Title: Block Copolymer Membranes for Efficient Capture of a Chemotherapy Drug

Abstract

We introduce the use of block copolymer membranes for an emerging application, "drug capture". The polymer is incorporated in a new class of biomedical devices, referred to as ChemoFilter, which is an image-guided temporarily deployable endovascular device designed to increase the efficacy of chemotherapy-based cancer treatment. We show that block copolymer membranes consisting of functional sulfonated polystyrene end blocks and a structural polyethylene middle block (S-SES) are capable of capturing doxorubicin, a chemotherapy drug. We focus on the relationship between morphology of the membrane in the ChemoFilter device and efficacy of doxorubicin capture measured in vitro. Using small-angle X-ray scattering and cryogenic scanning transmission electron microscopy, we discovered that rapid doxorubicin capture is associated with the presence of water-rich channels in the lamellar-forming S-SES membranes in aqueous environment.

Authors:

Chen, X. Chelsea ^[1]; Oh, Hee Jeung ^[1]; Yu, Jay F. ^[2]; Yang, Jeffrey K. ^[2]; Petzetakis, Nikos ^[1]; Patel, Anand S. ^[2]; Hetts, Steven W. ^[2]; Balsara, Nitash P. ^[1]

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+ Show Author Affiliations

1. Department of Chemical and Biomolecular Engineering, University of California−Berkeley, Berkeley, California 94720, United States
2. Department of Radiology and Biomedical Imaging, University of California−San Francisco, San Francisco, California 94107, United States

Publication Date:

Sat Jul 23 00:00:00 EDT 2016

Research Org.:

Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States); University of California, Berkeley, CA (United States); Univ. of California, San Francisco, CA (United States)

Sponsoring Org.:

USDOE Office of Science (SC), Basic Energy Sciences (BES); National Inst. of Health (NIH) (United States)

OSTI Identifier:

1271469

Alternate Identifier(s):

OSTI ID: 1314044; OSTI ID: 1373378; OSTI ID: 1474958

Report Number(s):

LBNL-1005980
Journal ID: ISSN 2161-1653

Grant/Contract Number:  

AC02-05CH11231; 1R01CA194533; 1R41CA183327

Resource Type:

Published Article

Journal Name:

ACS Macro Letters

Additional Journal Information:

Journal Name: ACS Macro Letters Journal Volume: 5 Journal Issue: 8; Journal ID: ISSN 2161-1653

Publisher:

American Chemical Society (ACS)

Country of Publication:

United States

Language:

English

Subject:

36 MATERIALS SCIENCE; 37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY