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Title: Dosage compensation can buffer copy-number variation in wild yeast

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OSTI ID: 1227972
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Published Article
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Additional Journal Information:
Journal Name: eLife Journal Volume: 4; Journal ID: ISSN 2050-084X
eLife Sciences Publications, Ltd.
Country of Publication:
United States

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None, None. Dosage compensation can buffer copy-number variation in wild yeast. United States: N. p., 2015. Web. doi:10.7554/eLife.05462.
None, None. Dosage compensation can buffer copy-number variation in wild yeast. United States. doi:10.7554/eLife.05462.
None, None. Fri . "Dosage compensation can buffer copy-number variation in wild yeast". United States. doi:10.7554/eLife.05462.
title = {Dosage compensation can buffer copy-number variation in wild yeast},
author = {None, None},
abstractNote = {},
doi = {10.7554/eLife.05462},
journal = {eLife},
number = ,
volume = 4,
place = {United States},
year = {2015},
month = {5}

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DOI: 10.7554/eLife.05462

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Cited by: 29 works
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Works referenced in this record:

Expression divergence between duplicate genes
journal, November 2005

Adaptive Downregulation of Mitochondrial Function in Down Syndrome
journal, January 2013

Aneuploidy Underlies Rapid Adaptive Evolution of Yeast Cells Deprived of a Conserved Cytokinesis Motor
journal, November 2008

Genome-wide expression studies in Autism spectrum disorder, Rett syndrome, and Down syndrome
journal, January 2012

  • Lintas, Carla; Sacco, Roberto; Persico, Antonio M.
  • Neurobiology of Disease, Vol. 45, Issue 1
  • DOI: 10.1016/j.nbd.2010.11.010

Phosphorylation network rewiring by gene duplication
journal, January 2011

  • Freschi, Luca; Courcelles, Mathieu; Thibault, Pierre
  • Molecular Systems Biology, Vol. 7, Issue 1
  • DOI: 10.1038/msb.2011.43

Chromosome 21 and Down syndrome: from genomics to pathophysiology
journal, October 2004

  • Antonarakis, Stylianos E.; Lyle, Robert; Dermitzakis, Emmanouil T.
  • Nature Reviews Genetics, Vol. 5, Issue 10
  • DOI: 10.1038/nrg1448

A dynamic model of proteome changes reveals new roles for transcript alteration in yeast
journal, January 2011

  • Lee, M. Violet; Topper, Scott E.; Hubler, Shane L.
  • Molecular Systems Biology, Vol. 7, Issue 1
  • DOI: 10.1038/msb.2011.48

Effects of Aneuploidy on Cellular Physiology and Cell Division in Haploid Yeast
journal, August 2007

Expression in Aneuploid Drosophila S2 Cells
journal, February 2010

Control of Transcription by Cell Size
journal, November 2010

Precise estimates of mutation rate and spectrum in yeast
journal, May 2014

  • Zhu, Y. O.; Siegal, M. L.; Hall, D. W.
  • Proceedings of the National Academy of Sciences, Vol. 111, Issue 22
  • DOI: 10.1073/pnas.1323011111

Fast and accurate short read alignment with Burrows-Wheeler transform
journal, May 2009

Variations in Stress Sensitivity and Genomic Expression in Diverse S. cerevisiae Isolates
journal, October 2008

The Repertoire and Dynamics of Evolutionary Adaptations to Controlled Nutrient-Limited Environments in Yeast
journal, December 2008

Trimmomatic: a flexible trimmer for Illumina sequence data
journal, April 2014

Mitochondrial dysfunction as a central actor in intellectual disability-related diseases: An overview of Down syndrome, autism, Fragile X and Rett syndrome
journal, October 2014

Altered expression of mitochondrial and extracellular matrix genes in the heart of human fetuses with chromosome 21 trisomy
journal, January 2007

Ribosomal protein L32 of Saccharomyces cerevisiae influences both the splicing of its own transcript and the processing of rRNA.
journal, April 1997

  • Vilardell, J.; Warner, J. R.
  • Molecular and Cellular Biology, Vol. 17, Issue 4
  • DOI: 10.1128/MCB.17.4.1959

Effects of genome-wide copy number variation on expression in mammalian cells
journal, November 2011

Identification of Aneuploidy-Tolerating Mutations
journal, October 2010

Pathway connectivity and signaling coordination in the yeast stress‐activated signaling network
journal, November 2014

  • Chasman, Deborah; Ho, Yi‐Hsuan; Berry, David B.
  • Molecular Systems Biology, Vol. 10, Issue 11
  • DOI: 10.15252/msb.20145120

Understanding the Basis for Down Syndrome Phenotypes
journal, January 2006

Genetic Properties Influencing the Evolvability of Gene Expression
journal, July 2007

Aneuploidy underlies a multicellular phenotypic switch
journal, June 2013

  • Tan, Z.; Hays, M.; Cromie, G. A.
  • Proceedings of the National Academy of Sciences, Vol. 110, Issue 30
  • DOI: 10.1073/pnas.1301047110

Quantitative proteomic analysis reveals posttranslational responses to aneuploidy in yeast
journal, July 2014

“Changing by doubling”, the impact of Whole Genome Duplications in the evolution of eukaryotes
journal, February 2009

  • Jaillon, Olivier; Aury, Jean-Marc; Wincker, Patrick
  • Comptes Rendus Biologies, Vol. 332, Issue 2-3
  • DOI: 10.1016/j.crvi.2008.07.007

The Gene Balance Hypothesis: From Classical Genetics to Modern Genomics
journal, February 2007

Natural Gene-Expression Variation in Down Syndrome Modulates the Outcome of Gene-Dosage Imbalance
journal, August 2007

  • Prandini, Paola; Deutsch, Samuel; Lyle, Robert
  • The American Journal of Human Genetics, Vol. 81, Issue 2
  • DOI: 10.1086/519248

Natural Variation in the Yeast Glucose-Signaling Network Reveals a New Role for the Mig3p Transcription Factor
journal, December 2012

  • Lewis, Jeffrey A.; Gasch, Audrey P.
  • G3: Genes|Genomes|Genetics, Vol. 2, Issue 12
  • DOI: 10.1534/g3.112.004127

Population genomics of domestic and wild yeasts
journal, February 2009

  • Liti, Gianni; Carter, David M.; Moses, Alan M.
  • Nature, Vol. 458, Issue 7236
  • DOI: 10.1038/nature07743

Identification of dosage-sensitive genes in Saccharomyces cerevisiae using the genetic tug-of-war method
journal, December 2012

The evolutionary dynamics of the Saccharomyces cerevisiae protein interaction network after duplication
journal, January 2008

  • Presser, A.; Elowitz, M. B.; Kellis, M.
  • Proceedings of the National Academy of Sciences, Vol. 105, Issue 3
  • DOI: 10.1073/pnas.0707293105

Incipient Balancing Selection through Adaptive Loss of Aquaporins in Natural Saccharomyces cerevisiae Populations
journal, April 2010

Dynamic Large-Scale Chromosomal Rearrangements Fuel Rapid Adaptation in Yeast Populations
journal, January 2013

A framework for variation discovery and genotyping using next-generation DNA sequencing data
journal, April 2011

  • DePristo, Mark A.; Banks, Eric; Poplin, Ryan
  • Nature Genetics, Vol. 43, Issue 5
  • DOI: 10.1038/ng.806

Aneuploidy confers quantitative proteome changes and phenotypic variation in budding yeast
journal, October 2010

  • Pavelka, Norman; Rancati, Giulia; Zhu, Jin
  • Nature, Vol. 468, Issue 7321
  • DOI: 10.1038/nature09529

Transcriptional consequences of aneuploidy
journal, July 2012

  • Sheltzer, J. M.; Torres, E. M.; Dunham, M. J.
  • Proceedings of the National Academy of Sciences, Vol. 109, Issue 31
  • DOI: 10.1073/pnas.1209227109

Chromosomal duplication is a transient evolutionary solution to stress
journal, November 2012

  • Yona, A. H.; Manor, Y. S.; Herbst, R. H.
  • Proceedings of the National Academy of Sciences, Vol. 109, Issue 51
  • DOI: 10.1073/pnas.1211150109

Characteristic genome rearrangements in experimental evolution of Saccharomyces cerevisiae
journal, November 2002

  • Dunham, M. J.; Badrane, H.; Ferea, T.
  • Proceedings of the National Academy of Sciences, Vol. 99, Issue 25
  • DOI: 10.1073/pnas.242624799

The Characterisation of Three Types of Genes that Overlie Copy Number Variable Regions
journal, May 2011

Redundancy and rewiring of genetic networks following genome-wide duplication events
journal, April 2012

Hsp90 stress potentiates rapid cellular adaptation through induction of aneuploidy
journal, January 2012

  • Chen, Guangbo; Bradford, William D.; Seidel, Chris W.
  • Nature, Vol. 482, Issue 7384
  • DOI: 10.1038/nature10795

New Insights into the Troubles of Aneuploidy
journal, November 2012

Rapid evolution of expression and regulatory divergences after yeast gene duplication
journal, January 2005

  • Gu, X.; Zhang, Z.; Huang, W.
  • Proceedings of the National Academy of Sciences, Vol. 102, Issue 3
  • DOI: 10.1073/pnas.0409186102

edgeR: a Bioconductor package for differential expression analysis of digital gene expression data
journal, November 2009

Eucaryotic genome evolution through the spontaneous duplication of large chromosomal segments
journal, December 2003

HTSeq--a Python framework to work with high-throughput sequencing data
journal, September 2014

Bacterial gene amplification: implications for the evolution of antibiotic resistance
journal, August 2009

  • Sandegren, Linus; Andersson, Dan I.
  • Nature Reviews Microbiology, Vol. 7, Issue 8
  • DOI: 10.1038/nrmicro2174

Integrative phenomics reveals insight into the structure of phenotypic diversity in budding yeast
journal, May 2013

  • Skelly, D. A.; Merrihew, G. E.; Riffle, M.
  • Genome Research, Vol. 23, Issue 9
  • DOI: 10.1101/gr.155762.113

Duplicate genes increase gene expression diversity within and between species
journal, May 2004

  • Gu, Zhenglong; Rifkin, Scott A.; White, Kevin P.
  • Nature Genetics, Vol. 36, Issue 6
  • DOI: 10.1038/ng1355

A general lack of compensation for gene dosage in yeast
journal, January 2010

  • Springer, Michael; Weissman, Jonathan S.; Kirschner, Marc W.
  • Molecular Systems Biology, Vol. 6, Issue 1
  • DOI: 10.1038/msb.2010.19

Comparative genomics of wild type yeast strains unveils important genome diversity
journal, January 2008

Inventory control: cytochrome c oxidase assembly regulates mitochondrial translation
journal, December 2010

  • Mick, David U.; Fox, Thomas D.; Rehling, Peter
  • Nature Reviews Molecular Cell Biology, Vol. 12, Issue 1
  • DOI: 10.1038/nrm3029

Growth Rates Made Easy
journal, October 2013

  • Hall, B. G.; Acar, H.; Nandipati, A.
  • Molecular Biology and Evolution, Vol. 31, Issue 1
  • DOI: 10.1093/molbev/mst187

Up-to-date catalogues of yeast protein complexes
journal, December 2008

  • Pu, Shuye; Wong, Jessica; Turner, Brian
  • Nucleic Acids Research, Vol. 37, Issue 3
  • DOI: 10.1093/nar/gkn1005

Dosage Sensitivity Shapes the Evolution of Copy-Number Varied Regions
journal, March 2010

Evidence for Domesticated and Wild Populations of Saccharomyces cerevisiae
journal, January 2005

Widespread aneuploidy revealed by DNA microarray expression profiling
journal, July 2000

  • Hughes, Timothy R.; Roberts, Christopher J.; Dai, Hongyue
  • Nature Genetics, Vol. 25, Issue 3
  • DOI: 10.1038/77116

Aneuploidy and Isochromosome Formation in Drug-Resistant Candida albicans
journal, July 2006

Yeast mitochondrial NAD + -dependent isocitrate dehydrogenase is an RNA-binding protein
journal, January 1993

  • Elzinga, Sandra D. J.; Bednarz, Amy L.; van Oosterum, Katinka
  • Nucleic Acids Research, Vol. 21, Issue 23
  • DOI: 10.1093/nar/21.23.5328

Copy-Number Variation: The Balance between Gene Dosage and Expression in Drosophila melanogaster
journal, January 2011

  • Zhou, Jun; Lemos, Bernardo; Dopman, Erik B.
  • Genome Biology and Evolution, Vol. 3
  • DOI: 10.1093/gbe/evr023

Exploiting Natural Variation in Saccharomyces cerevisiae to Identify Genes for Increased Ethanol Resistance
journal, September 2010

Genome and gene duplications and gene expression divergence: a view from plants: Gene duplication and expression divergence
journal, May 2012

CYP6 P450 Enzymes and ACE-1 Duplication Produce Extreme and Multiple Insecticide Resistance in the Malaria Mosquito Anopheles gambiae
journal, March 2014

Local climatic adaptation in a widespread microorganism
journal, February 2014

  • Leducq, Jean-Baptiste; Charron, Guillaume; Samani, Pedram
  • Proceedings of the Royal Society B: Biological Sciences, Vol. 281, Issue 1777
  • DOI: 10.1098/rspb.2013.2472