A biokinetic model for systemic nickel

Journal Article · Sun Jan 01 04:00:00 UTC 2017 · Health Physics

DOI: https://doi.org/10.1097/HP.0000000000000579 · OSTI ID:1336598

Melo, Dunstana ^[1]; Leggett, Richard Wayne ^[2]

---

1. Melohill Technology LLC, Rockville, MD (United States)
2. Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

The International Commission on Radiological Protection (ICRP) is updating its suite of reference biokinetic models for internally deposited radionuclides. This paper reviews data for nickel and proposes an updated biokinetic model for systemic (absorbed) nickel in adult humans for use in radiation protection. Compared with the ICRP s current model for nickel, the proposed model is based on a larger set of observations of the behavior of nickel in human subjects and laboratory animals and provides a more realistic description of the paths of movement of nickel in the body. For the two most important radioisotopes of nickel, 59Ni and 63Ni, the proposed model yields substantially lower dose estimates per unit of activity reaching blood than the current ICRP model.

• Research Organization: Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)
• Sponsoring Organization: ORNL work for others
• Grant/Contract Number: AC05-00OR22725
• OSTI ID: 1336598
• Journal Information: Health Physics, Journal Name: Health Physics Journal Issue: 1 Vol. 112; ISSN 0017-9078
• Publisher: Health Physics SocietyCopyright Statement
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
biokinetics nickel occupational exposure radionuclides