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Title: X-Ray Structure and Inhibition of 3C-like Protease from Porcine Epidemic Diarrhea Virus

Journal Article · · Scientific Reports
DOI:https://doi.org/10.1038/srep25961· OSTI ID:1253809
; ;  [1]
  1. Purdue
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Research Organization:
Argonne National Laboratory (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Sponsoring Organization:
National Institutes of Health (NIH)
OSTI ID:
1253809
Journal Information:
Scientific Reports, Vol. 6, Issue 05, 2016; ISSN 2045-2322
Country of Publication:
United States
Language:
ENGLISH

References (22)

Mechanism of the Maturation Process of SARS-CoV 3CL Protease journal March 2005
Coronavirus Main Proteinase (3CLpro) Structure: Basis for Design of Anti-SARS Drugs journal June 2003
An apparently new syndrome of porcine epidemic diarrhoea journal March 1977
PHENIX: a comprehensive Python-based system for macromolecular structure solution. text January 2010
Emergence of Porcine epidemic diarrhea virus in the United States: clinical signs, lesions, and viral genomic sequences journal July 2013
Porcine epidemic diarrhoea virus: a comprehensive review of molecular epidemiology, diagnosis, and vaccines journal January 2012
Structural Basis of Inhibition Specificities of 3C and 3C-like Proteases by Zinc-coordinating and Peptidomimetic Compounds journal January 2009
Propagation of the virus of porcine epidemic diarrhea in cell culture. journal January 1988
Structure of coronavirus main proteinase reveals combination of a chymotrypsin fold with an extra alpha-helical domain journal July 2002
Design of Wide-Spectrum Inhibitors Targeting Coronavirus Main Proteases journal September 2005
Features and development of Coot journal March 2010
Completion of the Porcine Epidemic Diarrhoea Coronavirus (PEDV) Genome Sequence journal January 2001
PHENIX: a comprehensive Python-based system for macromolecular structure solution journal January 2010
Long-Range Cooperative Interactions Modulate Dimerization in SARS 3CL pro † journal December 2006
Identification of the membrane protein of porcine epidemic diarrhea virus journal June 1995
Occurrence and investigation of enteric viral infections in pigs with diarrhea in China journal March 2013
Discovery, Synthesis, And Structure-Based Optimization of a Series of N -( tert -Butyl)-2-( N -arylamido)-2-(pyridin-3-yl) Acetamides (ML188) as Potent Noncovalent Small Molecule Inhibitors of the Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) 3CL Protease journal January 2013
X-ray structure and inhibition of the feline infectious peritonitis virus 3C-like protease: Structural implications for drug design journal November 2015
Structure of the SARS coronavirus main proteinase as an active C 2 crystallographic dimer journal October 2005
Genome Sequences of Porcine Epidemic Diarrhea Virus: In Vivo and In Vitro Phenotypes journal May 2014
Orbital Steering in the Catalytic Power of Enzymes: Small Structural Changes with Large Catalytic Consequences journal July 1997
[20] Processing of X-ray diffraction data collected in oscillation mode book January 1997

Cited By (1)

Porcine Epidemic Diarrhea Virus 3C-Like Protease-Mediated Nucleocapsid Processing: Possible Link to Viral Cell Culture Adaptability journal November 2016

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