Proteinuria in Hiroshima and Nagasaki atomic bomb survivors (in Japanese and English)
A study of the epidemiology of proteinuria was conducted on about 5000 persons comprising a portion of the clinical sample under study at the Atomic Bomb Casualty Commission. In addition, data from previous examinations of similar samples were analyzed. Proteinuria was more common in Hiroshima than in Nagasaki. The rates for men and women did not differ within cities. Age-specific rates of proteinuria were peculiar, peaking in adolescence and old age. In the subjects under study proteinuria was frequently inconstant and usually represented excretion of less than 1.0 g of protein per day. Prior exposure to radiation as measured by distance from the hypocenter was correlated with increased proteinuria rates in 18-year-old subjects who were in utero ATB. Subjects exposed after birth did not show this tendency. It is unsettled whether radiation results in renal disease by increasing the subject's susceptibility to the usual causes of glomerulonephritis or by some more direct mechanism. Persons with proteinuria had higher mean blood pressures and serum urea nitrogen levels than controls and had other findings indicative of generalized cardiovascular-renal disease. Persons with thyroid disease had an increased risk of proteinuria whereas the converse was true of those with a history of treatment for peptic ulcer. Many other factors were tested for a relation to proteinuria, including family history of renal disease, socioeconomic status, urinary symptoms, ingestion of medications, physical findings, hemoglobin levels, height, weight, ABO blood groups, audiometry, vibrometry, and serum cholesterol levels. Although urinary symptoms were more common in persons with proteinuria, the findings in other areas were not sufficiently different to suggest meaningful relations. 20 references, 2 figures, 13 tables.
- Research Organization:
- Atomic Bomb Casualty Commission, Hiroshima (Japan)
- DOE Contract Number:
- AC01-76EV03081
- OSTI ID:
- 5239561
- Report Number(s):
- ABCC-TR-22-66; ON: DE84008143
- Country of Publication:
- United States
- Language:
- Japanese and English
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A-BOMB SURVIVORS
UROGENITAL SYSTEM DISEASES
EPIDEMIOLOGY
AGE DEPENDENCE
BLOOD PRESSURE
DATA COMPILATION
DELAYED RADIATION EFFECTS
DOSE-RESPONSE RELATIONSHIPS
HIROSHIMA
NAGASAKI
PROTEINS
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BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL WASTES
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JAPAN
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560151* - Radiation Effects on Animals- Man
560161 - Radionuclide Effects
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