Di-macrocyclic terephthalamide ligands as chelators for the PET radionuclide zirconium-89
Abstract
The development of bifunctional chelators (BFCs) which can stably chelate zirconium-89 ((89)Zr) while being conjugated to targeting molecules is an area of active research. Herein we report the first octadentate terephthalamide ligands, which are easily radiolabeled with (89)Zr and are highly stable in vitro. Lastly, they represent a novel class of chelators, which are worthy of further development as BFCs for (89)Zr.
- Authors:
-
- Wake Forest, Winston-Salem, NC (United States). School of Medicine
- Lumiphore, Inc., Berkeley, CA (United States)
- Univ. of California, Berkeley, CA (United States). Dept. of Chemistry
- Publication Date:
- Research Org.:
- Washington Univ., St. Louis, MO (United States). School of Medicine
- Sponsoring Org.:
- USDOE Office of Science (SC), Nuclear Physics (NP)
- OSTI Identifier:
- 1347094
- Grant/Contract Number:
- SC0008657; IIP-1215462
- Resource Type:
- Accepted Manuscript
- Journal Name:
- ChemComm
- Additional Journal Information:
- Journal Volume: 51; Journal Issue: 12; Journal ID: ISSN 1359-7345
- Publisher:
- Royal Society of Chemistry
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
Citation Formats
Pandya, Darpan N., Pailloux, Sylvie, Tatum, David, Magda, Darren, and Wadas, Thaddeus J. Di-macrocyclic terephthalamide ligands as chelators for the PET radionuclide zirconium-89. United States: N. p., 2014.
Web. doi:10.1039/c4cc09256b.
Pandya, Darpan N., Pailloux, Sylvie, Tatum, David, Magda, Darren, & Wadas, Thaddeus J. Di-macrocyclic terephthalamide ligands as chelators for the PET radionuclide zirconium-89. United States. https://doi.org/10.1039/c4cc09256b
Pandya, Darpan N., Pailloux, Sylvie, Tatum, David, Magda, Darren, and Wadas, Thaddeus J. Thu .
"Di-macrocyclic terephthalamide ligands as chelators for the PET radionuclide zirconium-89". United States. https://doi.org/10.1039/c4cc09256b. https://www.osti.gov/servlets/purl/1347094.
@article{osti_1347094,
title = {Di-macrocyclic terephthalamide ligands as chelators for the PET radionuclide zirconium-89},
author = {Pandya, Darpan N. and Pailloux, Sylvie and Tatum, David and Magda, Darren and Wadas, Thaddeus J.},
abstractNote = {The development of bifunctional chelators (BFCs) which can stably chelate zirconium-89 ((89)Zr) while being conjugated to targeting molecules is an area of active research. Herein we report the first octadentate terephthalamide ligands, which are easily radiolabeled with (89)Zr and are highly stable in vitro. Lastly, they represent a novel class of chelators, which are worthy of further development as BFCs for (89)Zr.},
doi = {10.1039/c4cc09256b},
journal = {ChemComm},
number = 12,
volume = 51,
place = {United States},
year = {Thu Dec 18 00:00:00 EST 2014},
month = {Thu Dec 18 00:00:00 EST 2014}
}
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