skip to main content
DOE PAGES title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Amplifying the Red-Emission of Upconverting Nanoparticles for Biocompatible Clinically Used Prodrug-Induced Photodynamic Therapy

Abstract

A class of biocompatible upconverting nanoparticles (UCNPs) with largely amplified red-emissions was developed. The optimal UCNP shows a high absolute upconversion quantum yield of 3.2% in red-emission, which is 15-fold stronger than the known optimal β-phase core/shell UCNPs. When conjugated to aminolevulinic acid, a clinically used photodynamic therapy (PDT) prodrug, significant PDT effect in tumor was demonstrated in a deep-tissue (>1.2 cm) setting in vivo at a biocompatible laser power density. Furthermore, we show that our UCNP–PDT system with NIR irradiation outperforms clinically used red light irradiation in a deep tumor setting in vivo. This study marks a major step forward in photodynamic therapy utilizing UCNPs to effectively access deep-set tumors.Lastly, it also provides an opportunity for the wide application of upconverting red radiation in photonics and biophotonics.

Authors:
 [1];  [2];  [1];  [1];  [1];  [1];  [3];  [3];  [4];  [5];  [1]
  1. Univ. of Massachusetts, Amherst, MA (United States)
  2. Univ. of Massachusetts, Amherst, MA (United States); Dalian Univ. of Technology, Dalian (China)
  3. Soochow Univ., Suzhou, Jiangsu (China)
  4. Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Molecular Foundry
  5. Dalian Univ. of Technology, Dalian (China)
Publication Date:
Research Org.:
Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
Sponsoring Org.:
USDOE Office of Science (SC), Basic Energy Sciences (BES)
OSTI Identifier:
1257361
Grant/Contract Number:  
AC02-05CH11231; R01MH103133; RGY0090/2014
Resource Type:
Accepted Manuscript
Journal Name:
ACS Nano
Additional Journal Information:
Journal Volume: 8; Journal Issue: 10; Journal ID: ISSN 1936-0851
Publisher:
American Chemical Society
Country of Publication:
United States
Language:
English
Subject:
77 NANOSCIENCE AND NANOTECHNOLOGY; upconverting; nanoparticles; red-emission; prodrug; photodynamic therapy

Citation Formats

Punjabi, Amol, Wu, Xiang, Tokatli-Apollon, Amira, El-Rifai, Mahmoud, Lee, Hyungseok, Zhang, Yuanwei, Wang, Chao, Liu, Zhuang, Chan, Emory M., Duan, Chunying, and Han, Gang. Amplifying the Red-Emission of Upconverting Nanoparticles for Biocompatible Clinically Used Prodrug-Induced Photodynamic Therapy. United States: N. p., 2014. Web. doi:10.1021/nn505051d.
Punjabi, Amol, Wu, Xiang, Tokatli-Apollon, Amira, El-Rifai, Mahmoud, Lee, Hyungseok, Zhang, Yuanwei, Wang, Chao, Liu, Zhuang, Chan, Emory M., Duan, Chunying, & Han, Gang. Amplifying the Red-Emission of Upconverting Nanoparticles for Biocompatible Clinically Used Prodrug-Induced Photodynamic Therapy. United States. doi:10.1021/nn505051d.
Punjabi, Amol, Wu, Xiang, Tokatli-Apollon, Amira, El-Rifai, Mahmoud, Lee, Hyungseok, Zhang, Yuanwei, Wang, Chao, Liu, Zhuang, Chan, Emory M., Duan, Chunying, and Han, Gang. Thu . "Amplifying the Red-Emission of Upconverting Nanoparticles for Biocompatible Clinically Used Prodrug-Induced Photodynamic Therapy". United States. doi:10.1021/nn505051d. https://www.osti.gov/servlets/purl/1257361.
@article{osti_1257361,
title = {Amplifying the Red-Emission of Upconverting Nanoparticles for Biocompatible Clinically Used Prodrug-Induced Photodynamic Therapy},
author = {Punjabi, Amol and Wu, Xiang and Tokatli-Apollon, Amira and El-Rifai, Mahmoud and Lee, Hyungseok and Zhang, Yuanwei and Wang, Chao and Liu, Zhuang and Chan, Emory M. and Duan, Chunying and Han, Gang},
abstractNote = {A class of biocompatible upconverting nanoparticles (UCNPs) with largely amplified red-emissions was developed. The optimal UCNP shows a high absolute upconversion quantum yield of 3.2% in red-emission, which is 15-fold stronger than the known optimal β-phase core/shell UCNPs. When conjugated to aminolevulinic acid, a clinically used photodynamic therapy (PDT) prodrug, significant PDT effect in tumor was demonstrated in a deep-tissue (>1.2 cm) setting in vivo at a biocompatible laser power density. Furthermore, we show that our UCNP–PDT system with NIR irradiation outperforms clinically used red light irradiation in a deep tumor setting in vivo. This study marks a major step forward in photodynamic therapy utilizing UCNPs to effectively access deep-set tumors.Lastly, it also provides an opportunity for the wide application of upconverting red radiation in photonics and biophotonics.},
doi = {10.1021/nn505051d},
journal = {ACS Nano},
number = 10,
volume = 8,
place = {United States},
year = {2014},
month = {9}
}

Journal Article:
Free Publicly Available Full Text
Publisher's Version of Record

Citation Metrics:
Cited by: 107 works
Citation information provided by
Web of Science

Save / Share:

Works referencing / citing this record:

Direct optical lithography of functional inorganic nanomaterials
journal, July 2017


Prospects For Application of Upconversion Particles NaYF4:Er,Yb for Phototherapy [ПЕРСПЕКТИВЫ ПРИМЕНЕНИЯ АПКОНВЕРСИОННЫХ ЧАСТИЦ NaYF4:Er,Yb ДЛЯ ФОТОТЕРАПИИ]
journal, January 2018


Direct optical lithography of functional inorganic nanomaterials
journal, July 2017


Prospects For Application of Upconversion Particles NaYF4:Er,Yb for Phototherapy [ПЕРСПЕКТИВЫ ПРИМЕНЕНИЯ АПКОНВЕРСИОННЫХ ЧАСТИЦ NaYF4:Er,Yb ДЛЯ ФОТОТЕРАПИИ]
journal, January 2018


Near-Infrared-Triggered Photodynamic Therapy toward Breast Cancer Cells Using Dendrimer-Functionalized Upconversion Nanoparticles
journal, September 2017

  • Wang, Bing-Yen; Liao, Ming-Liang; Hong, Guan-Ci
  • Nanomaterials, Vol. 7, Issue 9
  • DOI: 10.3390/nano7090269

Carbon-Dot-Decorated TiO 2 Nanotubes toward Photodynamic Therapy Based on Water-Splitting Mechanism
journal, March 2018

  • Yang, Dan; Yang, Guixin; Sun, Qianqian
  • Advanced Healthcare Materials, Vol. 7, Issue 10
  • DOI: 10.1002/adhm.201800042

Halogenated Aza-BODIPY for Imaging-Guided Synergistic Photodynamic and Photothermal Tumor Therapy
journal, July 2018

  • Zhao, Menglong; Xu, Yunjian; Xie, Mingjuan
  • Advanced Healthcare Materials, Vol. 7, Issue 18
  • DOI: 10.1002/adhm.201800606

Nanocarriers and Their Loading Strategies
journal, November 2018

  • Wang, Neng; Cheng, Xuejun; Li, Nan
  • Advanced Healthcare Materials, Vol. 8, Issue 6
  • DOI: 10.1002/adhm.201801002

Facile Phototherapeutic Nanoplatform by Integrating a Multifunctional Polymer and MnO 2 for Enhancing Tumor Synergistic Therapy
journal, June 2019

  • Zhao, Menglong; Xie, Mingjuan; Guo, Jungu
  • Advanced Healthcare Materials, Vol. 8, Issue 15
  • DOI: 10.1002/adhm.201900414

Ultrasmall Biocompatible WO 3− x Nanodots for Multi-Modality Imaging and Combined Therapy of Cancers
journal, May 2016


Metal-Organic-Framework-Derived Mesoporous Carbon Nanospheres Containing Porphyrin-Like Metal Centers for Conformal Phototherapy
journal, July 2016


Enhancing Photodynamic Therapy through Resonance Energy Transfer Constructed Near-Infrared Photosensitized Nanoparticles
journal, June 2017


Gold and Hairpin DNA Functionalization of Upconversion Nanocrystals for Imaging and In Vivo Drug Delivery
journal, March 2017

  • Han, Sanyang; Samanta, Animesh; Xie, Xiaoji
  • Advanced Materials, Vol. 29, Issue 18
  • DOI: 10.1002/adma.201700244

Confining Excitation Energy in Er 3+ -Sensitized Upconversion Nanocrystals through Tm 3+ -Mediated Transient Energy Trapping
journal, May 2017


Upconversion in Nanostructured Materials: From Optical Tuning to Biomedical Applications
journal, January 2018

  • Sun, Tianying; Ai, Fujin; Zhu, Guangyu
  • Chemistry - An Asian Journal, Vol. 13, Issue 4
  • DOI: 10.1002/asia.201701660

Recent Advancements in Ln‐Ion‐Based Upconverting Nanomaterials and Their Biological Applications
journal, July 2019

  • Chhetri, Bijay P.; Karmakar, Alokita; Ghosh, Anindya
  • Particle & Particle Systems Characterization, Vol. 36, Issue 8
  • DOI: 10.1002/ppsc.201900153

Glutathione Activatable Photosensitizer-Conjugated Pseudopolyrotaxane Nanocarriers for Photodynamic Theranostics
journal, September 2016


Au Nanoclusters Sensitized Black TiO 2− x Nanotubes for Enhanced Photodynamic Therapy Driven by Near-Infrared Light
journal, November 2017


Insight into the efficiency of oxygen introduced photodynamic therapy (PDT) and deep PDT against cancers with various assembled nanocarriers
journal, September 2019

  • Zhao, Jie; Duan, Li; Wang, Anhe
  • WIREs Nanomedicine and Nanobiotechnology, Vol. 12, Issue 1
  • DOI: 10.1002/wnan.1583

Enhanced red up-conversion luminescence in La4−x−yGd10Ge2B6O34:Ybx,Ery synthesized by the liquid-phase homogenization with tartaric acid
journal, July 2019

  • Krut’ko, V. A.; Komova, M. G.; Pominova, D. V.
  • Journal of Sol-Gel Science and Technology, Vol. 92, Issue 2
  • DOI: 10.1007/s10971-019-05082-4

Luminescent Rare-earth-based Nanoparticles: A Summarized Overview of their Synthesis, Functionalization, and Applications
journal, July 2016

  • Escudero, Alberto; Carrillo-Carrión, Carolina; Zyuzin, Mikhail V.
  • Topics in Current Chemistry, Vol. 374, Issue 4
  • DOI: 10.1007/s41061-016-0049-8

Confining energy migration in upconversion nanoparticles towards deep ultraviolet lasing
journal, January 2016

  • Chen, Xian; Jin, Limin; Kong, Wei
  • Nature Communications, Vol. 7, Issue 1
  • DOI: 10.1038/ncomms10304

Advances in highly doped upconversion nanoparticles
journal, June 2018


Biomimetic nanoflowers by self-assembly of nanozymes to induce intracellular oxidative damage against hypoxic tumors
journal, August 2018


Design of an intelligent sub-50 nm nuclear-targeting nanotheranostic system for imaging guided intranuclear radiosensitization
journal, January 2015

  • Fan, Wenpei; Shen, Bo; Bu, Wenbo
  • Chemical Science, Vol. 6, Issue 3
  • DOI: 10.1039/c4sc03080j

Lanthanide upconversion luminescence at the nanoscale: fundamentals and optical properties
journal, January 2016

  • Nadort, Annemarie; Zhao, Jiangbo; Goldys, Ewa M.
  • Nanoscale, Vol. 8, Issue 27
  • DOI: 10.1039/c5nr08477f

Delivery of a hydrophobic phthalocyanine photosensitizer using PEGylated gold nanoparticle conjugates for the in vivo photodynamic therapy of amelanotic melanoma
journal, January 2016

  • Camerin, Monica; Moreno, Miguel; Marín, María J.
  • Photochemical & Photobiological Sciences, Vol. 15, Issue 5
  • DOI: 10.1039/c5pp00463b

Reactive oxygen species generating systems meeting challenges of photodynamic cancer therapy
journal, January 2016

  • Zhou, Zijian; Song, Jibin; Nie, Liming
  • Chemical Society Reviews, Vol. 45, Issue 23
  • DOI: 10.1039/c6cs00271d

Anti-Stokes shift luminescent materials for bio-applications
journal, January 2017

  • Zhu, Xingjun; Su, Qianqian; Feng, Wei
  • Chemical Society Reviews, Vol. 46, Issue 4
  • DOI: 10.1039/c6cs00415f

Overcoming the Achilles' heel of photodynamic therapy
journal, January 2016

  • Fan, Wenpei; Huang, Peng; Chen, Xiaoyuan
  • Chemical Society Reviews, Vol. 45, Issue 23
  • DOI: 10.1039/c6cs00616g

Revisiting the optimized doping ratio in core/shell nanostructured upconversion particles
journal, January 2017

  • Shen, Bin; Cheng, Shengming; Gu, Yuyang
  • Nanoscale, Vol. 9, Issue 5
  • DOI: 10.1039/c6nr07687d

A “win–win” nanoplatform: TiO 2 :Yb,Ho,F for NIR light-induced synergistic therapy and imaging
journal, January 2017


Interconversion between KSc 2 F 7 :Yb/Er and K 2 NaScF 6 :Yb/Er nanocrystals: the role of chemistry
journal, January 2018

  • Wang, Yangbo; Yang, Bingxiao; Chen, Kun
  • Dalton Transactions, Vol. 47, Issue 14
  • DOI: 10.1039/c7dt04658h

NIR/blue light emission optimization of NaY 1−(x+y) Yb x F 4 :Tm y upconversion nanoparticles via Yb 3+ /Tm 3+ dopant balancing
journal, January 2018

  • Bagheri, Ali; Li, Zheye; Boyer, Cyrille
  • Dalton Transactions, Vol. 47, Issue 26
  • DOI: 10.1039/c7dt04768a

An upconversion nanoplatform with extracellular pH-driven tumor-targeting ability for improved photodynamic therapy
journal, January 2018


Recent progress in upconversion luminescence nanomaterials for biomedical applications
journal, January 2018

  • Duan, Chengchen; Liang, Liuen; Li, Li
  • Journal of Materials Chemistry B, Vol. 6, Issue 2
  • DOI: 10.1039/c7tb02527k

Recent advances in the synthesis and application of Yb-based fluoride upconversion nanoparticles
journal, January 2020

  • Chen, Bing; Wang, Feng
  • Inorganic Chemistry Frontiers, Vol. 7, Issue 5
  • DOI: 10.1039/c9qi01358j

Near-infrared photoactivatable control of Ca2+ signaling and optogenetic immunomodulation
journal, December 2015