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Title: 3D Printed Absorber for Capturing Chemotherapy Drugs before They Spread through the Body

Abstract

Despite efforts to develop increasingly targeted and personalized cancer therapeutics, dosing of drugs in cancer chemotherapy is limited by systemic toxic side effects. We have designed, built, and deployed porous absorbers for capturing chemotherapy drugs from the bloodstream after these drugs have had their effect on a tumor, but before they are released into the body where they can cause hazardous side effects. The support structure of the absorbers was built using 3D printing technology. This structure was coated with a nanostructured block copolymer with outer blocks that anchor the polymer chains to the 3D printed support structure and a middle block that has an affinity for the drug. The middle block is polystyrenesulfonate which binds to doxorubicin, a widely used and effective chemotherapy drug with significant toxic side effects. The absorbers are designed for deployment during chemotherapy using minimally invasive image-guided endovascular surgical procedures. We show that the introduction of the absorbers into the blood of swine models enables the capture of 64 ± 6% of the administered drug (doxorubicin) without any immediate adverse effects. Problems related to blood clots, vein wall dissection, and other biocompatibility issues were not observed. This development represents a significant step forward in minimizingmore » toxic side effects of chemotherapy.« less

Authors:
ORCiD logo [1];  [2];  [1]; ORCiD logo [1]; ORCiD logo [1]; ORCiD logo [3]; ORCiD logo [3];  [2];  [2];  [2];  [4];  [4];  [5];  [2]; ORCiD logo [1]
  1. Univ. of California, Berkeley, CA (United States)
  2. Univ. of California, San Francisco, CA (United States)
  3. Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
  4. Carbon, Inc., Redwood City, CA (United States)
  5. Carbon, Inc., Redwood City, CA (United States); Univ. of North Carolina, Chapel Hill, NC (United States); North Carolina State Univ., Raleigh, NC (United States)
Publication Date:
Research Org.:
Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
Sponsoring Org.:
USDOE Office of Science (SC), Basic Energy Sciences (BES) (SC-22)
OSTI Identifier:
1559189
Grant/Contract Number:  
AC02-05CH11231
Resource Type:
Accepted Manuscript
Journal Name:
ACS Central Science
Additional Journal Information:
Journal Volume: 5; Journal Issue: 3; Journal ID: ISSN 2374-7943
Publisher:
American Chemical Society (ACS)
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES; 59 BASIC BIOLOGICAL SCIENCES

Citation Formats

Oh, Hee Jeung, Aboian, Mariam S., Yi, Michael Y. J., Maslyn, Jacqueline A., Loo, Whitney S., Jiang, Xi, Parkinson, Dilworth Y., Wilson, Mark W., Moore, Terilyn, Yee, Colin R., Robbins, Gregory R., Barth, Florian M., DeSimone, Joseph M., Hetts, Steven W., and Balsara, Nitash P. 3D Printed Absorber for Capturing Chemotherapy Drugs before They Spread through the Body. United States: N. p., 2019. Web. doi:10.1021/acscentsci.8b00700.
Oh, Hee Jeung, Aboian, Mariam S., Yi, Michael Y. J., Maslyn, Jacqueline A., Loo, Whitney S., Jiang, Xi, Parkinson, Dilworth Y., Wilson, Mark W., Moore, Terilyn, Yee, Colin R., Robbins, Gregory R., Barth, Florian M., DeSimone, Joseph M., Hetts, Steven W., & Balsara, Nitash P. 3D Printed Absorber for Capturing Chemotherapy Drugs before They Spread through the Body. United States. doi:10.1021/acscentsci.8b00700.
Oh, Hee Jeung, Aboian, Mariam S., Yi, Michael Y. J., Maslyn, Jacqueline A., Loo, Whitney S., Jiang, Xi, Parkinson, Dilworth Y., Wilson, Mark W., Moore, Terilyn, Yee, Colin R., Robbins, Gregory R., Barth, Florian M., DeSimone, Joseph M., Hetts, Steven W., and Balsara, Nitash P. Wed . "3D Printed Absorber for Capturing Chemotherapy Drugs before They Spread through the Body". United States. doi:10.1021/acscentsci.8b00700. https://www.osti.gov/servlets/purl/1559189.
@article{osti_1559189,
title = {3D Printed Absorber for Capturing Chemotherapy Drugs before They Spread through the Body},
author = {Oh, Hee Jeung and Aboian, Mariam S. and Yi, Michael Y. J. and Maslyn, Jacqueline A. and Loo, Whitney S. and Jiang, Xi and Parkinson, Dilworth Y. and Wilson, Mark W. and Moore, Terilyn and Yee, Colin R. and Robbins, Gregory R. and Barth, Florian M. and DeSimone, Joseph M. and Hetts, Steven W. and Balsara, Nitash P.},
abstractNote = {Despite efforts to develop increasingly targeted and personalized cancer therapeutics, dosing of drugs in cancer chemotherapy is limited by systemic toxic side effects. We have designed, built, and deployed porous absorbers for capturing chemotherapy drugs from the bloodstream after these drugs have had their effect on a tumor, but before they are released into the body where they can cause hazardous side effects. The support structure of the absorbers was built using 3D printing technology. This structure was coated with a nanostructured block copolymer with outer blocks that anchor the polymer chains to the 3D printed support structure and a middle block that has an affinity for the drug. The middle block is polystyrenesulfonate which binds to doxorubicin, a widely used and effective chemotherapy drug with significant toxic side effects. The absorbers are designed for deployment during chemotherapy using minimally invasive image-guided endovascular surgical procedures. We show that the introduction of the absorbers into the blood of swine models enables the capture of 64 ± 6% of the administered drug (doxorubicin) without any immediate adverse effects. Problems related to blood clots, vein wall dissection, and other biocompatibility issues were not observed. This development represents a significant step forward in minimizing toxic side effects of chemotherapy.},
doi = {10.1021/acscentsci.8b00700},
journal = {ACS Central Science},
number = 3,
volume = 5,
place = {United States},
year = {2019},
month = {1}
}

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