Biomarkers of Radiosensitivity in A-Bomb Survivors Pregnant at the Time of Bombings in Hiroshima and Nagasaki

Miles, Edward F.; Tatsukawa, Yoshimi; Funamoto, Sachiyo; Kamada, Naoko; Nakashima, Eiji; Kodama, Yoshiaki; Seed, Thomas; Kusonoki, Yoichiro; Nakachi, Kei; Fujiwara, Saeko; Akahoshi, Masazumi; Neriishi, Kazuo

doi:10.5402/2011/264978

Title: Biomarkers of Radiosensitivity in A-Bomb Survivors Pregnant at the Time of Bombings in Hiroshima and Nagasaki

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Abstract

Purpose . There is evidence in the literature of increased maternal radiosensitivity during pregnancy. Materials and Methods . We tested this hypothesis using information from the atomic-bomb survivor cohort, that is, the Adult Health Study database at the Radiation Effects Research Foundation, which contains data from a cohort of women who were pregnant at the time of the bombings of Hiroshima and Nagasaki. Previous evaluation has demonstrated long-term radiation dose-response effects. Results/Conclusions . Data on approximately 250 women were available to assess dose-response rates for serum cholesterol, white blood cell count, erythrocyte sedimentation rate, and serum hemoglobin, and on approximately 85 women for stable chromosome aberrations, glycophorin A locus mutations, and naïve CD4 T-cell counts. Although there is no statistically significant evidence of increased radiosensitivity in pregnant women, the increased slope of the linear trend line in the third trimester with respect to stable chromosome aberrations is suggestive of an increased radiosensitivity.

Authors:

Miles, Edward F. ^[1]; Tatsukawa, Yoshimi ^[2]; Funamoto, Sachiyo ^[3]; Kamada, Naoko ^[3]; Nakashima, Eiji ^[3]; Kodama, Yoshiaki ^[4]; Seed, Thomas ^[5]; Kusonoki, Yoichiro ^[6]; Nakachi, Kei ^[6]; Fujiwara, Saeko ^[2]; Akahoshi, Masazumi ^[7]; Neriishi, Kazuo ^[2]

Division of Radiation Oncology, Department of Radiology, Naval Medical Center Portsmouth, 620 John Paul Jones Circle, Portsmouth, VA 23314, USA
Department of Clinical Studies (Hiroshima), Radiation Effects Research Foundation (RERF), 5-2 Hijiyama Park, Minami-ku, Hiroshima City, Japan
Department of Statistics, RERF, 5-2 Hijiyama Park, Minami-ku, Hiroshima City, Japan
Department of Genetics, RERF, 5-2 Hijiyama Park, Minami-ku, Hiroshima City, Japan
Associate Chief of Research, RERF, 5-2 Hijiyama Park, Minami-ku, Hiroshima City, Japan
Department of Radiation Biology/Molecular Epidemiology, RERF, 5-2 Hijiyama Park, Minami-ku, Hiroshima City, Japan
Department of Clinical Studies (Nagasaki), RERF, 8-6 Nakagawa 1-chome, Nagasaki City, Japan

Publication Date:: Sat Jan 01 00:00:00 EST 2011

Sponsoring Org.:: USDOE

OSTI Identifier:: 1198184

Resource Type:: Published Article

Journal Name:: ISRN Obstetrics and Gynecology

Additional Journal Information:: Journal Name: ISRN Obstetrics and Gynecology Journal Volume: 2011; Journal ID: ISSN 2090-4436

Publisher:: Hindawi (International Scholarly Research Network)

Country of Publication:: Country unknown/Code not available

Language:: English

Citation Formats


                    Miles, Edward F., Tatsukawa, Yoshimi, Funamoto, Sachiyo, Kamada, Naoko, Nakashima, Eiji, Kodama, Yoshiaki, Seed, Thomas, Kusonoki, Yoichiro, Nakachi, Kei, Fujiwara, Saeko, Akahoshi, Masazumi, and Neriishi, Kazuo. Biomarkers of Radiosensitivity in A-Bomb Survivors Pregnant at the Time of Bombings in Hiroshima and Nagasaki.  Country unknown/Code not available: N. p., 2011. 
Web.  doi:10.5402/2011/264978.

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                    Miles, Edward F., Tatsukawa, Yoshimi, Funamoto, Sachiyo, Kamada, Naoko, Nakashima, Eiji, Kodama, Yoshiaki, Seed, Thomas, Kusonoki, Yoichiro, Nakachi, Kei, Fujiwara, Saeko, Akahoshi, Masazumi, & Neriishi, Kazuo. Biomarkers of Radiosensitivity in A-Bomb Survivors Pregnant at the Time of Bombings in Hiroshima and Nagasaki.  Country unknown/Code not available.  https://doi.org/10.5402/2011/264978

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                    Miles, Edward F., Tatsukawa, Yoshimi, Funamoto, Sachiyo, Kamada, Naoko, Nakashima, Eiji, Kodama, Yoshiaki, Seed, Thomas, Kusonoki, Yoichiro, Nakachi, Kei, Fujiwara, Saeko, Akahoshi, Masazumi, and Neriishi, Kazuo. Sat .  
"Biomarkers of Radiosensitivity in A-Bomb Survivors Pregnant at the Time of Bombings in Hiroshima and Nagasaki".  Country unknown/Code not available.  https://doi.org/10.5402/2011/264978.

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@article{osti_1198184,

  title        = {Biomarkers of Radiosensitivity in A-Bomb Survivors Pregnant at the Time of Bombings in Hiroshima and Nagasaki},

  author       = {Miles, Edward F. and Tatsukawa, Yoshimi and Funamoto, Sachiyo and Kamada, Naoko and Nakashima, Eiji and Kodama, Yoshiaki and Seed, Thomas and Kusonoki, Yoichiro and Nakachi, Kei and Fujiwara, Saeko and Akahoshi, Masazumi and Neriishi, Kazuo},

  abstractNote = {Purpose . There is evidence in the literature of increased maternal radiosensitivity during pregnancy. Materials and Methods . We tested this hypothesis using information from the atomic-bomb survivor cohort, that is, the Adult Health Study database at the Radiation Effects Research Foundation, which contains data from a cohort of women who were pregnant at the time of the bombings of Hiroshima and Nagasaki. Previous evaluation has demonstrated long-term radiation dose-response effects. Results/Conclusions . Data on approximately 250 women were available to assess dose-response rates for serum cholesterol, white blood cell count, erythrocyte sedimentation rate, and serum hemoglobin, and on approximately 85 women for stable chromosome aberrations, glycophorin A locus mutations, and naïve CD4 T-cell counts. Although there is no statistically significant evidence of increased radiosensitivity in pregnant women, the increased slope of the linear trend line in the third trimester with respect to stable chromosome aberrations is suggestive of an increased radiosensitivity.},

  doi          = {10.5402/2011/264978},

  journal      = {ISRN Obstetrics and Gynecology},

  number       = ,

  volume       = 2011,

  place        = {Country unknown/Code not available},

  year         = {Sat Jan 01 00:00:00 EST 2011},

  month        = {Sat Jan 01 00:00:00 EST 2011}

}

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