
- Nanoscale, Vol. 4, Issue 15
Upconversion: Tunable Near Infrared to Ultraviolet Upconversion Luminescence Enhancement in (α-NaYF 4 :Yb,Tm)/CaF 2 Core/Shell Nanoparticles for In situ Real-time Recorded Biocompatible Photoactivation (Small 19/2013)
journal, October 2013
- Shen, Jie; Chen, Guanying; Ohulchanskyy, Tymish Y.
- Small, Vol. 9, Issue 19
Tuning upconversion through energy migration in core–shell nanoparticles
journal, October 2011
- Wang, Feng; Deng, Renren; Wang, Juan
- Nature Materials, Vol. 10, Issue 12
Upconversion Multicolor Fine-Tuning: Visible to Near-Infrared Emission from Lanthanide-Doped NaYF 4 Nanoparticles
journal, April 2008
- Wang, Feng; Liu, Xiaogang
- Journal of the American Chemical Society, Vol. 130, Issue 17
Enhancing multiphoton upconversion through energy clustering at sublattice level
journal, November 2013
- Wang, Juan; Deng, Renren; MacDonald, Mark A.
- Nature Materials, Vol. 13, Issue 2
Upconverting Near-Infrared Light through Energy Management in Core-Shell-Shell Nanoparticles
journal, October 2013
- Wen, Hongli; Zhu, Hai; Chen, Xian
- Angewandte Chemie International Edition, Vol. 52, Issue 50
Doxorubicin conjugated NaYF4:Yb3+/Tm3+ nanoparticles for therapy and sensing of drug delivery by luminescence resonance energy transfer
journal, November 2012
- Dai, Yunlu; Yang, Dongmei; Ma, Ping'an
- Biomaterials, Vol. 33, Issue 33
Upconversion Nanoparticles: Design, Nanochemistry, and Applications in Theranostics
journal, March 2014
- Chen, Guanying; Qiu, Hailong; Prasad, Paras N.
- Chemical Reviews, Vol. 114, Issue 10
Stem Cell Labeling using Polyethylenimine Conjugated (α-NaYbF 4 :Tm 3+ )/CaF 2 Upconversion Nanoparticles
journal, January 2013
- Zhao, Liang; Kutikov, Artem; Shen, Jie
- Theranostics, Vol. 3, Issue 4
Mn2+ Dopant-Controlled Synthesis of NaYF4:Yb/Er Upconversion Nanoparticles for in vivo Imaging and Drug Delivery
journal, January 2012
- Tian, Gan; Gu, Zhanjun; Zhou, Liangjun
- Advanced Materials, Vol. 24, Issue 9
Rare-Earth Nanoparticles with Enhanced Upconversion Emission and Suppressed Rare-Earth-Ion Leakage
journal, April 2012
- Wang, Ye-Fu; Sun, Ling-Dong; Xiao, Jia-Wen
- Chemistry - A European Journal, Vol. 18, Issue 18
Red-Emitting Upconverting Nanoparticles for Photodynamic Therapy in Cancer Cells Under Near-Infrared Excitation
journal, December 2012
- Tian, Gan; Ren, Wenlu; Yan, Liang
- Small, Vol. 9, Issue 11
Tunable Near Infrared to Ultraviolet Upconversion Luminescence Enhancement in (α-NaYF 4 :Yb,Tm)/CaF 2 Core/Shell Nanoparticles for In situ Real-time Recorded Biocompatible Photoactivation
journal, May 2013
- Shen, Jie; Chen, Guanying; Ohulchanskyy, Tymish Y.
- Small
Drug delivery with upconversion nanoparticles for multi-functional targeted cancer cell imaging and therapy
journal, February 2011
- Wang, Chao; Cheng, Liang; Liu, Zhuang
- Biomaterials, Vol. 32, Issue 4
Near-infrared light induced in vivo photodynamic therapy of cancer based on upconversion nanoparticles
journal, September 2011
- Wang, Chao; Tao, Huiquan; Cheng, Liang
- Biomaterials, Vol. 32, Issue 26
Doxorubicin conjugated NaYF4:Yb3+/Tm3+ nanoparticles for therapy and sensing of drug delivery by luminescence resonance energy transfer
journal, November 2012
- Dai, Yunlu; Yang, Dongmei; Ma, Ping'an
- Biomaterials, Vol. 33, Issue 33
Phase II clinical study of photodynamic therapy using mono-l-aspartyl chlorin e6 and diode laser for early superficial squamous cell carcinoma of the lung
journal, October 2003
- Kato, Harubumi; Furukawa, Kinya; Sato, Masami
- Lung Cancer, Vol. 42, Issue 1
Photosensitized oxidation of 2′,7′-dichlorofluorescin: singlet oxygen does not contribute to the formation of fluorescent oxidation product 2′,7′-dichlorofluorescein
journal, October 2002
- Bilski, P.; Belanger, A. G.; Chignell, C. F.
- Free Radical Biology and Medicine, Vol. 33, Issue 7
Upconversion Nanoparticles: Design, Nanochemistry, and Applications in Theranostics
journal, March 2014
- Chen, Guanying; Qiu, Hailong; Prasad, Paras N.
- Chemical Reviews, Vol. 114, Issue 10
Activatable Photosensitizers for Imaging and Therapy
journal, May 2010
- Lovell, Jonathan F.; Liu, Tracy W. B.; Chen, Juan
- Chemical Reviews, Vol. 110, Issue 5
Lanthanide-Doped Na x ScF 3+ x Nanocrystals: Crystal Structure Evolution and Multicolor Tuning
journal, May 2012
- Teng, Xue; Zhu, Yihan; Wei, Wei
- Journal of the American Chemical Society, Vol. 134, Issue 20
Upconversion Multicolor Fine-Tuning: Visible to Near-Infrared Emission from Lanthanide-Doped NaYF 4 Nanoparticles
journal, April 2008
- Wang, Feng; Liu, Xiaogang
- Journal of the American Chemical Society, Vol. 130, Issue 17
Covalently Assembled NIR Nanoplatform for Simultaneous Fluorescence Imaging and Photodynamic Therapy of Cancer Cells
journal, April 2012
- Liu, Kai; Liu, Xiaomin; Zeng, Qinghui
- ACS Nano, Vol. 6, Issue 5
(α-NaYbF 4 :Tm 3+ )/CaF 2 Core/Shell Nanoparticles with Efficient Near-Infrared to Near-Infrared Upconversion for High-Contrast Deep Tissue Bioimaging
journal, August 2012
- Chen, Guanying; Shen, Jie; Ohulchanskyy, Tymish Y.
- ACS Nano, Vol. 6, Issue 9
In vivo photodynamic therapy using upconversion nanoparticles as remote-controlled nanotransducers
journal, September 2012
- Idris, Niagara Muhammad; Gnanasammandhan, Muthu Kumara; Zhang, Jing
- Nature Medicine, Vol. 18, Issue 10
Enhancing multiphoton upconversion through energy clustering at sublattice level
journal, November 2013
- Wang, Juan; Deng, Renren; MacDonald, Mark A.
- Nature Materials, Vol. 13, Issue 2
Recent advances in the chemistry of lanthanide-doped upconversion nanocrystals
journal, January 2009
- Wang, Feng; Liu, Xiaogang
- Chemical Society Reviews, Vol. 38, Issue 4
Upconversion nanoparticles in biological labeling, imaging, and therapy
journal, January 2010
- Wang, Feng; Banerjee, Debapriya; Liu, Yongsheng
- The Analyst, Vol. 135, Issue 8
Absolute quantum yield measurements of colloidal NaYF4: Er3+, Yb3+ upconverting nanoparticles
journal, January 2010
- Boyer, John-Christopher; van Veggel, Frank C. J. M.
- Nanoscale, Vol. 2, Issue 8
Orthorhombic KSc2F7:Yb/Er nanorods: controlled synthesis and strong red upconversion emission
journal, January 2013
- Ding, Yujie; Teng, Xue; Zhu, Hao
- Nanoscale, Vol. 5, Issue 23
5-Aminolevulinic Acid-Based Photodynamic Therapy: Principles and Experimental Research
journal, February 1997
- Peng, Qian; Berg, Kristian; Moan, Johan
- Photochemistry and Photobiology, Vol. 65, Issue 2
On the Selectivity of 5-Aminolevulinic Acid-Induced Protoporphyrin IX Formation
journal, May 2004
- Collaud, Sabine; Juzeniene, Asta; Moan, Johan
- Current Medicinal Chemistry-Anti-Cancer Agents, Vol. 4, Issue 3
Upconverting nanoparticles as nanotransducers for photodynamic therapy in cancer cells
journal, February 2008
- Chatterjee, Dev K.; Yong, Zhang
- Nanomedicine, Vol. 3, Issue 1
Phase I clinical trial of the use of zinc phthalocyanine tetrasulfonate as a photosensitizer for photodynamic therapy in dogs
journal, April 2007
- Borgatti-Jeffreys, Antonella; Hooser, Stephen B.; Miller, Margaret A.
- American Journal of Veterinary Research, Vol. 68, Issue 4
Stem Cell Labeling using Polyethylenimine Conjugated (α-NaYbF 4 :Tm 3+ )/CaF 2 Upconversion Nanoparticles
journal, January 2013
- Zhao, Liang; Kutikov, Artem; Shen, Jie
- Theranostics, Vol. 3, Issue 4
Works referencing / citing this record:
An upconversion nanoplatform with extracellular pH-driven tumor-targeting ability for improved photodynamic therapy
journal, January 2018
- Ai, Fujin; Wang, Na; Zhang, Xiaoman
- Nanoscale, Vol. 10, Issue 9
Recent progress in upconversion luminescence nanomaterials for biomedical applications
journal, January 2018
- Duan, Chengchen; Liang, Liuen; Li, Li
- Journal of Materials Chemistry B, Vol. 6, Issue 2
Overcoming the Achilles' heel of photodynamic therapy
journal, January 2016
- Fan, Wenpei; Huang, Peng; Chen, Xiaoyuan
- Chemical Society Reviews, Vol. 45, Issue 23
Facile preparation of versatile gadolinium-chelated protein nanocomposite for T 1 magnetic resonance imaging-guided photodynamic and photothermal synergetic therapy
journal, January 2018
- Liu, Pei; Zheng, Hongyi; Yang, Zhe
- Journal of Materials Chemistry B, Vol. 6, Issue 11
Dopant-dependent crystallization and photothermal effect of Sb-doped SnO 2 nanoparticles as stable theranostic nanoagents for tumor ablation
journal, January 2018
- Yu, Nuo; Peng, Chen; Wang, Zhaojie
- Nanoscale, Vol. 10, Issue 5
Upconversion in Nanostructured Materials: From Optical Tuning to Biomedical Applications
journal, January 2018
- Sun, Tianying; Ai, Fujin; Zhu, Guangyu
- Chemistry - An Asian Journal, Vol. 13, Issue 4
Manipulating energy transfer in lanthanide-doped single nanoparticles for highly enhanced upconverting luminescence
journal, January 2017
- Zhuo, Zhu; Liu, Yongsheng; Liu, Dajiu
- Chemical Science, Vol. 8, Issue 7
Insight into the efficiency of oxygen introduced photodynamic therapy (PDT) and deep PDT against cancers with various assembled nanocarriers
journal, September 2019
- Zhao, Jie; Duan, Li; Wang, Anhe
- WIREs Nanomedicine and Nanobiotechnology, Vol. 12, Issue 1
Reactive oxygen species generating systems meeting challenges of photodynamic cancer therapy
journal, January 2016
- Zhou, Zijian; Song, Jibin; Nie, Liming
- Chemical Society Reviews, Vol. 45, Issue 23
Upconverting NIR Photons for Bioimaging
journal, December 2015
- Li, Zhanjun; Zhang, Yuanwei; La, Hieu
- Nanomaterials, Vol. 5, Issue 4
Carbon-Dot-Decorated TiO 2 Nanotubes toward Photodynamic Therapy Based on Water-Splitting Mechanism
journal, March 2018
- Yang, Dan; Yang, Guixin; Sun, Qianqian
- Advanced Healthcare Materials, Vol. 7, Issue 10
Glutathione Activatable Photosensitizer-Conjugated Pseudopolyrotaxane Nanocarriers for Photodynamic Theranostics
journal, September 2016
- Tong, Hongxin; Chen, Yangjun; Li, Zuhong
- Small, Vol. 12, Issue 45
Revisiting the optimized doping ratio in core/shell nanostructured upconversion particles
journal, January 2017
- Shen, Bin; Cheng, Shengming; Gu, Yuyang
- Nanoscale, Vol. 9, Issue 5
Blue Te Nanoneedles with Strong NIR Photothermal and Laser-Enhanced Anticancer Effects as “All-in-One” Nanoagents for Synergistic Thermo-Chemotherapy of Tumors
journal, August 2018
- Yu, Nuo; Li, Jinning; Wang, Zhaojie
- Advanced Healthcare Materials, Vol. 7, Issue 21
A “win–win” nanoplatform: TiO 2 :Yb,Ho,F for NIR light-induced synergistic therapy and imaging
journal, January 2017
- Zhou, Jie; Luo, Pei; Sun, Chong
- Nanoscale, Vol. 9, Issue 12
Metal-Organic-Framework-Derived Mesoporous Carbon Nanospheres Containing Porphyrin-Like Metal Centers for Conformal Phototherapy
journal, July 2016
- Wang, Shunhao; Shang, Lu; Li, Linlin
- Advanced Materials, Vol. 28, Issue 38
Advances in highly doped upconversion nanoparticles
journal, June 2018
- Wen, Shihui; Zhou, Jiajia; Zheng, Kezhi
- Nature Communications, Vol. 9, Issue 1
Low power density 980 nm-driven ultrabright red-emitting upconversion nanoparticles via synergetic Yb 3+ /Tm 3+ cascade-sensitization
journal, January 2019
- Liu, Jiao; Wu, Shihong; Chu, Huiyuan
- Journal of Materials Chemistry C, Vol. 7, Issue 43
Novel Bioactive and Therapeutic Dental Polymeric Materials to Inhibit Periodontal Pathogens and Biofilms
journal, January 2019
- Chi, Minghan; Qi, Manlin; A., Lan
- International Journal of Molecular Sciences, Vol. 20, Issue 2
Luminescent Rare-earth-based Nanoparticles: A Summarized Overview of their Synthesis, Functionalization, and Applications
journal, July 2016
- Escudero, Alberto; Carrillo-Carrión, Carolina; Zyuzin, Mikhail V.
- Topics in Current Chemistry, Vol. 374, Issue 4
Dynamically tuning near-infrared-induced photothermal performances of TiO 2 nanocrystals by Nb doping for imaging-guided photothermal therapy of tumors
journal, January 2017
- Yu, Nuo; Hu, Yong; Wang, Xiaoyong
- Nanoscale, Vol. 9, Issue 26
Prospects For Application of Upconversion Particles NaYF4:Er,Yb for Phototherapy [ПЕРСПЕКТИВЫ ПРИМЕНЕНИЯ АПКОНВЕРСИОННЫХ ЧАСТИЦ NaYF4:Er,Yb ДЛЯ ФОТОТЕРАПИИ]
journal, January 2018
- Kochubey, V. I.; Sagaidachnaya, Е. А.; Yanina, I. Yu.
- Izvestiya of Saratov University. New Series. Series: Physics, Vol. 18, Issue 4
Interconversion between KSc 2 F 7 :Yb/Er and K 2 NaScF 6 :Yb/Er nanocrystals: the role of chemistry
journal, January 2018
- Wang, Yangbo; Yang, Bingxiao; Chen, Kun
- Dalton Transactions, Vol. 47, Issue 14
BiVO 4 as highly efficient host for near-infrared to visible upconversion
journal, January 2019
- Regmi, Chhabilal; Kshetri, Yuwaraj K.; Jeong, Sang Hoon
- Journal of Applied Physics, Vol. 125, Issue 4
Facile Phototherapeutic Nanoplatform by Integrating a Multifunctional Polymer and MnO 2 for Enhancing Tumor Synergistic Therapy
journal, June 2019
- Zhao, Menglong; Xie, Mingjuan; Guo, Jungu
- Advanced Healthcare Materials, Vol. 8, Issue 15
Confining energy migration in upconversion nanoparticles towards deep ultraviolet lasing
journal, January 2016
- Chen, Xian; Jin, Limin; Kong, Wei
- Nature Communications, Vol. 7, Issue 1
Lanthanide upconversion luminescence at the nanoscale: fundamentals and optical properties
journal, January 2016
- Nadort, Annemarie; Zhao, Jiangbo; Goldys, Ewa M.
- Nanoscale, Vol. 8, Issue 27
Recent Advancements in Ln‐Ion‐Based Upconverting Nanomaterials and Their Biological Applications
journal, July 2019
- Chhetri, Bijay P.; Karmakar, Alokita; Ghosh, Anindya
- Particle & Particle Systems Characterization, Vol. 36, Issue 8
Effect of Tm3+ Concentration on the Generation of Reactive Oxygen Species in NaYb1 – xF4${\text{Tm}}_{x}^{{3 + }}$$ for the Multifunctional Photosensitizer
journal, December 2019
- Zhang, J. Y.; Wang, Q. Y.; Liang, H.
- Russian Journal of Physical Chemistry A, Vol. 93, Issue 13
Au Nanoclusters Sensitized Black TiO 2− x Nanotubes for Enhanced Photodynamic Therapy Driven by Near-Infrared Light
journal, November 2017
- Yang, Dan; Gulzar, Arif; Yang, Guixin
- Small, Vol. 13, Issue 48
Responsive Assembly of Upconversion Nanoparticles for pH‐Activated and Near‐Infrared‐Triggered Photodynamic Therapy of Deep Tumors
journal, July 2018
- Li, Fangyuan; Du, Yang; Liu, Jianan
- Advanced Materials, Vol. 30, Issue 35
Nanocarriers and Their Loading Strategies
journal, November 2018
- Wang, Neng; Cheng, Xuejun; Li, Nan
- Advanced Healthcare Materials, Vol. 8, Issue 6
NIR/blue light emission optimization of NaY 1−(x+y) Yb x F 4 :Tm y upconversion nanoparticles via Yb 3+ /Tm 3+ dopant balancing
journal, January 2018
- Bagheri, Ali; Li, Zheye; Boyer, Cyrille
- Dalton Transactions, Vol. 47, Issue 26
Near-Infrared-Triggered Photodynamic Therapy toward Breast Cancer Cells Using Dendrimer-Functionalized Upconversion Nanoparticles
journal, September 2017
- Wang, Bing-Yen; Liao, Ming-Liang; Hong, Guan-Ci
- Nanomaterials, Vol. 7, Issue 9
Gold and Hairpin DNA Functionalization of Upconversion Nanocrystals for Imaging and In Vivo Drug Delivery
journal, March 2017
- Han, Sanyang; Samanta, Animesh; Xie, Xiaoji
- Advanced Materials, Vol. 29, Issue 18
Delivery of a hydrophobic phthalocyanine photosensitizer using PEGylated gold nanoparticle conjugates for the in vivo photodynamic therapy of amelanotic melanoma
journal, January 2016
- Camerin, Monica; Moreno, Miguel; Marín, María J.
- Photochemical & Photobiological Sciences, Vol. 15, Issue 5
A Nd 3+ sensitized upconversion nanosystem with dual photosensitizers for improving photodynamic therapy efficacy
journal, January 2019
- Yang, Man; Wang, Han; Wang, Zhaohui
- Biomaterials Science, Vol. 7, Issue 4
Fine-tuning of multiple upconversion emissions by controlling the crystal phase and morphology between GdF 3 :Yb 3+ ,Tm 3+ and GdOF:Yb 3+ ,Tm 3+ nanocrystals
journal, January 2017
- Zhu, Yongsheng; Bi, Dongqin; Wang, Huiqiao
- RSC Advances, Vol. 7, Issue 5
Enhanced red up-conversion luminescence in La4−x−yGd10Ge2B6O34:Ybx,Ery synthesized by the liquid-phase homogenization with tartaric acid
journal, July 2019
- Krut’ko, V. A.; Komova, M. G.; Pominova, D. V.
- Journal of Sol-Gel Science and Technology, Vol. 92, Issue 2
Confining Excitation Energy in Er 3+ -Sensitized Upconversion Nanocrystals through Tm 3+ -Mediated Transient Energy Trapping
journal, May 2017
- Chen, Qiushui; Xie, Xiaoji; Huang, Bolong
- Angewandte Chemie, Vol. 129, Issue 26
One pot synthesis and systematic study of the photophysical and magnetic properties and thermal sensing of α and β-phase NaLnF 4 and β-phase core@shell nanoparticles
journal, January 2018
- Rodrigues, E. M.; Gálico, D. A.; Lemes, M. A.
- New Journal of Chemistry, Vol. 42, Issue 16
Anti-Stokes shift luminescent materials for bio-applications
journal, January 2017
- Zhu, Xingjun; Su, Qianqian; Feng, Wei
- Chemical Society Reviews, Vol. 46, Issue 4
Direct optical lithography of functional inorganic nanomaterials
journal, July 2017
- Wang, Yuanyuan; Fedin, Igor; Zhang, Hao
- Science, Vol. 357, Issue 6349
Emerging blood–brain-barrier-crossing nanotechnology for brain cancer theranostics
journal, January 2019
- Tang, Wei; Fan, Wenpei; Lau, Joseph
- Chemical Society Reviews, Vol. 48, Issue 11
Halogenated Aza-BODIPY for Imaging-Guided Synergistic Photodynamic and Photothermal Tumor Therapy
journal, July 2018
- Zhao, Menglong; Xu, Yunjian; Xie, Mingjuan
- Advanced Healthcare Materials, Vol. 7, Issue 18
Ultrasmall Biocompatible WO 3− x Nanodots for Multi-Modality Imaging and Combined Therapy of Cancers
journal, May 2016
- Wen, Ling; Chen, Ling; Zheng, Shimin
- Advanced Materials, Vol. 28, Issue 25
Near-Infrared-Triggered Azobenzene-Liposome/Upconversion Nanoparticle Hybrid Vesicles for Remotely Controlled Drug Delivery to Overcome Cancer Multidrug Resistance
journal, August 2016
- Yao, Chi; Wang, Peiyuan; Li, Xiaomin
- Advanced Materials, Vol. 28, Issue 42
NaYbF 4 @CaF 2 core–satellite upconversion nanoparticles: one-pot synthesis and sensitive detection of glutathione
journal, January 2018
- Chen, Bing; Wang, Feng
- Nanoscale, Vol. 10, Issue 42
Biomimetic nanoflowers by self-assembly of nanozymes to induce intracellular oxidative damage against hypoxic tumors
journal, August 2018
- Wang, Zhenzhen; Zhang, Yan; Ju, Enguo
- Nature Communications, Vol. 9, Issue 1
Enhancing Photodynamic Therapy through Resonance Energy Transfer Constructed Near-Infrared Photosensitized Nanoparticles
journal, June 2017
- Huang, Ling; Li, Zhanjun; Zhao, Yang
- Advanced Materials, Vol. 29, Issue 28
Near-infrared photoactivatable control of Ca2+ signaling and optogenetic immunomodulation
journal, December 2015
- He, Lian; Zhang, Yuanwei; Ma, Guolin
- eLife, Vol. 4
Recent advances in the synthesis and application of Yb-based fluoride upconversion nanoparticles
journal, January 2020
- Chen, Bing; Wang, Feng
- Inorganic Chemistry Frontiers, Vol. 7, Issue 5
Design of an intelligent sub-50 nm nuclear-targeting nanotheranostic system for imaging guided intranuclear radiosensitization
journal, January 2015
- Fan, Wenpei; Shen, Bo; Bu, Wenbo
- Chemical Science, Vol. 6, Issue 3
Confining Excitation Energy in Er 3+ -Sensitized Upconversion Nanocrystals through Tm 3+ -Mediated Transient Energy Trapping
journal, May 2017
- Chen, Qiushui; Xie, Xiaoji; Huang, Bolong
- Angewandte Chemie International Edition, Vol. 56, Issue 26
Gold and Hairpin DNA Functionalization of Upconversion Nanocrystals for Imaging and In Vivo Drug Delivery
journal, October 2017
- Han, Sanyang; Samanta, Animesh; Xie, Xiaoji
- Advanced Materials, Vol. 29, Issue 40
Confining energy migration in upconversion nanoparticles towards deep ultraviolet lasing
journal, January 2016
- Chen, Xian; Jin, Limin; Kong, Wei
- Nature Communications, Vol. 7, Issue 1
Advances in highly doped upconversion nanoparticles
journal, June 2018
- Wen, Shihui; Zhou, Jiajia; Zheng, Kezhi
- Nature Communications, Vol. 9, Issue 1
Biomimetic nanoflowers by self-assembly of nanozymes to induce intracellular oxidative damage against hypoxic tumors
journal, August 2018
- Wang, Zhenzhen; Zhang, Yan; Ju, Enguo
- Nature Communications, Vol. 9, Issue 1
Plasmonic Nanoparticle-based Hybrid Photosensitizers with Broadened Excitation Profile for Photodynamic Therapy of Cancer Cells
journal, October 2016
- Wang, Peng; Tang, Hong; Zhang, Peng
- Scientific Reports, Vol. 6, Issue 1
Design of an intelligent sub-50 nm nuclear-targeting nanotheranostic system for imaging guided intranuclear radiosensitization
journal, January 2015
- Fan, Wenpei; Shen, Bo; Bu, Wenbo
- Chemical Science, Vol. 6, Issue 3
Manipulating energy transfer in lanthanide-doped single nanoparticles for highly enhanced upconverting luminescence
journal, January 2017
- Zhuo, Zhu; Liu, Yongsheng; Liu, Dajiu
- Chemical Science, Vol. 8, Issue 7
Strong Light-Field Driven Nanolasers
text, January 2019
- Hollinger, Richard; Malevich, Pavel; Shumakova, Valentina
- GSI Helmholtzzentrum fuer Schwerionenforschung, GSI, Darmstadt
Novel Bioactive and Therapeutic Dental Polymeric Materials to Inhibit Periodontal Pathogens and Biofilms
journal, January 2019
- Chi, Minghan; Qi, Manlin; A., Lan
- International Journal of Molecular Sciences, Vol. 20, Issue 2
Upconverting NIR Photons for Bioimaging
journal, December 2015
- Li, Zhanjun; Zhang, Yuanwei; La, Hieu
- Nanomaterials, Vol. 5, Issue 4
Near-Infrared-Triggered Photodynamic Therapy toward Breast Cancer Cells Using Dendrimer-Functionalized Upconversion Nanoparticles
journal, September 2017
- Wang, Bing-Yen; Liao, Ming-Liang; Hong, Guan-Ci
- Nanomaterials, Vol. 7, Issue 9
Core-Shell Nanostars for Multimodal Therapy and Imaging
journal, January 2016
- Li, Mengyuan; Li, Lele; Zhan, Changyou
- Theranostics, Vol. 6, Issue 13
Nanoscale “fluorescent stone”: Luminescent Calcium Fluoride Nanoparticles as Theranostic Platforms
journal, January 2016
- Li, Zhanjun; Zhang, Yuanwei; Huang, Ling
- Theranostics, Vol. 6, Issue 13
O2-generating MnO2 nanoparticles for enhanced photodynamic therapy of bladder cancer by ameliorating hypoxia
journal, January 2018
- Lin, Tingsheng; Zhao, Xiaozhi; Zhao, Sheng
- Theranostics, Vol. 8, Issue 4
Near-infrared photoactivatable control of Ca2+ signaling and optogenetic immunomodulation
journal, December 2015
- He, Lian; Zhang, Yuanwei; Ma, Guolin
- eLife, Vol. 4