Block Copolymer Membranes for Efficient Capture of a Chemotherapy Drug
Abstract
We introduce the use of block copolymer membranes for an emerging application, "drug capture". The polymer is incorporated in a new class of biomedical devices, referred to as ChemoFilter, which is an image-guided temporarily deployable endovascular device designed to increase the efficacy of chemotherapy-based cancer treatment. We show that block copolymer membranes consisting of functional sulfonated polystyrene end blocks and a structural polyethylene middle block (S-SES) are capable of capturing doxorubicin, a chemotherapy drug. We focus on the relationship between morphology of the membrane in the ChemoFilter device and efficacy of doxorubicin capture measured in vitro. Using small-angle X-ray scattering and cryogenic scanning transmission electron microscopy, we discovered that rapid doxorubicin capture is associated with the presence of water-rich channels in the lamellar-forming S-SES membranes in aqueous environment.
- Authors:
-
- Department of Chemical and Biomolecular Engineering, University of California−Berkeley, Berkeley, California 94720, United States
- Department of Radiology and Biomedical Imaging, University of California−San Francisco, San Francisco, California 94107, United States
- Publication Date:
- Research Org.:
- Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States); University of California, Berkeley, CA (United States); Univ. of California, San Francisco, CA (United States)
- Sponsoring Org.:
- USDOE Office of Science (SC), Basic Energy Sciences (BES); National Inst. of Health (NIH) (United States)
- OSTI Identifier:
- 1271469
- Alternate Identifier(s):
- OSTI ID: 1314044; OSTI ID: 1373378; OSTI ID: 1474958
- Report Number(s):
- LBNL-1005980
Journal ID: ISSN 2161-1653
- Grant/Contract Number:
- AC02-05CH11231; 1R01CA194533; 1R41CA183327
- Resource Type:
- Published Article
- Journal Name:
- ACS Macro Letters
- Additional Journal Information:
- Journal Name: ACS Macro Letters Journal Volume: 5 Journal Issue: 8; Journal ID: ISSN 2161-1653
- Publisher:
- American Chemical Society (ACS)
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 36 MATERIALS SCIENCE; 37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
Citation Formats
Chen, X. Chelsea, Oh, Hee Jeung, Yu, Jay F., Yang, Jeffrey K., Petzetakis, Nikos, Patel, Anand S., Hetts, Steven W., and Balsara, Nitash P. Block Copolymer Membranes for Efficient Capture of a Chemotherapy Drug. United States: N. p., 2016.
Web. doi:10.1021/acsmacrolett.6b00459.
Chen, X. Chelsea, Oh, Hee Jeung, Yu, Jay F., Yang, Jeffrey K., Petzetakis, Nikos, Patel, Anand S., Hetts, Steven W., & Balsara, Nitash P. Block Copolymer Membranes for Efficient Capture of a Chemotherapy Drug. United States. https://doi.org/10.1021/acsmacrolett.6b00459
Chen, X. Chelsea, Oh, Hee Jeung, Yu, Jay F., Yang, Jeffrey K., Petzetakis, Nikos, Patel, Anand S., Hetts, Steven W., and Balsara, Nitash P. Sat .
"Block Copolymer Membranes for Efficient Capture of a Chemotherapy Drug". United States. https://doi.org/10.1021/acsmacrolett.6b00459.
@article{osti_1271469,
title = {Block Copolymer Membranes for Efficient Capture of a Chemotherapy Drug},
author = {Chen, X. Chelsea and Oh, Hee Jeung and Yu, Jay F. and Yang, Jeffrey K. and Petzetakis, Nikos and Patel, Anand S. and Hetts, Steven W. and Balsara, Nitash P.},
abstractNote = {We introduce the use of block copolymer membranes for an emerging application, "drug capture". The polymer is incorporated in a new class of biomedical devices, referred to as ChemoFilter, which is an image-guided temporarily deployable endovascular device designed to increase the efficacy of chemotherapy-based cancer treatment. We show that block copolymer membranes consisting of functional sulfonated polystyrene end blocks and a structural polyethylene middle block (S-SES) are capable of capturing doxorubicin, a chemotherapy drug. We focus on the relationship between morphology of the membrane in the ChemoFilter device and efficacy of doxorubicin capture measured in vitro. Using small-angle X-ray scattering and cryogenic scanning transmission electron microscopy, we discovered that rapid doxorubicin capture is associated with the presence of water-rich channels in the lamellar-forming S-SES membranes in aqueous environment.},
doi = {10.1021/acsmacrolett.6b00459},
journal = {ACS Macro Letters},
number = 8,
volume = 5,
place = {United States},
year = {Sat Jul 23 00:00:00 EDT 2016},
month = {Sat Jul 23 00:00:00 EDT 2016}
}
https://doi.org/10.1021/acsmacrolett.6b00459
Web of Science
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