DOE PAGES title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Exploiting Bioprocessing Fluctuations to Elicit the Mechanistics of De Novo Lipogenesis in Yarrowia lipolytica

Journal Article · · PLoS ONE

Not Available

Research Organization:
Massachusetts Inst. of Technology (MIT), Cambridge, MA (United States)
Sponsoring Organization:
USDOE; USDOE Office of Science (SC)
Grant/Contract Number:
SC0008744
OSTI ID:
1338431
Journal Information:
PLoS ONE, Journal Name: PLoS ONE Journal Issue: 1 Vol. 12; ISSN 1932-6203
Publisher:
Public Library of Science (PLoS)Copyright Statement
Country of Publication:
United States
Language:
English

References (50)

Factors underlying the variability of lipid droplet fluorescence in MA-10 leydig tumor cells journal October 1994
Metabolic Fluxes and Metabolic Engineering journal January 1999
Enzyme kinetics for a two-step enzymic reaction with comparable initial enzyme-substrate ratios journal December 1988
Identification and characterization of DGA2, an acyltransferase of the DGAT1 acyl-CoA:diacylglycerol acyltransferase family in the oleaginous yeast Yarrowia lipolytica. New insights into the storage lipid metabolism of oleaginous yeasts journal August 2011
Functional overexpression and characterization of lipogenesis-related genes in the oleaginous yeast Yarrowia lipolytica journal February 2016
The biogenesis and functions of lipid bodies in animals, plants and microorganisms journal September 2001
Using Fluctuation Analysis to Establish Causal Relations between Cellular Events without Experimental Perturbation journal December 2014
The life cycle of lipid droplets journal April 2015
Open Questions in Lipid Droplet Biology journal January 2014
Cell-to-Cell Heterogeneity in Lipid Droplets Suggests a Mechanism to Reduce Lipotoxicity journal August 2013
Triacylglycerol Synthesis Enzymes Mediate Lipid Droplet Growth by Relocalizing from the ER to Lipid Droplets journal February 2013
Engineering the push and pull of lipid biosynthesis in oleaginous yeast Yarrowia lipolytica for biofuel production journal January 2013
Review of methods to probe single cell metabolism and bioenergetics journal January 2015
An evolutionary metabolic engineering approach for enhancing lipogenesis in Yarrowia lipolytica journal May 2015
The oxidative pentose phosphate pathway is the primary source of NADPH for lipid overproduction from glucose in Yarrowia lipolytica journal July 2015
Accumulation of High-Value Lipids in Single-Cell Microorganisms: A Mechanistic Approach and Future Perspectives journal March 2014
Summing up the noise in gene networks journal January 2004
Single-cell proteomic analysis of S. cerevisiae reveals the architecture of biological noise journal May 2006
Central dogma at the single-molecule level in living cells journal July 2011
Stochasticity of metabolism and growth at the single-cell level journal September 2014
Inhibition of eukaryotic translation elongation by cycloheximide and lactimidomycin journal January 2010
Regulation of noise in the expression of a single gene journal April 2002
Regulation of amino-acid metabolism controls flux to lipid accumulation in Yarrowia lipolytica journal March 2016
Stochasticity in gene expression: from theories to phenotypes journal May 2005
Lipid droplets: a unified view of a dynamic organelle journal March 2006
The biophysics and cell biology of lipid droplets journal November 2013
Origins of Cell-to-Cell Bioprocessing Diversity and Implications of the Extracellular Environment Revealed at the Single-Cell Level journal December 2015
Microchemostat—microbial continuous culture in a polymer-based, instrumented microbioreactor journal January 2006
Single microbe trap and release in sub-microfluidics journal January 2013
A trap-and-release integrated microfluidic system for dynamic microarray applications journal January 2007
Stochastic effects are important in intrahost HIV evolution even when viral loads are high journal October 2012
Heterogeneity in protein expression induces metabolic variability in a modeled Escherichia coli population journal August 2013
Enzyme Induction as an All-Or-None Phenomenon journal July 1957
Visualization of yeast cells by electron microscopy journal January 2012
Yeast lipid metabolism at a glance journal March 2014
Stochastic Gene Expression in a Single Cell journal August 2002
Challenges in Engineering Microbes for Biofuels Production journal February 2007
Using Gene Expression Noise to Understand Gene Regulation journal April 2012
The Innate Growth Bistability and Fitness Landscapes of Antibiotic-Resistant Bacteria journal November 2013
Single-Cell Metabolomics: Analytical and Biological Perspectives journal December 2013
Lost in Transition: Start-Up of Glycolysis Yields Subpopulations of Nongrowing Cells journal January 2014
Control of Lipid Accumulation in the Yeast Yarrowia lipolytica journal October 2008
It Is All about Metabolic Fluxes journal December 2003
Lipid Droplets and Cellular Lipid Metabolism journal July 2012
Emerging Roles for Lipid Droplets in Immunity and Host-Pathogen Interactions journal November 2012
Vesicle Photonics journal July 2013
Lipophagy: Connecting Autophagy and Lipid Metabolism journal January 2012
Lipid droplets are functionally connected to the endoplasmic reticulum in Saccharomyces cerevisiae journal June 2011
Transcriptomic Analyses during the Transition from Biomass Production to Lipid Accumulation in the Oleaginous Yeast Yarrowia lipolytica journal November 2011
Target of Rapamycin (TOR) in Nutrient Signaling and Growth Control journal December 2011