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Title: Di-macrocyclic terephthalamide ligands as chelators for the PET radionuclide zirconium-89

Abstract

The development of bifunctional chelators (BFCs) which can stably chelate zirconium-89 ((89)Zr) while being conjugated to targeting molecules is an area of active research. Herein we report the first octadentate terephthalamide ligands, which are easily radiolabeled with (89)Zr and are highly stable in vitro. Lastly, they represent a novel class of chelators, which are worthy of further development as BFCs for (89)Zr.

Authors:
 [1];  [2];  [3];  [2];  [1]
  1. Wake Forest, Winston-Salem, NC (United States). School of Medicine
  2. Lumiphore, Inc., Berkeley, CA (United States)
  3. Univ. of California, Berkeley, CA (United States). Dept. of Chemistry
Publication Date:
Research Org.:
Washington Univ., St. Louis, MO (United States). School of Medicine
Sponsoring Org.:
USDOE Office of Science (SC), Nuclear Physics (NP) (SC-26)
OSTI Identifier:
1347094
Grant/Contract Number:  
SC0008657; IIP-1215462
Resource Type:
Accepted Manuscript
Journal Name:
ChemComm
Additional Journal Information:
Journal Volume: 51; Journal Issue: 12; Journal ID: ISSN 1359-7345
Publisher:
Royal Society of Chemistry
Country of Publication:
United States
Language:
English
Subject:
37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY

Citation Formats

Pandya, Darpan N., Pailloux, Sylvie, Tatum, David, Magda, Darren, and Wadas, Thaddeus J. Di-macrocyclic terephthalamide ligands as chelators for the PET radionuclide zirconium-89. United States: N. p., 2014. Web. doi:10.1039/c4cc09256b.
Pandya, Darpan N., Pailloux, Sylvie, Tatum, David, Magda, Darren, & Wadas, Thaddeus J. Di-macrocyclic terephthalamide ligands as chelators for the PET radionuclide zirconium-89. United States. doi:10.1039/c4cc09256b.
Pandya, Darpan N., Pailloux, Sylvie, Tatum, David, Magda, Darren, and Wadas, Thaddeus J. Thu . "Di-macrocyclic terephthalamide ligands as chelators for the PET radionuclide zirconium-89". United States. doi:10.1039/c4cc09256b. https://www.osti.gov/servlets/purl/1347094.
@article{osti_1347094,
title = {Di-macrocyclic terephthalamide ligands as chelators for the PET radionuclide zirconium-89},
author = {Pandya, Darpan N. and Pailloux, Sylvie and Tatum, David and Magda, Darren and Wadas, Thaddeus J.},
abstractNote = {The development of bifunctional chelators (BFCs) which can stably chelate zirconium-89 ((89)Zr) while being conjugated to targeting molecules is an area of active research. Herein we report the first octadentate terephthalamide ligands, which are easily radiolabeled with (89)Zr and are highly stable in vitro. Lastly, they represent a novel class of chelators, which are worthy of further development as BFCs for (89)Zr.},
doi = {10.1039/c4cc09256b},
journal = {ChemComm},
number = 12,
volume = 51,
place = {United States},
year = {2014},
month = {12}
}

Journal Article:
Free Publicly Available Full Text
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Cited by: 17 works
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