Di-macrocyclic terephthalamide ligands as chelators for the PET radionuclide zirconium-89

Pandya, Darpan N.; Pailloux, Sylvie; Tatum, David; Magda, Darren; Wadas, Thaddeus J.

doi:10.1039/c4cc09256b

Title: Di-macrocyclic terephthalamide ligands as chelators for the PET radionuclide zirconium-89

Journal Article · Thu Dec 18 04:00:00 UTC 2014 · ChemComm

DOI: https://doi.org/10.1039/c4cc09256b · OSTI ID:1347094

Pandya, Darpan N. ^[1]; Pailloux, Sylvie ^[2]; Tatum, David ^[3]; Magda, Darren ^[2]; Wadas, Thaddeus J. ^[4]

Wake Forest, Winston-Salem, NC (United States). School of Medicine; DOE Office of Scientific and Technical Information (OSTI)
Lumiphore, Inc., Berkeley, CA (United States)
Univ. of California, Berkeley, CA (United States). Dept. of Chemistry
Wake Forest, Winston-Salem, NC (United States). School of Medicine

The development of bifunctional chelators (BFCs) which can stably chelate zirconium-89 ((89)Zr) while being conjugated to targeting molecules is an area of active research. Herein we report the first octadentate terephthalamide ligands, which are easily radiolabeled with (89)Zr and are highly stable in vitro. Lastly, they represent a novel class of chelators, which are worthy of further development as BFCs for (89)Zr.

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Research Organization:: Washington Univ., St. Louis, MO (United States). School of Medicine

Sponsoring Organization:: USDOE Office of Science (SC), Nuclear Physics (NP) (SC-26)

Grant/Contract Number:: SC0008657

OSTI ID:: 1347094

Journal Information:: ChemComm, Journal Name: ChemComm Journal Issue: 12 Vol. 51; ISSN CHCOFS; ISSN 1359-7345

Publisher:: Royal Society of ChemistryCopyright Statement

Country of Publication:: United States

Language:: English

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Evaluation of a 3-hydroxypyridin-2-one (2,3-HOPO) Based Macrocyclic Chelator for ⁸⁹ Zr ⁴⁺ and Its Use for ImmunoPET Imaging of HER2 Positive Model of Ovarian Carcinoma in Mice N. Tinianow, Jeff; Pandya, Darpan N.; Pailloux, Sylvie L. Theranostics, Vol. 6, Issue 4 https://doi.org/10.7150/thno.14261	journal	January 2016
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Direct comparison of the in vitro and in vivo stability of DFO, DFO* and DFOcyclo* for 89Zr-immunoPET Raavé, René; Sandker, Gerwin; Adumeau, Pierre European Journal of Nuclear Medicine and Molecular Imaging, Vol. 46, Issue 9 https://doi.org/10.1007/s00259-019-04343-2	journal	June 2019
The study of Zr adsorption on nanodispersed hydroxyapatite: X-ray photoelectron study Teterin, Yuri A.; Kazakov, Andrey G.; Teterin, Anton Yu Journal of Radioanalytical and Nuclear Chemistry, Vol. 321, Issue 1 https://doi.org/10.1007/s10967-019-06586-7	journal	June 2019
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Zirconium tetraazamacrocycle complexes display extraordinary stability and provide a new strategy for zirconium-89-based radiopharmaceutical development Hong, Yuan,; Ulrich, Bierbach,; J., Wadas, Thaddeus The University of North Carolina at Chapel Hill University Libraries https://doi.org/10.17615/7nnh-vb76	text	January 2017
Rational Design, Synthesis and Preliminary Evaluation of Novel Fusarinine C-Based Chelators for Radiolabeling with Zirconium-89 Zhai, Chuangyan; He, Shanzhen; Ye, Yunjie Biomolecules, Vol. 9, Issue 3 https://doi.org/10.3390/biom9030091	journal	March 2019

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