DOE PAGES title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: X-ray structure and inhibition of the feline infectious peritonitis virus 3C-like protease: Structural implications for drug design

Authors:
; ; ; ; ;
Publication Date:
Sponsoring Org.:
USDOE
OSTI Identifier:
1250605
Grant/Contract Number:  
AC02-06CH11357
Resource Type:
Publisher's Accepted Manuscript
Journal Name:
Bioorganic and Medicinal Chemistry Letters
Additional Journal Information:
Journal Name: Bioorganic and Medicinal Chemistry Letters Journal Volume: 25 Journal Issue: 22; Journal ID: ISSN 0960-894X
Publisher:
Elsevier
Country of Publication:
United Kingdom
Language:
English

Citation Formats

St. John, Sarah E., Therkelsen, Matthew D., Nyalapatla, Prasanth R., Osswald, Heather L., Ghosh, Arun K., and Mesecar, Andrew D. X-ray structure and inhibition of the feline infectious peritonitis virus 3C-like protease: Structural implications for drug design. United Kingdom: N. p., 2015. Web. doi:10.1016/j.bmcl.2015.10.023.
St. John, Sarah E., Therkelsen, Matthew D., Nyalapatla, Prasanth R., Osswald, Heather L., Ghosh, Arun K., & Mesecar, Andrew D. X-ray structure and inhibition of the feline infectious peritonitis virus 3C-like protease: Structural implications for drug design. United Kingdom. https://doi.org/10.1016/j.bmcl.2015.10.023
St. John, Sarah E., Therkelsen, Matthew D., Nyalapatla, Prasanth R., Osswald, Heather L., Ghosh, Arun K., and Mesecar, Andrew D. Sun . "X-ray structure and inhibition of the feline infectious peritonitis virus 3C-like protease: Structural implications for drug design". United Kingdom. https://doi.org/10.1016/j.bmcl.2015.10.023.
@article{osti_1250605,
title = {X-ray structure and inhibition of the feline infectious peritonitis virus 3C-like protease: Structural implications for drug design},
author = {St. John, Sarah E. and Therkelsen, Matthew D. and Nyalapatla, Prasanth R. and Osswald, Heather L. and Ghosh, Arun K. and Mesecar, Andrew D.},
abstractNote = {},
doi = {10.1016/j.bmcl.2015.10.023},
journal = {Bioorganic and Medicinal Chemistry Letters},
number = 22,
volume = 25,
place = {United Kingdom},
year = {Sun Nov 01 00:00:00 EDT 2015},
month = {Sun Nov 01 00:00:00 EDT 2015}
}

Journal Article:
Free Publicly Available Full Text
Publisher's Version of Record
https://doi.org/10.1016/j.bmcl.2015.10.023

Citation Metrics:
Cited by: 13 works
Citation information provided by
Web of Science

Save / Share:

Works referenced in this record:

Potent inhibition of feline coronaviruses with peptidyl compounds targeting coronavirus 3C-like protease
journal, February 2013


Genomic RNA sequence of Feline coronavirus strain FIPV WSU-79/1146
journal, August 2005

  • Dye, Charlotte; Siddell, Stuart G.
  • Journal of General Virology, Vol. 86, Issue 8
  • DOI: 10.1099/vir.0.80985-0

Feline coronavirus antibodies in cats
journal, August 1992


Evaluating the 3C-like protease activity of SARS-Coronavirus: Recommendations for standardized assays for drug discovery
journal, April 2008


Feline infectious peritonitis
journal, January 2005


Exposure to FIV and FIPV in wild and captive cheetahs
journal, January 1993

  • Brown, Eric W.; Olmsted, Robert A.; Martenson, Janice S.
  • Zoo Biology, Vol. 12, Issue 1
  • DOI: 10.1002/zoo.1430120112

Broad-Spectrum Inhibitors against 3C-Like Proteases of Feline Coronaviruses and Feline Caliciviruses
journal, February 2015

  • Kim, Yunjeong; Shivanna, Vinay; Narayanan, Sanjeev
  • Journal of Virology, Vol. 89, Issue 9
  • DOI: 10.1128/JVI.03688-14

Coot model-building tools for molecular graphics
journal, November 2004

  • Emsley, Paul; Cowtan, Kevin
  • Acta Crystallographica Section D Biological Crystallography, Vol. 60, Issue 12, p. 2126-2132
  • DOI: 10.1107/S0907444904019158

Pathogenesis of feline enteric coronavirus infection
journal, December 2008

  • Pedersen, Niels C.; Allen, Claire E.; Lyons, Leslie A.
  • Journal of Feline Medicine and Surgery, Vol. 10, Issue 6
  • DOI: 10.1016/j.jfms.2008.02.006

Features and development of Coot
journal, March 2010

  • Emsley, P.; Lohkamp, B.; Scott, W. G.
  • Acta Crystallographica Section D Biological Crystallography, Vol. 66, Issue 4
  • DOI: 10.1107/S0907444910007493

Design, synthesis, and bioevaluation of viral 3C and 3C-like protease inhibitors
journal, December 2013

  • Prior, Allan M.; Kim, Yunjeong; Weerasekara, Sahani
  • Bioorganic & Medicinal Chemistry Letters, Vol. 23, Issue 23
  • DOI: 10.1016/j.bmcl.2013.09.070

Feline Infectious Peritonitis Viruses Arise by Mutation from Endemic Feline Enteric Coronaviruses
journal, March 1998


Completion of the Porcine Epidemic Diarrhoea Coronavirus (PEDV) Genome Sequence
journal, January 2001

  • Kocherhans, Rolf; Bridgen, Anne; Ackermann, Mathias
  • Virus Genes, Vol. 23, Issue 2, p. 137-144
  • DOI: 10.1023/A:1011831902219

Broad-Spectrum Antivirals against 3C or 3C-Like Proteases of Picornaviruses, Noroviruses, and Coronaviruses
journal, August 2012

  • Kim, Y.; Lovell, S.; Tiew, K. -C.
  • Journal of Virology, Vol. 86, Issue 21
  • DOI: 10.1128/JVI.01348-12

Pathogenic characteristics of persistent feline enteric coronavirus infection in cats
journal, July 2010

  • Vogel, Liesbeth; Van der Lubben, Mariken; Te Lintelo, Eddie G.
  • Veterinary Research, Vol. 41, Issue 5
  • DOI: 10.1051/vetres/2010043

Design and Synthesis of Peptidomimetic Severe Acute Respiratory Syndrome Chymotrypsin-like Protease Inhibitors
journal, November 2005

  • Ghosh, Arun K.; Xi, Kai; Ratia, Kiira
  • Journal of Medicinal Chemistry, Vol. 48, Issue 22
  • DOI: 10.1021/jm050548m

PHENIX: a comprehensive Python-based system for macromolecular structure solution
journal, January 2010

  • Adams, Paul D.; Afonine, Pavel V.; Bunkóczi, Gábor
  • Acta Crystallographica Section D Biological Crystallography, Vol. 66, Issue 2, p. 213-221
  • DOI: 10.1107/S0907444909052925