Continuous Succinic Acid Production by Actinobacillus succinogenes on Xylose-Enriched Hydrolysate
Abstract
Bio-manufacturing of high-value chemicals in parallel to renewable biofuels has the potential to dramatically improve the overall economic landscape of integrated lignocellulosic biorefineries. However, this will require the generation of carbohydrate streams from lignocellulose in a form suitable for efficient microbial conversion and downstream processing appropriate to the desired end use, making overall process development, along with selection of appropriate target molecules, crucial to the integrated biorefinery. Succinic acid (SA), a high-value target molecule, can be biologically produced from sugars and has the potential to serve as a platform chemical for various chemical and polymer applications. However, the feasibility of microbial SA production at industrially relevant productivities and yields from lignocellulosic biorefinery streams has not yet been reported.
- Authors:
-
- Univ. of Pretoria, Hatfield (South Africa); National Renewable Energy Lab. (NREL), Golden, CO (United States)
- National Renewable Energy Lab. (NREL), Golden, CO (United States)
- Univ. of Pretoria, Hatfield (South Africa)
- Publication Date:
- Research Org.:
- National Renewable Energy Lab. (NREL), Golden, CO (United States)
- Sponsoring Org.:
- USDOE Office of Energy Efficiency and Renewable Energy (EERE), Transportation Office. Bioenergy Technologies Office
- OSTI Identifier:
- 1233689
- Report Number(s):
- NREL/JA-5100-65596
Journal ID: ISSN 1754-6834
- Grant/Contract Number:
- AC36-08GO28308
- Resource Type:
- Accepted Manuscript
- Journal Name:
- Biotechnology for Biofuels
- Additional Journal Information:
- Journal Volume: 8; Related Information: Biotechnology for Biofuels; Journal ID: ISSN 1754-6834
- Publisher:
- BioMed Central
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 09 BIOMASS FUELS; biorefinery; Actinobacillus succinogenes; succinic acid; continuous fermentation; corn stover hydrolysates
Citation Formats
Bradfield, Michael F. A., Mohagheghi, Ali, Salvachua, Davinia, Smith, Holly, Black, Brenna A., Dowe, Nancy, Beckham, Gregg T., and Nicol, Willie. Continuous Succinic Acid Production by Actinobacillus succinogenes on Xylose-Enriched Hydrolysate. United States: N. p., 2015.
Web. doi:10.1186/s13068-015-0363-3.
Bradfield, Michael F. A., Mohagheghi, Ali, Salvachua, Davinia, Smith, Holly, Black, Brenna A., Dowe, Nancy, Beckham, Gregg T., & Nicol, Willie. Continuous Succinic Acid Production by Actinobacillus succinogenes on Xylose-Enriched Hydrolysate. United States. doi:10.1186/s13068-015-0363-3.
Bradfield, Michael F. A., Mohagheghi, Ali, Salvachua, Davinia, Smith, Holly, Black, Brenna A., Dowe, Nancy, Beckham, Gregg T., and Nicol, Willie. Sat .
"Continuous Succinic Acid Production by Actinobacillus succinogenes on Xylose-Enriched Hydrolysate". United States. doi:10.1186/s13068-015-0363-3. https://www.osti.gov/servlets/purl/1233689.
@article{osti_1233689,
title = {Continuous Succinic Acid Production by Actinobacillus succinogenes on Xylose-Enriched Hydrolysate},
author = {Bradfield, Michael F. A. and Mohagheghi, Ali and Salvachua, Davinia and Smith, Holly and Black, Brenna A. and Dowe, Nancy and Beckham, Gregg T. and Nicol, Willie},
abstractNote = {Bio-manufacturing of high-value chemicals in parallel to renewable biofuels has the potential to dramatically improve the overall economic landscape of integrated lignocellulosic biorefineries. However, this will require the generation of carbohydrate streams from lignocellulose in a form suitable for efficient microbial conversion and downstream processing appropriate to the desired end use, making overall process development, along with selection of appropriate target molecules, crucial to the integrated biorefinery. Succinic acid (SA), a high-value target molecule, can be biologically produced from sugars and has the potential to serve as a platform chemical for various chemical and polymer applications. However, the feasibility of microbial SA production at industrially relevant productivities and yields from lignocellulosic biorefinery streams has not yet been reported.},
doi = {10.1186/s13068-015-0363-3},
journal = {Biotechnology for Biofuels},
number = ,
volume = 8,
place = {United States},
year = {2015},
month = {11}
}
Free Publicly Available Full Text
Publisher's Version of Record
Other availability
Search WorldCat to find libraries that may hold this journal
Cited by: 19 works
Citation information provided by
Web of Science
Web of Science
Save to My Library
You must Sign In or Create an Account in order to save documents to your library.
Works referenced in this record:
Dilute-Sulfuric Acid Pretreatment of Corn Stover in Pilot-Scale Reactor: Investigation of Yields, Kinetics, and Enzymatic Digestibilities of Solids
journal, January 2003
- Schell, Daniel J.; Farmer, Jody; Newman, Millie
- Applied Biochemistry and Biotechnology, Vol. 105, Issue 1-3, p. 69-86
Succinic acid production from sugarcane bagasse hemicellulose hydrolysate by Actinobacillus succinogenes
journal, October 2010
- Borges, Elcio Ribeiro; Pereira, Nei
- Journal of Industrial Microbiology & Biotechnology, Vol. 38, Issue 8
Kinetic evaluation of products inhibition to succinic acid producers Escherichia coli NZN111, AFP111, BL21, and Actinobacillus succinogenes 130ZT
journal, June 2010
- Li, Qiang; Wang, Dan; Wu, Yong
- The Journal of Microbiology, Vol. 48, Issue 3
Advances in biofilm reactors for production of value-added products
journal, May 2010
- Cheng, Kuan-Chen; Demirci, Ali; Catchmark, Jeffrey M.
- Applied Microbiology and Biotechnology, Vol. 87, Issue 2
Succinic acid production with Actinobacillus succinogenes: rate and yield analysis of chemostat and biofilm cultures
journal, August 2014
- Brink, Hendrik Gideon; Nicol, Willie
- Microbial Cell Factories, Vol. 13, Issue 1
The biorefinery concept: Using biomass instead of oil for producing energy and chemicals
journal, July 2010
- Cherubini, Francesco
- Energy Conversion and Management, Vol. 51, Issue 7
Technology development for the production of biobased products from biorefinery carbohydrates—the US Department of Energy’s “Top 10” revisited
journal, January 2010
- Bozell, Joseph J.; Petersen, Gene R.
- Green Chemistry, Vol. 12, Issue 4, p. 539-554
A new process for the continuous production of succinic acid from glucose at high yield, titer, and productivity
journal, January 2007
- Meynial-Salles, Isabelle; Dorotyn, Sophie; Soucaille, Philippe
- Biotechnology and Bioengineering, Vol. 99, Issue 1, p. 129-135
Continuous succinic acid production by Actinobacillus succinogenes in a biofilm reactor: Steady-state metabolic flux variation
journal, April 2014
- Bradfield, M. F. A.; Nicol, W.
- Biochemical Engineering Journal, Vol. 85
Insights into Actinobacillus succinogenes Fermentative Metabolism in a Chemically Defined Growth Medium
journal, November 2005
- McKinlay, J. B.; Zeikus, J. G.; Vieille, C.
- Applied and Environmental Microbiology, Vol. 71, Issue 11
Batch and continuous cultures of Mannheimia succiniciproducens MBEL55E for the production of succinic acid from whey and corn steep liquor
journal, November 2003
- Lee, P. C.; Lee, S. Y.; Hong, S. H.
- Bioprocess and Biosystems Engineering, Vol. 26, Issue 1
Characterization of pilot-scale dilute acid pretreatment performance using deacetylated corn stover
journal, January 2014
- Shekiro III, Joseph; Kuhn, Erik M.; Nagle, Nicholas J.
- Biotechnology for Biofuels, Vol. 7, Issue 1
The impacts of deacetylation prior to dilute acid pretreatment on the bioethanol process
journal, January 2012
- Chen, Xiaowen; Shekiro, Joseph; Franden, Mary Ann
- Biotechnology for Biofuels, Vol. 5, Issue 1
Production of succinic acid from sugarcane molasses supplemented with a mixture of corn steep liquor powder and peanut meal as nitrogen sources by Actinobacillus succinogenes
journal, March 2015
- Shen, N.; Qin, Y.; Wang, Q.
- Letters in Applied Microbiology, Vol. 60, Issue 6
SignalP 4.0: discriminating signal peptides from transmembrane regions
journal, September 2011
- Petersen, Thomas Nordahl; Brunak, Søren; von Heijne, Gunnar
- Nature Methods, Vol. 8, Issue 10
Succinic Acid Production from Acid Hydrolysate of Corn Fiber by Actinobacillus succinogenes
journal, October 2008
- Chen, Kequan; Jiang, Min; Wei, Ping
- Applied Biochemistry and Biotechnology, Vol. 160, Issue 2
A complete industrial system for economical succinic acid production by Actinobacillus succinogenes
journal, May 2011
- Li, Jian; Zheng, Xiao-Yu; Fang, Xiao-Jiang
- Bioresource Technology, Vol. 102, Issue 10
A fibrous bed bioreactor to improve the productivity of succinic acid by Actinobacillus succinogenes : A fibrous bed bioreactor to improve the productivity
journal, December 2013
- Yan, Qiang; Zheng, Pu; Dong, Jin-Jun
- Journal of Chemical Technology & Biotechnology, Vol. 89, Issue 11
Biotechnology of succinic acid production and markets for derived industrial products
journal, May 1999
- Zeikus, J. G.; Jain, M. K.; Elankovan, P.
- Applied Microbiology and Biotechnology, Vol. 51, Issue 5
Continuous and batch cultures of Escherichia coli KJ134 for succinic acid fermentation: metabolic flux distributions and production characteristics
journal, January 2013
- van Heerden, Carel D.; Nicol, Willie
- Microbial Cell Factories, Vol. 12, Issue 1
Medium Evaluation and Plastic Composite Support Ingredient Selection for Biofilm Formation and Succinic Acid Production by Actinobacillus succinogenes
journal, January 2003
- Urbance, Susan E.; Pometto, Anthony L.; DiSpirito, Alan A.
- Food Biotechnology, Vol. 17, Issue 1
Fermentation of lignocellulosic hydrolysates. I: inhibition and detoxification
journal, August 2000
- Palmqvist, Eva; Hahn-Hägerdal, Bärbel
- Bioresource Technology, Vol. 74, Issue 1, p. 17-24
A low-cost solid–liquid separation process for enzymatically hydrolyzed corn stover slurries
journal, July 2015
- Sievers, David A.; Lischeske, James J.; Biddy, Mary J.
- Bioresource Technology, Vol. 187
Deconstruction of Lignocellulosic Biomass to Fuels and Chemicals
journal, July 2011
- Chundawat, Shishir P. S.; Beckham, Gregg T.; Himmel, Michael E.
- Annual Review of Chemical and Biomolecular Engineering, Vol. 2, Issue 1, p. 121-145
Succinic Acid: A New Platform Chemical for Biobased Polymers from Renewable Resources
journal, May 2008
- Bechthold, I.; Bretz, K.; Kabasci, S.
- Chemical Engineering & Technology, Vol. 31, Issue 5, p. 647-654
A genomic perspective on the potential of Actinobacillus succinogenes for industrial succinate production
journal, January 2010
- McKinlay, James B.; Laivenieks, Maris; Schindler, Bryan D.
- BMC Genomics, Vol. 11, Issue 1
Combining metabolic engineering and metabolic evolution to develop nonrecombinant strains of Escherichia coli C that produce succinate and malate
journal, January 2008
- Jantama, Kaemwich; Haupt, M. J.; Svoronos, Spyros A.
- Biotechnology and Bioengineering, Vol. 99, Issue 5, p. 1140-1153
Impact of corn stover composition on hemicellulose conversion during dilute acid pretreatment and enzymatic cellulose digestibility of the pretreated solids
journal, January 2010
- Weiss, Noah D.; Farmer, Joseph D.; Schell, Daniel J.
- Bioresource Technology, Vol. 101, Issue 2
Recent advances in production of succinic acid from lignocellulosic biomass
journal, November 2013
- Akhtar, Junaid; Idris, Ani; Abd. Aziz, Ramlan
- Applied Microbiology and Biotechnology, Vol. 98, Issue 3
Succinic acid-producing biofilms of Actinobacillus succinogenes: reproducibility, stability and productivity
journal, May 2014
- Maharaj, K.; Bradfield, M. F. A.; Nicol, W.
- Applied Microbiology and Biotechnology, Vol. 98, Issue 17
Succinic acid production by Actinobacillus succinogenes NJ113 using corn steep liquor powder as nitrogen source
journal, May 2013
- Xi, Yong-lan; Chen, Ke-quan; Dai, Wen-yu
- Bioresource Technology, Vol. 136
Process Design and Economics for the Conversion of Lignocellulosic Biomass to Hydrocarbons: Dilute-Acid and Enzymatic Deconstruction of Biomass to Sugars and Biological Conversion of Sugars to Hydrocarbons
report, October 2013
- Davis, R.; Tao, L.; Tan, E. C. D.
- NREL/TP-5100-60223
Environmental and physiological factors affecting the succinate product ratio during carbohydrate fermentation by Actinobacillus sp. 130Z
journal, May 1997
- der Werf, M. J. Van; Guettler, Michael V.; Jain, Mahendra K.
- Archives of Microbiology, Vol. 167, Issue 6
Cereal-based biorefinery development: Utilisation of wheat milling by-products for the production of succinic acid
journal, August 2009
- Dorado, M. Pilar; Lin, Sze Ki Carol; Koutinas, Apostolis
- Journal of Biotechnology, Vol. 143, Issue 1
Towards large scale fermentative production of succinic acid
journal, December 2014
- Jansen, Mickel LA; van Gulik, Walter M.
- Current Opinion in Biotechnology, Vol. 30
Fermentative production of succinic acid from straw hydrolysate by Actinobacillus succinogenes
journal, April 2009
- Zheng, Pu; Dong, Jin-Jun; Sun, Zhi-Hao
- Bioresource Technology, Vol. 100, Issue 8
Optimization of succinic acid production from cane molasses by Actinobacillus succinogenes GXAS137 using response surface methodology (RSM)
journal, December 2014
- Shen, Naikun; Wang, Qingyan; Qin, Yan
- Food Science and Biotechnology, Vol. 23, Issue 6
Respiratory glycerol metabolism of Actinobacillus succinogenes 130Z for succinate production
journal, July 2014
- Schindler, Bryan D.; Joshi, Rajasi V.; Vieille, Claire
- Journal of Industrial Microbiology & Biotechnology, Vol. 41, Issue 9
Prospects for a bio-based succinate industry
journal, July 2007
- McKinlay, James B.; Vieille, C.; Zeikus, J. Gregory
- Applied Microbiology and Biotechnology, Vol. 76, Issue 4
Determining Actinobacillus succinogenes metabolic pathways and fluxes by NMR and GC-MS analyses of 13C-labeled metabolic product isotopomers
journal, March 2007
- McKinlay, James B.; Shachar-Hill, Yair; Zeikus, J. Gregory
- Metabolic Engineering, Vol. 9, Issue 2
A wheat biorefining strategy based on solid-state fermentation for fermentative production of succinic acid
journal, November 2008
- Du, Chenyu; Lin, Sze Ki Carol; Koutinas, Apostolis
- Bioresource Technology, Vol. 99, Issue 17
Isolation and characterization of a new succinic acid-producing bacterium, Mannheimia succiniciproducens MBEL55E, from bovine rumen
journal, April 2002
- Lee, S. Lee, S. Hong, H. Chang, P.
- Applied Microbiology and Biotechnology, Vol. 58, Issue 5
Succinic acid production by Actinobacillus succinogenes using hydrolysates of spent yeast cells and corn fiber
journal, January 2011
- Chen, Ke-Quan; Li, Jian; Ma, Jiang-Feng
- Bioresource Technology, Vol. 102, Issue 2
Biocommodity Engineering
journal, October 1999
- Lynd, L. R.; Wyman, C. E.; Gerngross, T. U.
- Biotechnology Progress, Vol. 15, Issue 5
Continuous Production of Succinic Acid Using an External Membrane Cell Recycle System
journal, November 2009
- Kim, Moon Il
- Journal of Microbiology and Biotechnology, Vol. 19, Issue 11
Succinic acid production from wheat using a biorefining strategy
journal, July 2007
- Du, Chenyu; Lin, Sze Ki Carol; Koutinas, Apostolis
- Applied Microbiology and Biotechnology, Vol. 76, Issue 6
Evaluation of succinic acid continuous and repeat-batch biofilm fermentation by Actinobacillus succinogenes using plastic composite support bioreactors
journal, June 2004
- Urbance, Susan E.; Pometto, Anthony L.; DiSpirito, Alan A.
- Applied Microbiology and Biotechnology, Vol. 65, Issue 6
Ultrasonic pretreatment and acid hydrolysis of sugarcane bagasse for succinic acid production using Actinobacillus succinogenes
journal, May 2013
- Xi, Yong-lan; Dai, Wen-yu; Xu, Rong
- Bioprocess and Biosystems Engineering, Vol. 36, Issue 11
Substrate and product inhibition kinetics in succinic acid production by Actinobacillus succinogenes
journal, September 2008
- Lin, Sze Ki Carol; Du, Chenyu; Koutinas, Apostolis
- Biochemical Engineering Journal, Vol. 41, Issue 2
Effects of Growth Mode and Pyruvate Carboxylase on Succinic Acid Production by Metabolically Engineered Strains of Escherichia coli
journal, April 2002
- Vemuri, G. N.; Eiteman, M. A.; Altman, E.
- Applied and Environmental Microbiology, Vol. 68, Issue 4
High Xylose Yields from Dilute Acid Pretreatment of Corn Stover Under Process-Relevant Conditions
journal, January 2009
- Weiss, Noah D.; Nagle, Nicholas J.; Tucker, Melvin P.
- Applied Biochemistry and Biotechnology, Vol. 155, Issue 1-3
Economical succinic acid production from cane molasses by Actinobacillus succinogenes
journal, April 2008
- Liu, Yu-Peng; Zheng, Pu; Sun, Zhi-Hao
- Bioresource Technology, Vol. 99, Issue 6
Improved Xylan Hydrolysis of Corn Stover by Deacetylation with High Solids Dilute Acid Pretreatment
journal, December 2011
- Chen, Xiaowen; Shekiro, Joseph; Elander, Rick
- Industrial & Engineering Chemistry Research, Vol. 51, Issue 1
Continuous succinic acid fermentation by Actinobacillus succinogenes
journal, April 2013
- van Heerden, C. D.; Nicol, W.
- Biochemical Engineering Journal, Vol. 73
Succinic acid production on xylose-enriched biorefinery streams by Actinobacillus succinogenes in batch fermentation
journal, February 2016
- Salvachúa, Davinia; Mohagheghi, Ali; Smith, Holly
- Biotechnology for Biofuels, Vol. 9, Issue 1
Actinobacillus succinogenes sp. nov., a novel succinic-acid-producing strain from the bovine rumen
journal, January 1999
- Guettler, M. V.; Rumler, D.; Jain, M. K.
- International Journal of Systematic Bacteriology, Vol. 49, Issue 1
Metabolic engineering of Escherichia coli to minimize byproduct formate and improving succinate productivity through increasing NADH availability by heterologous expression of NAD+-dependent formate dehydrogenase
journal, November 2013
- Balzer, Grant J.; Thakker, Chandresh; Bennett, George N.
- Metabolic Engineering, Vol. 20
Analysis of biodegradation performance of furfural and 5-hydroxymethylfurfural by Amorphotheca resinae ZN1
journal, January 2014
- Ran, Hong; Zhang, Jian; Gao, Qiuqiang
- Biotechnology for Biofuels, Vol. 7, Issue 1
Fermentation process for continuous production of succinic acid in a fibrous bed bioreactor
journal, October 2014
- Yan, Qiang; Zheng, Pu; Tao, Sheng-Tao
- Biochemical Engineering Journal, Vol. 91
Works referencing / citing this record:
Metabolic engineering of Escherichia coli to produce succinate from woody hydrolysate under anaerobic conditions
journal, January 2020
- Zhu, Fayin; Wang, Chengqiang; San, Ka-Yiu
- Journal of Industrial Microbiology & Biotechnology, Vol. 47, Issue 2
Organic acids as antimicrobial food agents: applications and microbial productions
journal, November 2019
- Coban, Hasan Bugra
- Bioprocess and Biosystems Engineering, Vol. 43, Issue 4
From second generation feed-stocks to innovative fermentation and downstream techniques for succinic acid production
journal, October 2019
- Mancini, Enrico; Mansouri, Seyed Soheil; Gernaey, Krist V.
- Critical Reviews in Environmental Science and Technology, Vol. 50, Issue 18
Metabolic Engineering of Actinobacillus succinogenes Provides Insights into Succinic Acid Biosynthesis
journal, June 2017
- Guarnieri, Michael T.; Chou, Yat-Chen; Salvachúa, Davinia
- Applied and Environmental Microbiology, Vol. 83, Issue 17
Opportunities, challenges, and future perspectives of succinic acid production by Actinobacillus succinogenes
journal, September 2018
- Dessie, Wubliker; Xin, Fengxue; Zhang, Wenming
- Applied Microbiology and Biotechnology, Vol. 102, Issue 23
Improved succinate production from galactose‐rich feedstocks by engineered Escherichia coli under anaerobic conditions
journal, January 2020
- Zhu, Fayin; San, Ka‐Yiu; Bennett, George N.
- Biotechnology and Bioengineering, Vol. 117, Issue 4
Bio‐based succinic acid: an overview of strain development, substrate utilization, and downstream purification
journal, November 2019
- Dai, Zhongxue; Guo, Feng; Zhang, Shangjie
- Biofuels, Bioproducts and Biorefining, Vol. 14, Issue 5
Homogeneous solid dispersion (HSD) system for rapid and stable production of succinic acid from lignocellulosic hydrolysate
journal, September 2018
- Luthfi, Abdullah Amru Indera; Tan, Jian Ping; Harun, Shuhaida
- Bioprocess and Biosystems Engineering, Vol. 42, Issue 1
Process design and economic evaluation of integrated, multi‐product biorefineries for the co‐production of bio‐energy, succinic acid, and polyhydroxybutyrate (PHB) from sugarcane bagasse and trash lignocelluloses
journal, December 2018
- Nieder‐Heitmann, Mieke; Haigh, Kathleen; Görgens, Johann F.
- Biofuels, Bioproducts and Biorefining, Vol. 13, Issue 3