Filovirus pathogenesis and immune evasion: insights from Ebola virus and Marburg virus
Abstract
Ebola viruses and Marburg viruses, members of the filovirus family, are zoonotic pathogens that cause severe disease in people, as highlighted by the latest Ebola virus epidemic in West Africa. Filovirus disease is characterized by uncontrolled virus replication and the activation of host responses that contribute to pathogenesis. Underlying these phenomena is the potent suppression of host innate antiviral responses, particularly the type I interferon response, by viral proteins, which allows high levels of viral replication. Here, in this Review, we describe the mechanisms used by filoviruses to block host innate immunity and discuss the links between immune evasion and filovirus pathogenesis.
- Authors:
-
- Univ. of California, Riverside, CA (United States)
- Washington Univ., St. Louis, MO (United States)
- Icahn School of Medicine at Mount Sinai, New York, NY (United States)
- Publication Date:
- Research Org.:
- Argonne National Laboratory (ANL), Argonne, IL (United States)
- Sponsoring Org.:
- U.S. Department of Defense and the Defense Threat Reduction Agency; National Institutes of Health (NIH)
- OSTI Identifier:
- 1351402
- Grant/Contract Number:
- U19 AI109945; R01 AI059536; U19 AI109664; U19 AI070489; R01 AI081914; HDTRA1-12-1-0051; HDTRA1-14-1-0013
- Resource Type:
- Accepted Manuscript
- Journal Name:
- Nature Reviews Microbiology
- Additional Journal Information:
- Journal Volume: 13; Journal Issue: 11; Journal ID: ISSN 1740-1526
- Publisher:
- Springer Nature
- Country of Publication:
- United States
- Language:
- ENGLISH
- Subject:
- 60 APPLIED LIFE SCIENCES; Ebola virus; Marburg virus; Viral immune evasion; Viral pathogenesis; Virus-host interactions; Virus structures
Citation Formats
Messaoudi, Ilhem, Amarasinghe, Gaya K., and Basler, Christopher F. Filovirus pathogenesis and immune evasion: insights from Ebola virus and Marburg virus. United States: N. p., 2015.
Web. doi:10.1038/nrmicro3524.
Messaoudi, Ilhem, Amarasinghe, Gaya K., & Basler, Christopher F. Filovirus pathogenesis and immune evasion: insights from Ebola virus and Marburg virus. United States. https://doi.org/10.1038/nrmicro3524
Messaoudi, Ilhem, Amarasinghe, Gaya K., and Basler, Christopher F. Tue .
"Filovirus pathogenesis and immune evasion: insights from Ebola virus and Marburg virus". United States. https://doi.org/10.1038/nrmicro3524. https://www.osti.gov/servlets/purl/1351402.
@article{osti_1351402,
title = {Filovirus pathogenesis and immune evasion: insights from Ebola virus and Marburg virus},
author = {Messaoudi, Ilhem and Amarasinghe, Gaya K. and Basler, Christopher F.},
abstractNote = {Ebola viruses and Marburg viruses, members of the filovirus family, are zoonotic pathogens that cause severe disease in people, as highlighted by the latest Ebola virus epidemic in West Africa. Filovirus disease is characterized by uncontrolled virus replication and the activation of host responses that contribute to pathogenesis. Underlying these phenomena is the potent suppression of host innate antiviral responses, particularly the type I interferon response, by viral proteins, which allows high levels of viral replication. Here, in this Review, we describe the mechanisms used by filoviruses to block host innate immunity and discuss the links between immune evasion and filovirus pathogenesis.},
doi = {10.1038/nrmicro3524},
journal = {Nature Reviews Microbiology},
number = 11,
volume = 13,
place = {United States},
year = {Tue Oct 06 00:00:00 EDT 2015},
month = {Tue Oct 06 00:00:00 EDT 2015}
}
Web of Science
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