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Title: A biokinetic model for systemic nickel

The International Commission on Radiological Protection (ICRP) is updating its suite of reference biokinetic models for internally deposited radionuclides. This paper reviews data for nickel and proposes an updated biokinetic model for systemic (absorbed) nickel in adult humans for use in radiation protection. Compared with the ICRP s current model for nickel, the proposed model is based on a larger set of observations of the behavior of nickel in human subjects and laboratory animals and provides a more realistic description of the paths of movement of nickel in the body. For the two most important radioisotopes of nickel, 59Ni and 63Ni, the proposed model yields substantially lower dose estimates per unit of activity reaching blood than the current ICRP model.
Authors:
 [1] ;  [2]
  1. Melohill Technology LLC, Rockville, MD (United States)
  2. Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
Publication Date:
Grant/Contract Number:
AC05-00OR22725
Type:
Accepted Manuscript
Journal Name:
Health Physics
Additional Journal Information:
Journal Volume: 112; Journal Issue: 1; Journal ID: ISSN 0017-9078
Publisher:
Health Physics Society
Research Org:
Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
Sponsoring Org:
Work for Others (WFO)
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; biokinetics nickel occupational exposure radionuclides
OSTI Identifier:
1336598

Melo, Dunstana, and Leggett, Richard Wayne. A biokinetic model for systemic nickel. United States: N. p., Web. doi:10.1097/HP.0000000000000579.
Melo, Dunstana, & Leggett, Richard Wayne. A biokinetic model for systemic nickel. United States. doi:10.1097/HP.0000000000000579.
Melo, Dunstana, and Leggett, Richard Wayne. 2017. "A biokinetic model for systemic nickel". United States. doi:10.1097/HP.0000000000000579. https://www.osti.gov/servlets/purl/1336598.
@article{osti_1336598,
title = {A biokinetic model for systemic nickel},
author = {Melo, Dunstana and Leggett, Richard Wayne},
abstractNote = {The International Commission on Radiological Protection (ICRP) is updating its suite of reference biokinetic models for internally deposited radionuclides. This paper reviews data for nickel and proposes an updated biokinetic model for systemic (absorbed) nickel in adult humans for use in radiation protection. Compared with the ICRP s current model for nickel, the proposed model is based on a larger set of observations of the behavior of nickel in human subjects and laboratory animals and provides a more realistic description of the paths of movement of nickel in the body. For the two most important radioisotopes of nickel, 59Ni and 63Ni, the proposed model yields substantially lower dose estimates per unit of activity reaching blood than the current ICRP model.},
doi = {10.1097/HP.0000000000000579},
journal = {Health Physics},
number = 1,
volume = 112,
place = {United States},
year = {2017},
month = {1}
}